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      • KCI등재
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      • KCI우수등재

        홍삼 복합제의 체지방 감소 작용 기전의 연구

        신현대,박철영,팽정령,오승준,김영설,김성운,양인명,김진우,최영길 대한비만학회 2000 The Korean journal of obesity Vol.9 No.4

        The effects of red ginseng compound preparation in weight loss have been confirmed, though its specific mechanism is unclear. The changes in both clinicai and lab results show body fat reduction through increase in energy metabolism after the administration. Therefore the effects of red ginseng compound preparation are likely to be caused by activation of sympathetic nervous system by beta-adrenalin system. The experiment was done in order to confirm this hypothesis on cellular level by administrating red ginseng compound preparation and extracting peripheral WBC to analyze adrenalin activation and its receptor RNA. Calorie-restricted diet and red ginseng compound preparation were given to 20 obese patients (BMI $gt; 27 kg/㎡) and 10 controls for duration of 4 weeks. (male to female ratio was 5:15) Changes in weight were from 80.5±15.3 kg (base line) to 79.2±14.7 kg (after taking red ginseng compound preparation) in the patient group, but in the control group did not decrease significantly. In similar sense, Bdecreased from 30.9±4.5 kg/㎡ (base line) to 30.4±4.3 kg/㎡ (after taking red ginseng compound preparation) in the patient group. However, BMI was not decreased in control group. Waist hip ratio was unchanged in both groups. The percent body fat was 35.16% (base line), 33.87% (after dieting), and 31.68% (after taking red ginseng compound preparation). Plasma epinephrine was increased in the patient group from 0.15±0.08ng/mL to 0.21±0.07 ng/mL, but in the contral group, the epinephrine level was decreased from 0.17±0.07 ng/mL to 0.14±0.05 ng/mL. The plasma norepinephrine levels of both groups showed no particular difference. To observe the possibility of 3 receptor expression, RT-PCR was done before and after drug administration. The results showed significant increase in receptor expression in both groups, in patient group increased from 0.87±0.45 to 1.79±0.78, and also increased in the control group from 0.62±0.33 to 0.91±0.53. The increase is quite significant in the patient group. The cAMP prod reflects the activity of beta-adrenaline was 10.1±6.1 S.I in patient group and 7.1±3.9 S.I in the control before drug administration. After administration, these changed to 12.3±6.1 S.I in the patient group and 4.8±1.4 S.I in the control group. Although this seems to show some increase in the patient group, it had no significant meaning statistically. The results shown above showed that the effects of red ginseng compound preparation in weight loss seem to result from increase in beta adrenaline activity, though this has not much meaning statistically. In particular, when we look at the increase of beta 3 adrenaline receptors in patient group, it can be that the effect of red ginseng compound preparation is lipolysis through the beta 3 receptor.

      • KCI등재

        주상두상골 유합술로 치료한 Kinebock씨 질환

        신현대,최정희,이광진,안상로,양준영,이준규 대한골절학회 1999 대한골절학회지 Vol.12 No.2

        We reviewed 14 patients treated with scaphocapitate fusion for Kienbock's disease(Lichtman stage III ) with mean follow-up of 26 months (ranging from 1 years to 5 year). There were five mens and nine womens. The mean age of patients at the time of operation was 46.1 years (ranging from thirty one to sixty). According to Lichtman's classification, All patients were stage III. Clinical assessments were evaluated using by pain relief, limitation in range of motion and clinical improvement. Radiologic assessment was evaluated by carpal height ratio. The mean range of motion is flexion 30 degree, extension 41 degree preoperatively, and flexion 29 degree, extension 41 degree postoperatively. The mean carpal height ratio is 0.49 preoperatively and 0.48 postoperatively. All of cases are relief of pain. Therefore radiographic and clinical satisfactory results were obtained. In conclusion, scaphocapitate fusion appear to be a very effective method for Lichtman stage III of symptomatic Kienbock' s disease.

