한국판 정신질환의 내재화된 낙인 척도의 신뢰도 및 타당도 연구

황태연,이우경,한은선,권의정 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.5

Objectives : The Internalized Stigma of Mental Illness (ISMI) scale designed to measure the subjective experience of stigma with sub-scales measuring Alienation, Stereotype Endorsement. Perceived Discrimination, Stigma Resistance, and Social Withdrawal. The purpose of this study was to examine the reliability and validity of the Korean version of ISMI. Methods : The subjects were 194 schizophrenic patients and 205 peoples with depressive disorder. K-ISMI, CES-D (The Center for Epidemiologic Studies Depression Scale) and Self Esteem scale were performed. Results : Results showed that the ISMI had high internal consistence and split-half reliabilities. The internal consistency coefficients (Cronbach alpha) of each subscale ranged from .83 to .93. The validity of the ISMI was investigated by principal axis factoring analysis, yielding 5 factors of alienation, Perceived discrimination, negative stereotype, stigma resistance, devaluation and social withdrawal. 5 subscales explained 60.67% of total variance. Concurrent validity was supported by comparisons against scales measuring related constructs. As expected, the ISMI had positive correlations with CES-D, and it had negative correlation with self-esteem scale. Subsidiary analysis showed that schizophrenic patients showed higher internalized stigma than depressed patients. Conclusion : Overall, the findings support the utility of ISMl as a tool to evaluate internalized stigma of persons with mental illness. Interventions that can lessen internalized stigma may well hasten the recovery process in individuals with mental illness.

축산시설의 입지특성 분석 : 안성시 미양면을 중심으로

황한철,전우정,이남호,홍성구,김진태 안성산업대학교 1998 論文集 Vol.30 No.2

It is necessary to evaluate the location suitability of livestock facilities to guide reasonable livestock. The evaluation system could help plan new livestock facilities in rural areas. The assessment was performed based on location characteristics of livestock facilities such as land utilization around livestock facilities, size of livestock facilities, water and drainage condition, accessibility and distance from roads, floor condition, distance from village and house, direction of livestock facilities, ventilation facilities, animal Waste treatment, and so forth. In this study, location characteristics of livestock facilities were showed each location factors using statistical analysis.

전기장이 걸린 양자우물 구조의 바닥상태 특성

황형준,권태진,최정우 慶熙大學校 材料科學技術硏究所 1999 材料科學技術硏究論集 Vol.12 No.-

We estimate the ground state energy and wavefunction in the biased quantum well structure by using the periodic boundary condition. In this calculation, we assumed that the probability of finding the particle has maximum value at the ground state energy and the amplitude of the wavefunction should not depend on a period. The obtained energy value was in good agreement with the result predicted by the complex energy method.

艾灸가 家兎의 筋損傷에 미치는 影響

黃炳泰,羅昌洙,黃祐準 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

To know that how be effected muscle injury by moxibustion treatment, we have measured the changes in concentration of electrolytes(K^+, Na^+, Cl^-), activity of LDH and CPK from blood serum after complete compression with rubber tourniquet around the femoral area of rabbit. And we also examined effects of moxibustion applied to a meridian point Jog Sam Ri(S 36), Kan Soo(B18) on changes of concentration of electrolytes (K^+, Na^+, Cl^-), activity of LDH and CPK from blood serum at 30, 60, 90 minutes and 18 hours after release of tourniquet. The results obtained from this study were as follows; 1. Among the concentration of electrolytes, that of K^+ in B 18 group at all times for blood serum has shown a significant increase than in control group, that of Cl^- in S 36 and B 18 group at 18 hours for blood serum has shown a significant decrease than in control group. 2. The activity of LDH in B 18 group for blood serum has shown a significant decrease compared with control group, but in s 36 group has not shown a significant decrease compared with control group. 3. The activity of CPK in B 18 group for blood serum has shown a significant decrease compared with control group, but in S 36 group has shown a increase compared with control group. According to the above results, we have identified that moxibustion can recover muscle injury, and have considered that better effect upon in B18 than in S 36.

