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손은화,인상환,표석능 대한면역학회 2005 Immune Network Vol.5 No.2
Cancer vaccine is an active immunotherapy to stimulate the immune system to mount a response against the tumor specific antigen. Working as a stimulant to the body's own immune system, cancer vaccines help the body recognize and destroy targeted cancers and may help to shrink advanced tumors. Research is currently underway to develop therapeutic cancer vaccines. It is also possible to develop prophylactic vaccines in the future. The whole cell approach to eradicate cancer has used whole cancer cells to make vaccine. In an early stage of this approach, whole cell lysate or a mixture of immunoadjuvant and inactivated cancer cells has been used. Improved vaccines are being developed that utilize cytokines or costimulatory molecules to mount an attack against cancer cells. In case of melanoma, these vaccines are expected to have a therapeutic effect of vaccine. Furthermore, it is attempting to treat stomach cancer, colorectal cancer, pancreatic cancer, and prostate cancer. Other vaccines are being developing that are peptide vaccine, recombinant vaccine and dendritic cell vaccine. Out of them, reintroduction of antigen-specific dendritic cells into patient and DNA vaccine are mostly being conducted. Currently, research and development efforts are underway to develop therapeutic cancer vaccine such as DNA vaccine for the treatment of multiple forms of cancers.
이상기,인상환,정영호,구기서 환경독성보건학회 1996 환경독성보건학회지 Vol.11 No.3
To elucidate the fatal blood concentration of paraquat (Gramoxone), a contact herbicide, we investigated blood concentration of paraquat in 91 cases of paraquat intoxication. The blood paraquat concentration of 91 cases due to ingestion of paraquat was 0.9 $\mu$g/ml-1023.5$\mu$g/ml and has been subdivided according to survival time. 48 of 91 cases were identified survival time. In 34 of 48 cases died within a day after ingestion of paraquat, blood paraquat concentration was ranged from 2.3-636.61$\mu$g/ml, and in 12 of 48 cases died 1-4 days after ingestion of paraquat, blood paraquat concentration was ranged from 0.9- 25.1 $\mu$g/ml.
이상기,인상환,정영호,구기서 한국환경독성학회 1996 환경독성보건학회지 Vol.11 No.2
To elucidate the fatal blood concentration of paraquat(Gramoxone), a contact herbicide, we investigated blood concentration of paraquat in 91 cases of paraquat intoxication. The blood paraquat concentration of 91 cases due to ingestion of paraquat was 0.9 ㎍/ml -1023.5 ㎍/ml and has been subdivided according to survival time. 48 of 91 cases were identified survival time. In 34 of 48 cases died within a day after ingestion of paraquat, blood paraquat concentration was ranged from 2.3~ 636. 6 ㎍/ml, and in 12 of 48 cases died 1~4 days after ingestion of paraquat, blood paraquat concentration was ranged from 0.9~25.1㎍/ml.