증식당뇨망막증에서 아르곤레이저 광응고술의 치료 효과

안병헌,민병무,최시환,서병로,박우찬 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

Vitreous hemorrhage, which is the major cause of blindness in proliferative diabetic retinopathy, has been prevented clinically with laser photocoagulation. We reviewed 57 cases(98 eyes) of proliferative diabetic retinopathy which were treated by argon laser and followed up for more than 6 months. Of these 98 eyes, 81 eyes(83%) showed a satisfactory response after standard panretinal photocoagulation. 14 eyes(14%) revealed the vitreous hemorrhage after panretinal photocoagulation and higher incidence of vitreous hemorrhage in the cases of new vessel on the optic disc. In the cases(26 eyes) of new vessel on the optic disc, 2000 laser burns revealed lower incidence of vitreous hemorrhage(1/5, 20%) in comparison with 1500 laser burns(8/21, 38%). These results indicate that initial augmented laser therapy prevented the vitreous hemorrhage effectively.

The prediction of the tooth size in the mixed dentition for Korean

Moon, Sung-Hwan,Kim, Seong-Oh,Yu, Hyung-Seong,Choi, Byung-Jai,Choi, Hyung-Jun,Lee, Jae-Ho 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2

이번 연구의 목적은 혼합치열기 아동에서 미맹출된 견치와 소구치의 크기를 예측하는데 있어서 한국인에 맞는 방정식을 만들기 위함이다. 미맹출 치아의 크기를 예측하는 것은 혼합치열기 교정 진단과 치료계획 수립에 있어서 매우 중요하다. 미맹출된 견치와 소구치 크기를 예측하는 방법은 몇가지가 있지만 그중에서도 가장 흔하게 쓰이는 것이 모이어의 예측표와 다나카와 존스턴의 방정식이 있다. 하지만 그것들은 백인을 위해서 제작된 것이고 치아 크기는 인종에 따라서 다르다고 알려져 있다. 이번 연구에서는 치아크기를 측정하여 하악 영구 절치의 크기 합과 견치 및 소구치의 크기 합 사이의 상관관계를 구하고 회귀방정식을 이용해서 한국인에 맞는 예측표를 만들었다. 연세대학교 치과대학에 재학중인 178명의 한국 학생(남 108명, 여 70명, 평균연령 21.63)을 대상으로 실험하였다. 영구치의 근원심 폭경을 석고모형상에서 calipers를 이용해서 측정하였다. 성별간의 치아 크기는 차이가 있었다(p<0.05). Correlation coefficient는 0.57에서 0.64의 범위였고, standard errors of the estimates 는 여성에서 0.6으로써 남성보다 우수하였다. r^(2)값은 0.27에서 0.41의 범위를 나타내었다. Estimating the size of unerupted teeth is an essential aspect of orthodontic diagnosis and treatment planning in the mixed dentition. Several methods were introduced and used for the prediction. The most common methods among these would be Moyers probability chart and Tanaka and Johnston equations. These are currently used widely, but they were developed for Caucasians. Because there are clear racial differences in teeth size, the objectives of this study were to produce correlation coefficients between the combined mesiodistal widths of the permanent mandibular incisors and those of the canines and premolars for each quadrant, and prediction tables with regression equations, specifically for Korean. 178 young adults (70 women, 108 men, mean age 21.63 years) were selected from the College of Dentistry, Yonsei University, Seoul, Korea. The mesiodistal crown diameters of the permanent teeth were measured with calipers. Significant sexual dimorphism was found in tooth sizes. The correlation coefficients between the total mesiodistal width of the mandibular permanent incisors and those of the maxillary and mandibular canines and premolars were found to be between 0.52 and 0.64. The standard error of the estimatation was better (0.60) for women and the r^(2) values ranged from 0.27 to 0.41 for both sexes, Prediction tables were prepared for Korean. This study showed larger canine and premolar diameters than Tanaka and Johnston's and Moyers' studies which might be due to the racial differences. Further investigations with a larger sample size will be needed for more representative data on the Korean population.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Tacrolimus LC-MS/MS 분석법과 신생 쥐 전혈에서의 약물동태학 연구

이병요,백인환,권광일 충남대학교 약학대학 의약품개발연구소 2011 藥學論文集 Vol.26 No.-

중이진주종에서 플라스미노젠 활성인자 발현의 임상적 의의

김형종,김진환,임현준 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

혈소판 응집 억제제의 효과 측정법에 대한 고찰과 지원자에서 Triflusal의 혈소판 응집 억제능 평가

이병요,장힘찬,백인환,윤휘열,권광일 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-

The anti-platelet agent is a member of a class of pharmaceuticals that decreases platelet aggregation and inhibits thrombus formation. They are effective in the arterial circulation and widely used in primary and secondary prevention of thrombotic cerebrovascular or cardiovascular disease. As a method for estimating the effects of anti-platelet agent, platelet aggregation was conventionally measured using the optical method or the impedance method. Several alternate methods currently in development or recently developed were considered, including luminescence method, flow cytometry, laser-light scattering method, and Verify Now-P2Y12 assay. Principles, advantages, and disadvantages of the optical method, impedance method, and the other alternate platelet aggregation methods were discussed in this report. 15 human volunteers were recruited for the evaluation of the efficacy of triflusal using the optical method. After the oral administration of a single dose of 900mg, 15 subjects received eight doses administered at 24-hour intervals of 600mg triflusal. Using platelet rich-plasma from above subjects, we performed baseline platelet aggregation test induced by adenosine diphosphate(ADP), collagen, and arachidonic acid. The results of platelet aggregation test after triflusal administration were compared with the baseline study. Triflusal significantly inhibited platelet aggregation induced by ADP (33.0±21.3%) and arachidonic acid (99.1±1.2%), respectively. Therefore, we concluded that anti-platelet aggregation effect of triflusal can be studied successfully with the optical method. Each of the platelet aggregation methods has value for evaluating the effects by various mechanisms of the anti-platelet agents. The ideal method for estimating the platelet aggregation as it relates to safety and efficacy in patients treated with anti-platelet agents will need to be determined in clinical trials.

