65세 이상의 노령층에서 고지혈증의 위험요인

김용배,장원기,황보영,김화성,안규동,이병국,이용진,김세훈,김승수,김승훈,김영록,김웅빈,이성수 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

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정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

性別 및 年齡에 따른 體格과 體力의 特性과 變化에 關한 縱斷的 硏究Ⅱ : Emphasised on College Men of Department of Physical Education 體育專功 大學生을 中心으로

金尙國,姜東洹,張周鎬,金昇一,徐再均,金耕知,孫斗玉,鮮于攝,崔榮烈,尹宇相,金亨燉,方永鎭,朴英震,柳在忠 慶熙大學校 體育科學大學 1989 體育科學論叢 Vol.- No.2

The purpose of this study was to compare the characteristics, change in physique and physical function of college students majoring physical education and Taekwondo (454 males and 64 females of age groups ranging from 18 to 26). The results are as following: 1. The male group of 23yrs old in physical education showed highest values in 7 items(Weight, Chest Girth, Fore Arm Girth, Thigh Girth, Calf Girth, Scapular Skinfold Thickness and Suprailiac Skinfold Thickness). 2. In the Physical function, the male group of 18yrs old showed highest values in Power, Flexibility, and then 21yrs old at Back Strength, Vital Capacity, and 23yrs old at Grip Strength, and 25yrs old at Blood Pressure, respectively. 3. In the physique, the male group of 22yrs old showed highest values in Weight, Chest Girth, Thigh Girth, Calf Girth, and then 24yrs old Upper Arm Girth, Fore Arm Girth, and 19yrs old at Height, Upper Limb Length, respectively. 4. In Physical Function, the 22yrs old showed highest values in Back Strength, Vital Capacity, and then 23yrs old at Side Step, Trunk Extension, but 18yrs old showed lower Values in Grip Strength, Side Step, Vital Capacity and Blood Pressure. 5. The female group of 22yrs old showed highest values in 8 items(Height, Sitting Height, Waist Girth, Upper Limb Length, Lower Limb Length, Skinfold Thickness), and then 18yrs old at 5 items (Weight, Upper Arm Girth, Fore Arm Girth, Thigh Girth, Calf Girth), respectively. 6. In the physical function, the 22yrs old showed highest Values in Grip strength, Back Strength, Power, 5 Minute Run, and 18yrs old at flexibility, Harvard Step Test, respectively. 7. In the change of the physique for two years(1988-1989) in the male group, majoring Physical education the 22yrs old showed increase in 4 items, and the 20yrs old in 3 items, but 18yrs old showed decrease in 3 items. 8. In the change of the physical function for two years in the male group, the 20yrs old showed increase in 4 items, and the 21, 25, 26yrs old in 3 items, but the 19yrs old showed decrease in 6 items, and 18, 22 yrs old in 5 items, respectively. 9. The change of the physique for two years in all female group, of 18, 19, 20, 21yrs old showed increase in 11 items except Skinfold Thickness. 10. In the change of physical function for two years in female group, the 18yrs old showed increase in 3 items, and then 20yrs old in 5 items, but 19, 22yrs old decreased 12 items, respectively. 11. The highest significant difference in physique between male and female was found in weight(mean Value 17.5%), and the lowest difference was found Thigh Girth, Calf Girth(1,3%), Upper Limb Length, Lower Limb Length(2.5%). 12. The Highest difference in physical function was Strength (mean Value 40%), Vital Capacity (33%), Power(22%), but Lower Trunk Flexion, Foot Balance(3.4%). 13. In the difference of Physique and physical function between physical education major and taekwondo major, the physical education showed higher values in skinfold Thickines (mean Value 16.5%), Weight, Waist Girth(4.7%) and Strength(33%), Endurance(5.6%), but subjects majoring Taekwondo showed higher values in Flexibility and Foot Balance. 14. In all male groups, Waist Girth, Scapular Skinfold Thickness, Back Strength, Sargent Jump, Trunk Extension and Diastolic Blood Pressure were showed a significantly related at 0.001 level.

性別 및 年齡에 따른 體格과 體力의 特性과 變化에 關한 縱斷的 硏究 Ⅰ : 體育專攻 大學生을 中心으로 Emphasised on College Men of Physical Education

金尙國,姜東洹,金昇一,徐再均,金耕知,孫斗玉,鮮于攝,崔榮烈,尹宇相,金亨燉,方永鎭,李錫元 慶熙大學校 體育科學大學 1988 體育科學論叢 Vol.- No.1

