성인 복부에 발생한 비정형 Spitz 모반 1예

오승민,안혜진,신민경,정기헌 대한피부과학회 2022 대한피부과학회지 Vol.60 No.8

Atypical Spitz nevi are defined as melanocytic proliferations with intermediate histopathologic features between thoseof Spitz nevi and Spitzoid melanoma. Diagnosis of atypical Spitz nevi can be challenging, and there remains a lackof consensus among dermatopathologists regarding an exact definition. A 59-year-old female presented with anasymptomatic, 1.2-×0.8-cm-sized erythematous nodule on the abdomen. Histopathological findings demonstratedspindle and epithelioid cells with prominent nucleoli in nests from the dermo-epidermal junction to the reticulardermis with a few epidermal pagetoids spread. Immunohistochemical analysis revealed positive S-100, negativeHMB-45, and a Ki-67 index of 10%. A final diagnosis of atypical Spitz nevus was made, and the tumor was resectedvia total surgical excision. Herein, we report a rare case of adult-onset atypical Spitz nevus on the abdomen.

Identification of Estrogenic and Antiestrogenic Activities ofRespirable Diesel Exhaust Particles by Bioassay-directed Fractionation

오승민,Byung Taek Ryu,정규혁 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1

Bioassay-directed fractionation was performed to identify causative chemical groups of DEPs with estrogenic and antiestrogenic activities. Bioassay-directed fractionation consists of a cell bioassay (E-SCREEN) in conjunction with acid-base partitioning (F1 and F2) and silica gel column fractionation of neutral fractions (F3-F7). Crude extract (CE) of DEPs in dichloromethane (DCM) exhibited both estrogenic and antiestrogenic activity. Estrogenic activity of CE and some fractions (F1, F2, F3, F5 and F6) was induced through estrogen receptor (ER)-mediated pathways. In particular, the acid polar fraction (F2) of DEPs, which contains phenols, induced high levels of estrogenic activity compared to other fractions. The estrogenic activity of F2 (610.80 pg-bio-EEQ/g-DEPs) was higher than that of the total estrogenic activity of CE (222.22 pg-bio-EEQ/g-DEPs). This result indicates that the estrogenic activity induced by causative estrogenic fraction (F2) may be antagonized by unidentified chemicals in DEPs. On the other hand, non-polar fractions (F3 and F4) of DEPs include aliphatic and chlorinated hydrocarbon, polyaromatic hydrocarbons, and their alkyl derivatives, which play an important role in the antiestrogenic activity of DEPs. In particular, F4, which contains PAH and its derivatives, showed the highest antiestrogenic activity. Since in our previous study, dibenzo(a, h)anthracene and chrysene were identified in F4, and these chemicals have antiestrogenic activity, we assume that these chemicals are the major causative chemicals with antiestrogenic activity in DEPs. In contrast to the estrogenic activity of DEPs, antiestrogenic activity of CE was stronger than that of antiestrogenic fractions (F3 and F4) at non-cytotoxic concentrations, indicating that additive or synergistic effects by unidentified chemicals contained in DEPs occurred

