加味枳朮丸 및 保和丸이 損傷된 肝組織에서의 膠原質生成 및 肝細胞再生에 미치는 影響

金成桓,姜秉淇 圓光大學校 韓醫學硏究所 1997 원광한의학 Vol.7 No.1

肝硬變症은 상당량의 肝細胞의 消失과 血管彎曲을 同伴하는 綱狀組織의 虛脫과 織維組織增殖 그리고 殘存 肝細胞群의 再生結節을 特徵으로 하는 모든 形態의 慢性肝疾患으로서 여러 原因으로 肝炎이 發生하고 慢性肝炎으로 移行되어 肝細胞 및 組織構造가 破壞되어 肝細胞 壞死後에 結合組織의 生成을 誘發하여 肝職維化가 進行되어 發生하는 疾患이다. 韓醫學에서는 肝硬變이 積聚, 鼓腸, 單腹脹, 비괴, 黃疸의 範疇에 들어 있는데 病因은 濕熱이나 肝鬱등이 日久하여 肝脾가 損傷되어 氣滯血瘀로 因하여 氣血이 瘀結하여 發生한다고 한다. 여기서의 瘀滯의 槪念은 肝構造의 細胞代謝障碍 肝織維素의 增殖等과 一致한다고 여겨진다. 加味枳朮丸은 食積, 酒積, 茶積, 肉積 等의 諸積症에 쓰이는 處方이고, 保和丸은 飮食所傷으로 적취비괴증에 쓰이는 處方으로서 이 두 處方은 氣血瘀結로 인한 積聚症에 應用할 수 있으므로, 慢性 肝疾患에도 有效할 것으로 思料된다. 膽道結紮 및 DMN으로 肝炎 및 肝硬變證을 誘發한 후 加味枳朮丸과 保和丸을 投與한 結果 다음과 같은 結論을 얻었다. 1. 膽道結紮로 인한 血淸 total bilirubin 과 direct bilirubin의 上昇은 保和丸을 投與한 實驗群 모두에서 抑制되었으며 두 處方간의 差異는 보이지 않았다. 2. 膽道結紮로 인한 血淸 AST의 上昇은 加味枳朮丸과 保和丸을 投與한 實驗群 모두에서 抑制되는 樣相을 보였으며, 특히 加味枳朮丸을 投與한 實驗群에서 抑制效果가 더 좋았으나 그 差異는 크지 않았다. 3. 膽道結紮로 인한 血淸 ALT의 上昇은 加味枳朮丸을 投與한 實驗에서 抑制되었으며 加味枳朮丸의 抑制效果가 保和丸보다는 좋았다. 4. Dimethylnitrosamine의 腹腔注射 後 誘發된 肝損傷에서 血淸 AST의 上昇은 加味枳朮丸과 保和丸 모두에서 抑制되었으며 加味枳朮丸의 抑制效果가 더 좋았으나 그 差異는 크지 않았다. 5. Dimethylnitrosamine의 腹腔注射 後 誘發된 肝損傷에서 血淸 ALT의 上昇은 加味枳朮丸과 保和丸을 投與한 實驗群 모두에서 抑制되는 樣相을 보였으며 두 處方間의 差異는 볼 수 없었다. 6. 膽道結紮과 Dimethylnitrosamine으로 誘發한 肝損傷으로 因하여 肝組織내의 hydroxyproline量의 增加는 加味枳朮丸과 保和丸의 投與로 모두 抑制되는 效果를 보였으며 두 處方間의 差異는 볼 수 없었다. This study was to investigate the protective and anticirrhotic effects of Gamijichulwhan and Bowhawhan on the liver cirrhosis or fibrosis induced by prolonged bile duct ligation; a new experimental model for cirrhosis and the intraperitoneal injection of dimethylnitrosamine in the rat. The development of fibrosis or cirrhosis and its inhibition by the two prescriptions were examined by the chemical analysis of AST, AST, and hydroxyproline, and histological observations. The results obtained were as follows. 1. The increase of serum asparate aminotransferase induced by bile duct ligation was inhibited by the administration of Gamijichulwhan and Bowhawhan. 2. The increase of serum alanine aminotransferase induced by bile duct ligation in rats was inhibited by the administration of Gamijichulwhan and Bowhawhan. 3. The increased level of serum AST and ALT induced by the intraperitoneal injection of dimethylnitrosamine was inhibited by the administration of Gamijichulwhan and Bowhawhan. 4. The increasing level of hydroxyproline volume in the damaged liver tissues in rat were decreased by the oral administgration of Gamijichulwhan and Bowhawhan extract. But there was no significant differences in the inhibition rate between the two experimental groups. 5. The histological observation the damaged liver tissue and immunohistchemical observation of bromodeoxyuridine in the liver tissue of rats showed the significantly hepatoprotective effects of Gamijichulwhan and Bowhawhan extract, and revealed the regenerative effects of Gamijichulwhan and Bowhawhan extract on the damaged liver induced by bile duct ligation and the intraperitoneal injection of dimethylnitrosamine.

