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톨루엔을 포함한 유기용제의 직업적 폭로로 인한 신경내분비계 영향
이채언,이종태,정의화,손혜숙,문덕환,전진호,강정학,이창희,김휘동,김종한,정귀옥 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2
Long term occupational exposure to solvent mixtures may cause adverse effects to the central nervous system with neurobehavioral symptoms. And some organic slovents have been suggested to cause impairment of tuberoinfundibular dopaminergic activity and neurochemical mechanisms controlling pituitary secretion. For the purpose of assessing neuroendocrine effects in occupational solvents exposure, hormonal study settings (shoes-manufacturing industry & fishing products industry) and compared with nonexposed controls(33 men, 85 women). Male workers exposed to solvent mixtures had significantly lower plasma level of follicle-stimulating hormone(FSH) than nonexposed male controls. While female workers exposed to solvent mixtures had significantly lower plasma levels of growth hormone(GH), and thyroid-stimulating hormone(TSH) than nonexposed female controls. The results of significant decrease in plasma concentrations of pituitary hormones(FSH, GH, and TSH) in workers exposed solvent mixtures indicate that occupational exposure to solvent mixtures may induce neuroendocrine effects through an effect on hypothalamic pituitary axis.
난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화
이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3
Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.
서중조건하에서의 콘크리트 충전 강관 기둥의 시공을 위한 실험적 연구
이장환,강용학,정근호,김진호,최문식,정상진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)
The basic Physical properties, Slump, Slump flow, Air content, Bleeding, and Settlement of concrete was investigated to test Characteristic of Setting and to evaluate the relation between Model specimen and Heat of hydration for construction Over the High Temperature(CFT). The objective of this study is to take the partial core after the cementation of Model specimen, test the compression intensity and analyze the relation to Test piece.
iPhone을 이용한 실시간 부산 버스도착 안내시스템 설계 및 구현
이학수,최희종,김진일 東義大學校産業技術開發硏究所 2011 産業技術硏究誌 Vol.25 No.-
일상생활에서 가장 밀접하게 이용하는 버스 승차에 대한 불편함을 줄이고자 최근 주목 받고 있는 iPhone을 기반으로 부산 버스도착 안내시스템 설계하고 구현하였다. 본 시스템은 인터넷에 접속하여 검색할 필요 없이 응용프로그램에서 사용자가 원하는 정보를 제공하고, 사용자 편의 기능을 구현한 활용 가능한 실시간 부산 버스도착 안내시스템이다. 개발결과는 iPhone에 장착하여 사용할 수 있도록 앱스토어에 업로드하였다.
고성토의 암성토에 대한 흙의 함유율이 다짐에 미치는 효과에 관한 실험적 연구
이종출,이영대,정진호,류재학,정두회 釜慶大學校 1999 釜慶大學校 論文集 Vol.4 No.1
We have carried out the field compaction tests in the site in which the high rock fill embankments are going to be constructed about 25m in height, to examine the effect of the soil fraction to the total embankment materials which are the mixture of rock fills and soils on the degree of field compaction. We have made four sets of in-situ concrete boxes of the size of 1.5m×1.5m×0.6m to obtain the maximum dry density of total embankment materials after compacting by using a 10-ton vibrating tamping roller. We have found, as a result, that the optimum passing number of the roller to yield the 90% of relative compaction economically attainable has appeared to be 8 passes, and that the percent of the soil fraction to the total embankment materials to yield the 90% of relative compation in the field has appeared to be 41.78% by weight.
李學沂,林龍進 慶北大學校 1976 論文集 Vol.21 No.-
In order to investigate the possibility as a dyestuff, the spectra of imidazole azo derivatives were studied in comparison with phenyl azo ones. The λmax of imidazole azo derivatives was 17-23 nm longer wave region than that of phenyl derivatives and it means that imidazole azo dyes have more bathochromic effect than phenly azo dyes. The spectra of substituted 2'-oxyphenyl azo imidazole showed isosbestic points in accordance with the variation of pH range in the methanol-water solution. It will be due to the protonation and deprotonation of dyes in acid-alkali solution. The authors discussed these imidazole azo dervatives on the possibility as a disperse azo dye.
위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동
이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.
李學沂,林龍進,沈相喆 경북대학교 공과대학 1971 工大硏究誌 Vol.1 No.-
The pyrolysis of dry lithiun salt of fumaraldehyde tosylhydrazone which was prepared by reacting fumaraldehyde and tosylhydrazine was studied. The products of therm a decomposition, acetylene, ethytlene and unidentified gaseous substances, were separated by GC to learn the ratio of the products which was variable according to the reaction conditions. The investigaton of the path route to form acetylene, ethylene and unidentified compounds remains for further work to learn the mechanism of tetrahedrane formation.
天安 및 忠淸地域의 産婦人科 應急患者에 관한 臨床的 硏究
李元起,朴忠學,朴鎭完,許義宗,李昌益 단국대학교 1995 論文集 Vol.29 No.-
The objective of this study is to analyze clinical evaluation of 313 patients in Obstetrics and Gynecology who visited Emergency Room in Dankook University Hospital from June, 1994 to December, 1994 for the purpose of successful and perfect emergency care of the patients in Obtetrics and Gynecology in Cheonan-Chungcheong District in the futrure. Today, the goal of modern obstetrics is the well-being of both mother and fetus. And there are many gynecologic diseases which lead the female patient to emergency room with the chief complaint of severe abdominal pain or vaginal bleeding, etc. We have of emergency patients, clinical characteristics of the patients, the time of patient's entrance in emergency room, the monthly distribution of visit, the crowding day of visit, the distribution of the patients according to living area, the admission rate, and the management of the patients, etc. Followings are the results summarized : 1. The mean age was 29.8 years(range form 10 to 85). The mean number of gravidity and parity were 2.0 and 1.1 respectively. The mean number of abortion and living child were 1.0 and 1.0 respectively. 2. The most predominant monthly distribution of visit were August and December. 3. The admission rate was 48.2% and the discharge rate was 49.5%. 4. Distribution of department was Internal Medicine, Pediatrics, Orthopedics, and Obstetrics & Gynecology, in order. 5. The most crowding day of visit was Sunday(22.0%). The peak time of patint's entrance in emergency room was between 20:00 PM and 24:00 PM(24.3%), and the second peak time was between 16:00 PM and 20:00 PM(21.4). 6. Of 313 patients, 53% were known to live in Cheonan city and Cheonan county. 82.7% were known to live in Chungcheong District. 7. In 151 patients who admitted the ward, 53% were obstetric patients and 47% were gynecologic patients. 8. In 80 obstetric patients of admission, the most common chief complaint was labor pain(76.3%). In 71 gynecologic patients of admission, the incidence of disease was abortion(32.3%), ectopic pregnancy(25.4%), and pelvic inflammatory disease(11.3%), in order. 9. Major operations were performed in 40 patients of 151 admitted patients(26.5%). Minor operations including Dilatation and Curettage were performed in 12 patients(7.6%). 10 In 155 patients of discharge, the incidence of disese was abortion(36 patients), pelvic inflammatory disease(20 patients), false labor(15 patients), and uterine bleeding(11 patients), in order.