코로나19에서의 대학생활 적응에 대한 신입생의 인식유형 연구: B대학 사회복지학과 신입생을 중심으로

오승민 학습자중심교과교육학회 2022 학습자중심교과교육연구 Vol.22 No.12

Objectives The purpose of this study was to investigate the freshmen experiences and perceptions on college life while adjusting to the COVID-19 pandemic. Methods The P-sample consisted of 33 full-time freshmen enrolled in the department of social welfare. Using Q-methodology, these students categorized 34 Q-sample statements from October 1 to 20. Results Analyzing the scores from the 34 statements using Q factor analysis through QUANL-PC program, freshmen perceptions on college life adjustment were classified into three types: (a) showing approval of online learning but preferring for face to face learning and having low academic achievement, (b) showing adaptive online learning but pursuing face to face learning and having moderate academic achievement, (c) showing adaptive online learning and having high academic achievement. Conclusions Result of this study suggests that actual online learning is needed to better evaluate the benefits, challenges and useful strategies of successful students and to revised in order to help freshmen to successfully adjust to college life, improve academic performance and develop employee competencies. 목적 본 연구는 Q방법론을 적용하여 코로나19의 팬데믹에서 B대학 신입생이 인식하는 대학생활 적응에 대한 유형을 분류하고 각유형별 특성과 차이점을 분석하였다. 방법 문헌분석과 B대학 사회복지학과 신입생을 대상으로 2차례 표적집단인터뷰와 반구조화 질문지를 통한 설문조사를 실시하여총 185개의 진술문을 추출하였다. 이후 전문가 협의 및 토의를 통해 34개의 Q표본을 선정하였다. B대학의 사회복지학과 신입생33명의 P표본에게 2021년 9월 1일부터 9월 20일까지 Q분류를 하게 하였고 이를 QUANL-PC 프로그램을 이용하여 요인분석을실시하였다. 결과 코로나19의 팬데믹에서 B대학 신입생이 인식하는 대학생활 적응에 대한 유형은 3가지로 추출되었다. 유형 1은 ‘부적응형’으로 비대면 학습 환경에는 수용적이나 대학생활 전반에 대한 아쉬움이 있고 학업성취에 어려움이 있는 것으로 나타났다. 유형 2는‘대면 선호 적응형’으로 대면 학습환경에 대한 아쉬움이 크고 비대면 학습 환경에서의 학습관리에 다소 어려움이 있으나 학업 전반에걸쳐 적응적인 모습을 보였다. 유형 3은 ‘적응형’으로 비대면 학습 환경에 적응적이고 학습관리를 잘하며 학업성취도가 높고 취업에매우 적응적인 모습을 보이는 것으로 나타났다. 결론 연구결과를 바탕으로 위드코로나의 시대에 신입생의 대학생활 적응을 도울 수 있는 학습자 중심의 학습환경 구축을 통한 원활한 학업성취와 취업역량 증진에 대한 실제적인 방안에 대해 논의하였다.

柔軟宇宙飛行體의 3次元 定式化와 非線型歸還 姿勢制御에 관한 研究

吳承玟,魏祥奎 한국항공우주학회 1987 한국항공우주학회 학술발표회 논문집 Vol.- No.-

의과대학생의 멘토링 프로그램 필요 요구 및 희망 진로와의 연관성

오승민,신홍임,전우택,양은배,Oh, Seung-Min,Shin, Hong-Im,Jeon, Woo-Taek,Yang, Eun-Bae 연세대학교 의과대학 2008 의학교육논단 Vol.10 No.2

Purpose & Method : To describe medical students' need on the mentoring program and relationship with career choice, 186/251 (74.1%) of first-and second-year medical students at Yonsei University College of Medicine. Seoul. Korea were surveyed. Result : 66.1% of medical students replied that he/she would volunteer as a mentee in mentoring program. Medical students' need area in mentoring program was specialty choice (62.9%). research development(18.8%), adapting to school life (13.9%) and effective learning skill (2.7%). 47.2% of medical students replied that his/her wishful career and working place is university faculty. Medical students who replied that he/she would volunteer as a mentee showed more needs on the research mentoring program(P=0.0112) and faculty career(P=0.0185) than those who replied that he/she would not volunteer as a mentee. Conclusion For successful implementation of mentoring program. this analysis on medical students' need should be considered.

Long-term Contact Angle Variation of Various Liquids by Interconnected Reentrant Structures

