조기 위암의 조직 분화도에 따른 내시경적 육안 소견

김남재,이경태,김진희,송규상,이승민,정현용,김석현,노승무,이병석,조준식 대한소화기내시경학회 2000 Clinical Endoscopy Vol.20 No.2

Background/Aims : The aim of this study was to investigate the endoscopic findings of early gastric cancer according to histological differentiation. Methods : One hundred eight cases of early gastric cancer (EGC) which had been confirmed surgically over a 1 year and 7 month period, were studied to assess the relationship between histological differentiation and endoscopic findings. Results : All elevated types of EGC (41 cases) were found to be differentiated carcinoma. 48.2% (30/67 cases) of the depressed type EGC was determined to be differentiated carcinoma, while the others (51.8%) were undifferentiated carcinoma. Twenty-four of thirty cases with differentiated depressed type EGC showed a reddish discolored surface (80%), and the others manifested a whitish or mixed colored surface of red and white. In the undifferentiated depressed type EGC, 73% (27/37 cases) revealed a whitish or mixed colored surface, while the others (27%) showed a reddish discoloration. In the differentiated depressed type EGC, the character of the depressed surface was mainly regular and soft or fine granular (77%), while that of the undifferentiated cases appeared as uneven large granules (43.2%) or fine granules (43.2%), sclerotic (2.8%) and/or elevated (10.8%). The margin of the depressed type EGC with differentiated carcinoma was mainly of a shoaling beach type (83.3%), and that of the undifferentiated carcinoma was not uniform and existed as a cliff type (60%), Riasis coast type (11.4%) and shoaling beach type (28.6%). Conclusions : All elevated types of EGC showed differentiated types, and histological differentiation of depressed type EGC was macroscopically determined by the size of lesions, color, and character of the depressed surface and margin of the depression.

석면관련 폐질환의 진단에 있어서 흉부고해상도전산화단층촬영검사(HRCT)의 유용성

이현재,손지언,,홍영습,,이영일,예병진,유창훈,정갑열,김상훈,임형준,장은철,김정만,김준연 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 석면에 노출된 근로자에서 석면관련 폐질환의 양상을 분석하고 진단에 있어 HRCT의 유용성을 연구하여 석면에 대한 의학적 감시프로그램의 개발에 기여하고자 하였다. 방법: 석면에 직접 노출되는 작업자 68명과 간접 노출되는 작업자 94명 등 총 162명에 대해 OSHA 석면 표준, 의학적 감시 프로그램에 따라 단순 흉부방사선검사, 폐활량검사 및 우리나라 실정에 맞게 일부 수정한 의학적 설문지를 통해 면접조사의 방식으로 환자에 관한 정보를 수집하였으며, 자료의 신뢰성을 확보하기 위하여 면접조사는 1달 이상의 기간을 두고 2차례에 걸쳐 실시된 후 확인, 수정하였다. 또한, 석면관련 폐질환을 확진하기 위하여 HRCT를 추가적으로 실시하였다. 결과: HRCT결과 석면관련 폐질환의 유병율은 162명의 근로자중 17명으로 10.5%였는데, 직접 노출군에서 10명 (14.7%), 간접 노출군에서 7명 (7.4%)이었다. HRCT와 비교할 때 단순 흉부방사선검사의 민감도와 특이도는 각각 70.6%와 98.6%이었고, 양성 예측도와 음성 예측도는 각각 85.7%와 96.6%으로, HRCT는 단순흉부방사선검사에 비해 민감도가 높아 초기 석면관련 폐질환을 진단하는데 효과적이었다. 석면관련 폐질환의 진단에 있어 HRCT와 폐활량검사 사이에 유의한 관련성이 관찰되었다. HRCT 결과 석면관련 폐질환의 유무와 의학적 설문조사 결과의 빈도분석을 실시한 결과, 유의한 변수는 작업기간, 흡연량, 호흡기질환의 과거력, 기침, 호흡곤란이었다. 결론: HRCT는 석면관련 폐질환의 진단에 있어 단순 흉부방사선검사와 비교하여 민감도가 높아 초기 진단에 유용하므로 단순 흉부방사선선검사 결과 석면관련 폐질환소견을 보일 때뿐만 아니라, 정상소견을 보이더라도 폐활량 검사결과와 근무력, 흡연력, 호흡기질환의 과거력, 기침, 호흡곤란 등의 호흡기 증상을 참고하여 HRCT검사를 고려해야 한다. 또한, 본 연구에서 관련성이 없었던 요인들에 대해서도 향후 연관성을 규명하는 광범위한 전향적 연구가 필요하다. Objectives: This study was carried out to improve the medical surveillance program of workers exposed to asbestos by examining the usefulness of High Resolution Computed Tomography (HRCT) in the diagnosis of asbestos-related lung disease. Methods: The study subjects comprised 162 workers in a ship-repairing yard, 68 of whom had been directly exposed to asbestos and 94 indirectly exposed. The 'Occupational Safety & Health Administration (OSHA) asbestos standard, medical surveilance program' and HRCT were conducted to analyze the aspects of the asbestos-related lung disease. The OSHA asbestos standard, medical surveilance program consists of simple chest x-ray, spirometry and medical questionnarie. Results: Seventeen (10.5%) of the 162 subjects, 10 (14.7%) directly exposed and 7 (7.4%) indirectly exposed, revealed asbestos-related lung disease on HRCT. The sensitivity and specificity of simple chest x-ray for asbestos-related lung disease were 70.6% and 98.6%, and the positive and negative predictive values were 85.7% and 96.6% respectively, as compared with HRCT, HRCT was an effective diagnostic tool especially to detect early asbestos-related lung disease. The study results indicated a relative significant association between the results of spirometry and HRCT. The variables significantly associated with asbestos-related lung disease on HRCT were work duration, smoking history (pack-years), past history of respiratory disease, cough and dyspnea. Conclusions: In the diagnosis of asbestos-related lung disease, HRCT should be considered not only for workers with positive findings on simple chest x-ray, but also workers with specific findings on spirometry, occupational history, smoking history, and past history of respiratory disease, or with respiratory symptoms such as cough and dyspnea.