蒲公英 水抽出物이 鎭通·抗炎作用에 미치는 影響

金石根,宋昊埈 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

This study carried out to know the effects of white flower (WHT) and yellow flower (YHT) of Herba Taraxaci on the antialgesia and antiinflammatory. The antialges were measured by the frequency of the writhing syndrome. The antiinflammatory were measured by the hindpaw edema and evalu ating the amount of reactive oxygen intermediate (ROI) in the neutrophils and macrophages. The result obtained were as follows : 1. Both WHT and YHT showed significantly analgesic effects. YHT was found to be more significant than WHT. 2. There were significant effect both WHT and YHT on the antiinflammatory, WHT were more significant than YHT of the two. 3. There were significant effect both WHT and YHT on the amount of ROI in the neutrophils and macrophages, YHT were more significant than YHT of the two. The results of this study suggested that Herba Taraxaci might be effective on the antialgestics and inflammatory diseases.

蟲垂炎에 대한 韓醫學的 考察

문석재 圓光大學校 韓醫學硏究所 1996 원광한의학 Vol.6 No.1

Appendictis is an acute abdomen and regarded to belong to chang ong(腸癰) in oriental medicine. Chang ong includes appen-diceal abscess, abdominal abscess, peritonitis, pelvic inflammation, and pelvic abscess as well as appendictis. Today while the treatment of appendictis is surgical removal in principle unless apparent contraindication, medication therapy is applied in oriental medicine. Recently medication therapy is reported to be effective in many cases. So I bibliographically investigated on the cause, symptom and diagnosis of appendictis, and prescreptions and herbs used for the disease. And following results are obtained: 1. Appendictis is developed by failure of transporting and distributing of nutrients in the intestine owing to retension of dampness, heat blockage, stagnation of qi, blood stasis and malnutrition due to parasitic infestation, which caused by emotional stress, improperdiet, debility of stomach and intestine, invasion of pathogenic factor, and intemperate daily life. 2. Common manifestation of appendicitis is lower abdominal pain, referred and rebound tenderness, fever, chill, sweating, painful on thigh extension. And its characteristic symptom is RLQ pain. 3. The stage is classified into blood stasis stage, accumulating fever stage, and poisonous fever stage. 4. Principle of therapy is treating exterior syndrome in acute stage such as promoting blood circulation and purgation, clearing away heat and toxic material, and promoting blood circulation by removing blood stasis. 5. Most common prescription for appendictis is Daewhang Mokdanpi Tang. Euiein Tang, and Daewhang Tang. 6. Herb drugs used for the treatment are Daewhang, Mangcho, Kwaruin and Hekchuck as the drug for promoting blood circulation and purgation, and Kemeunwha, Pogongyoung, Chunyeonja, Yiongyo, Whangkum and Hyunsam for clearing away heat and toxic material, Doin, Mokdanpi, Hyunhosaek and Dangkui for promoting blood circulation by removing blood stasis, and Paejang, Euiein, Chunsankap and Chogakja for promotingpus discharge.