오승민,김석,조영태 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.5

웨이트트레이닝에 의한 체지방 감소가 개인적인 특성과 피부두겹 변화에 미치는 영향

오승민 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.11

This study proposes an efficient weight training strategy to reduce body fat, by identifying the effects of weight training on body fat reductions based on individual characteristics and changes in skinfold thickness. We analyzed the effects of 12-weeks weight training on changes in skinfold thickness and the resulting body fat reductions by considering individual traits of the subject. Our results indicate that individual characteristics have no statistically significant effects on changes in skinfold thickness, but were statistically significant for changes in the amount of body fat. Second, changes in skinfold thickness showed statistically significant effects on changes in body fat. Third, weight training induced changes in skinfold thickness were more significant in men than in women. Men also exhibited greater changes in body fat than women after weight training. Taken together, these findings confirm that changes in skinfold thickness and body fat observed through the 12-week weight training had variations depending on individual characteristics, and changes in skinfold thickness significantly affect the changes in body fat. The weight training program proposed by this study considers incorporation of individual characteristics, rather than accomplishing the same outcome with uniform methods and amounts of training. Furthermore, this program induces changes in skinfold thickness before implementing random efforts for reducing body fat. 본 연구는 12주간 웨이트트레이닝에 의한 체지방 감소가 개인적인 특성과 피부두겹의 변화 등에 어떠한 영향을 미치고 있는지를 분석하여 보다 효과적인 웨이트트레이닝 전략을 제안한 연구이다. 분석결과 첫째 개인특성이 피부두겹의 변화에 유의한 영향을 미치지 않았으나 체지방 변화에는 높은 수준의 영향을 미치는 것으로 나타났다. 둘째, 피부두겹의 변화는 체지방 변화에 통계적으로 유의한 영향을 주었다. 셋째, 웨이트트레이닝에 의한 피부두겹의 변화는 남성이 여성에 비해 상대적으로 높은 변화수준을 보였다. 체지방 변화에 있어서도 남성이 여성에 비해 높은 변화를 보이는 것으로 나타났다. 본 결과를 종합하면 12주간의 웨이트트레이닝을 통해 나타난 피부두겹과 체지방의 변화는 개인특성에 의해 수준의 차이가 존재하고 있으며, 피부두겹의 변화는 체지방 변화에 높은 수준의 영향을 미치고 있음을 확인할 수 있다. 이는 본 연구의 웨이트트레이닝 프로그램은 획일적인 방법과 양으로 같은 성과를 나타내려는 노력보다는 개인특성에 맞는 웨이트트레이닝의 시간, 양, 수준을 고려한 규칙적인 웨이트트레이닝 프로그램을 실시한다면 현대인의 비만 문제를 해결하고, 건강관련 체력을 향상시키는데 보다 긍정적인 영향을 미칠 것으로 생각된다.

일-가정 갈등이 주도적 경력행동에 미치는 영향과 인사평가 공정성 및 성별의 조절효과

오승민,한태영 한국여성심리학회 2017 한국심리학회지 여성 Vol.22 No.4

The purpose of this study was to investigate the promotive effect of work-family conflict of married workers on proactive career behaviors, different from the previous research that has studied negative effects of the conflict on job attitude or behaviors. Also it tested moderation effects of performance evaluation justice and gender difference, provided that organizational efforts to ameliorate work-family conflict has actually not been working as much as expected due to workers' worry of unfavorable evaluation and the unbalanced gender role. The study conducted a survey research gathering data from 257 married workers, and analyzed the data using multiple regression analyses. The results showed that work-family conflict has a positive effect on proactive career behavior, and that performance evaluation justice has a moderation effect on the relationships between work-family conflict and proactive career behavior. However, gender did not show a significant moderation effect. Based on the results and limitations, the study provided implications for future research and practice.

Antiestrogenic Potentials of ortho-PCB Congeners by Single or Complex Exposure

오승민,Byung Taek Ryu,Sang Ki Lee,정규혁 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.2

