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Complication of Intraoperative Radiation Therapy (IORT) in Gastric Cancer
김명세(Myung Se Kim),김성규(Sung Kyu Kim),송선교(Sung Kyo Song),김홍진(Hong Jin Kim),권굉보(Koing Bo Kwan),김흥대(Heung Dae Kim) 대한방사선종양학회 1992 Radiation Oncology Journal Vol.10 No.2
영남대학교 의료원 치료방사선과에서 1988년 6월 15일에 위함 환자의 수술중 방사선치료를 시작한 이래 1992년 8월 30일까지 총 58예에서 시도하여 그중 53예에서 IORT를 실시하였으며, 정기적인 추적검사에서 한명의 국소개발 환자도 보고되지 않고 있다. 출혈(3예), 장관폐쇄(3예), 폐혈증(2예), 골수기능저차(1예)를 포함한 총 9예(17%)의 합병증이 보고되었고, 이중 6예(13%)가 사망하였다. IORT(1500cGy), 외부 방사선치료 (-4500cGy)와 강한 항암제를 병합치료 하였음에도 불구하고 주등(수술과 항암제 치료)의 25.2%, 김등(수술 불가능한 환자에서 항암제 투여)의 18%, 리등(수술)의 18.5%, Kraming등(IORT 2800-3500cGy)의 35.3%에 비해 낮은 합병증을 보여 IORT가 위암의 치료에 공헌할 수 있음을 시사하였다. 그러나 비교적 높은 치사율(11.3%)은 더욱 세심한 수술수기 및 수술 후 환자의 치료가 필요하며 외부 방사선치료와 항암제치료의 적절한 시기 조절 및 치료선량의 가감이 필요할 것으로 생각된다. Local control is the important prognostic factor in cancer treatment because local control decrease the relative risk of metastatic spread and increase distant metastasis free survival. IORT is the modality which could increase local control without increasing complication, combined with curative operation. Eventhough we could achieve significant deacreased local failure by IORT and curative resection, it should not be committed as a main treatment modality without proving acceptable complications. Therapeutic Radiology Department of Yeungnam University Medical Center have tried 58 IORT from June 15, 1988 and performed 53 IORT in patients with gastric cancer. No local failure had been reported including interstinal obstrution, hemorrhage, sepsis, and bone marrow depression. These complications could be comparable to Jo's 25.2% (chemotherapy + operation), Kim's 18% (chemotherapy only in inoperable patients), because our treatment regimen is consisted of IORT (1500cGy), external irradiation (--4500cGy) and extensive chemotherapy (FAM, 5FU + MMC, BACOP). Our data encouraged us to re-inforce further IORT in stomach cancer treatment.
대스팬 지붕구조물의 바람에 의한 동적거동을 고려한 풍하중 평가에 관한 연구
김대영,김지영,김한영,이명호,김상대 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)
Generally, wind loads for large span structures are evaluated with surface pressure data acquired in wind tunnel test. Unlike cladding wind loads, the structural wind loads could be over-estimated with only peak pressures of each surface pressure point because the peak pressures on a surface are not well correlated at a given time. Also, the load shapes of wind loads, and the load effects and dynamic behaviors of a structure should be considered in the wind load assessment. In this study, several wind load evaluation methods were applied to Gwangmyeong Velodrome dome and the results were compared to analyze the properties of each method for the suggestion of a proper evaluation procedure.
