관상동맥 시술 도중 발생한 좌주간부 관상동맥 박리에 대한 스텐트 삽입 치료의 단장기 임상 결과 : acute and long-term results

이세환,이승환,홍명기,김영학,이철환,한기훈,송종민,강덕현,송재관,김재중,박성욱,박승정 대한내과학회 2004 대한내과학회지 Vol.66 No.6

목적 : 심도자 사용 시술과 관련된 좌주간부 관상동맥박리에 대한 적절한 치료는 아직 확실히 정립되지 않은 상태이다. 이에 본 연구는 좌주간부 관상동맥 박리에 대한 스텐트 삽입술의 단장기 임상결과를 후향적으로 분석하였다. 방법 : 좌주간부 관상동맥 박리에 대한 치료로 즉각적인 스텐트 삽입술을 시행하는 것이 안전하고 효과적인 방법임을 가설하였고, 이러한 즉각적인 스텐트 삽입을 시행한 10명의 환자를 대상으로 단장기적 임상경과를 의무기록 고찰과 전화 면담을 통해서 평가하였다. 결과 : 전체 환자 모두 처음부터 좌주간부 관상동맥에 유의한 협착을 가진 환자는 없었으며, 8명의 환자는 심도자의 조작으로 인한 박리가 발생한 경우였고(진단적 혈관 조영술 중에 3명, 유도 도자 조작 중에 5명), 나머지 2명은 다른 병변에 스텐트 삽입시술을 하는 중에 박리가 발생하였다. 이 10명의 환자에서 모두 즉각적인 스텐트 삽입술이 시행되었고, 4명의 환자에서 시술 도중 혈압 저하로 Intra-aortic Ballon Pump (IABP)를 장착하였다. 모든 환자에서 성공적으로 스텐트가 삽입되었고, 병원내 사망은 1명도 없었다. 6개월 추적 관상동맥 조영술은 8명의 환자에서 시행되었다. 혈관 조영상의 재협착(직경 협착 50% 이상)은 8명 모두에게서 관찰되지 않았으며, 퇴원 후 평균 31±25개월의 추적관찰 결과 주요 심장사건은 1건도 발생하지 않았다. 결론 : 비록 대상 환자가 적은 연구였지만 좌주간부 관상동맥 박리에 대한 스텐트 삽입술은 기술적으로 안전하고 빠르게 시행 할 수 있으며, 훌륭한 단장기적인 치료 효과를 보여준다. Background : The optimal treatment of patients with left main coronary artery (LMCA) dissection during catheter-based procedure remains uncertain. We retrospectively analyzed the acute and long-term results of bail-out stenting for LMCA dissection. Methods : In cases with significant LMCA dissection occurring during catheter-based procedure, prompt stent implantation may be safe and associated with favorable clinical outcome. We evaluated the acute and long-term results of bail-out stenting for LMCA dissection occurring during catheter-bases procedure in 1- patients. Results : Initially, there was significant stenosis of LMCA segment in these patients. Catheter-induced dissection occurred in 8 patients (during diagnostic angiography in 3 patients and guiding catheter manipulation in 5 patients). Two patients suffered dissection in the setting of stent deployment in other vessels. Therefore, bail-out stenting LMCA dissection was performed in a total of 10 patients. In 4 patients, hypotension developed and intra-aortic balloon pump was placed during procedure. Stents were successfully deployed in all patients. There was no in-hospital mortality. Six-month angiographic follow-up was performed in 8 patients. Angiographic restenosis(diameter stenosis 50%) was not observed in all patients at follow-up study. During a mean follow-up of 31±25 months after hospital discharge, there was no major adverse cardiac event (death, myocardial infarction, and target lesion revascularization). Conclusion : Bail-out LMCA stenting is technically feasible, and showed good acute and long-term results in a small series of patients.

Novel Methylation Biomarker for Non-invasive Diagnostics in Lung Cancer

오태정,( Chang Hun Lee2 ),( Min Ki Lee ),( Yeul Hong Kim ),( Sang Yull Lee ),( Hyo Sung Jeon ),( Shin Yup Lee ),( Seung Soo Yoo ),( Jae Yong Park ),( Sung Whan An ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

