정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

조선후기 천문학자 이덕성의 생애와 천문활동

안영숙,민병희,서윤경,이기원,AHN, YOUNG SOOK,MIHN, BYEONG-HEE,SEO, YOON KYEONG,LEE, KI-WON 한국천문학회 2017 天文學論叢 Vol.32 No.2

The life and astronomical activity of Lee Deok-Seong (李德星, 1720-1794) was studied using various historical sources, including the astronomical almanac, Seungjeongwon-Ilgi (Daily records of Royal Secretariat of Joseon dynasty), and the Gwansang-Gam's logbooks during Joseon dynasty (A.D. 1392-1910). We present the results of the study including the following main findings. First, from the investigation of Lee's family tree, we find that a number of his relatives were also astronomers, notably Samryeok-Gwan (三曆官, the post of calendrical calculation). Second, we find that he took part in the compilation of an annual astronomical almanac over a period of at least 16 years. His major achievements in the astronomy of the Joseon dynasty were to establish a new method of calendar-making calculation and to bring astronomical materials to the Joseon court through a visit to China. The Joseon dynasty enforced the Shixianli (時憲曆, a Chinese calendar made by Adam Shall) in 1654 without fully understanding the calendar. So an astronomer and an envoy were dispatched to China in order to master the intricacies of the calendar and to learn as much of Western science as was available in that time and place. Lee Deok-Seong worked at the Gwansang-Gam (觀象監, Royal Astronomical Bureau) during the reigns of King Yeongjo (英祖) and Jeongjo (正祖). As best as we can ascertain in relation with the calculations in the Shixian calendar, Lee visited China four times. During his trips and interactions, he learned a new method for calendar-making calculations, and introduced many Western-Chinese astronomical books to Joseon academia. Lee greatly improved the accuracy of calendrical calculations, even while simplifying the calculation process. With these achievements, he finally was promoted to the title of Sungrok-Daebu (崇祿大夫), the third highest grade of royal official. In conclusion, history demonstrates that Lee Deok-Seong was one of the most outstanding astronomers in the late-Joseon dynasty.

라미부딘 내성 만성 B형 간염 환자에서의 아데포비어의 치료 효과

이지숙,장리라,이상욱,한병훈,윤병철 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Backgrounds/Aims : Adefovir dipivoxil(ADV) has been shown to be effective against lamivudine resistant strain of hepatitis B virus. But continuation of lamivudine therapy or switching to Adefovir dipivoxil in patients with viral breakthrough after long term lamivudine therapy are controversial. To find efficacy of adefovir dipivoxil, we retrospectively assessed clinical course after lamivudine resistance in patients who changed adefovir dipivoxil and continued lamivudine therapy. Methods : 58 patients with lamivudine resistant HBV mutants after at least 6 months of lamivudine treatment were included in this study. 24 of the 58 patients were treated with ADV and rest of them were continued the lamivudine therapy after lamivudine resistance. The continuous lamivudine treatment group (n=34) was divided into two groups according to ALT count (ALT≧40, n=19 vs ALT<40, n=16) The clinical course and the biochemical and virological response of the switching adefovir group were compared with those of continuing lamivudine group. HBV genotypes and YMDD mutation site was anaylzed by TRUGENE HBV Genotyping. Results : At twelve months, the levels of median serum HBV DNA and ALT was decreased and albumin was improved significantly(P<0.01) in adefovir switching group compared with lamivudine sustained group, especially ALT was elevated more than 40. There is no significant differences between adefovir switching group and lamivudine sustained group (ALT<40, n=15). This study showed that adefovir dipivoxil reduces HBV replication and improves not only biochemical markers of disease activity, but also liver function. HBV genotypes of 58 patients were all C and rtM204I/V mutant was the most common. Conclusion : This study provides an evidence that adefovir dipivoxil can be effective in the treatment of lamivudine-resistant HBV mutants, especially ALT elevated.