Di-ortho PCB congeners 52, 138, 153 and 180, and the mono-ortho coplanar congener 118 have been detected as a complex mixture in human tissue in Korea. This study examined the antiestrogenic effects of samples exposed to single or combination treatment of the ortho-PCB congeners. In order to determined the combined toxicity, a sample mixture (M1, M2, M3, M4, and M5) was designed based on the ortho-PCB congeners found in Korean human tissue. With the exception of PCB 52, the ortho-PCB congeners (PCB 118, 138, 153, and 180) showed weak antiestrogenic activity. The antiestrogenic activity of di-ortho PCB congeners (PCB 138, 153, and 180) was induced by the depletion of endogenous E2 as well as through the ER-dependent pathway, whereas the antiestrogenic activity of mono-ortho PCB 118 was only induced through the depletion of endogenous E2. When the MCF7-BUS cells were treated with mixtures containing the no effective concentration (10-6 M) of the PCB congeners, M3 (PCB 118 + PCB 138 + PCB 180) and M4 (PCB 118 + PCB 138) had an antiestrogenic effect but the other mixtures (M1; PCB 52 + PCB 118 + PCB 138 + PCB 180, M2; PCB 118 + PCB 138 + PCB 153 + PCB 180, M5; PCB 118 + PCB 180) did not. Although the mechanism for the interaction between the PCB congeners is not completely understood, it was presumed that exposure to a mixture of the PCB congeners might have synergistic effects on their antiestrogenicity through the ER-independent pathway.

혼합 및 암수분리 사육이 토종닭의 사양성적과 행동에 미치는 영향

오승민,윤세영,이재영,전세민,오동엽,하재정,송영한,김진수 강원대학교 동물자원공동연구소 2019 동물자원연구 Vol.30 No.3

본 연구에서는 혼합 및 암수분리 사육이 토종닭(한협 3호)의 사양성적과 행동에 미치는 영향에 대하여 조사하였다. 암수의 성비를 0:100(FO), 100:0(MO) 및 50:50(MI)으로 3처리를 하여서 13주간 조사하였다. 체중의 경우 혼합사육(MI) 그룹에 비하여 암수분리(FO, MO) 사육 그룹의 증체량 및 체중이 유의적으로 높게 나타났으며(p<0.05), 암수 그룹 사이에는 MO그룹이 유의적으로 높게 나타났다(p<0.05). 사료섭취량의 경우 암수분리 사육 구간에서(d14-21, 21-28) 유의적으로 높게 나타났으나(p<0.05), d35- 42 구간에서 혼합그룹에서 유의적으로 높게 나타났다. (p<0.05). 사료효율에서는 전 구간에서 유의적인 차이는 나타나지 않았다(p<0.05). 사료섭취시간은 MO 처리구와 비교하였을 때, FO와 MI처리구에서 유의적으로 높게 나타났다(p<0.05). 휴식시간은 MO와 MI에서 유의적으로 높게 나타났으며 FO에서 낮은 수치를 보였다(p<0.05). 걷기 행동은 MO에서 다소 긴 경향을 보였으나, 유의적인 차이는 인정되지 않았다. 음수행동과 다른 닭 쪼는 행동은 처리구간 유의적인 차이가 나타나지 않았으나, 쪼기행동은 MO, MI, FO의 순으로 유의적인 차이가 나타났다(p<0.05). 결론적으로 토종닭을 암수혼합 사육할 때, 암수의 성비는 토종닭의 사양성적과 행동에 영향을 미칠 가능성이 있다고 생각된다. The purpose of this study was to determine the effects of mixed or split-sex feeding on growth performance and behavior of Korean native chickens. Three variants of the sex ratio, FO (female only), MO (male only) and MI (mixed) were tested in Korean native chickens (Hanhyop 3) that were between the ages of 7 and 91 days. Body weight gain was the highest (p<0.05) in the MO treatment and the lowest (p<0.05) in the MI treatment. The feed intake (FI) of birds in the MO treatment was higher (p<0.05) than that of birds in the MI treatment during days 14-21, also MO treatment was higher (p<0.05) than that of birds in the MI treatment during days 21-28. However, the FI of birds in the MI group was higher (p<0.05) than that of birds in FO treatment during days 35-42. The behavioral frequency of walking, drinking, and aggressive pecking were not affected by sex ratio treatment. The behavioral frequency of feeding was higher in the FO treatment than that of birds in the other treatments. The comfort time of birds in the MI treatment was longer (p<0.05) than that of birds in the other treatments. The behavioral frequency of pecking was higher in the MO treatment than that of birds in the other treatments. The study suggests that when male and female Korean native chickens are reared together, sex ratio can influence growth performance and behavior frequency.