정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

백서 간재생중 H2B Histone 유전자 발현에 대한 Octamer Binding Transcription Factor의 역할

임규,방재웅,최두식,손미영,이영철,박청,김태동,김영래,박종일,윤완희,박승길,황병두 한국노화학회 2001 한국노화학회지 Vol.11 No.1

Shell crown을 이용한 계속 가공 의치 제작에 관한 연구

임병철 김천대학교 1990 김천대학교 논문집 Vol.11 No.-

The auther, on the occasion, must a pulling out the natural tee-th by periodontal disease even though it has the ideal teeth an-atomy without a dental caries, devised a technique on the const-ruction crown and bridge by the duplicating of it. Throughout this auther devised method, the following advantages are studied. 1. This method can a recovery to the functional occlusion state and through a long period of adjustment to various habits functional movements. 2. This method need not a higher Technique than cone technique and F.G.P. technique. 3. Using the error of negative index, can a readjustment by examination with verticulator.

우리 나라 치과기공사의 직업성 질병과 관련요인에 대한 조사연구

임병철,민경진 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.2

This study was performed to identify the occupational diseases in the dental technicians working in Korea, and to elucidate the maul related affecting factors for the occurrence of the occupational diseases. The research was carried out using a mail questionnaire and data collection was done for two months from April 15, 2000. The questionnaires were delivered to 1000 dental technicians working at 250 dental laboratories which were chosen among the total 1330 dental laboratories in south Korea. And 763 questionnaires were collected, then 739 questionnaires were used for a logistic and a multiple regression analyses. The results obtained ill this study are summarized as follows: 1.The occupational diseases in the dental technicians included pneumoconiosis, chronic bronchitis, asthma, pneumonia, hyposmia, allergic dermatitis, eczema, contagious dermatitis, contral nervous disorder, dysfunction of finger, vertebral disorder, dysfunction of interphalangeal joint, ophthalmitis, auditory dysfunction, otitismedia, optic trauma, and burn. 2.The main related affecting factors for the occurrence of the occupational diseases in the dental technicians were elucidated as follows: On the ccurrence of chronic bronchitis, vibration of equipment and job career were affected positively. On the ccurrence of asthma, job career and career on current working part were affected positively, but exhaust ventilation, work hour were affected negatively. On the occurrence of eczema, career on current working part and vibration of equipment were affected positively, but personal protective equipment, local exhaust ventilation, isolation of gas source were affected negatively. And eczema was occurred more in methyl methacrylate work than in any other work part. On the occurrence of finger dysfunction, vibration of equipment and noise of work place were affected positively. But personal protective equipment, local exhaust ventilation, isolation of dust and gas source were affected negatively. But finger dysfunction was occurred more in metal polishing than in any other work part. On the occurrence of auditory dysfunction, noise of work place were affected negatively. The results obtained in this study can give a valuable information for a prevention of the occupational diseases in the dental technicians working in Korea, and for keeping them in healthy. This study also can be helpful for a researcher who is aiming at a identification of occupational diseases and a elucidation of related affecting factors in a similar occupation.

복식전자궁적출술 후 경막외 통증 관리시 0.1% Bupivacaine/Morphine과 0.1% Ropivacaine/Morphine의 비교

임일환,문철준,반종석,민병우 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.5

Background: Local anesthetics combined with an opioid are frequently used as a postoperative epidural analgesia, to minimize individual doses and to reduce unwanted side effects. The aims of this study were to compare analgesic effectiveness, occurrence of motor block and other side effects of a 48 hr postoperative continuous epidural infusion of 0.1% bupivacaine/morphine or 0.1% repivacaine/morphine. Methods: Forty female patients scheduled for an elective total abdominal hysterectomy under general anesthesia were randomized in a double-blind fashion to receive either 0.1% bupivacaine with 0.02 mg/ml morphine or 0.1% ropivacaine with 0.02 mg/ml morphine using a continuous epidural analgesia pump at a rate of 4 ml/hr during the postoperative 48 hours. After toe operation, we assessed the blood pressure, heart rate, visual analog scale (VAS), side effects, additional analgesic requirement and time to ambulation for 48 hours in 12-hour intervals. Results: There were no significant differences in VAS on rest and cough between the groups, but VAS on deep breathing and position change were significantly lower in the bupivacaine group compared to the ropivacaine group. Side effects were similar in both groups except paresthesia. Time to ambulation was earlier in the ropivacaine troup compared to the bupivacaine group. Conclusions: Both the postoperative continuous epidural infusion of 0.1% bupivacaine with morphine and 0.1% ropivacaine with morphine provided similar pain relief and side effects. However, earlier recovery of ambulation in patients receiving ropivacaine/morphine will improve outcome after abdominal surgery. (Korean J Anesthesiol 2002; 43: 633~639)