나프타분해플랜트의 부탄추출공정에서 부탄증기의 연속누출에 의한 화재사고의 영향평가

윤대건,이헌창,함병호,조지훈,김태옥 韓國火災 ·消防學會 1998 한국화재소방학회논문지 Vol.10 No.4

나프타분해플랜트의 부탄추출공정에서 부탄증기의 연속 누출에 의한 제트화재와 플래쉬화재의 사고결과에 대한 영향을 평가하고 사고결과에 미치는 공정변수들의 영향을 해석하였다. 877 kPa과 346.75K의 공정조건에서 부탄증기가 87.8 kg/s의 속도로 8m의 높이에서 연속누출되는 경우에 표준조건으로 설정한 대기 및 환경조건에서 사고결과를 해석한 결과, 제트화재에서는 화염의 형태와 크기를 예측할 수 있었으며 누출지점으로부터 200m에서 API모델로 산출한 목사열은 약 5kW/m^2이었고 플래쉬화재가 일어날 수 있는 연소범위는 11.2~120.2m이었다. 그리고 사고결과에 미치는 조업압력의 영향은 조업온도보다 크며 압력이 증가할수록 사고결과 값이 증가하였다. 이때 플래쉬화재에서 X_UFL에 미치는 공정압력의 영향은 X_LFL에서보다 약 1/10이하를 나타내었다. The consequence analysis for jet and flash fire accidents by the continuous release of butane vapor was performed and effects of process variables on consequences were analyzed in standard conditions. For the continuous release(87.8 kg/s) of butane vapor at 8 m elevated height in the debutanizing process of the naphtha cracking plant operating at 877 kPa, 346.75 K, we found that for the jet fire accident, shape and size of the flame could be predicted and thermal radiation estimated by API model at 200 m distance from release point was 1.5 kW/m^2, and that for the flash fire accident, effect range was 11.2~120.2m. Also, simulation results showed that effects of operating pressures on consequences were large than those of operating temperatures and results of accidents were increased with increasing operating pressures. At this time, effects of operating pressures on X_UFL. were smaller

국적 항공사의 경쟁력 강화를 위한 포지셔닝 전략에 관한 연구

윤병국,이동희 한국관광정보학회 2001 觀光情報硏究 Vol.- No.9

The international airline industry has a phenomenal growth since the Airline Deregulation Act was enacted in 1978. In recent years, Korea's national flag carriers are facing steep challenges to survive in the ever-growing competition. Under the situation, positioning can be used as a competitive strategy tool. The purpose of the study was to analyze the image of seven airlines that fly to Korea and to develop positioning strategies for Korea's national flag carriers. For the empirical research, the survey data were collected from 700 passengers: 600 passengers who were on board Korean Air and Asiana Airlines and 100 from people who have flown seven major airlines: Korean Air, Asiana Airlines, Japan Airline, United Airline, Cathay Pacific Airways, Thai Airways, Singapore Airlines. Out of 700 samples, 377 were used for statistical analysis. Results of this study are summarized as follows: First, safety was the most significant attribute which influences on airlines image and airlines decision-making. On-time operation was the second most important attribute, but passengers were very unsatisfied with the actual performance. passengers who had the membership with airlines considered importantly the 'system-related service' factores such as frequent flyer program, mileage service, efficient reservation system and quick check-in procedure. Second, according to the results of comparative analysis of airlines, passengers assessed that the Korean Air has a strong image in convenient schedule and frequent flyer program. For the Asiana Airlines, passengers evaluated that the airline's image was found on quality of cabin service, safety, quality in-flight meal, low fares, and on-time operation. For the foreign airlines, passengers expressed that each airline has distinctive image. Future research on airline positioning strategies need to enlarge to more famous airlines. Thus, it is expected to help to set up competitive strategies for Korea's national flag carrier.

C#과 3차원 그래픽 라이브러리를 사용한 택스쳐 맵핑 기법 연구

이성진;하창수;최병윤 동의대학교 산업기술연구소 2010 産業技術硏究誌 Vol.24 No.-

To make 3D games, it requires rendering engine, animation engine, sound engine, server engine, physical engine, map editor and game artificial intelligence. Rendering engine have to support 3D object display function, objects control function for realtime object display, object animation making function, game environment control function, camera move, rotation, scaling, shrinking control function, light source and shadow control function, special effect display function, texture based special function and shader utilization. In this paper, we describe how to render models using Visual studio 2005 C#. The models are created by 3DMAX and exported as X file that represents mesh information and then texture mapped using DirectX library.

세포질내 정자주입법(ICSI)에 있어서 정자흡입 및 난자내 주입방법에 관한 연구

이택후,김항진,송건호,김대근,전상식,박윤규,서태광,전병균,류은경,이은숙,문진수,김광철 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Study on Method of Sperm Aspiration and Injection into an Oocyte in Intracytoplasmic Sperm Injection(ICSI) Immobilization of spermatozoa prior to intracytoplasmic sperm iniection(ICSI) sometimes results in crooked tail and this makes it difficult to aspirate sperm into an injection pipette tail first. Head-first sperm aspiration into an injection pipette avoid this problem due to the bigger size of the sperm head. The effect of head or tail-first sperm injection into an oocyte on fertilization cleavage, percentage of grade I embryos and development to blastocyst stage in ICSI program has been studied. A single living immobilized spermatozoa from oligoasthenozoospermic patient was injected into an oocyte head-first or tail-first according to the treatment. Eighteen hours after microinjection, oocytes ware inspected for survival and fertilization Fertilized oocytes with two pronuclei were cultured in 30μl drop of mHTF supplemented with 10% heat-inactivated follicular fluid(FF) at 37℃. On day 2. embryo transfer was performed with cleaved embryos. The remaining 2-8 cell stage embryos were co-cultured with BRL cells in mHTF + 10% FF for 72 hours and the developmental stage was observed. The data were analyzed by Analysis of Variance. A total of 164 oocytes from 36 cycles were assigned to earth treatment and ICSI was performed(88 head-first, tail-first). The rates of normal fertilization were 81.8% and 76.3% for head-first and tail-first, respectively. Of the fertilized oocytes, the percentage of cleaved embryos and the percentage of grade 1 embryo among cleaved embryos were 88.9% and 68.8%, 93.1% and 74.1% for head-first and tail-first, respectively. Of the 2-8 cell embryos cultured, 44.4%(16/36) and 50.0%(10/20) for head first and tail first, respectively developed to blastocyst stage. There were no differences in fertilization, cleavage, rates of grade 1 embryos, and development to blastocyst stage. In conclusion, head-first or tail-first sperm injection into an oocyte in ICSI program does not affect fertilization and subsequent embryo development to blastocyst stage in vitro.