전통음료 섭취에 영향을 주는 변인에 관한 분석연구

이현주,손경희,이민준 한국조리과학회 2002 한국식품조리과학회지 Vol.18 No.1

This study was conducted to (a) investigate the frequency of Korean beverage consumption, (b) analyze the characteristics of socio-demographically classified group according to drinking frequency, (c) investigate the attitude for and awareness of Korean beverage and (d) analyze the factors which influence Korean beverage consumption. The survey was carried out by self-administered questionnaires with 2,200 subjects residing in Seoul. A total of 1,885 samples were used for analysis by using t-test, one way analysis of variance (ANOVA), Duncan's multiple comparison test, factor analysis, and analysis of covariance (ANOCOVA)with SAS computer program. Among various Korean beverage, Doggulre tea was consumed most frequently at an average of 7.4 times per month, and followed by rice beverage, Mi Su, Citron tea, Shick Hae and canned Shick Hae. Among the age groups, the group of 20s showed the lowest frequency of Korean beverage consumption exempt rice beverage. According to occupation group, middle and high school and college student groups showed a high frequency of consumption of cereal based drink such as rice beverage, Mi Su and Yulmu tea. The behavior examination aimed at learning the perceptions relevant to the choice of beverage showed that the subjects believe Korean beverage healthful and nutritious but not familiar through advertisement, not easy to buy, and not to be a habitual drink. The factors influencing the frequency of Korean beverage consumption were shown as health-related factors and habitual/practical factors.

퇴행성 골관절염에 있어서 Diacerhein(Artrodar^(�)) 제제의 효과에 대한 임상적 연구 : Prioxicam 제제 투여군과의 비교연구

이준규,신현대,이정구 최신의학사 1990 最新醫學 Vol.33 No.2

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

류마티스성 관절염 및 퇴행성 골관절염에 있어서의 Tenoxicam ^� 제제의 임상적 연구

이준규,임현수,이정웅,김석범 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

The authors have conducted a clinical study to evaluate the efficacy, tolerance and safety with newly developed Tenoxicam^ⓡ to thirty-four cases of the patient of Rheumatoid arthritis and Degenerative osteoarthritis during 4 months from January 1988 to April 1988. Treatment for the patient was done with one tablet of Tenoxicam^ⓡ (20mg) per oral once a day for 4 weeks. The evaluation of the patient was done at second and fourth week after initial administration of the drug. Results were as follows: 1. Out of 34 cases, male were 4(11.8%), female were 30(88.2%), and predominent age group was 40-59 years old 17(50.0%). 2. The diagnosis of these patients were Rheumatoid arthritis 22(64. 7%) and Degenerative osteoarthritis 12(35.3%). 3. Overall efficacy, there was marked improvement in global condition, pain on movement, pain at night and stiffness. 4. Side effects were seen in 4 patients such as 2 case of heartburn, 1 case of nausea and vomiting and 1 case of diarrhea. 5. There were no significant difference between pre-and post-treatment laboratory check. 6. Conclusion: The oral Tenoxicam^ⓡ was very effective for the treatment of Rheumatoid arthritis and Degenerative osteoarthritis, and side effects were few and generally mild.