유산양 유방염에 대한 Chitosan 약침의 치료 효과

황수현,서진석,김덕환,김명철,신상태,전무형,南三郞,김영찬,이우근,표수일 충남대학교 수의과대학 동물의과학연구소 1999 動物醫科學硏究誌 Vol.7 No.-

To improve the therapeutic method for mastitis, treatment effect of chitosan pharmacopuncture was examined in three milking goats(A,B and C). Mastitis was artificially induced in two milking goats(A and B) and one goat(C) was naturally infected case with mastitis. The acupoint used was Yang-Ming and chitosan suspensions(provided from Tottory University, Japan: 30㎎ of chitosan/㎖)were injected to the acupoint with 5㎖/time for 3 days, respectively. As for the change of somatic cells in milk along with chitosan pharmacopuncture, they showed a decreasing tendency after increase on the 3rd day in all udders of B. In addition, as for the change of total leukocyte counts of peripheral blood with chitosan pharmacopuncture, they showed a decreasing tendency after increase on the 3rd day in B and C except A which showed a increasing tendency until on the 7th day. In the change of neutrophil/lymphocyte(N/L) ratio, increasing tendency was seen in A and C but increasing tendency after slight decrease was observed in B. Further, in the change of serum total protein and A/G ratio, serum total protein content was decreased after slightly increase on the 3rd day in A, and they were decreased after increase until on the 7th day in B and C, respectively. As for the change of A/G ratio, different pattern increasing tendency was shown in A, B and C.

표피성장인자, 염기성 섬유모세포 성장인자 및 각질세포 성장인자가 LNCaP 전립선암 세포주의 PSA 분비와 PSA mRNA 발현에 미치는 영향

이홍우,김준철,서성일,황태곤 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.8

MR Spectroscopy로 진단한 Leigh 병 1례

황성욱,황태규,김용우 인제대학교 2006 仁濟醫學 Vol.27 No.-

Leigh syndrome is a progressive and degenerating central nerve system disease with symmetrically localized necrotic changes on the both gray and white matter, called subacute necrotizing encephalopathy. The causes of this disease have been revealed that defect of various enzymes (pyruvate dehydrogenase, repiratory complex Ⅰ, Ⅳ, Ⅴ, etc.)related to mitrochondrial carbonate metabolism and energy generating mechanisms. The clinical course is variable, and symptoms such as non-specific- seizure, respiratory failure, nystagmus, decreased muscle tone, developmental delay, vomiting and lethargy etc. appeared. And the diagnostic tool is not clear, so the diagnosis is difficult. Brain MRI and MR spectroscopy have been used to diagnose Leigh syndrome. We experienced 1 case of Leigh syndrome with typical MR, MR spectroscopic findings. MRI shows the lesions on midbrain, both basal ganglia, caudate nucleus, putamen, periaqueductal area, and periventricular white matter. MR spectroscopic findings showing high lactate peak were appropriate to Leigh disease. The patient is a 16-month-old girl with generalized weakness, and died within 1 month after first admission on our hospital. We report this case with typical MR spectroscopic findings.