한국치과기공사의 직장이동에 영향 미치는 제요인에 관한 연구

임병철 김천대학교 1989 김천대학교 논문집 Vol.10 No.-

This Study was practised in order to presentation to the factors in fluencing at the transferablility of one’s post by some postal questionaires, from dental techni- cian in korea, and results through the study are as follows: 1) For the three years, the dental technician that had transferred of one`s post, more than one time, was 112 person`s (58.9%) of 190 persons 2) The frequency of the post_transfer differed in accordance with given individual character, I. e. , it showed high when the age was young (p<0.005), and when the married was higher than the unmarried (p<0.005 and when the educa_ tional experience was high, it showed high (p<0.005), and when the dependent family was less, it showed high (p<0.005)and when the experience was less, it showed high (p<0.005) and according to kind of their job, it was high as showed in a example of the next order, porcelain < partial and complete denture< crown and bridge < assistance (p<0.005) 3) The sex did not affect significantly to the frequncy of the post transfer, statisti- cally. 4)The frquency of the post transfer diffrerd in accordance with given condition of one`s post, I. e., it showed high when th treament was not a satisfaction (p<0.005), and when too much duty on their jod was given, it showed high (p<0.005) 5) The human relation with senior the human relation with colleaques, circumstan tial factor at workshop, the model of the prosthodontic material being supplied, the prospect of technique acquirement, and the requst time for the prosthodontic material being supplied, e. t. c. did not affect significantly to the frequency of the post transfer, statistically. 6) The factors of the main post transferability appeared to the dissatisfaction treat ment (47. 9 % ) , the too much duty on their job was given (37. 4 % ) , the pros- pect of technique acquirement was not given (34 . 2 % ) , and the discord with manager (24. 2 % ) , e. t. c. ,