호텔 예식이벤트의 마케팅 방안 연구

이복희,임범종,윤병국 한국관광정보학회 2002 觀光情報硏究 Vol.- No.11

This study analyzed factors that customers consider importantly in selection the wedding events of hotels located in Yusung Area and how these factors are dimensioned. Thus, this study analyzed demographics of buyers of hotel wedding service such as sex, age, job, marital status, income, etc., and examined of there is any significant difference in hotel selection factors as each of demographic variable changes. The study also analyzed of general factors such as service, price, equipments, menu, information source, affects hotel selection in wedding event. The continuous study of hotel wedding is needed to provide high-quality service through understanding customers needs and wants and thus to magnify the market and to develop the diferentiated wedding event product based on customers' continuous feedback which as one do the most important profit source of the hotel.

運動選手의 意識構造에 關한 硏究(I) : 排球選手를 中心으로

李殷洪,尹炳烈 弘益大學校 1983 弘大論叢 Vol.15 No.2

We can make a conclusion like this through examining and analysing the psychological structure about the sports centering around men's university and business players of all over the country. 1. Conclusion 1) The motivation to become a volley ball player is due to the proposal of parents and acquaintances(including the teachers and seniors.) The principle reason is 45.3% which is saying that the environmental conditions and postulates can find talent in a good player and improve that talent. 2) In the part of the satisfaction's degree in the player's life, "I am satisfied" is 44.2% and "I am not satisfied" is 37.4% and the principle reason of satisfaction is because of a beneficial job and in preserving their own good health and the largest reason of unsatisfaction is that because there is no future and they have a low apititude. I could reckon that it is followed to find the aptitude of players well and improve the player's welfare. 3) In the part of occupation but player which they want to choose, to be teacher approaching 40.5% is the most desirable branch, and the field of administration and commerce to be also expressed 20% says that they want to be convinient economically and study the field to be able to use book in the rest time. 4) This results say that most of them read the book in the rest time. 5) In the satisfaction's degree of only business players. 51.2% of them are not satisfied of their remuneration, and the reason of that result is that they are hard to earn the life and allowance like bonus etc. is too small, and so they aren't satisfied of the remuneration, therefore I could think that the fundamental countermeasure to preserve and rear the players, similarly incomes must be firstly edified. 6) The view that Olympic game must be continues to be enforced in spite of political and ideological polutions is 45.3% and the contrary view is 44.7%, which is almost similar with each other and expressed such phenomenons and the most principle reason to be enforced is expressed that it gives us many chances of cultural exchange and the most principle reason not to be is expressed that between policy and sports must be distinguish and I could think that they have the considerable negative thoughts of political usage and intervention to sports. 7) About the custody of 88th Seoul Olympic, 86.3% of them think it good phenomenon because the possibility of all national development through exchange of culture and economy is more important than that of sports, and negative view is seemed to prevent and object because of economical blow of citizens. 8) In Olympic game, the view that there is the signification in the attendance is 50% because, as I think olympic is the sacred festival and to the contrary, the players who think that there is no siginification in the attendance is 47.9%, for they think that the games without victory don't exist. I could think because the phenomenon that the recenter it comes, the stronger desire of victory reveals controlling trend. 2. Overture 1) If I propose on the basis of research till now, (1) in research's subject, if women player is also examined, it will be more overall "contrast study" and if be distinguished from men and women, university and business to contrast, and determine the quarter of research. I think that it will be seemed to be going to be a better study. 2) I could think that if the solving term of psychological reason is actually inserted and studied on the basis fo this study in guarding the players, it will be an important file.

지역농산물을 활용한 가공사업의 의의와 과제 : 청주지역의 사례

윤병선, 하재찬, 이혜정 건국대학교 사회정책연구소 2012 사회과학연구 Vol.26 No.-

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