韓醫學 敎育의 提高를 위한 韓醫科大學 敎科課程硏究

辛民敎 圓光大學校 韓醫學硏究所 1995 원광한의학 Vol.5 No.1

Recently, the internationalization and globalization is rapidly processed in the world and every field. With the trend, the education of Oriental Medicine is also reformed for the effective education and the current demand. In this paper, I suggested some opinions as a result of comparing the curriculum of Korea with that of China. 1. There are many subjects in the general course that has few relation with the major course. Accordingly, the unnecessary subjects should be substituted with the high-related subjects with the major. 2. The education of Chineses classics and classical literature of Korean Traditional Medicine should be strengthened for achieved the goal of education of Korean Traditional Medicine. 3. The education course should be established on the subjects suitable for the goal of education of Korean Traditional Medicine, not according to the faculty members. 4. The comparison of the education course between China and Korea suggested the necessity of establishing the characteristic education course peculiar to Orinetal Medicine. 5. The course of Keum-Guae-Yo-Raik, Pushing and pulling maneuver. Acute febrili disesase, and Bone and traumatology should be established. Also, the clinical base of modern medicine such as internal medicine, surgery, obstetrics and gynecology should be established for understanding generally modern medicine. 6. For the clinical training, now the theory and practice is carried out simultaneously. It is necessary to reform the course of clinical training like that of China. So at the last year of course, the collective practise is necessary and the time of clinical training should be increased.

韓醫學에 있어서 姙娠의 成立에 關한 文獻的 考察

金鍾桓,金哲源,朴炳烈 圓光大學校 韓醫學硏究所 1993 원광한의학 Vol.3 No.1

This study was carried out in order to secure th foundamental material on the conceptive completetion which is able to apply to sterility, contraceptive methodog and family planning practically in a view of Oriental Medicine. As I researched the contents written in 30 kinds of classical literatures from Whangjaenaikyung(黃帝內經) to the Chung(淸) dynasty. The results of the study are as follows. 1. The conception is supervised by the Kidney(腎) which is the visera have a reproductive function in male and female and the place where the conception is forfomed directly is the Uterus(女子胞). 2. 20 years of age off and on is a mature period of Yin(陰) and YANG(陽) and from that is the suitable periods for the conception. 3. The conditions, regulation of menstral disturbances(調經) and beginning of sexual fuction(天癸) for female, invigoration of sperms(壯精; to promote the Kidney function for increasing vilility and sexual potency of the male) by tonifying the Kidney(補腎) for male, Tao of aggregation for semen(聚精之道), that of obtainment for species(種子之道) and so, are neccesary for the conception. 4. The fetus is formed by reciprocal cohension of Chung(精) and Hyeol(血), with a according that Chung(精) and Hyeol(血) is respectively explained to a sperm and a ovum. 5. Because of having cyclic changes of ovary which is extremely susceptible to fertilization namely ovulation period. If sexual intercourse, female can make the fetus surely. Thus that period is called inonzyhu(絪蘊之候), geokhu(的候) and kagi(佳期) in Oriental Medicine. It is thought that the obtained results will be help to treatments of clinical diseases on the associated with the conception and family planning. So further study on this is desired continuosly.