The purpose of this study was to compare the characterists and change in physique and physical function by college student of physical education major(287males and 40 females of age groups ranging from 18 to 26). The results were as following; 1) The characteristics of physique and physical function by sex and age. ① The male group of 18yrs old showed higher values in Height, Weight, Upper Limb Length, Strength, Flexibility, and Vital Capacity than any other groups, but female group showed lower values in Height, Weight, Chest Girth, Lower Limb Length, Thigh, Girth, Calf Girth and all of the Physical function. ② The male group of 19yrs old showed high values in power and Agility, then female group showed in Strength and Flexibility. ③ The male group of 20yrs old showed the lower values in Weight, Waist Girth, Upper Limb Length, Fore Arm Girth, Thigh Girh.Calf Girth, Vital Capacity, and female group are very lowed in Upper Arm Lenght, Fore Arm Length, Skin Fold Thickness and 5 minute Run. ④ The male group of 23yrs old showed the high values in Upper Arm Girth, Fore Arm Girth and Balance, and then female group higher in Weight, Chest Girth, Waist Girth, Upper Arm Girth, Fore Arm Girth, Thigh Girth, Power, Shuttle Run, Balance and vital capacity than any other age Groups. ⑤ In male group, Chest Girth, and Blood Pressure were significantly related, and Side Step and Trunk Extension were nagatively related to the age at 0.1% level, and then in female group, Sargent Jump, Standing Long Jump and Vital Capacity were showed a significantly related at 0.5% level. 2) The difference of physique and physical function between male and female by age. ① Everage difference in whole physique items except skinfold thickness was 9.8%, and that 21.1% in all of physical function except Trunk Flextion between male and female group subjects. ② About the ages, the 18yrs old male group showed the 22.8% higher values of 26 items, but 22yrs old male group were about 12.2% in 23 items, thus it is very lower than any other groups. 3) The difference of physique and physical function between General group and physical education group in age-matched. ① In the physique male physical education groups showed about 7% higher in Weight, Chest Girth, Upper Limb Length, Upper Arm Girth, Thigh Girth, and female group showed about 7% higher in Weight and Upper Limb Length. ② In the physical function, Trunk Flextion, 5 minute Run, and Blood Pressure(Diastolic) were about 8% high values in whole group, and female group showed about 8% higher in Standing Long Jump, Shuttle Run, and Trunk Extension. ③ In 22yrs old male and female physical education group were very dominated in physique and physical function than the other age group against the general group.

자기공명영상용 라디오주파수 코일의 제작에 있어서 동조 및 매칭에 영향을 미치는 전기 용량 값들의 실험적 측정

양경승,신용진,김영섭,한재진,이성길,김승국,김영근,지연상 조선대학교 기초과학연구소 2003 自然科學硏究 Vol.26 No.-

Radio frequency coil which is capable of transmit and receive the signal has been used for image production in magnetic resonance imaging(MRI). Tuning and matching characteristic of radio frequency coil is major factor determining the image quality. In experiment the used coil was called a staircase type coil which is simplified the birdcage coil and referred to a simple LC resonant circuit. Because the inductance values of the coils are fixed coil performance was examined by changing of the capacitance values. In this study capacitance values were experimentally determined to increase of-tuning and matching effect in junction of the coil between coil endring and BNC cable to obtain the high quality of image.

족부혈관평가의 3차원 MRA와 DSA의 유용성 비교 연구

김승국,한재진 광주보건대학 2002 論文集 Vol.27 No.-

The purpose of this study is to compare the 3-dimensional MR angiography(MRA) with digital subtraction angiography(DSA) for the evaluation of pedal artery. MR angiography was performed using three-dimensional FISP acquisition before, and four sequential acquisitions after the injection of gadolinium(0.2mmol/㎏, 3m1/sec). MRA was compared with DSA for correct identification of the arterial segment. Out of 168 segments, 32 segmints were invisible in both MRA and DSA. At the level of ankle, 48 segments were visible in both examinations, and 18 segments were visible only in MRA. In the foot area, 34 segments were visible in MRA, but not in DSA. Three arterial segments were visible only in DSA. 3D MRA is comparable to DSA for the evaluation of pedal artery, thus it gives additional informations for planning of treatment in lower extremity artery.

암환자 분포의 비교분석

김승국,지연상 광주보건대학 2002 論文集 Vol.27 No.-

This paper is based on the records of researching the patients with cancer in the Chunnam National University Hospital from January 1996 to December 2000 and referred to records of the Headquarters of Korea Central Cancer Registory, Ministry of Health and Welfare, Republic of Korea and National Cancer Center. The results are as the following: 1. Among the total O.P.D 4,246,293 the patients of therapeutic radiology are 136,324 in 3.21% 2. Among the 9,329 cancer patients, stomach cancer patients are 1,480(15.86%), liver cancer patients are 1,227(13.15%), lung cancer patients are 1,079(11.57%). Sexual ratio of male to female appeared 1.45:1. Therefore, male cancer patients are more than female patients. 3. The age distribution of cancer was 2,968(31.81%) by 55∼64 age, 2,172(23.28%) by 65∼74 age, and 1,715(18.38%) by 45∼54age. Therefore, above the 70% of all cancer patients were 45∼75 ages. 4. Among the 9,815 therapeutic radiology patients, 1,755(17.89%) are in the uterus system, 2,772(23.7%)are in the head and neck, 1,519(15.48%) are in the lung. Therefore, the proportion of three kinds of therapeutic radiology patients is about 50%. 5. The occupational distribution of 9,329 cancer patients(95∼2000 year) are 2,181(23.28%) by house wives, 2,165(23.21%) by orderly farmers, 380(4.07%) by businessmen, and 314(3.37%) by salary men. Miners, forest men and soldiers didn't nearly appear. 6. The number of patients of cancer diagnosis 6,862(73.56%) was by the biopsy of primary region, and 1,842(19.74%) by clinical examination. Therefore, those two kinds of methods took a proportion of about 94%. From 1996, the number of deceases in GI, PD has been increasing continuously. The total number in GI was 57(28.64%), in PD was 54(27.14%), and in GS was 11(5.53%). Therefore, those three kinds of deceases took a proportion of about 60%.

