VIP를 분비하며 신경절신경종의 분화를 가지는 갈색 세포종 1예

나민아,김상수,김동욱,최재훈,이태근,공옥녀,안준협,김지연,성한동,정철호,손석만,김인주,김용기 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

갈색 세포종은 신경내분비종양의 하나로 VIP를 포함한 다양한 신경내분비 펩타이드를 분비할 수 있다. 저자들은 만성 설사와 체중 감소를 주소로 내원한 환자에서 좌측 부신에 VIP를 생성하는 갈색 세포종을 진단하여 성공적으로 제거한 후 증상이 모두 호전된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide, which may cause secretory diarrhea by stimulating the production of adenylate cyclase. Neuroendocrine tumors, secreting vasoactive intestinal peptide (VIP), are almost always of a pancreatic in origin. However, a pheochromocytoma may produce several neuropeptides, containing VIP, as they are considered to be neuroendocrine tumors. A 57-year-old woman, who presented with chronic watery diarrhea, hypokalemia, weight loss and a left adrenal mass, is described. Histologically, the tumor was diagnosed as a pheoch-romocytoma, with ganglioneuronal differentiation, and was histochemically confirmed to produce a vasoactive intestinal polypeptide. A left adrenal VIP-producing pheochromocytoma was successfully resected. After surgery, her diarrhea subsided and the electrolytes, affected neuroendocrine hormone levels, blood pressure and blood sugar level were normalized (J Kor SOC Endocrinol 18:227-231, 2003).

골다공증을 동반한 척추제 압박골절을 가진 노령환자에서 경피적 척추제 성형술 후 생활이 질 향상

박재우,공민호,이상구,송관영,강동수 The Korean Neurosurgical Society 2003 Journal of Korean neurosurgical society Vol.34 No.6

SVE와 Bioventing 기술을 이용한 유류 오염 토양의 지중처리

김석현,공성호,김상민,김용수 漢陽大學校 環境科學硏究所 2001 環境科學論文集 Vol.22 No.-

산업의 발달과 함께 유류의 소비가 점점 늘어나고 있다. 그러나 느린 노출 속도와 토양 오염에 대한 관심의 부족으로 유류 오염 지역이 점점 증가 되고 있다. 본 연구에서는 디젤로 오염된 토양에 SVE와 Bioventing 기술의 적용 가능성을 알아 보고자 하였다. SVE와 Bioventing을 차례로 실시하고 주위의 감시정으로부터 VOCs의 농도를 측정하여 오염물의 감소를 확인하였다. 본 현장의 경우 토양 내 모래의 함량이 많아 높은 Air Permeability를 나타내어 SVE 기술의 적용이 용이함을 알 수 있었다. 그러나 높은 Air Permeability로 인한 영향 반경 및 효율의 감소에 대해 추출정 Screen의 축소와 추출압력의 증가 등의 기술이 필요하였다. Bioventing 기술의 적용시 최소 주입 공기량은 3.5∼4.5㎥/h이었고 Bioventing과 미생물 제제를 병용하여 사용하여도 효과적임을 알 수 있었다. 본 현장에서 SVE와 Bioventing 기술의 적용으로 감시정의 VOCs의 농도가 800∼2400ppm에서 20ppm이하로 감소함을 확인하였다. Contamination of groundwater and soils by petroleum hydrocarbons has gained attention lately and caused serious pollution problems. Conventional remedial solutions for petroleum hydrocarbon contaminated soils (excavation and incineration) and groundwater (pump and treat) are expensive and can increase human exposure to contaminants. In-situ SVE or Bioventing, which induce air flow in the subsurface, can be an option that can restore petroleum hydrocarbon contaminated soil quickly, at lower cost, and with minimal health risk. This study investigated whether in-situ SVE and Bioventing can be applied to diesel contaminated soil or not. This study site consists of sandy soil to assure high air permeability. Owing to the high Air Permeability, the technology, such as the diminution of the monitoring well screen and the increasement of extraction presure, is required to control the decreasement of the influential area and efficiency. In the Bioventing technology, the range of a minimal air flow rate is from 3.5㎥/h to 4.5㎥/h. And it is more effective, used with microorganism. In conclusion, Initial level of VOCs of 800-2400ppm dropped to 20ppm after day operation of bioventing.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

An investigation of the properties of Cu-Be-x alloys prepared by horizontal continuous casting

홍현선,Man Sik Kong,Neung-Mo Sung,Seung Yun Lee,Kyung Min Kim 한양대학교 세라믹연구소 2007 Journal of Ceramic Processing Research Vol.8 No.3

