아태지역 무선통신 표준화 동향 및 향후 대응 방향

정용준(Yong-Jun Chung),김대중(Dae-Jung Kim),박주홍(Joo-Hong Park),하준홍(Joon Hong Ha),김남경(Nam-Kyoung Kim),진병문(Byoung-Moon Chin) 한국통신학회 2011 한국통신학회 학술대회논문집 Vol.2011 No.2

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

한국인에서 Lipoprotein lipase gene polymorphism의 빈도와 혈관질환과의 관계

정준용,박소영,김제,성인환,김영건,전은석 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

Background : Lipoprotein lipase(LPL) is a key enzyme in the metabolism of serum triglycerides(TG) which is utilized in the peripheral tissue as free fatty acid and stored in adipose tissue. LPL gene is consisted of 10 exons which encode 475 amino acids and over 9 LPL gene polymorphisms have been reported. It's polymorphisms are related to the lipid levels and the severity of atherosclerosis in the coronary artery disease. In Korea, LPL polymorphisms has not been reported yet. This study is purposed on the incidences of LPL gene mutations and on it's relationships with blood lipid levels and the severity of atherosclerosis. Methods : Our subjects were consisted of three groups, normal controls(n=50), coronary artery disease(CAD, n=51) and cerebrovascular disease(CVD, n=52). The PCR amplified genomic DNA from peripheral white blood cell were analyzed with restriction fragment length polymorphisms (RFLP by two different restriction enzyme(PVU II, Hind III). Results : Total cholesterol(TC) were higher in CVD than in controls and in CAD (203±60mg/ dl vs 188±37, 167±42, p<0.01). Triglyceride(TG) were also elevated in CAD(166±65mg/dl vs 122±62 in controls, p<0.05). HDL cholesterol(HDL-C) were higher in controls than in CVD and CAD(49±9mg/dl vs 36±10, 44±9, p<0.05). The incidences of Hind III RFLP and PVU II RFLP has no differences among groups. Only HDL-C was elevated in Hind III RFLP(-/-) homozygotes. Conclusions : The LPL gene mutations in intron 6 and 8 have no direct effects on the lipid profiles and the severity of coronary artery disease. Although LPL is a key enzyme in TG metabolism, two mutations in this study could not change the activity of LPL, nor were not a marker of linked other site mutations. The mutation(s) in exon which encode amino acid for enzyme activity should be detected to analyze the pathophysiology of the atherogenesis.

Real-Time RT-PCR 기법을 이용한 사이토카인 유전자 발현의 정량분석

정준용 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

The analysis of cytokine profiles plays a central part in the characterization of disease-related inflammatory pathways and the identification of functional properties of immune cells, both for research and for clinical diagnosis. Because tissue biopsy samples are too small to allow the detection of cytokine protein, the detection of mRNA expression level by reverse transcription-polymerase chain reaction (RT-PCR) analysis is often used to investigate the cytokine profiles in inflammatory lesions. RT-PCR itself is a qualitative method, indicating the presence or absence of specific mRNA. The most widely accepted method is qualitative competitive RT-PCR, based on internal shortened standards. Recently, real-time RT-PCR has been introduced for quantitative analysis of cytokine expression profiles. The real-time RT-PCR is becoming widely used to quantify cytokines from cells, tissues, tissue biopsies or body fluids. Being a very powerful and sensitive method it can be used to quantify mRNA expression levels of cytokines, which are often very low in the tissues under investigation. The method allows for the direct detection of PCR product during the exponential phases of the reaction, combining amplification and detection in one single step. In the review, I discussed the principle of real-time RT-PCR, the different methodologies and chemistries available, the assets, and some of pitfalls. Also, validation for a large panel of human cytokines and other factors playing a role in the immune system is discussed in detail. In summary, the real-time RT-PCR technique is very accurate and sensitive, allows a high throughput, and can be performed on very small samples.