To identify aberrantly hypermethylated DNA in lung cancer cells we established a genome-wide analysis for hypermethylation sites, namely Methyl DNA Isolation and Amplification (MeDIA) coupled-CpG microarray analysis. In the comprehensive methyaltion profiling analysis between human lung cancer, A549 cells and normal NHBE cells, we observed that several clusters of genes show a significant level of aberrancy in CpG island methylation pattern in cancer cells compared to normal cells. We further identified PCDHGA12 gene as a new marker of non-invasive diagnostics for lung cancer based on followings. 1) Transcription of PCDHGA12 gene is reactivated after treatment of A549 cells with demethylating agent. 2) Bisulfide clonal-sequencing reveals that CpG island of PCDHGA12 shows a distinctive differential methylation between two cell lines. 3) Pyrosequencing-based quantitative methylation assay for such region in tumor and non-tumorous tissues from lung cancer patients shows aberrant hypermethylation in 37 (92%) of the 40 tumor tissues. In clinical validation by pyrosequencingin induced-sputum of lung cancer patients (n=87) and healthy controls (n=51), we observed aberrant hypermethylation incident at significantly elevated level in samples derived from lung cancer patients. According to the optimal threshold calculated by ROC curve analysis, sensitivity and specificity of PCDHGA12 was 86.2% and 82.4%, respectively. PCDHGA12 methylation status could be a potential methylation biomarker alone or combined with others for the screen and the detection of relapse of lung cancer.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

建築工業敎育科 敎育改善에 관한 硏究 : 敎育課程을 中心으로 Focused on the development of curriculum

李昌甲,朴萬植,延吉煥,崔武革,李基男 충남대학교 공업교육연구소 1981 論文集 Vol.4 No.1

Due to the radical change of society and the technological innovation, it is inevitable to rearrange the educational objective of the Department of Architectural Engineering Education and to reorganize the curriculum responding to the objective. In this study, all the current curricula of architectural institutions have been analized to identify problems, and the educational objective of the department of architectural engineering education have been established based on the objective of the College of Industrial Education. As the result of the above studies, the model curriculum for the major subjects have been developed in order to have following characteristics. 1. The required subjects were limited to the basic fields in order to cover the education in the technical high school. 2. The elective subjects were organized into three fields, namely, architecture, structural engineering, and building materials and construction to meet the diversified demands to a possible maximum extent.

大邱市 北郊의 都市化에 關한 硏究 : a case of chilgok myeon, Chilgok county

李奐基,楊辰錫 慶北大學校 師範大學 地理敎育科 1979 地理敎育 Vol.6 No.-

This study was concerned about characteristices of Urbanization in regions around metropolitan. It has the purpose to make clear the structure of Urbanization in the northern outskirt of Daegu, Chilgok myeon, chilgok country, after searching the procedure of urbanization(1966-1976) and the actual Condition of urbanization. 1) In examining closely the procedure of urbanization, the comparative method was used and tried to understand the urbanization phenomenon as a regional phenomenon, As this study was geographic research in Urbanization. 2) Materials were dependent on existing statisties and those that I myself collected in the field by field-work. 3) In order to analyze actual conditions and procedure of urbanization, the following two indexs were used: (1) Changes of population-changes of total population, increase and decrease of population of each Dong(village), and change of industrial population. (2) Increase of Urban fuctional element-increase of houses, of shops, of factories of traffics and a jump of land price. The result of the analysis by the above method and indexes could be summarized as follows: 1) For nine years from 1966 to 1975, the population went on an an increase of 51.5%. In other words 7,124 persons increased from 13,828 persons in 1966 to 20,952 persons in 1975. such a rapid population increase was affected by the suburban explosin of Daegu. The density of population increased 152.4 persons/㎢ from 295.7 persons/㎢ in 1966 to 448.1 persons/㎢ in 1975. As for industrial population, the rate of the rural industrial population(1966-1971) was 13.7% down from 84.4% to 70.7%. On the other hand, the rate of urban industrial population was 5.3% up from 19.3% to 24.6%. In changes of population, the differences of each village being great, it was possible to divide the whole area into the growing, the nongrowing and the declining region. 2) Of urbanizing functional element increase; House increase rate from 1966 to 1976 was 39.5% but the house shortage rate increased 24% for the same period. And so the great house shortage took place. As for shop increase, all shops(84 shops) are retail trades, related with Daegu city. With factories and houses increasing, in this area we can find out the seperated urbanization phenomenon. As of 1976 August, the total of 79 factories were built in chilgok myeon dependent on the zoning program of Daegu city urban design. These factories are closely related with the technical development of Daegu. Traffics a day were 3,230 cars and so increased 15.6% a year. As the roads in this area were the most convenient, when compared with those in other area from Daegu. The urbanization on this area is growing rapider than in other area. During 1966-1976 the land price jumped 400-8300%. In other words this means the growing rate of urbanization. The urbanization of Chilgok myeon will continue in the future and social problems caused by the urbanization should be taken consideration in the policy.