男左·女右 理論에 따른 顔面神經痲痺의 臨床的 考察

李寬順,金南權,林圭庠 圓光大學校 韓醫學硏究所 1997 원광한의학 Vol.7 No.1

著者는 臨床에서 흔히 患者들로부터 구안와사의 豫候에 대해 "男左女右"와 關聯하여 질문을 받으므로 이에 대한 臨床的 妥當性을 알아보기 위해 1995年 9月 1日부터 1996年 8月 31日 까지 1年間 圓光大學校 附屬 全州韓方病院 外官科 外來에 來院하여 구안와사를 診斷받은 總 148명을 對象으로 發病動機 및 身體狀態, 年齡別 分布, 男女 左右別 發生率, 總 來院患者에 대한 治療率, 年齡別 發生率, 男女 左右에 따른 治療率을 각각 臨床 觀察하여 다음과 같은 결과를 얻었다. 1. 發病動機 및 身體狀態는 風寒과 연관되는 原因이 가장 많았으며, 肉體過勞, 精神過勞, 飮酒 등의 순으로 나타났고, 2가지 이상의 原因이 있는 경우는 精神過勞와 肉體過勞가 겸해오는 경우가 많았다. 2. 年齡別 分布는 50-59세가 가장 높았고, 40-49세, 30-39세, 20-29세, 60-69세, 70세 이상, 1-9세, 1세 이하의 순으로 각각 나타났다. 3. 男女 左右別 發病率은 右側 顔面神經이 痲痺된 男子 患者가 가장 많았으며, 右側 顔面神經이 痲痺된 女子 患者, 左側 顔面神經이 痲痺된 男子 患者, 左側 顔面神經이 痲痺된 女子 患者 순으로 나타났으나 發病率에 큰 차이는 없었다. 4. 總 來院患者 148명에 對한 治療率은 52.53%로 나타났다. 5. 年齡別 治療率은 1-9세가 가장 높았으며, 70세 이상, 50-59세, 40-49세, 60-69세, 20-29세, 30-39세, 10-19세의 순이었고, 주로 中·老年層이 治療率이 높게 나타났다. 6. 男女와 左右에 따른 治療率은 顔面神經痲痺의 女子 患者가 가장 높게 나타났고, 右側 顔面神經痲痺의 男子 患者, 左側 顔面神經痲痺의 女子 患者, 左側 顔面神經痲痺의 男子 患者의 순으로 나타났고, 男女 모두 右側에 發病한 患者의 治療率이 左側보다 높게 나타났으나, 특별한 有意性은 없었다. 以上의 結果로 보아 韓醫學的 生理 病理理論인 男左女右의 豫候와 治療率은 一致하지 않았으나 此後 좀더 많은 患者數와 오랜 期間의 臨床을 통한 硏究가 要求될 것으로 思料된다. The author analyzed 148cases of Facial Palsy, who were treated in the Jeon-ju Oriental Medical Hospital of Wonkwang University from September 1995 to August 1996. I've examined the 148 cases in the view of the etiologic distributions, the age, the relationship of the sex and paralytic side, and the ratio of recovery according to the age, the relations of sex and paralytic side. The following results are obtained. 1. The ratio of punghan(風寒) was 18.24%(27 cases), overwork was 14.86%(22 cases), stress was 12.84%(19 cases), excessive drinking was 2.70%(4 cases), teeth pain was 2.02%(3 cases), and idiopathy was 37.84(56) and etc. 2. The ratio of 5th decade were 20.95%(31 cases), 4th decade was 18.25%(27 cases), 3th decade was 17.57%(26 cases), 2th decade was 14.19%(21 cases), 6th decade was 12.16%(18 cases), over seventy was 10.81%(16 cases), teenagers was 4.05%(6 cases), under teenagers was 1.35%(2 cases), and infant was 0.67%(1 case). 3. The ratio of the male-right was 28.38%(42 cases), female-right was 25.68%(38 cases), male-left was 22.30%(33 cases), female-left was 21.62%(32 cases), female-both side was 1.35%(2 cases) and male-both side was 0.67%(1 case) in order. 4. When we examined the degree of recovery about the 148 patients, perfect cure was seen in 17.57%( 26 cases), excellent in 25.00%(37 cases), good in 22.30%(33 cases), fair in 20.27%(30 cases), poor in 14.86%(22 cases). The total remedial value of the 148 patients was revealed 52.53%. 5. When we examined the 148 patients the remedial value of the infant was 50.00%, under teenagers 62.50%, teenagers 41.67%, 2th decade 47.62%, 3th decade 44.23%, 4th decade 54.63%, 5th decade 58.87%, 6th decade 51.39%, over seventieth 60.94%. The remedial value of under teenagers, 4th decade, 5th decade, over seventieth were higher than the total remedial value(52.53%) 6. In the point of the relationship of the sex and the paralytic side, the remedial value of male-left was 51.47%, male-right 53.45%, male-both side 50.00%, femaled-left 47.62%, female-right 58.75% and female-both 37.50%. The remedial value of male-right(53.45%) and female-fight(58.75%) were higher than the total remedial value(52.53%). These results demonstrated that in the point of prognostic view, there was little concerned with the traditional rule of sex-paralytic relationship that man is awed left paralysis and woman right paralysis.

未來의 韓醫學 어떻게 할 것인가?

