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측정오차와 외란을 고려한 유도전동기의 강인한 속도제어에 관한 연구
蔡英茂,尹炳道,金燦起,鄭憲主 충주대 산업과학기술연구소 1995 産業科學論文集 Vol.3 No.-
It is difficult to control industrial drive systems because of load disturbance, parameter variation and measurement noise. So a theorem is required to have robustness for the measurement noise and disturbance. This paper is among the researches of solving these problems. Sliding mode state observer is robust for measurement noise, modeling-error and load disturbance. The pole of sliding mode state observer can be placed at (0,0) in Z-plane for fast response. This method is, namely, deadbeat control. One side, sliding mode state observer output is discontinuous on a switching hyperplance, that causes harmful effects such as current harmonics and speed oscillation. In this paper, also the reducing method of the chattering of sliding mode state observer output is proposed. In this paper, the method of designing a robust sliding mode state observer taking account of the ability of disturbance and noise attenuation is proposed. Also, the proposed control system is digitally implemented with TMS320C31.
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陸昌洙,洪淳達,金雄柱,鄭勳采 충북대학교 엽연초연구소 1983 煙草硏究 Vol.10 No.-
Experiment was conducted to investigate the relation of growth characteristics, nutrient amount absorbed by tobacco plant, chemical components, changes of NH4 -N and NO3-N in the soil, yield, quality and price per 10a. Nc2326 and Burley 21-tobacco plant grew in sandy loam and clay loam by treated different levels of nitrogen, phosphorous and potassium fertilizers. the results were summarized as follows. 1.The plant height, length and width of the largest leaf, fresh weight and dry weight of tobacco leaves and stem of NC2326 and Burley21 were greater in clay loam than those in the sandy loam during growing. 2.The amount of nitrogen and phosphorous in tobacco leaves and stem absorbed by NC 2326 grown in clay loam were increased by 60days after transplanting, and then decreased, and amount absorbed by Burley 21 increased continuously in sandy loam and clay loam till the harvesting time. 3.The contents of potassium, calsium and magnesium in the leaves of NC 2326 and Burley 21 were increased continously during growing period and the amount of patassium uptake was greatest. 4.Total nitrogen, total alkaloid and reducing sugar in the dry leaves of NC 2326 and Burley 21 showed no differences between the plot of sandy loam and clay, but Burley 21 showed higher content of total nitrogen and alkaloid than NC2326. 5.Changes of NH4-N and NO3 -N in soil decreased gradually during growing period. Amount of NH4 -N in the plot of Burley 21 was higher than that in NC 2326 during glowing period. 6.The best yield was shown in the NC 2326 glowing in clay loam soil and quality was highest in the sandy loam. The highest price per 10a, 590, 400, was shown in clay loam with 10-10-20kg/10a fertilization.
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이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
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Intravesical bacillus Calmette–Guérin-induced myopathy presenting as rhabdomyolysis: a case report
Chae Hun Lee,Byeong Joo Choi,Jung Hun Kim,Tae Woong Yang,Gi Jeong Kim,Ha Young Shin,Se Hoon Kim,Seung Woo Kim 영남대학교 의과대학 2023 Yeungnam University Journal of Medicine Vol.40 No.4
Intravesical bacillus Calmette–Guérin (BCG) instillation is an adjuvant treatment for non–muscle-invasive urinary bladder cancer. Although most complications associated with BCG immunotherapy are mild and self-limiting, rare albeit serious complications have been reported. Only a few cases of BCG-related rhabdomyolysis have been reported. In this study, we present the case of a 72-year-old woman who developed severe weakness and hyperCKemia following intravesical BCG instillation. A muscle biopsy was performed, and a diagnosis of drug-induced myopathy was made.