요통 환자에서 척추후지 내측지 고주파 열응고술의 효과

정용훈,임경준,이은영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

Background: A number of patients complain of lower back pain due to facet joint problems, and radiofrequency thermocoagulation (RFTC) of medial branches is known to be an effective method of relieving pain caused by the problems. However, objective outcome assessments for this modality are limited so far. Therefore, the authors investigated the effect of the RFTC on the low back pain. Methods: The object of this study was 25 patients who had facet joint syndrome and underwent RFTC. Pain relief was estimated at 2 weeks, 6 weeks, 3 months, and 6 months after the procedure using a visual analog scale (VAS), and was regarded to be successful if pain reduction exceeded 50% on the VAS at 6 weeks. Results: Seven of the 25 patients did not respond favorably to RFTC application and their pain reduction was less than 50%. Of the 18 patients who showed a successful response, 17 had a favorable result up to 3 months and 15 patients up to 6 months after the procedure. Conclusion: Our result showed that lumbar medial branch rhizotomy using RFTC, is an effective treatment modality for patients with lumbar facet joint syndrome, and showing a successful response its effect is maintained for at least 6 months after the procedure in most patients.

부산지방의 GPS 측량을 위한 삼각점 성과관리기법

정영미,장용구,강인준 釜山大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.50 No.-

GPS는 범지구적 위치결정장비로 그 정도가 아주 높고 활용범위도 광범위하기 때문에 전세계적으로 빠르게 확산되고 있는 실정이다. 그러나 GPS는 위치입력체계가 세계좌표인 WGS84 좌표를 사용하고 있고 BESSEL타원체로의 좌표변화시 동경원점을 기준으로 좌표변화이 이루어지기 때문에 우리나라에서 사용하기에는 어려움이 있다. 또한, 현재 우리나라의 삼각점 성과관리는 종이로 관리되고 있기 때문에 검색 및 수정, 보관에 있어서 비효율적이다. 본 연구는 GPS에 의해 결정된 WGS84좌표를 우리나라에 맞는 TM좌표로 변환하기 위하여 7-parameter를 결정하고 이타원체상수를 이용하여 GPS측량에 의한 성과의 정확한 변환좌표값을 생성하고 이 성과의 효율적인 관리를 위한 데이터베이스시스템을 구축하고자 한다. GPS(Gobal Positioning System) is fastly spreading to the world with higher accuracy and available for widely application. GPS, to be completed in 1990s, is widely used and can determine the position anywhere on earth with satellites which are four of total 24 on the six planes of altitude 20,200 Kilometers. But GPS is difficult to using our country because input system of position is WGS84(World Geodetic System 1984) of world coordinate, and of converting Bessel ellipsoid haved Tokyo's origin station. Also, management in triangulation station in our country is inefficiency at search, revision and storage of data because of using papers. This study is creating exactly converted coordinate value to using constant of ellipsoid after determined 7-parameter for converting to TM (Transverse Mercator) from WGS84.

수술후 경막외강에 주입한 ketamine의 진통효과에 관한 연구

정기호,조남수,임경준,유병식,정종달,김용일 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Author divided 60 patients who got lower abdomen or lower extremity surgical operation into three groups. Each group consisted of 20 patients. We injected ketamine 10㎎, 20㎎, and 30㎎ respectively into the epidural space when the patient complained of pain postoperatively and observed the postoperative analgesic effect of ketamine. Finally, we concluded the following : 1) The onset time of analgesic effect. : The analgesic effect appeared within 10 minutes in 3 groups and the significant difference among them was not seen. 2) The duration of analgesic effect : The duration of analgesia was relatively short with less than 1 hour on an average in all 3 groups and was not constant. 3) Cardiopulmonary system. : The significant change of blood pressure, pulse and respiratory rate was not seen in all three groups and and the difference among them also was not seen. 4) Side effects. : Sedative action(16%), nausea(10%), dizziness(5%), headache(3.3%) From above results, the epidural administration of ketamine is not suitable for postoperative pain management because of a lot of side effects as well as short and inconstant duration of analgesic effeet.