호르몬 불응성 전립선암 환자에서 mitoxantrone과 prednisone의 병합화학요법 후 통증완화 및 삶의 질 측정

이홍우,이지열,김세웅,이충범,강성학,조용현,황태곤,박용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 호르몬 불응성 전립선암 환자의 생명을 연장시키는 치료법은 현재로는 없으며, 현 시점에서의 치료목표는 증상의 경감 및 소실에 따른 삶의 질 향상에 두고 있다. 호르몬 불응성 전립선암의 고식적인 치료에 일차적인 치료법으로 간주되는 mitoxantrone과 prednisone의 화학요법이 호르몬 불응성 전립선암 환자의 통증완화 및 삶의 질에 어떠한 영향을 미치는지 알아보았다. 방법 : 1998년 7월부터 1999년 12월까지 증상이 있는 18명의 호르몬 불응성 전립선암 환자를 대상으로 하였으며, 일차적인 치료의 목표는 환자 본인이 기록하는 McGill-Melzack 6단계 통증척도에서 진통제의 증량 없이 2점이 감소(또는 첫 점수가 1점일 경우 통증의 완전소실)하는 것으로 하였다. 이러한 기준은 최소 3주 간격으로 시행한 자가 기록조사에서 연속적으로 2번 이상 유지될 때 유효한 것으로 간주하였다. 건강과 관련된 삶의 질 측정은 전신적 치료의 임상적 응용을 위한 실제적인 측정방법으로 개발되어 환자가 직접 작성하는 전립선암 특이성 삶의 질 측정기구(Prostate Cancer-Specific Quality-of-Life Instrument : PROSQOLI)의 비례연속형의 자가측정 척도(linear analogue self-assessment scale : LASA)를 이용하였으며, ECOG performance status를 사용하여 전신상태의 변화도 측정하였다. 결과 : 통증의 경감으로 나타나는 고식적인 치료의 반응은 66.7%(12/18)에서 나타났으며, 반응의 지속기간은 2개월에서 10개월까지로 평균 4.2±3.6개월이었다. PROSQOLI로 측정한 삶의 질은 통증에 대한 고식적인 치료반응을 보인 12명(66.7%) 모두가 삶의 질이 개선되었으며 특히 통증, 변비, 소변보기, 전반적인 복지상태에서의 유의한(p<0.05) 증가를 보였다. 치료 후 혈장 PSA 수치는 고식적인 반응의 유무에 관계없이 별 다른 변화를 보이지 않았으며, 골주사 또는 전산화 단층촬영으로 측정한 방사선학적 병변은 고식적인 반응을 보인 2명을 제외하고 치료 전과 비교하여 차이를 보이지 않았다. 병합 화학요법과 관련된 특별한 부작용은 관찰되지 않았다. 결론 : 통증을 동반한 호르몬 불응성 전립선암에서 mitoxantrone과 prednisone의 병합화학요법은 66.7%의 환자에서 통증의 감소 및 삶의 질이 향상되었다. 현재는 혈장 PSA 수치, 병소의 크기나 개수등이 치료의 지침이나 치료결과의 판정을 위한 객관적인 기준으로 사용되는 경향이 있지만, 앞으로는 환자를 중심으로 통증을 포함한 삶의 질 측정이 고식적 치료 후 치료결과 판정에 있어 객관적이고 적절한 방법이 될 것이다. Background : There is no evidence that therapeutic modalities prolong the survival of patients with hormone-refractory prostate cancer nowadays. The main goal of treatment is therefore improvement in quality-of-life including palliation of symptoms. We performed this study to investigate the benefit of mitoxantrone and prednisone chemotherapy in patients with symptomatic hormone-refractory prostate cancer using relevant end points of palliation regarding to pain and quality-of-life. Methods : From July 1998 to December 1999, we assessed the 18 patients with symptomatic hormone-refractory prostate cancer receiving mitoxantrone and low dose prednisone. The treatment end point was a palliative response defined as a 2-point decrease in pain assessed by a 6-point pain scale complemented by patients (or complete loss of pain if initially 1+) without an increase in analgesic medication and maintained for two consecutive evaluations at least 3 weeks apart. Health-related quality-of-life was evaluated with a series of linear analogue self-assessment(LASA) scale of the Prostate Cancer-Specific Quality-of-Life Instrument (PROSQOLI) and performance status was also measured. Results : Palliative responses were observed in 12(66.7%) of 18 patients. The duration of palliative responses were 4.2±3.6 months(range: 2 to 10 months). Treatment was well tolerated without specific side effects. There were no differences in prostate-specific antigen (PSA) level following treatment and no significant changes of radiologic findings evaluated by bone scan and/or CT were noted except 2 cases after chemotherapy. All the responding patients had an improvement in quality-of-life scales and performance status, however serum PSA levels were not changed. Conclusions : Chemotherapy with mitoxantrone and prednisone provides palliation and an improvement in quality-of-life for more than half (66.7%) of the patients with symptomatic hormone-refractory prostate cancer.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

남조류의 체외 대사부산물이 다른 조류의 광합성에 미치는 타감작용

김범철,허우명,황길순,안태석,심재형 江原大學校 附設 環境硏究所 1994 環境硏究 Vol.11 No.-

The effect of cyanobacterial extracellular byproducts upon the aIgal photosynthesis was assessed to elucidate the allelopathic effect of algal blooms in eutrophic lake. Algal cultures were filtered with 0.2μm membrane filters to remove algal cells and sterilized. 0 to 30m1aliquots of filtrate were added to 25m1 culture suspensions of other algal species, and the (14)^C uptake rates wert measured. The filtrates of cyanobacterial cultures(Anabaena flos-aquae, Phormidium sp.) inhibited the photosynthesis of green algae(Selenastrum capricornutum and Scenedesmus brasiliensis), while the filtrate of Selenastrum capricornutum and Scenedesmuns brasiliensis did not inhibit Anabaena flos-aqiae. In the autoinhibition test Anabaena flos-aquae, Selenastrum capricornutum, and Scenedesmus brasiliensis showed positive, negative, and no effects, respectively.