악성 흉막액에 관한 임상적 고찰

박우찬,최승혜,정상설,김인철 대한외과학회 1996 대한외과학회 학술대회 초록집 Vol.1996 No.11

Role of Ovarian Function Suppression in Premenopausal Women with Early Breast Cancer

박우찬 한국유방암학회 2016 Journal of breast cancer Vol.19 No.4

Historically, endocrine therapy for breast cancer began with ovarian ablation (OA) for the treatment of premenopausal patients. After the identification of estrogen receptors and the development of many antiestrogens, tamoxifen has been approved and used as the standard endocrine therapy for hormonal receptor (HR)-positive premenopausal patients to date. With the development of luteinizing hormone-releasing hormone agonists, the paradigm of endocrine therapy for premenopausal women with HR-positive breast cancer began to change from OA to ovarian function suppression (OFS). To date, the indication for OFS was limited to those premenopausal patients with HR-positive breast cancer who were unable to use tamoxifen as the primary adjuvant endocrine therapy. However, following the definitive demonstration of the therapeutic role of OFS added to tamoxifen or aromatase inhibitor after chemotherapy in large randomized trials, such as Tamoxifen and Exemestane Trial or Suppression of Ovarian Function Trial, the American Society of Clinical Oncology guidelines for the use of endocrine therapy in premenopausal HR-positive breast cancer were recently updated to recommend OFS in high-risk patients who required adjuvant chemotherapy. In contrast, the role of OFS to protect ovarian function during chemotherapy in premenopausal women has remained controversial, and some evidence showing the protective effect of OFS on the ovaries during chemotherapy as well as its therapeutic effect for breast cancer in premenopausal women with HR-negative breast cancer was recently published. Further evaluation is necessary to determine its exact role. In conclusion, the role of OA or OFS has been evolving, not only to improve the efficacy of breast cancer treatment, but also to preserve ovary function. OFS remains a main strategy for premenopausal women with HR-positive early breast cancer, though its exact role should be determined in further studies.

유방암 치료를 위한 분자표적

박우찬,김이수,김태현,박병우,박호용,송병주,이재복,전창완,최운정 한국유방암학회 2009 Journal of breast cancer Vol.12 No.4

Advances in molecular biology have made it possible to understand the tumor biology of breast cancer at the molecular level and have revealed molecular targets for the therapy of breast cancer. Nowadays, targeting agents are used as mono-therapy or as combined therapy with other anticancer drugs for the treatment of breast cancer. Much more efforts is also being made in the development of better therapeutic agents targeting molecules having an important role in tumor biology. In this article, promising molecules for targeted therapy are reviewed for their roles in the pathophysiology and the treatment of breast cancer. We also introduce and summarize new preclinical agents, developed or on developing, with preliminary results from clinical trials. Given the progress currently being made, targeted therapy could become a main strategy for the treatment of breast cancer in the near future.

유방암 수술 결정을 위한 수술 전 자기공명영상의 임상적 의의

박우찬 한국유방암학회 2006 Journal of breast cancer Vol.9 No.4

Purpose: Currently MRI (Magnetic Resonance Imaging) is widely used for the preoperative staging of breast cancer. In this study, we assessed the impact of preoperative breast MRI on the surgical management of breast cancer in women. Methods: From March 2004 to October 2006, 162 cases were enrolled for preoperative MRI for the staging of breast cancer. The MRI findings and clinicopathological results were investigated and the accuracy of breast MRI was analyzed with respect to the detection of multiplicity, nipple involvement and bilaterality of the breast cancers. Results: For detecting multifocal lesions, the sensitivity and specificity of breast MRI were 100% and 48.5%, respectively, and the results of bresat ultrasound were 100% and 63.4%, respectively. For detecting nipple invasion, the sensitivity and specificity of breast MRI was 80% and 74.6%, and for ultrasound was 33.3% and 86.4%. In 27 cases (16.7%) the type of surgery was changed according to the preoperative MRI findings; however, in only 6 cases were the MRI findings in concordance with the pathological findings of the mastectomy specimen. Conclusion: In clinical application of breast MRI for preoperative staging, the decision to undertake surgery for breast cancer based on a MRI findings should be prudent due to its low specificity.

