정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

RELATIONSHIP BETWEEN THE WIENER INTEGRAL AND THE ANALYTIC FEYNMAN INTEGRAL OF CYLINDER FUNCTION

Kim, Byoung Soo Chungcheong Mathematical Society 2014 충청수학회지 Vol.27 No.2

Cameron and Storvick discovered a change of scale formula for Wiener integral of functionals in a Banach algebra $\mathcal{S}$ on classical Wiener space. We express the analytic Feynman integral of cylinder function as a limit of Wiener integrals. Moreover we obtain the same change of scale formula as Cameron and Storvick's result for Wiener integral of cylinder function. Our result cover a restricted version of the change of scale formula by Kim.

RELATIONSHIP BETWEEN THE WIENER INTEGRAL AND THE ANALYTIC FEYNMAN INTEGRAL OF CYLINDER FUNCTION

Byoung Soo Kim 충청수학회 2014 충청수학회지 Vol.27 No.2

Cameron and Storvick discovered a change of scale for-mula for Wiener integral of functionals in a Banach algebra S on classical Wiener space. We express the analytic Feynman integral of cylinder function as a limit of Wiener integrals. Moreover we obtain the same change of scale formula as Cameron and Storvick s result for Wiener integral of cylinder function. Our result cover a restricted version of the change of scale formula by Kim.

製紙工程에서 分離한 슬라임 形成細菌의 最適 生長條件 探索

김은희,조병묵,오정수 동국대학교 생명자원과학대학 연습림 1997 연습림논문집 Vol.- No.5

The eight bacteria isolated from paper­making process were tested under the condition of 30℃, 35℃, 40℃ with pH 5, 7, 9. The growth of Pseudomonas paucimobilis B was the most excellent at 30℃ with pH 7. Staphylococcus sapropyticus was very good at 35℃ with pH 7 and pH 9. Pseuomonas cepacia generally grew well at every pH condition except for 40℃, pH 9. Acinetobactor calcoaceticus was excellent at 35℃ with pH 7 and at 30℃ with pH 9. Actinobacillus capsulatus showed the good growth in every tested condition except for pH 5 of 35℃, 40℃. The unidentified sprain was very good at 35℃ with pH 7 and pH 9. Staphylococcus auricularis had a unique growth pattern at pH 9 at every tested temperature condition. Acidovorax sp. was good at pH 7 and pH 9 of 30℃, 35℃, 40℃. This isolated bacteria generally showed good growth at pH 7 of 35℃, 40℃.

유동해석을 위한 통합형 시스템 개발에 관한 연구

김기연,김병수 충남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.16 No.1

The on-going effort and progress in developing an integrated system for general-purpose flow analysis is described. As an outcome of the efforts devoted so far, a new system, ICFDIT (an acronym of Interactive Computational Fluid Dynamics with Integrated Tool), is developed and introduced. The new system which includes a pre-processor, a maim-processor (flow solver), and a post-processor can be used to solve fluid dynamics problems in a convenient graphical environment. The structure of the system is described, and the usage and examples are demonstrated. Some issues for improvement of the system are also discussed.

원형 비강진 1예

김영조,박홍표,정병수,최규철 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Pityriasis rotunda is an uncommon cutaneous disorder consisting of asymptomatic, strikingly circular, scaly lesions on the trunk and extremities, with the histologic appearance of ichthyosis vulgaris. A case of pityriasis rotunda in a 35-year-old woman in whom no diagnosable disorder could be demonstrated is presented.

금형스프링을 이용한 송배전용 연결구조체의 내력실험

김호수,정희범,김진완,이배연,오병훈 청주대학교 산업과학연구소 2016 産業科學硏究 Vol.34 No.1

This study presents an experimental process to secure the capacity of mold spring connection structure for electric distribution cable. To this end, this study evaluates the capacity and safety of connection structure through the capacity experiment according to the various design variables

급성 단핵구성 백혈병에서 발생한 피부 백혈병 1예

김영조,홍문희,정병수 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

인공 대기오염 조건에 의한 종이 시트의 열화 거동

김형진,오정수,조병묵 동국대학교 생명자원과학대학 연습림 2000 연습림논문집 Vol.- No.6

Paper is an important material being considered as a contributor for the development and succession of human culture. With the introduction of mass production system by fourdrinier paper machine, the addition of lots kinds of chemicals and additives is necessarily required for controlling papermaking process. The modern machine-made paper has a irreversible problem for acidification or deterioration of paper before the passage of time around 100 years, due to the chemical additions. The deterioration factors of paper can be divided by several classes, such as factors by raw materials of pulp, by papermaking processes, and by external environment. Among these, some factors occurring aging in paper are temperature, moisture, and air pollutant materials. In particular, air pollution, like SO_2 and NO_2 by industrial and automobile origins has been a topic of focusing attentions for preservation of an old books. In this study, the conditions of artificial air pollutants and heat acceleration were controlled in special gas exposure system and weather-o-meter. The aging treatment was carried out in three kinds of commercial paper prepared with different types of fibrous material. The aging behaviors of paper by the factors of temperature, moisture, sulfur dioxide or nitrogen dioxide were investigated and analyzed from the results in physical and chemical properties of paper.

소아와 청장년기 아토피 피부염 환자에서 MAST 화학발광법에 관한 비교연구

김성한,최규철,정병수 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

Background and Objective: The MAST-CLA (multiple allergosorbent test-chemiluminescent assay) is a new assay for serum allergen specific IgE and allows many allergens to be tested simultaneously. Futhermore, it has shown good sensitivity, specificity and a correlation with the RAST and skin prick test. The purpose of this study was comparatively to evaluate results of the MAST-CLA between child and adolescence atopic dermatitis. Materials and Methods: Our study was designed by analyzing outpatients with atopic dermatitis through the MAST-CLA with a total IgE and allergen specific IgE in fifty children and twenty adolescence patients. Results: The results were as followings; 1) Among the subjects, 77% (child group; 76%, adolescence group; 80%) of patients showed elevated serum total IgE levels and 57.1% (child group; 50%, adolescence group; 75%) revealed at least more than one allergen specific IgE by the MAST-CLA. But, this did not show statistical significance. 2) Patients positive rates of commonly detected allergens were D. farinae 47% (child group; 42%, adolescence group; 60%), D. pteronyssinus 34% (child group; 28%, adolescence group; 50%), house-dust 23% (child group; 20%, adolescence group; 30%). But, all food allergens were positive lower than 5%. 3) The positive allergen specific IgE in food allergens was detected in only child atopic dermatitis patients. This difference between child and adolescence group showed statistical significance(P=0.027). 4) Good correlation was obtained between total IgE levels and number of positive allergen speficif IgE in the MAST-CLA, with 0.465 correlation coefficient. Conclusion: Our results suggest that MAST-CLA may be used as an effective method to evaluate inhalant allergens in adolescence more than child atopic dermatitis patients. Additionally, it is recommended that more speficif allergens should be added to Korean panel of MAST-CLA.