한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

양극산화와 절연파괴로 형성한 인산칼슘 함유 티타늄 산화피막의 특성

최원호,이용승,김동환,권용훈,배태성 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.1

This study was performed to investigate the surface properties of electrochemically oxidized pure titanium by anodic spark deposition technique. Titanium plates of 10×10×1 ㎜ were polished sequentially from # 300 to # 1,000 emery paper. They were ultrasonically washed in ethyl alcohol and acetone for 5 min and dried in a desiccator. Titanium plates and titanium screw implants were anodized in an electrolytic solution that was dissolved calcium and phosphate in water. The electrolytic voltage was set in the range of 190-340 V and the current density was 30 ㎃/㎠. The surface oxide film was characterized by X-ray deffractometer(XRD), scanning electron microscope(SEM) and X-ray photoemission spectroscopy(XPS). The main crystal structure of the titanium oxide was anatase type as analyzed with thin-film X-ray diffractometery. The diameter of micropores increased with increasing the spark forming voltage. The porous coatings showed the growth of cell structure and more compact texture with increasing the spark forming voltage. Microcracks were examined in the coating formed at voltage of 340 V. Ca/P ratio in coatings was increased with increasing the voltage.

Pulse Power를 이용한 혐기성 소화 효율 증대

최한나,전용우,정윤진,홍승모 대한상하수도학회 2003 상하수도학회지 Vol.17 No.3

Anaerobic digestion is commonly used in wastewater treatment plants to stabilize sludge produced in primary and secondary treatment, to produce renewable energy as methane, and to reduce the volume of solids for ultimate disposal. Previous studies on anaerobic digestibility of primary and secondary sludge present that secondary sludge showed poor anaerobic digestibility and less gas production. The objectives of this research were to study the effects of pulse power pretreatment on anaerobic digestibility of waste activated sludge. These objectives were achieved through operation of carefully-controlled laboratory digesters under various conditions. The conclusion made from this study are as follows: 1) To maximize the efficiency of pulse power pretreatment for waste activated sludge, the optimum operation conditions for coaxial reactor with 7 rings are decided as follows; a) optimum pulse repetition rate : 110㎐, b)feeding service : once-through mode, c) optimum hydraulic retention time : 1.0-1.5sec 2) Pretreated WAS by pulse power system showed increase of SCOD, ECP, and V.A by 13.6, 4.6, and 7.1 times. 3) From the results from operation of lab scaled anaerobic digester, pulse power sludge pretreatment increased GPR from 0.39㎥gas/㎏VS_add · day to 0.66㎥gas/㎏VS_add · day and methane content from 43.9% to 87.9%. Thus, increase of methane production rate was increased by 3.4times. 4) During the steady state operation of anaerobic digester, the removal efficiency of TCOD and VS were improved by 44.6% and 31.5% respectively after pulse power pretreatment of waste activated sludge.

임신 중기 급성 A형 간염의 치료 1예

김미영,문성택,김윤숙,전섭,최승도,선우재근,배동한 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

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최고경영자, 전략 및 구조요인이 중소기업의 성과에 미치는 영향

최용호,신진교,김승호 한국중소기업학회 2003 中小企業硏究 Vol.25 No.2

본 연구에서는 중소기업의 성과에 대한 최고경영자 특성, 전략 및 조직구조의 영향을 분석하고 있다. 131개 중소기업을 대상으로 자료를 수집·분석한 결과 중소기업의 최고 경영자-전략 및 구조-성과에 대한 연구모형은 타당한 것으로 나타났으며, 최고경영자 특성, 마케팅차별화전략, 분권화 및 계층화가 중소기업의 성과에 유의한 영향을 미치는 것으로 나타났다. 본 연구가 발견한 특징적인 현상은 중소기업이 분권화와 계층화를 동시에 높일 때 성과가 향상된다는 사실이다. 이는 소위 모순경영에 관한 이론적 함의를 제공하는 것으로 볼 수 있다. 또한 중소기업 최고경영자의 특성은 성과에 직접적인 영향을 미치기도 하지만, 전략 및 구조를 통해 간접적인 매개효과도 동시에 지니는 것으로 나타났다. 마지막으로 본 연구결과에 대한 해석과 토론, 이론적 및 실무적인 시사점과 한계점, 그리고 향후의 연구방향이 논의되고 있다. This study investigated the impact of top management, management strategy, and organizational structure on the organizational performance. The data were collected from 131 small and medium sized firms located in Daegu. Empirical results indicated that characteristics of top management, marketing differentiation strategy, decentralization, and stratification influenced on organizational performance significantly. And characteristics of top management have both direct and indirect effect on the organizational performance through management strategy and organizational structure. This study also shown that to improve organizational performance, small and medium sized firms have to persue both decentralization and stratification. In doing so, they appear to be faced with a management of paradox. The implications of these findings, limitations, and future research directions were discussed.

B형간염 항원의 消長에 영향을 미치는 각종 인자의 연구

최승렬,양용상,한성운,조미연,김선웅,신영오 한국건강관리협회 2000 건협 Report Vol.3 No.-