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정윤성,신정환,장철훈,손한철,정석훈,이용성,김병국,이채훈,김성률 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
배경 : Penicillin 내성 폐렴구균의 분리율이 증가하고 있으며 내성균에 의한 중증 감염은 치료에 대한 반응이 나쁘다. 이에 본 연구에서는 영남지역에 있는 병원들의 임상 검체에서 분리된 폐렴구균들 대상으로 항균제 감수성 검사를 실시하여 폐렴구균에 의한 감염증의 적절한 치료에 도움을 주고자 하였다. 방법 : 영남지역의 5개 병원에서 분리된 폐렴구균 61균주를 대상으로 디스크 확산법 또는 한천희석법으로 감수성 검사를 실시하였다. 결과 : Oxacillin 디스크를 이용한 penicillin 감수성 검사에서는 내성율이 91.2%였고 한천희석법에서는 감수성 9.8%, 중등도 및 고도 내성 각각 37.7%, 52.5%였다. 디스크 확산법에서 6개의 감수성 균주 중 한 개를 찾아내는데 실패하여 16.7%의 major error를 나타내었다. Ceftriaxone은 감수성 45.9%, 중등도 및 고도 내성 각각 42.6%, 11.5%였다. Penicillin과 ceftriaxone에 모두 내성인 경우는 전체의 54.1%, penicillin 내성 균주의 60.0%였다. 디스크 확산법에 의한 감수성 검사에서 vancomycin은 모두 감수성이었고, chloramphenicol 21%, erythromycin 82%, trimethoprim/sulfamethoxazole 79%, tetracycline 84%의 내성을 보였고 다약제 내성율은 59%였다. 결론 : 영남 지역 임상 검체에서 분리된 폐렴구균의 항균제 내성 비율이 매우 높아서 폐렴구균에 의한 중증 감염증의 적절한 치료를 위해서는 penicillin 이외의 여러 항균제에 대한 감수성 검사가 반드시 필요하다고 생각한다. Background : The resistance rate of Streptococcus pneumoniae to penicillin has been rapidly increasing worldwide, and treatment failures coupled with severe infections due to penicillin-resistant S. pnemoniae have been reported. In this study, we evaluated antimicrobial susceptibilities of S. pnemoniae isolated from clinical specimens in the Southeastern area of Korea. Methods: A total of 61 pneumococcal isolates obtained from patients who visited or were admitted to 5 hospitals in the Southeastern area of Korea during the period 1997 to 1998. Antimicrobial susceptibility tests for 61 isolates were performed using disk diffusion or agar dilution methods. Results : Penicillin susceptibility tests showed that 91.8% and 90.2% of isolates were not susceptible to penicillin by oxacillin disk diffusion and dilution methods, respectively. Moderate and high level resistance rate to penicillin were 37.7% and 52.5%, respectively. Using the oxacillin disk diffusion method, we failed to find one among 6 penicillin-susceptible isolates, with 16.7% major error. Moderate and high level resistance rate to ceftriaxone were 42.6% and 11.5%, respectively. The concomitant resistance rate to penicillin and ceftriaxone was 54.1% of the total and 60.0% of penicillm-resislant isolates. Resistance rates of the isolates to vancomycin, chloramphenicol, erythromycin, trimethoprim/sulfamethoxazole, and tetracycline were 0%, 21%,82%, 79%, and 84%, respectively. Multidrug-resistance to three or more classes of antimicrobials was 59.0%. Conclusion: In this study, we revealed that extremely high resistance rate of 5. pneumoniae to many antimicrobial agents in Southeastern area of Korea. Therefore, accurate susceptibility tests to penicillin, 3rd generation cephalosporin and other antimicrobial agents are highly recommended for adequate treatment of severe pneumococcal infections.
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채학병(Chae, Hak-Byeong),민정기(Min, Jeong-Gi),이상권(Lee, Sang-Gwon),정국삼(Jeong, Guk-Sam),원정훈(Won, Jeong-Hun) 한국화재소방학회 2013 한국화재소방학회 학술대회 논문집 Vol.2013 No.추계
본 연구에서는 현재 사용되고 있는 건축물 내의 화장실 칸막이 재료를 대상으로 ISO 5660-1 콘칼로리미터(Cone calorimeter) 실험을 실시하여 대상 실험 재료들의 연소 특성을 비교 평가 하였다. 모두 5종류의 실험체를 사용하였으며, 화재 발생시 연소 중요 평가항목인 착화시간(Time to ignition), 총 방출열량(Total heat release), 최고 열방출율(Peak heat release rate), 평균 열방출율(Mean heat release rate)을 중점적으로 평가하였다. 실험결과, 착화시간은 일반 합판패널에서 빠르게 일어났으며, 총 방출열량, 최고 열방출율, 평균 열방출율은 고밀도 압축패널에서 높게 나타난 것으로 분석되었다.
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