康舜洙 圓光大學校 韓醫學硏究所 1993 원광한의학 Vol.3 No.1

Oriental medicine the system of which is deductive using the cosmic dual forces, is passive and stagnant while Western medicine, the system of which is inductive, active and positive. The importance of the existence of Oriental medicine needs to be understood from the more extensive standpoint, meanwhile, the thought is the hasty conclusion that Oriental medicine is the relic of the past and has no value of its existence from the scientific terms. The need for the contribution to the medicine of the future through the scientific study on the merit and characteristic of Oriental medicine is required. To make a scientific progress in Oriental medicine in the future, the first step is to emerge from the deductive method based on the cosmic dual forces, expropriate the mechanism of the human body through the modern scientific knowledge, rearrange the dialectic feature in Chinese medicine by examineing it scientifically along with rearrangement about the effect of a natural object generated by its combination as well as scientific examination of the natural object used as a medicine and the new thesis on meridian point which is the remedy system of acupuncture, moxacutery and massage. From now on through the active progress from the multilateral scientific study on Oriental medicine it must contribute to the medicine of the future.

經絡과 經穴의 客觀化를 위한 經絡現象의 理解

具成泰,孫仁喆 圓光大學校 韓醫學硏究所 1997 원광한의학 Vol.7 No.1

최근에 많은 연구자들이 經絡과 經穴의 客觀化를 위해서 많은 노력을 기울이고 있다. 이번 論文에서는 이러한 문제에 관해서 연구된 결과를 이용하여 經絡現象에 대해서 살펴본 결과 다음과 같은 結論을 얻게 되었다. 1. 經絡과 經穴은 形態學的으로 자체적인 독특한 構造는 아직까지 발견된 것이 없으며, 神經系와 內分泌系가 관련되어 있다. 2. 經絡은 에너지를 制御·統制하는 정보계로서 정보 에너지의 교환 통로가 된다. 3. 鍼治療의 疼痛에 대한 鍼痛作用의 機轉은 神經終末, 脊椎, 腦幹, 視床下部, 腦下垂體 등이 관련되어 있다. 4. 鍼治療의 疼痛에 대한 鍼痛作用의 機轉은 求心性 經絡(afferent pathway)와 遠心性 經絡(efferent pathway descending pain inhibitory system)로 나누어 볼 수 있다. 5. 한의학 이론의 氣至感應과 PSM(propagated sensation along the meridians)은 밀접한 관계가 있으며 鍼의 治療效果에 대한 客觀的인 根據가 된다. 6. 經穴은 칼슘이온 농도가 높아서 전류가 잘 통하며, 그리하여 電氣抵抗이 낮은점이 된다. In recent years, not a few researchers have paid much attention to objectification of the meridian and acupuncture point. In the present paper, by using the result of the investigation on this problem, have made a survey on the understanding of Merdian Phenomena Conclusion was as follows. 1. Characteristic structure of the meridians and acupuncture points have not yet been found in morphology, but it has been reported that it is connected with nervous system and endocrine system. 2. The meridian is transporting channel of information and energy as a energy control system. 3. Mechanism of acupuncture analgesia in acupuncture therapy is related with nerve ending, spinal cord, brain stem, hypothalamus, pituitary gland etc. 4. Mechanism of acupuncture analgesia divides into two paths. One of these is the afferent pathway and the other is the efferent pathway(descending pain inhibitory system). 5. 'QiGiGamYuˇng'(氣至感應; special sensorized feeling of the Qi after acupuncturing or manipulation) and PSM (propagated sensation along the meridians) are deeply associated with each other, and are the objective evidence of acupuncture therapeutic effects. 6. Acupuncture points are the site in which electric stream is well conducted for the high density of calcium ion, therefore they are low electric resistance points.

