방사선 조사를 받은 두경부 병소의 재건을 위한 유리피판술

채수욱,고경석,김주봉,박상훈,한상훈,이택종,남순열,김상윤 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Radiation therapy is an effective cancer treatment modality as a primary treatment in early cancer and as an adjuvant treatment in advanced cancer, especially in head and neck lesions, but it also causes irreversible chronic damages to overlying normal tissues that may lead to wound complications. As well, at the microscopic level, radiation injury causes both stasis and occlusion of small vessels. Therefore, surgical reconstruction of previously-irradiated lesions in the head and neck poses a great problem. Fifth-six patients with head and neck lesions underwent 57 microsurgical reconstructions between 1990-1998. Thirteen patients were irradiated before surgery. The previous radiation dose was 30∼75.6 Gy. The free tissue transfer was successful in 52 of the 57 microsurgical reconstructions(91.2%). The success rate was 92.3%(12/13) in previously-irradiated patients and 90.9%(40/44) in nonirradiated patients. Postoperative complications, such as flap loss, fistula, and infection, developed in 4 irradiated patients and 8 nonirradiated patients. Overall complication rate was 30.8%(4/13) in previously-irradiated patients and 18.2%(8/44) in nonirradiated patients. Although the failure rate of previously-irradiated patients was higher than that of nonirradiated patients, there was no statistically significant difference between them. Thus, free tissue transfers in patients with previously-irradiated head and neck lesions are suitable for one-stage reconstruction.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

회전하는 탁구공의 비행경로 예측에 대한 연구

한민성,이훈식 한국운동역학회 2006 한국운동역학회지 Vol.16 No.1

원판형 진행파 초음파 모터의 동특성 해석

한상훈,김종선,변흠필 한국 항공대학교 항공산업기술연구소 1998 航空宇宙産業技術硏究所 硏究誌 Vol.8 No.-

본 연구에서는 압전작동기를 이용한 원판형 진행파 초음파 모터에 대한 동역학적 모델과 성능분석을 수행하였다. 초음파 모터는 거의 대부분이 모터가 사용될 용도에 따라 그 외경의 크기가 미리 정해지므로 이러한 기본 제원이 설정된 후 해석적 모델을 이용한 모터변수 선정 및 동특성 해석에 관한 수치적 예를 보였다. 고정자의 자유 진동해석과 압전작동기에 의해 가진된 강제진동해석, 고정자산의 모델, 고정자와 회전자와의 접촉특성모델들을 통해 고정자의 진동형상, 고유진동수, 고정자산의 배열, 회전속도, 전달토크, 응답특성등 모터의 동특성과 성능특성을 수치적으로 연구하였다. This paper deals with the dynamic analysis and the performance prediction of a piezoelectric annular traveling wave ultrasonic motor. The vibrational characteristics of the stator plate is studied based on the laminated plate theory and the rotor is modeled as a rigid plate. It is also studied some relations between the mechanism of friction, the pressure distribution and other driving factors using Hertzian contact theory. The transient and steady state characteristics of the motor such as natural frequencies mod shapes, speed characteristics, driving torque, etc, are studied and compared with the other research works through the numerical analysis.

Chlamydia psittaci strain fransis의 plasmid pCpA1과 C. psittaci strain 6BC의 plasmid의 염기서열 상동성 분석

한상훈,정규회,G. V. Stokes,윤병수 경기대학교 1999 論文集 Vol.43 No.2

In Chlamydia, there is not efficient transformation vector system. This defect makes hard to study of Chlamydia. As a first process for E. coli-to-chlamydia shuttle vector construction, we executed DNA sequencing analysis of Chlamydia psittaci 6BC plasmid whole origine and parts of ORFs. We compared them with already known Chlamydia psittaci francis pCpA1 whole origine and parts of ORFs sequences using Computer DNA sequence analysis program PCGENE and demonstrated that partially analyzed origins and ORFs on two plasmids matched perfectly each other.