The effects of the solid solution and aging treatment on the microstructure, hardness and electrical conductivity of Cu alloys containing 0.7 wt% and 1.8 wt% Be were investigated. These Cu-Be alloys contain Co, Si, Ni and Mn as alloying elements. An horizontal continuous casting process was applied to obtain unidirectionally solidified billets. A solid solution treatment of the sample was carried out at 865 oC and aging treatments were performed in the range 270-550 oC. For the Cu-1.8 wt% Be alloys, the electrical conductivity generally increased as the aging temperature increased in the range of 270-370 oC. For the Cu-0.7 wt% Be alloys, the electrical conductivity increased as the aging time increased in the range of 10-180 min. The effects of the solid solution and aging treatment on the microstructure, hardness and electrical conductivity of Cu alloys containing 0.7 wt% and 1.8 wt% Be were investigated. These Cu-Be alloys contain Co, Si, Ni and Mn as alloying elements. An horizontal continuous casting process was applied to obtain unidirectionally solidified billets. A solid solution treatment of the sample was carried out at 865 oC and aging treatments were performed in the range 270-550 oC. For the Cu-1.8 wt% Be alloys, the electrical conductivity generally increased as the aging temperature increased in the range of 270-370 oC. For the Cu-0.7 wt% Be alloys, the electrical conductivity increased as the aging time increased in the range of 10-180 min.

연속 저항 회로망을 이용한 국소 광적응 윤곽검출 시각칩의 설계

김경문,김정환,박종호,공재성,신장규,이민호 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

동측에 발생한 대퇴골 경부 및 간부 골절의 치료

권진우,김기환,문상호,공규민,손경태,이상훈,권태우 대한골절학회 2003 대한골절학회지 Vol.16 No.3

목적: 동측의 대퇴골 경부 골절과 간부 골절이 동반된 경우에서 수술적 치료에 대해 본원에서 실시한 수술 방법들의 결과를 분석하였다. 대상 및 방법: 수술 후 1년 이상 추시 관찰이 가능하였던 11례를 대상으로 하였으며 경부 골절은 Garden 제 1형이 3례, 제 2형이 6례, 제 3형이 1례, 제 4형이 1례였다. 간부 골절은 중간부가 7례, 원위부가 4례였다. 추시 기간은 최소 1년 이상으로 평균 33개월이었고 11례 전부가 남자였으며 나이는 22세에서 54세로 평균 38세였다. 각 수술 방법에 따른 수술시간을 측정하였으며 방사선학으로 골유합의 시기, 부정유합, 불유합 등을 평가하였고 임상적으로는 골절부의 동통 및 관절 운동장애를 평가하였다. 결과: 치료 방법으로는 경부는 다발성 피고정술이 8례, 활강압방 고 나사못고정술이 1례였으며 간부의 경우는 중간부는 역행적 Ender정 고정술이 4례 , 금속판 고정술이 1례, 재건상 골수강내 고정술이 2례, 역행적 금속정 고정술이 1례였고, 원위부는 금속판 고정술이 1례, 역행적 교합성 금속정 고정술이 3례였다. 평균 수술시간은 재건상 골수강내 골종술이 180분, 다발성 핀고정술 및 금속판 고정술이 220분, 다발성 핀고정술 및 역행적 골수강내 고정술이 200분이었다. 골유합 기간은 간부 골절의 경우 평균 5개월이었다. 경부 골절에 대한 합병증으로는 간부 골절에 대해서 Ender정 고정술을 한 1례와 간부에 금속판 고정술을 한 후 지연진단되어 경부에 다발성 핀고정술을 한 1례에서 대퇴골두에 무혈성 괴사증이 병발하였으며 재건상 골수강내 금속정 삽입술을 한 1례에서 수술시 경부 골절의 정복소실이 있었으며 간부 골절에 대한 합병증으로는 역행적 금속정 고정술을 한 2례 (Ender정 1례와 교합성 금속정 1례)에서 불유합이 생겨서 금속판 고정술 및 자가골이식술로 대치하였다. 그리고 Ender정 고정술을 한 1례에서 지속적인 슬관절 주위 동통이 있었다. 결론: 대퇴골 경부 골절과 동측의 간부 골절이 동반된 경우의 수술적 치료에서 재건상 골수강내 금속 고정술은 기술적으로 어려움이 많아서 경부와 간부의 치료를 각각 하는 것이 기술적으로 쉬웠다. 수술시는 경부 골절의 수술을 먼저 하여도 고정에 어려움이 없었으며 간부 골절은 분쇄 골절이 많기 때문에 견고한 내고정이 필요하였다. Purpose: The purpose of this study was to analysis the result of operative treatment in ipsilateral femur neck and shaft fracuture. Material and Methods: Eleven cases of ipsilateral femur neck and shaft fractures were operated and followed more than 1 year. There were 11 men and mean age at index operation was 38 years (range 22~54). In neck fracture there were 3 of type Ⅰ, 6 of type Ⅱ, and 1 of typeⅢ according to Garden classification, shaft fractures were located an middle 1/3 (7 cases), at distal 1/3 (4 cases). We evaluated the operation time, union time, nonunion, malunion, and clinical evaluation with pain and joint stiffness. Result: In neck fractures treatment methods were 8 of multiple pinning, 2 of reconstruction nail and 1 of CHS, in shaft fractures 2 of DCP, 7 of retrograde nailing (3 Ender nail, 4 interlocking nail). The mean operation time was 180 minutes in reconstruction nail, 220 minutes in multiple pinning and DCP and 200 minutes in multiple pinning and retrograde nailing. The mean time for shaft union was 5 months. The complications were 1 case of neck reduction loss during operation in reconstruction nailing group, 1 of persistant pain around knee in Ender nailing group. Conclusion: The author think that reconstruction nail fixation is technically difficult, thus neck and shaft fracture be fixed individually. Neck fracture can be fixed first without difficulty and shaft fractures should be fixed rigidly due to comminution.