韓國産 두배자루마디개미 亞科의 分類學的 硏究

金昌煥,金兵珍 全北大學校 生物學硏究所 1982 生物學硏究年報 Vol.3 No.-

Twelve genera, seventeen species under the Subfamily Myrmicinae were formerly reported in Korea. Among these, two species Pheidole fervida and Monomorium minutum, were collected only in north Korea, and collected localities of three species which Teranishi reported were not certain. After examining all of the species preserved at the Korean Entomological Institute of korea University and collected in the field of the South Korea from March, 1981 to March, 1982, 9 genera 13 species have been reviewed and the following unrecorded 2 species, Crematogasser laboriosa var, matsumurai Foreland Myrmica kurokii Forel are added to the fauna of Subfamily Myrmicinae of Korea. Subfamily Myrmicinae Ⅰ. Genus Crematogaster LUND 1. Crematogaster sordidula osakensis FOREL 2. Crematogaster laboriosa var. matsumurai FOREL Ⅱ. Genus Solenopsis WESTWOOD 3.Solenopsis fugax (LATREILLE) Ⅲ. Genus Monomorium MAYR 4. Monomorium pharaonis (LINNE´) Ⅳ. Genus Pristomyrmes MAYR 5. Pristomyrmex pungens MAYR Ⅴ. Genus Messor FOREL 6. Messor aciculata F. SMITH Ⅵ. Genus Tetramorium MAYR 7. Tetramorium caespitum LINNE´ Ⅶ. Genus Leptothorax MAYR 8. Leptothorax koreanus TERANISHI 9. Leptothorax conggruus F. SMITH Ⅷ. Geuns Aphaenogaster MAYR 10. Aphaenogaster famelica (F. SMITH) Ⅸ. Genus Myrmica LATREILLE 11. Myrmica sulcinodis NYLANDER 12. Myrmica scabrinodis saposhnikovi RUZSKY 13. Myrmica kurokii FOREL

우리나라 一部 干拓地域 住民에 對한 精神衛生학적 調査

全炳勳,印柱英,徐敬煥,許程 醫藥係社 1965 綜合 醫學 Vol.10 No.11

兩側 및 單側 電氣衝擊療法後의 腦波變化에 對한 硏究

楊秉煥,정경천,李定均,卞容旭 大韓神經精神醫學會 1979 신경정신의학 Vol.18 No.2

Changes on EEG after bilateral and unilateral ECT was studied in 12 young adult schizophrenic patients who were admitted st Seoul Municipal Mental Hospital. Their EEC data were obtained during the interictal period of serial ECT sessions and subjected to global quantitative analysis by visual assessment. Some significant findings are summarizcol as follows: Repeated ECT resulted in increased EEG slow wave activity more see in the frontal and temporal leads which became gradually generalized in forms of occasional burst and run. No spike and focalized activities were seen. The degree of slowing and its amplitude was directly related to the number of ECT sessions. As the successive four to six treatments were administered, the slowing became more persistent and widespreaded with high voltage paroxysmal activities, while the alpha rhythm became disturbed and disappeared. After seven to eight serial treatment, the percent time delta remained constant in plateau or falled off. Fourteen days after the last 10th treatment, 34 percent time of slow wave activities was recorded in frontal lead of bilateral ECT group and 25 percent of unilateral ECT group. Minor lateralized asymmetries of frequancy and amplitude which were predominently right sided, appeared more in the right unilateral ECT group (4 in 6 cases) than the bilateral group (1 in 6 cases). The amount of post-ECT slow wave activity did not revealed major difference between these kinds of ECTs and was closely related to the number of ECT sessions and to the pretreatment EEG with individual variations. No relationship was found between the therapeutic response, degree of amnesia or confusion, and EEG findings after electroconvulsive therapy.

지능형 원격 네트워크 온실

문병현,송주열,이현성,손경규,엄태환,김정우,김아름 대구대학교 정보통신연구소 2004 情報通信硏究 Vol.3 No.2

The system designed in this paper, can mark the interior state of greenhouse using sensors of temperature, humidity and illumination on greenhouse interior by greenhouse system for farm village area's agriculture automation. And, the real time monitor is possible real time monitoring by camera. Also, system that can supply water using spring cooler system and humidifier. The proposed system can sustain a designed environment of the greenhouse through rentilation fan, fluorescent light and roof door control. TCP/IP is used for the remote control of state the sensors in the client program. 본 논문에서 설계된 시스템은 농촌 지역의 농업 자동화를 위한 온실 시스템으로 온실 내부에 온도, 습도, 조도 센서를 이용한 온실 내부의 상태를 표시할 수 있으며 카메라를 이용하여 실시간 관측이 가능하다. 또한 본 시스템은 지붕 개폐, 스프링 쿨러와 가습기를 이용한 수분 공급, 환풍기, 형광등 등을 통하여 온실 내부의 환경을 유지시킬 수 있다. 모든 센서를 이용한 상태와 온실 제어를 TCP/IP를 이용한 클라이언트 프로그램에서 원격으로 관리할 수 있다.