X선 촬영에 있어서 관전압과 피사체가 농도 및 선량에 미치는 영향의 실험 (1)

김승국 광주보건대학 1991 論文集 Vol.16 No.-

Author investigated the density and dosage with various thickness of acryl phantom, field size and X-ray tube voltage. The obtained results can be summerized as follows : 1. The effect of density was much as applied voltage was lower, the thickness of object was thicker. 2. The variety of density by the variety of field size was nearly constant when the applied voltage and the thickness of Object was constant. 3, The transmission dose was much decreased when the applied voltage was higher, the thickness of Object was increased. Therefore it is thought that we needed to consider the applied voltage and objects if we make film density and n-value proper.

癌患者 診療 및 放射線治療에 關한 統計的 考察(Ⅱ) : 일부 地域을 中心으로

김승국 광주보건대학 1995 論文集 Vol.20 No.-

The paper is based on the record of researching the patients with cancer in the Chunnam National University Hospital from January 1989 to December 1993. The results are as follows ; 1. Among the total O.P.D 1,932,229, the patients of therapeutic radiology are classified into 77,688(4.02%), (11038 in 1989, 14201 in 1990, 15061 in 1991, 18437 in 1992, 18951 in 1993). 2. Among the 5126 cancer patients cervix and uterus cancer patients are 958(18.69%), stomach cancer patients are 795(15.51%), lung cancer patients are 534(10.42%). brin and thyroid cancer patients are 421(8.21%), liver cancer patients are 399(7.78%) and sexual ratio appeared 1.08 : 1, therefore, male patients are slightly more than the female patients. 3. The age distribution of cancer was that of 55~64 ages are 1,414(27.58%), 45~54 ages are 1260(24.58%), and 65~74 ages are 782(15.26%) and the 70% of all cancer patients are 45~74 ages. 4. Among the 5262 cancer patients 1091(20.73%) are in the uterus system, 918(17.45%) are in the head and neck part, 846(16.08%) are in the lungs. Therefore these three kinds of cancer consist of 50% more. 5. Among the intracavitary application therapy of 2797 cancer patients are 584 in 1989(20.88%), 283 in 1990(15.89%), 579 in 1991(20.70%), 647 in 1992(23.13%), 549 in 1994(19.63%) and the patients of medical insurance are 2257(80.69%) 6. The occupational distribution of 5126 cancer patients(89~93year), housewives are 1190(23.21%), orderly farmers are 985(19.22%), businessmen are 290(5.66%), salarymen are 211(4.12%) and public service personnels are 203(3.96%) * O.P.D. : Outpatients department

組織沒入의 影響變數와 過程模型에 관한 硏究

金範國,康承權 濟州大學校 觀光産業硏究所 1990 産經論集 Vol.4 No.-

The purpose of this thesis is to formulate a theoretical system on organizational commitment and to lay the foundation of empirical study hereafter. I made a historical survey of the researches on organizational commitment, examining factors affective on organizational commitment. I inquired into several process models that the previous researches lay out to explain the way employees got lost to the organizational commitment, suggesting an integrative organizational commitment model. These may be summarized as follows; 1. Each researcher gives different definitions on organizational commitment. But most researchers follow porter et al's definition. Namely, organizational commitment refers to the relative strength of an individual's identification with and involovement in a particular organization, and this consists of the following three structural elements. (a) a person's strong belief in and an acceptance of the organizations goals, (b) a person's willingness to exert considerable effort on behalf of the organization, and (c) a person's definite desire to maintain membership. 2. Each research also has a different opinion on the factors affective on organizational commitment. Several researchers are studying by setting up anticidents and outcomes or moderated variables. 3. In view of a process model that may illustrate how employees reach to the organizational commitment, I have examined not only R. H. Steer's models but also other organizational commitment process models proposed by a number of researchers. Therefore, this thesis presented an integrative organizational commitment model, by adding or substracting some variables on the basis of the results of the previous researches. We should admit that the validity of this research must be attested through empirical researches.