원인에 있어서 자유로운 행위의 연혁과 최근독일의 논의상황

韓尙勳 國民大學校 法學硏究所 2003 법학논총 Vol.15 No.-

Die Geschichte der actio libera in causa(alic) stammt aus Aristoteles. Er befurwortete Doppelvorwurf fu¨r eine Straftat im Vollrauschtat. Im Kircherecht des Mittelalters war das Thema in bezug auf die Handlung des Loths in Bibel sehr umstritten. Thomas von Aquin and Pufendorf entwickelten eigene Lehren. Erstmal in Deutchland war eine Regelung u¨ber alic im Codex juris Baarici criminlis von 1751 enthalten. 1794 hatte das Allgemeine Landrecht fu¨r die PreuBischen Staaten auch eine Vorschrift zu alic. Diese Regelung bestand im wesentlichen bis Mitte 19. Jahrhundert. Das geltende deutsche Strafgesetzbuch hat keine Vorschrift zu alic mehr. Deswegen werden verschiedene Ansichten nun in Deutschland vertreten: von Straflosigkeitslehre bis Tatbestandsmodell, Ausnahmemodell, Unrechtsmodell, Ausdehnungsmodell, usw. In Korea kann man keine bedeutsame Regelung oder Lehre fiber alic bis 20. Jahrhundert finden. Nur Jong Yak-yong schrieb 1819 in seinem Buch, dass eine Milderung der Straftat wegen Vollrausches nicht akzeptabel war and er kritisierte eine Entscheidung des Ko¨niges. Als das geltende Koreanische StGB 1953 entworfen and vero¨ffentlicht wurde, war §10 Ⅲ u¨ber alic neu eingefu¨hrt. Aber man kann nichts u¨ber Begrundung im Material finden. Aus diesem Grunde besteht es viele Unklarheiten u¨ber Auslegung des §10 Ⅲ. Trotzdem kann man vermuten, dass der Gesetzgeber einige auslandische Regelungen in Riicksicht nahm: z.B. Schweiz, Italien, Spanien. Aber man muss nicht iibersehen, class der Wortlaut des §10 Ⅲ nicht gleich mit den ausla¨ndischen ist. Das bedeutet, die Auslegung des §10 Ⅲ and alic stellt eine theoretische Aufgabe fu¨r die Koreanischen Strafrechtler and Rechtsprechung dar.

도시환경개선을 위한 생태학적 개발기법의 활용방안에 관한 연구

한상훈 경주대학교 지역개발연구소 2001 地域開發論叢 Vol.- No.4

This study aims to present practical principles to enhance ur ban environment throughout the applications of ecological development techniques in urban developments. To accomplish this purpose the author examines the concept of sustainable development in terms of environmental impact of traditional land developments and reviews sustainable development techniques scrutinized by the various scholars in the previous studies. Based on the results of the literature review this study proposes four principles in the formation of ecological environment in our cities. These are the implementation of ecological independence. Finally, this study presents some practical principles to enhance urban environment throughout the applications of ecological development techniques in the development and management of urban parks and green space.

營業秘密侵害에 대한 刑事處罰의 可能性과 改善方案 : Possibility of Penal Sanctions and Suggestion on Reform