항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

Desflurane이 흰쥐 Isolated Heart의 수축기능에 미치는 영향

최영석,이미경,윤석민,임상호,공명훈,정유성 대한마취과학회 1998 Korean Journal of Anesthesiology Vol.35 No.5

Background : Desflurane, a fluorinated methyl-ethyl ether, has some advantageous properties including low blood solubility, stability in soda lime, and resistance to biodegradation. Desflurane in vivo has demonstrated myocardial depressant property. The purpose of this study was to test the direct effects of desflurane on myocardial contractile function and coronary flow in the isolated heart. Methods : Twelve isolated rat hearts were continuously perfused with modified Krebs solution containing 6, 9 and 12 vol% of desflurane for 10 min at each concentration. Systolic left ventricular pressure and rate of change of ventricular pressure (dp/dt) were measured. Heart rate and coronary flow were also measured. To differentiate direct vasodilatory effect of desflurane from an indirect metabolic effect due to autoregulation of coronary flow, oxygen delivery, myocardial oxygen consumption and percent oxygen extraction were calculated. Results : Heart rate (control 266 22 beats/min) decreased to 250 23 beats/min at 6 vol%, 236 26 beats/min at 9 vol% and 223 22 beats/min at 12 vol% of desflurane. Systolic left ventricular pressure and dp/dt decreased in a concentration-dependent manner. In spite of decrement of myocardial oxygen consumption, coronary flow (control 12.0 1.2 ml/min) increased to 12.8 1.6 ml/min at 6 vol%, 12.9 1.6 ml/min at 9 vol% and 13.7 1.4 ml/min at 12 vol% of desflurane. Oxygen delivery increased proportionally with coronary flow. Percent oxygen extraction decreased in a concentration-dependent manner. Conclusion : These results suggest that desflurane has a direct myocardial depressing and coronary vasodilating effect in a concentration-dependent manner. (Korean J Anesthesiol 1998; 35: 825∼830)

Sesamin attenuates neuronal damage through inhibition of microglial activation following global cerebral ischemia in rats

( Min Jung Kong ),( Sung In Hong ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.2

Objectives: Sesamin, a major lignan in sesame seeds, has been reported to have neuroprotective effects against in vitro ischemia and in vivo MCAo-reperfusion cerebral ischemia model, however, there is no reports in an in vivo global cerebral ischemia model. The purpose of the study was to investigate the neuroprotective effect of sesamin in global cerebral ischemia induced by four-vessel occlusion (4-VO) in rats through inhibition of microglial activation in this model. Methods: The neuroprotective effects were investigated using a 10 min of 4-VO ischemia rat model by measuring intact pyramidal neurons in the CA1 region of the hippocampus using Nissle staining. The antiinflammatory or reducing neurotoxicity effect was investigated using immunohistochemisty, RT-PCR and western blot analysis of inflammatory or neurotoxic mediators. Results: Intraperitoneal injection of sesamin at doses of 0.3, 1.0, 3.0, and 10.0 mg/kg at 0 min and 90 min after ischemia conferred 26.6%, 30.1%, 42.5%, and 30.5% neuroprotection, respectively, compared to the vehicle-treated control group. A 3.0 mg/kg dose of sesamin inhibited microglia activation and consequently, cyclooxygenase-2, inducible nitric oxide, and interleukine-1β expressions at 48 h after reperfusion. Conclusions: Sesamin protects neuronal cell death through inhibition of microglial activation or the production of neurotoxic metabolites and proinflammatory mediators by microglia such as COX-2, iNOS and IL-1β in global cerebral ischemia.