      • KCI등재

        세계대학간 상대적 효율성 평가:DEA와 군집분석을 중심으로

        신현대,권기헌,서인석 한국정책분석평가학회 2009 政策分析評價學會報 Vol.19 No.4

        The world university rangking system composed of three organizations that have system of the THE-QS world university rangkings, Spain's Webometrics(world universities ranking on the web), Shanghai Jiao Tong University' Rangking System. These rangking system have all the advantages in more historical and big scale university because the method of evaluation based effectiveness. Recent years, the management environment of korean universities has changed rapidly to gain more competitiveness about world universities rangking. The world university ranking is regarded as international competitiveness of each universities. I analysised comparativeness of the world university rangking Systems and focused on criteria, item, weight, calcurating method. I certained the importance of the efficience, especially relative efficience. This study has examined DEA and how it measures the efficiency of world university Rangking. Data Envelopment Analysis is a useful nonparametric method to evaluate the relative efficiency of a set of decision-making units (DMUs) with multiple inputs and outputs. Also this study included cluster analysis. The outcome of this evaluation is as follows: Out of 61 universities, are the 7 efficient units i.e efficient universities (the value of efficiency is 100%). This study can provide substantial guidance for enhancing the expansion model on the Main World University Rangkings System. The overall results can contribute to the new change world university rangkings System. 세계적인 대학평가기관으로는 세계의 유력지인 더 타임즈평가(QS, Quacquarelli Symonds)와 중국상해교통대학, 스페인의 Webometrics 평가기관을 들 수 있는데, 세계대학 순위평가는 국가, 지역의 대학 실정과 역사적 환경이 다른 상태에서 실시하는 평가결과이며, 대부분 효과성 위주로 평가를 하고 있어 규모가 큰 대학과 역사가 오래된 대학이 유리한 결과가 나오게 되어 있다. 본 연구는 효과성 위주의 평가와는 달리 상대적 효율성의 관점에서 세계적 대학순위평가를 시도한 후 그에 따른 정책점 함의를 도출하고자 하였다. 현재의 세계적 대학순위평가를 분석・비교하고, 국가별로 학술역량이 우수한 대학을 중심으로 상대적 효율성을 평가하여, 국제적 규범의 성격을 지닌 세계적 대학순위평가 시스템의 평가기준 설정에 추가지표로 효율성부분을 적용하여 평가를 시도하였다. 효율성 평가기제로는 자료포락분석(DEA)과 대학간의 개체간 군집분석을 하였는데, 분석결과로는 규모가 작고 결과물이 높은 대학이 유리하여 기존의 세계대학평가 결과와는 상이한 결과를 보여주었다. 이는 향후 새로운 세계대학 순위평가에 있어 새로운 평가의 관점을 제공할 수 있을 것으로 사료되며, 세계 고등교육의 질 보장 시스템 구축과 대학순위 평가체제의 발전에 기여할 수 있을 것으로 기대된다.

      • KCI등재

        전위된 요골 원위부 골절에 대한 치료 - 전향적 연구 -

        신현대,최정희,이장익,이광진,황득수,양준영,이준규 대한골절학회 1999 대한골절학회지 Vol.12 No.2

        Fractures of the distal end of the radius, including Colles' fractures, represent the most common fractures of the upper extremity. Over the past years, many clinicians had thought of fractures of the distal radius as being a group of injuries with a relatively good prognosis. Today, fractures of the distal radius are recognized as very complex injuries with variable prognosis that depend upon the fracture type and the treatment given. We performed a prospective study in 51 patients(52 cases), by using treatment protocol of Palmer, we treated each fracture according to physiological age, activity, X-ray findings and stability after closed reduction. Final outcomes were evaluated by modified clinical scoring system, criteria for anatomical results and combined functional and anatomical results. Results by using modified clinical scoring system were excellent; 8 cases, good; 16 cases, fair; 22 cases, and poor; 6 cases. Results by using criteria for anatomical results were excellent; 8 cases, good; 26 cases, fair; 10 cases; and poor; 8 cases. In wrist rating scales of New York Orthopaedic Hospital, excellent; 7 cases, good; 32 cases, fair; 6cases, and poor; 7 cases. In our study, fractures of the distal radius were occurred frequently in active young male with high energy injuries. Criteria about acceptable range of reduction in treatment protocol of Palmer were too wide to obtain satisfactory results. Results from many assessment systems did not matched with each other because of differences of point of views. The results of this study proposed that even acceptable reduction is obtained, better outcomes will be brought by operative modality due to decreased frequency of reduction loss and radial shortening. And also, physical therapy after fracture treatment is considered as one of the important factors influencing functional results and the satisfaction of patients themselves.

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