韓尙勳 國民大學校 法學硏究所 2002 법학논총 Vol.14 No.-

In modern society the importance of science and technology is enormously growing. Korean companies have developed high technology very rapidly in fields of memory semiconductors, computer, automobile, home appliances. This means that Korean companies are now not out of range of the global economic espionage. For example, in 1998 a ghost company founded by some former researchers took illegaly industrial secrets of Samsung and LG, and sold them to a Taiwanese company. In the aftermath of this case, the legislature has revised the Unfair Competition Prevention and Business Secret Protection Act, (Unfair Competition Act) and broadened the range of criminal responsibility in case of divulgence of trade secrets on techniques. The Act is effective since July 1, 1999. Nevertheless it is not to oversee that the revised Act does not provide enough criminal protection against economic espionage. In this paper I look into protection systems of other major countries, such as USA, Germany, Japan, Swiss, Austria, Italy. Through this comparative study we can found out what kind of problems the Korean protection system has and how to remedy them. The Unfair Competition Act penalizes some acts of misappropriation of trade secrets on techniques. Any officer or employee of an enterprise who, without any justifiable reason, uses in a foreign country any business secrets on techniques useful to the enterprise or, with knowledge that the secrets will be used in a foreign country, divulges them to a third party shall be punished by imprisonment for not more than seven years or by a fine not exceeding one hundred million won(Unfair Competition Act §18 Ⅰ 1). As same shall be punished any ex-officer or employee of an enterprise who, with intent to gain any unfair profit or to inflict any loss on the enterprise, uses in a foreign country any business secrets on techniques useful to such enterprise or, with knowledge that the secrets will be used in a foreign country, divulges them to a third party, in violation of the duties of observance of secrecy under a contract or any similar relation(Unfair Competition Act §18 Ⅰ 2). These provisions are intending to prevent disclosure of trade secrets in favor of foreign countries. Any officer or employee of an enterprise who divulges any business secrets on techniques useful to the enterprise to a third party, without any justifiable reasons shall be punished by imprisonment for not more than five years or by a fine not exceeding fifty million won(Unfair Competition Act §18 Ⅱ 1). Any ex-officer or employee of an enterprise who divulges any business secrets on techniques useful to such enterprise to a third party, with intent to gain any unfair profit or to inflict any loss on the enterprise, in violation of the duties of observance of secrecy under a contract or any similar relation shall be punished also by imprisonment not more than five years or by a fine not exceeding fifty million won(Unfair Competition Act §18 Ⅱ 2). The punishment of imprisonment and fine under Art. 18 Ⅰ and Ⅱ shall be concurrently imposed(§18 Ⅳ). A public action against the offense referred to in Art. 18 paragraphs (1) and (2) shall be instituted only on the aggrieved person's complaint: Provided, That the same shall not apply where it is deemed necessary for national security or material public interests(§18 Ⅴ). Other than the Unfair Competition Act some provisions of criminal code, such as breach of trust(Art. 355 Ⅱ), theft, etc can apply to the theft of trade secrets, but with limitations. In application of the Unfair Competition Act some problems can be pointed out: 1) the Act does not criminalize outside-actor, in that only officers or employees, whether present or former, fall under the criminal provisions. The application range of the criminal provisions should be widened. 2) The Act focus mainly on ‘divulge’ or disclose of trade secrets on techniques, and very limitedly on ‘use’ of trade secrets. We must say that a professional industrial spy could avoid the punishment by the Act, let aside other acts. So the Act should be revised so as to encompass the actions like ‘obtain, acquire, take away, steal, copy, photocopy’ of trade secrets. 3) Attempt, or conspiracy should be put under punishment in order to provide an enough protection of the trade secrets. 4) Some procedural measures are necessary to prevent disclosure of trade secrets in criminal trials.

설갑상선 : 1 예 보고 A Case Report

한기석,배일헌,차상훈,김성진,박길선 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

갑상선 조직 전체가 설기저부에 발생한 이소성 설갑상선 증례를 경험하였기에 그 방사선학적 소견을 문헌고찰과 함께 보고하고자 한다. 증례는 59세 여자 환자로 40 일전부터 발생한 음성 변화를 주소로 내원하였다. 이학적 검사에서 설 기지부 중앙에 회백색의 격막에 둘러 쌓인 3 cm 가량의 종괴가 있었으며, 종괴는 내장으로 돌출하여 구인두를 막고 있었다. 경부 전산화 단층촬영 측면 정찰 촬영에서, 설 기저부에 후방으로 돌출하여 구인두를 막고 있는 경계가 분명한 연부조직 종괴가 보였으며, 전산화 단층촬영 동맥기와 정맥기에 주변의 혈관과 비슷한 강하고 균일한 조영증강을 보이는 장경 2.5 cm의 원형 종괴가 있었다. 또한 갑상선이 있어야 할 경부 전방 공간에서 정상 갑상선 조직은 전혀 보이지 않았다. 설 기저부의 종괴에서 생검을 시행하였으며 병리 검사에서 갑상선 조직으로 진단되어 설갑상선으로 확진되었다. The authors report a case of ectopic thyroid that whole thyroid tissue was replaced by lingual thyroid. A 59-year-old female presented with dysphonia duration of 40 days. On physical examination, there was a 3 cm sized well encapsulated whitish mass protruding to oral cavity in milline of tongue to base. Computerized tomography of neck revealed homogeneously enhancing well marginated 2.5 cm sized round mass in the cecum of tongue base on arterial and venous phase. And there was no normal thyroid gland in lower anterior neck.

Adamkiewicz 동맥의 폐색에 의한 척수경색 1례

이광훈,이종걸,이태연,신동익,이성현,이상수,한설희,차상훈 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4