FISH와 IHC를 이용한 HER2 검사 결과에 따른 유방암 환자의 생존분석

박우찬,박경신,김정수,오세정,정상설,이재학,김인철 대한외과학회 2003 대한외과학회 학술대회 초록집 Vol.2003 No.11

난소적출 및 수종 Hormone투여가 치아및 치은의 Collagen 생합성에 미치는 영향에 관한 실험적 연구

박우찬,정동균 대한구강생물학회 1980 International Journal of Oral Biology Vol.4 No.1

The effects of ovariectomy, several hormones and fluoride on the collagen turnover in teeth, pulp and gingiva were studied employing the Sprague-Dawley female rats. The rats were divided into non-treated and treated group, and treated group on which had been performed ovariectomy operation, was further subdivided into 5 groups, i.e., control, estrogen, testosterone, prednisolone and fluoride administered group. Then, each group was treated with ^3H-proline and sacrificed according to a predetermined schedule. Pulp, teeth and gingiva were removed immediately and decalcified for 3 days. After digestion of samples, separation and quantitative analysis of proline and hydroxyproline were performed employing thin layer chromatography and radioactivity of seperated amino acid was assayed by liquid scintillation counter. The results were as follows ; 1. In non-treated group, the incorporation rate of ^3H-proline into hydroxy-proline was greater in pulp of teeth than in hard tissue of teeth and gingiva. Collagen turnover of lower root, lower pulp and gingiva was more rapid than any other tissues tested. 2. In all the tissues from ovariectomized rats, the incorporation of ^3H-proline into collagen was markedly decreased. 3. The decreased effect of ^3H-proline incorporation into collagen by ovariectomy was markedly antagonized with estrogen, moderately or slightly with testosterone in all the tissues tested, whereas fluoride had a slightly antagonizing effect only in th lower incisor roots. The effect of ovariectomy on collagen turnover was augmented or not influenced by prednisolone.

유방암 치료 후 발생한 이차성 급성 백혈병 7예

박우찬,최영수,김기현,엄용화 한국유방암학회 2010 Journal of breast cancer Vol.13 No.1

Secondary acute leukemia is a rare and fatal complication after the treatment of breast cancer. Recently, we experienced 2 cases of acute leukemia that had developed during the follow-up period after adjuvant therapy of breast cancer. In addition, retrospective analysis of medical records of St. Mary’s hospital, the Catholic University of Korea, revealed another 5 cases of secondary leukemia following the treatment of breast cancer. Total 7 cases of secondary acute leukemia of breast cancer were reviewed and summarized according to their clinical characteristics. The mean age at diagnosis of primary breast cancer was 38.9 years (range, 16-49), and the average period from the completion of chemotherapy to the diagnosis of acute leukemia was 30.9 months (range, 11-40). The mean survival period of the 7 patients after diagnosis of leukemia was 4.6 months. Based on these findings, the risk of secondary leukemia following the treatment of breast should be considered in choosing chemotherapy and radiotherapy for the treatment of breast cancer especially in the young patients.

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박우찬 한국외국어대학교 여학생회 1976 엔담 Vol.4 No.-

좌식 입체정위법과 Vacuum-Assisted Biopsy Device를 이용한 비촉지성 미세석회화 유방 병변의 진단

박우찬,김학희,한송이,김정수,오세정,정상설,이재학,김인철 대한외과학회 2003 대한외과학회 학술대회 초록집 Vol.2003 No.5

35세 이하 젊은 여성에서 발생한 조기 유방암의 홀몬 수용체가 예후에 미치는 영향

박우찬,성관수,김정수,오세정,정상설 대한외과학회 2002 대한외과학회 학술대회 초록집 Vol.2002 No.10