스마트폰 뱅킹에서 사용하는 보안카드의 안전성 강화방안

이현종, 조인준 배재대학교 공학연구소 2014 공학논문집 Vol.16 No.1

전 세계적으로 스마트폰이 보급되면서 스마트폰을 활용한 여러 가지 서비스가 증가하고 있다. 다양한 앱의 개발 및 소셜 네트워크 서비스 등으로 사용자에게 편리성을 제공하고 있으나, 그 취약점 또한 해결해야할 하나의 과제이다. 그중에서도 스마트폰 뱅킹은 이미 그 가입자수가 상당수에 이름에도 스마트폰 뱅킹 니즈의 부재, 보안문제와 정보 유출 가능성에 대한 우려로 사용을 기피하고 있다. 특히 스마트폰 뱅킹에 사용되는 보안카드는 사용자의 편의를 위해 메모나 사진으로 저장하여 사용하고 있는 실정이며 이는 해킹에 의해 그대로 노출될 수 밖에 없다. 스마트폰 뱅킹은 스마트폰으로 플랫폼은 변경되었으나 인증방식은 기존의 PC 기반의 인터넷 뱅킹 인증방식을 도입하여 취약점을 그대로 갖고 있다. 특히 보안카드와 관련한 보안방식은 미흡한 실정이다. 본 논문에서는 스마트폰 환경에서 안전하게 보안카드를 사용할 수 있는 방안을 제시한다. 제안한 방안은 패스워드 기반의 암호화로 시스템에 접속시마다 키값이 변경되어 보안카드를 암호화하므로 보안의 강도를 높였고 노출의 우려가 없다.

류마티스성 관절염 및 퇴행성 골관절염에 있어서의 Tenoxicam(Tilcotil^(�))제제의 임상적 연구

이준규,임현수,이정웅,김석범 최신의학사 1988 最新醫學 Vol.31 No.6

만성 B형 간염 환자의 급성 악화 후 발생한 피부 결절 다발동맥염과 류마티스관절염

이주현,김민,이준성,장선희,윤보영,이윤우 인제대학교 2009 仁濟醫學 Vol.30 No.-

Cutaneous polyarteritis nodosa(CPAN) is a rare vascular disorder that affects small and medium-sized arteries in the reticular dermis and subcutaneous tissue. It has been described as a distinct clinical entity with benign and a chronic prolonged course without systemic involvement. Hepatitis B virus-related polyarteritis nodosa (HBV-related PAN) is typical form of classic PAN. Its pathogenesis is not well known, but considered an immune complex-mediated disease. The patients with HBV-related PAN often present with malignant hypertension, orchitis, and vascular nephropathy. But, HBV-related CPAN has been rarely reported. Rheumatoid vasculitis is a complication of rheumatoid arthritis that can be lead to variety of clinically significant skin and systemic conditions, It has been reported before or at the time of rheumatoid arthritis diagnosis but is usually seen an average of 10 to 14 years after arthritis onset. The histological features of cutaneous vasculitis in rheumatoid arthritis overlapped both the characteristics of cutaneous necrotizing venulitis and cutaneous polyarteritis nodosa. But polyarteritis nodosa-like rheumatoid vasculitis has rarely been reported. We report a case of rheumatoid arthritis and cutaneous polyarteritis nodosa in a chronic hepatitis B with acute exacerbation.

측두엽 간질에서 F-18-FDG PET에 나타난 측두엽 내외측 부위별 대사의 차이

이명철,이동수,정준기,김현집,송호천,이상건,여정석 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.1

Purpose: We investigated the difference of glucose metabolism of medial and lateral temporal lobes of patients with temporal lobe epilepsy (TLE) utilizing quantitative comparison of regional metabolic activities using asymmetric index. Materials and Methods: We studied 19 pathologically proven mesial TLE and 25 lateral TLE patients. Lateral TLE patients were either normal on magnetic resonance imaging (cryptogenic: n=14) or had structural lesions (lesional: n=11). Asymmetric index (ASI) was calculated as [(ipsilateral-contralateral)/(ipsilateral+ contralateral)]×200. Results: ASI of medial and lateral lobes of mesial TLE was decreased (-16.4±8.3 and -12.7±5.5, respectively). In cryptogenic lateral TLE, ASI of lateral temporal lobe was decreased (-11.8±4.7), whereas that of medial temporal lobe was not decreased (-4.6±6.3). ASI of medial lobe of lesional lateral TLE was -7.3±9.1, which was significantly different from that of mesial TLE (p<0.05). Patients with lesional lateral TLE had evident metabolic d or decrease (ASI: -22±10.5) in lateral temporal lobe. While we could not find the difference of metabolic activity in lateral temporal lobes between cryptogenic lateral TLE and mesial TLE patients, the difference of metabolic activity was significant in medial temporal lobes which was revealed by ASI quantitation. Conclusion: Asymmetric decrease of metabolic activity in both medial and lateral temporal lobes indicates medial temporal epilepsy. Symmetry of metabolic activity in medial temporal lobe combined with asymmetry of that in lateral temporal lobe may give hints that the epileptogenic zone is lateral.