白斑症의 文獻的 考察

朴庸權,金剛山 圓光大學校 韓醫學硏究所 1997 원광한의학 Vol.7 No.1

백반증(白斑症, Vitiligo)은 특발성 자가면역성에 의한 大小 各種의 局限된 범위의 피부멜라닌세포가 파괴된 상태로서, 색소가 脫失된 반(班)과 이를 둘어썬 과도색소침착이 보이며, 때로는 천천히 확대되기도 하는 질환이다. 백반증은 서양의학적인 용어이며, 한의학에서는 백전풍, 白駁風, 斑駁, 汗斑, 역양, 백전등으로, 일반인들은 백납이라 불리워지고 있다. 이에 본 연구에서는 古代에서 現代에 이르는 歷代 韓醫學書籍을 통하여 白斑症 및 白斑症 범주질환을 原因, 症狀, 治法, 治方으로 분류하고 정리한 결과 다음과 같은 결론을 얻었다. 1. 백반증은 一名 백전풍, 白駁風, 斑白, 汗斑, 역양, 白駁, 백납 등의 여러명칭으로 문헌에 기재되어 있었다. 2. 백반증의 原因은 風寒濕 등의 外因이나 七情內傷, 肺有壅熱 등의 內因들이 氣血不和를 일으켜 발생한다고 하였다. 3. 백반증의 증상은 面, 項部 등에서 주로 호발하며 白色斑點이 나타나고 疼痛이나 ??양감은 없었다. 4. 백반증의 治法과 治方은 內服藥이나 혹은 單用으로 外治法을 사용하는데 治方으로 浮萍丸, 蒼耳膏 등을 투여하거나 硫黃, 密陀僧 등의 약물을 外用으로 활용하고 있었다. In this study on Vitiligo, arranging seventeen kinds of separate volumes and papers published on Oriental medicine through the period from ancient to todays, I could get the result as folliws. 1. Vitiligo was writed several names such as begjunpung(백전풍), begbackpung(白駁風), banback(斑駁), hanban(汗斑), yuckyang(역양), begjun(반전) on literatures of oriental medicine. 2. The cause of Vitiligo is due to derangemint of Qui(氣) and Hul(血) caused exogeneous pathogenic factor such as Wind(風), Cold(寒) and Dampness(濕) or enogeneous pathogenic factor such as heat symptoms of the lung(肺有壅熱). 3. The symptom of Vitiligo may appear white-spot on face, neck area and have no pain, no itching sense. 4. The care of Vitiligo is classified as oral medication and external theraphy, and used the prescription- bupyunghwan(浮萍丸), changiego(蒼耳膏) or single drug-youhwang (硫黃), miltasueng(密陀僧).

土茯笭을 이용한 Rats의 水銀中毒 解毒에 관한 硏究

崔光敦,李起男 圓光大學校 韓醫學硏究所 1997 원광한의학 Vol.7 No.1

산업화 사회의 등장으로나타난 중금속 중독은 이미 세상을 경악시키고 있다. 이에 대해 의약학계에서 많은 연구들이 이루어지고 있으나 한의학적 접근이 아직 이루어지지 못하고 있는 실정이다. 이에 수은중독에 대해 한의학적으로 해독효과가 있다는 土茯笭을 이용하여 쥐를 통한 그 해독효과를 실험해 보았다. 조직내 수은함량, 조직내 MT함량, 혈액학적 변화, 장기조직 검사에서 유의한 결과가 밝혀졌으며 구체적인 해독의 기전과 성분은 알 수 없으나 토복령의 전해질 수분대사에 의한 작용인 것으로 사료된다. This study was performed to find out the antitoxic effects of Smilacis Glabrae aganist Mercuric Chloride poisoning. The experimental rats were divided into 4 groups such as mercury alone treatment group, and three dose groups of Smilacis Glabrae. Each group was administered with different dose of Smilacis Glabrae such as 15mg, 30mg, 45mg/kg wet weight in pallets for four weeds. Mercuric chloride was administered by 0.7mg/kg body weight rat per day. After giving the challenge dose, mercury, metallothionein concentration and histopathological changes were determined. The results were summarized as follows: 1. The simultaneously administration of Smilacis Glabrae and mercury significantly more decreased mercury concentration in liver compared to the administration of mercury only(P〈0.05). 2. The simultaneously administration of Smilacis Glabrae and mercury significantly more increased renal metallothionein concentration in liver compared to the administration of mercury only(P〈0.05). 3. When kidney and liver tissues were obsreved with as optical microscope, slight changes were visible in those tissues.