대학생의 노인복지에 대한 인식도

차병준,김무룡,김기열,차경미,김귀희,김현실,서인선,임상규,이순자,위광복,남철현 慶山大學校 保健福祉硏究所 1999 保健福祉硏究 Vol.2 No.-

The purpose of this study is to grasp the change of consciousness of young people in order to seek new approach of policy for aged era. 1,200 students attending collages and universities in three small or medium sized cities were inquired for 2 months, from October 1 to November 30, 1996. The result is as follows. 1. The characteristic of the respondents of this survey is that they include 72.1% of women, 40.4% of people aged between 20 to 21, and 49.1% of people who do not have any religion. Those who are from big cities and those who are form farming villages or fishing village occupy equally 40.2%, those who reside in that cities for a long period 49.0%, and those who live with their family 60.9%. 2. The family feature of the subject is that 31.5% of them are those whose father is the age of 55 and more than 55, 10% of them are those whose mothers age is so, 33.1% of them have 5 family members, 29.5% of them have the family income of 1,000,000 to 1,490,000 won, 83.9% of them are from middle class, 47.7% of them are the people whose grand parents have passed away, 70.4% of them live apart from their grand parents, and 60.9% of them are second child. 3. 64.0% of males, 70% of respondents who are aged over 24, 58.1% of respondents who are from rural communities, 62.4% of respondents who live in rural area, and 58.3% of respondents who live alone, prefer to live with grand parents, marked higher rate than other groups. The groups whose father and mother are the age of more than 55 marked higher rate of 55.9% and 58% each than any other groups(p<0.05). The groups whose family member is less than three, whose grand parents both have passed away in middle class, who live with their grand parents, and who are second children, give more positive answers than any other groups. 4. Those who are older, who are buddhists, who are from rural area or live in rural area, whose family is small, whose family income is small, who are from lower class and whose grand parents are still alive, shows preference to support their parents after marriage. 5. Females(89.4%), those who are from small or medium sized cities(89%), who live with their family(85.6%), whose father is the age of 55 and more than 55, whose mother is the age of 54 and less than 54, whose family member is 6, who are from middle class, whose grandparents are still alive and who are the eldest child in their family, give more response that they prefer to live apart from their children in their old age than any other groups. 6. What elderly people need most right now is past time(42.3%), and the respondents whose age is 20 to 21, who are buddhists, who are from middle sized cities and live alone, whose parents are the age of more than 55, who have small family income, who live with their grand parents and who are second children show higher level than any other groups. 7. 76.8% of respondents answer that they do not need their parent's fortune, marked still higher rate than the opposite answer. Those who are older, who are buddhists, who are from big cities, who reside in rural area, who live alone and have smaller family, who are in bad family economic conditions and who live with grand parents present higher rate of positive response. 8. 59.3% of respondents reply that they think about death from time to time, and those who are female, who are in the age of 20 to 21, who are christian, who live with their family, whose siblings or other family members offer their education expenses show higher rate than any other groups. 9. 92.3% of respondents answer that the budget for welfare facility for elderly people is very small. The younger the respondents are and the worse economic condition they have among those who live in big cities, the more answered that. 10. 50% of respondents think social security should provide for their old age, and 42.8% of them believe they themselves provide against it. The respondence that social security ought provide for it appeared more among those whose age are over 24, who are female, who reside in rural area, who are christian, who are in bad economic condition, and who ever used medical institutions in recent one month, marked higher level than other groups. 11. The adequate time of retirement is 59.97±5.60 for public officers, the highest and 59.28±6.35 for teachers, the next. 12. 35.2% of respondents reply that the adequate budget for the old age after their retirement at the age of 60 is 220 million won, showed the highest level of respondence. 13. The factors which affect on the old people in the charged welfare facilities are sex(p<0.01), the type of housing(p<0.05) and whole family income(p<0.05). 14. The factors which affect on remarriage are sex(p<0.05) and religion(p<0.05). For varying old population and expanded welfare service for them, government and relevant authority should give more attention to secure the budget, establish effective plans to expand various program and the facilities for elderly people in order that elderly people spend the rest of life time more happily and more fruitfully. To do that, each college and university should open Health courses, and educate and inform about health and welfare.