Resin-Modified Glass-lonomer와 Compomer의 경화 반응 특성의 비교에 관한 연구

엄정문,유현미,고용준 大韓齒科保存學會 2000 Restorative Dentistry & Endodontics Vol.25 No.1

칠절봉 신갈나무(Quercus mongolica)림의 군락구조와 토양환경

이호준,배병호,전영문,정흥락,홍문표,김용옥,길지현 建國大學校基礎科學硏究所 1998 理學論集 Vol.23 No.-

칠절봉 신갈나무림의 군락구조와 토양환경과의 관계를 파악하기 위해 식물사회학적 조사와 토양 환경을 분석하였다. 조사지역의 신갈나무림은 신갈나무군락, 철쭉꽃하위군, 큰개별꽃하위군으로 구분되었으며, 철쭉꽃하위군과 큰개별꽃하위군에서의 방형구당 평균출현종수는 각각 30종(24∼46종), 43종(31∼52종) 이었다. 피복지수치에 의한 계층별 우점순위는 교목층에서 신갈나무(6750.0), 아교목층에서 당단풍(2364.0) 관목층에서 철쭉꽃(988.5), 초본층에서 쌀새(1040.5)가 가장 높게 나타났다. 신갈 나무림의 DBH 분포는 2∼10㎝ 범위의 소경목이 전체의 29.7%를 차지하였으며 전체적으로 정규분포를 나타내어 교란 후 재생과정에 있는 것으로 조사되었다. 또한 후계목의 발달로 인한 극상상태로의 천이가 가능할 것으로 조사되었다. 전반적인 토양환경은 두 하위군 간에 뚜렷한 차이가 없었으며, 큰개별꽃하위군이 철쭉꽃하위군에 비하여 다소 양호한 것으로 조사되었다. 환경구배분석에서 까치박달, 물푸레나무, 함박꽃나무 등은 습한 곳에 분포하고 철쭉꽃, 전나무, 국수나무 등은 건조한 곳에 분포하는 것으로 나타났다. A relationship between the community structure composition and soil environmental factors of the Quercus mongolica forest on Mt. Chiljelbong was investigated from June 1996 to August 1997. The Q. mongolica community was classified into two subcommunity of Rhododendron schlippenbachii and Pseudostellaria palibiniana. The 30(24-46) species per quadrat were appeared in R. schlippenbachii subcommunity and 43(31-52)species in P. palibiniana subcommunity. The dominant sequences on each stratum determined by the coverage index showed that Q. mongolica was the most dominant in tree-1 layer with 6750.0, Acer pseudo-sieboldianum in tree-2 layer with 2364.0, R. schlippenbachii in shrub layer with 988.5, and Melica onoei in herb layer with 1040.5 value. The value of diameter breast height(DBH) showed a normal distribution displaying a highest value in the range of 2∼10㎝(29.7%) in Q. mongolica forest and it was investigated being at restoration phase after disturbance. It also was investigated that the succession to climax state would be possible due to growth of successive tree. Overall, which the soil conditions make little difference between two subcommunities, P. palibiniana subcommunity was favorable than those of R. schlippenbachii subcommunity. It was shown that in an environmental gradient analysis, Carpinus cordata, Fraxinus rhynchophylla, and Magnolia sieboldii were distributed in a mesic area, but R. schlippenbachii, Abies holophylla, and Stepanandra incisa in a xeric area.

시스틴 결석 : 증례 보고 A Case Report

이길용,노준,정충식 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.2

Cystine calculi is the consequence of cystinuria, an autosomal recessive defect of the transepithelial of cystine and dibasic acids in the kidney and intestine. The hardness and frequent reccurrence of cystine stones present a special challenge to the urologist. we report a case of 15-year-old man who had a cystine calculi, which was successfully treated with percutaneous lithotripsy (PCNL), extracorporeal shock wave lithotripsy (ESWL) &edical therapy include high fluid intake, alkalinization and chelating agent.