강원도 중학교 체육교사의 보건학습 지도 실태

이동욱,김승재,박기동,김세환 강원대학교 체육과학연구소 2000 江原大學校附設體育科學硏究所論文集 Vol.- No.23

The purpose of this study was to investigate current situations on middle school physical education(PE) teacher's health instruction in Kangwon-do. The results attained from 165 middle school physical education teacher's in Kangwon-do are listed below: 1.Although physical education recognize the absolute necessity of health instruction in middles schools in Kangwon-do, it can't be acknowledged that sufficient instruction is being performed due to numerous other reasons. 2.Mostly, physical education teachers are in change of health instruction, but sometime it is refered to nurse-teachers, 3.For appropriate health instruction, first of all, related teaching materials and training opportunities should be more available. Based on above conclusion, following suggestions are made: 1.Information about health instruction must be sought with a great weight when teachers have any training opportunity. 2.School classroom must equip necessary teaching materials for health instruction. 3.There have to be more opportunity for intensive training to teachers. 4.Health instruction includes subtle subjects like problems relates sex education. Physical education teachers be in change of course but it can asked to nurse teachers if it for a better quality of health instruction.(It should be more rational to request nurse-teachers if a young male physical education teacher is in a girl's school) Also, issues related to independence on health instruction subject must be carefully examined.

大邱達城公園 入場客의 行態

李奐基 啓明大學校 産業經營硏究所 1980 經營經濟 Vol.12 No.1

The pourpose of this study is to present the various data for better establishment of tourism geographical policy as well as to contribute to the improvement of park-planning, landscape gradening, and facilities and management of parks in implementing the urban park project. To analyze and identify the behavior pattern of the visitors of Dalseong Park,, the actual research on the characteristics and the distributions of the tourists has been emphasized. The details of the actual research on the visitors of Dalseong Park is as follows: 1) Research period: 14-20 May, 1979(one week-since the number of the visitors in the time marked the highest in the year) 2) Research method: personal interviews and written questionaires. 3) Selection of sujects: Rendom sampling method. 4) Number of respondents: 558 persons. In order to prove the process of changes and regional distributions of the visitors: some data and additional informations provided by the Office of Dalseong Park and the Park Division of Daegu City have been utilized in drawing the diagrams and maps. The summary of the examination on the behavior pattern of the visitors is as follows: 1) 73.3% of the total visitors are youth -most of the males are in twenties while the females are in teens. By measures above citioens, young or old, man or woman would be able to rest and eojoy their leisure time in the pleasant surrouodings and would make a park an urban-resource to play a part of a??tracting sight-seers to Daegu.

Paraquat중독 사망한 한국인의 혈액 농도

이상기,인상환,정영호,구기서 한국환경독성학회 1996 환경독성보건학회지 Vol.11 No.2

To elucidate the fatal blood concentration of paraquat(Gramoxone), a contact herbicide, we investigated blood concentration of paraquat in 91 cases of paraquat intoxication. The blood paraquat concentration of 91 cases due to ingestion of paraquat was 0.9 ㎍/ml -1023.5 ㎍/ml and has been subdivided according to survival time. 48 of 91 cases were identified survival time. In 34 of 48 cases died within a day after ingestion of paraquat, blood paraquat concentration was ranged from 2.3~ 636. 6 ㎍/ml, and in 12 of 48 cases died 1~4 days after ingestion of paraquat, blood paraquat concentration was ranged from 0.9~25.1㎍/ml.

生態的 接近方法에 의한 造景計劃 및 設計

李昶煥,李基誼,趙鉉吉 江原大學校 林科大學 森林科學硏究所 1989 Journal of Forest Science Vol.6 No.-

The purpose of this study is to emphasize the indispensability and generalization of ecological approach in landscape planning and design, by describing the main ecological principles and the process and method applying them to landscape planning and presenting the case study of ecological planning. Landscape architecture is the science dealing with nature and therefore ecological approach in it cannot be emphasized too much. The main ecological principles that must be considered in landscape planning and design are energy flow, food chains, biogeochemical cycles, limiting factors, carrying capacity and homeostasis, vegetational succession, ecotone and edge effect, ecological niche, etc.. The seven component factors of natural ecosystem are climate, geology, physiography, hydrology, soil, vegetation, wildlife. These seven factors are interrelated by the above mentioned ecological principles. In landscape planning and design process, it is necessary that landscape architect should interpret and assess not only the component factors of natural ecosystem but also the interrelationships and ecological principles immanent in them and apply the data to final plan.

인체 지방 및 간장조직 중 유기염소제류의 확인 및 정량기법 체계화

이상기,양자열,인상환,김기욱,이수연,오승민,김미영,정규혁 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-