한국인 상악 중절치의 교모에 관한 연구

임병철 김천대학교 1992 김천대학교 논문집 Vol.13 No.-

This study was aimed to helf the construction of esthetic dental prosthesis by investigation of the factors affecting on the attrition position and attrition angle of maxillary central incisors. Therefore, 158 complete cast of maxillary and mandibular extracted from the students of K. junior college were subjected for this study. And results through the study are as follows. 1. Through-out mesiodistal attrition area of the right central incisor were as follows. 1) It showed that square type arch and ovoid type arch is the highest frequence in attrition of all incisal edge, and tapering type arch is the highest frequence in attrition of distal area of incisal edge, by dental arch type, (p<0.05) 2) It showed that overlap of 1. Oxx below and 4. Ixx above is the highest frequ-ence in attrition of mesial area of incisal edge, and overlap of 1. 1-2m and 3. 1-4ra is the highest frequence in attrition of all incisal edge: and overlap of 2.1-3x is the highest frequence in attrition of distal area of incisal edge, by vertical overlap (p<0.01),​ and Horizontal overlap (p<0.001) 3) Sex, address, and incisal guide angle; did not affect significantly to throughout 2. Throughout mesiodistal attrition area of left central incisal were as follows. 1) It showed that square type arch and tapering type arch is the highest frequence in attrition of mesial area of incisal edge, and ovoid type arch is the highest frequence in attrition of all incisal edge, by dental arch type (p<0.001). 2) It showed that overlap of 1. Omx below is the highest frequence in attrition of mesial area of incisal edge, and overlap of 1.1-32 and 4. lmm above is the highest frequence in attrition of distal area of incisal edge, and overlap of 3. 1-4na is the high-est frequence in attrition of all incisal edge, by vertical overlap (p<0.001). 3) It showed that overlap of 4. Ona below is the highest frequence in attrition of mesial area of incisal edge, and overlap of 4. 1x above is the highest frequence in attrition of medium area of incisal area, by Horizontal overlap (p<0.001). 4) Sex, address, and dental arch type, did not affect significantly to throughout mesiodistal attrition, statistically. 3. Throughout labiolingual attrition area of right central incisor were as follows. 1) It showed that overlap of 2. Om below is the highest frequence in attrition of incisal area including labioincisal, and overlap of 2. luz above is the highest frequence in attrition of linguoincisal area, by vertical overlap (p<0.05). 2) It showed that overlap of lux below and 2. I am above is the highest frequence in attrition of linguoincisal area and overlap 1. 1-2n is the highest frequence in attrition of incisal area including labioincisal, by Horizontal overlap (p<0.001). 3) It showed that incisal guide angle of 10 degree below, 31-50degree, and 71 degree above, is the highest frequence in attrition of linguoincisal area, and incisal guide angle of 11-30 degree, and 51-70 degree is the highest frequence in attrition of incisal area including labioincisal, by incisal guide angle (p <0.05). 4) Sex, address, and dental arch type, did not affect significantly to labioincisal mesiodistal attrition, statistically attrition, statistically. 4. Throughout labioincisal attrition area of left central incisal were as follows. 1) It showed that overlap of Ian below is the highest frequence in attrition of inci-sal area including labioincisal and overlap of 1. Ima above is the highest frequence in attrition of linguoincisal area, by vertical overlap<0.01) and Horizontal overlap (p<0.05). 2) It showed that incisal guide angle of 51-70 degree is the highest frequence in attrition of insisal area including labioincisal, and incisal guide angle of 50 degree below and 71 degree above is the highest frequence in attrition of linguoincisal area, by incisal guide Angle (p<0.001). 3) Sex, address, and dental arch type, did not affect significantly to labioincisal attrition, satistically. 5. The average attrition angle of right central incisor were 25-12.49 degree. It was as follow that attrition angle have a bigger than it of average of right central incisor. Square type and tapering type by dental arch type, and overlap of 2. I am above by vertical overlap, and Horizontal overlap, and incisal guide angle of 10 degree below, 31-50 degree, 70 degree above by incisal guide Angle. 6. The average attrition angle of left central incisal were 2512.40 degree. It was as follow that attrition angle have a bigger than it of average of left central incisal. Tapering type arch by dental arch type, and overlap of 2. 1x above by vertical overlap and Horizontal overlap, and incisal guide angle of 31-50 degree, and 71 degree by incisal guide angle.

극장으로서의 사회, 연기자로서의 개인 : 알베르티의 다원적 자아재현에 관한 고찰 A Study on Alberti's Multiple Self-representation

임병철 한국서양중세사학회 2006 西洋中世史硏究 Vol.0 No.17

반건식-백필터에 의한 소각배가스 중의 HCI, SOx 제거 (Ⅰ)

배병훈,신남철,고경숙,김춘희,문종익,임경택 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

This study has been carried out to investigate the removal efficiencies of HCl/SOx in a Spray-Dryer/Fabric-Filter system. In HCl/SOx removal, we could identify the key factors such as spray dryer outlet temperature, molar equivalence ratio(MER) and fabric filter velocity, but we couldn't find out the correlation of HCl and SOx. The removals of HCl/SOx were inversely proportional to spray dryer outlet temperature(l30~170℃) and filter velocity(l.0~1.5 m/min), at the MER, HCl removal efficiency was strongly proportional to MER, but SOx, removal efficiency was not particularly increased by MER over 1.5. The removal efficiencies of HCl/SOx were improved over 10% at the fabric filter. In this Spray-Dryer/Fabric-Filter system, HCl/SOx removal efficiencies were about 99%, 96% respectively.