장기적 트립토판 결여식이 생쥐의 유해감각예민도에 미치는 영향
서영대,박제민,김명정,전명호,양구범,장세헌,강철중,김정태,김용식 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1
The depressive patients can be divided into two subgroups by presence and absence of pain symptoms. Those without pain symptoms have blunted pain sensitivity whereas those with pain have normal range of pain sensitivity, and are clinically characterized by anxiety and irritability. The aim of the study is to test if these clinical profiles of the depressives with pain symptoms are related with reduced level of brain serotonin(5-HT). Forty four mice were randomly divided into two groups : one group to be bred with tryptophan free diet and the other with normal control diet, each for 4 weeks. Before the beginning of the breeding period, measured were locomotor activity by open field test, anxiety by elevated plus maze and nociceptive sensitivity by tail flick test, before and after forced swimming(FS). During each FS, duration of immobilization was also measured. The sable sets of measurements were repeated at the end of the breeding period. The brain 5-HT and 5-hydroxyindoleacetic acid(5-HIAA) were measured by high performance liquid chromatography. The results were as follows 1.Four weeks of tryptophan free diet reduced significantly body weight, brain weight, and levels of 5-HT and 5-HIAA in the whole brain. 2.Tryptophan depletion did not influence basal nociceptive sensitivity as measured by tail flick latency before FS. The normal blunting of the pain sensitivity induced by forced swimming was preserved in the tryptophan depleted group. 3.Tryptophan depletion did not influence general locomotor activity in open field. 4.Tryptophan depletion increased significantly time spent on the open arms at the elevated plus maze test done before FS. This anxiolytic-like effect was reduced by FS. 5.Tryptophan depletion did not influence duration of immobilization during FS. From these results, it is suggested that the genesis of the depression with pain symptoms is not medicated by quantitative reduction of brain serotonin
신라대학교 2018년도 2학기 ‘부산의 하루’ 수강생 대상 설문조사 결과 분석
김대래, 김형구, 박명선 신라대학교 부산학연구센터 2018 부산연구 Vol.16 No.2
In 2018 2nd semester, 134 students who were attending the ‘A Day of Busan’ were asked to take this survey. Among them, 78 students were from Busan. This paper analyzed these 78 students. According to the respondents' grades, 52.6% of the respondents were in the first grade, slightly more than half, and the second was 33.3%. It can be seen that the 'A Day of Busan' course are mainly in interested in lower grades. According to the year of birth of the respondents, the birth rate in 1999 was 43.6% of the total, including one missing value. In this questionnaire, we surveyed and analyzed the religion of the students, the parent's home, the typical food of Busan, representative places in Busan, and the personality, strengths and weaknesses of Busan people. We also surveyed students' lives, for example, the number of participating in Pusan International Film Festival, the number of visits to professional baseball games, the number of overseas trips, using mobile phones time per day, the number of close friends, sleeping hours. Also we surveyed the population size of Busan. The proportion of students who replied that population size is less than the actual population of 3.45 million in Busan was similar to that of students who replied that it is more. 2018년도 2학기 ‘부산의 하루’ 수강생 가운데 부산출신 학생 78명을 대상으로 분석을 하였다. 응답자의 학년별 구성을 보면 1학년이 52.6%로 절반을 조금 넘고, 그 다음은 2학년으로 33.3%이었다. ‘부산의 하루’ 과목은 주로 저학년이 수강하는 것을 알 수 있다. 응답자의 출생연도를 보면 1999년 출생자가 결측값 1명을 포함한 전체에서 43.6%를 점하여 가장 높은 비율을 보였다. 응답학생 78명의 종교를 보면 무교가 61.5%로 압도적인 비중을 점하고 있다. 그 다음으로 불교가 20.5%, 개신교가 12.8%, 가톨릭이 3.8% 그리고 기타종교가 1.3%였다. 아버지의 고향은 부산이 53.8%로 절반을 넘으며, 그 다음은 경남으로 24.4%였다. 부산과 경남을 합하면 78.2%로 절대적인 비중을 점하고 있다. 어머니의 고향은 부산이 56.4%, 경남이 11.5%로 부산과 경남을 합하면 67.9%였다. 부산의 대표음식으로는 돼지국밥이 36.2%, 21.2%의 어묵, 15.7%의 밀면, 8.7%의 씨앗호떡, 7.4%의 생선회 순이었다. 타지역에서 오는 친구들에게 보여주고 싶은 곳으로는 광안리가 17.9%, 해운대로 13.1%, 서면으로 10.3였다. 그 다음으로는 롯데야구 6.1%, 광안리불꽃놀이 5.3%, 센텀시티 5.1%, 광안대교 4.9% 순으로 나타나 주로 광안리와 해운대 그리고 서면 쪽으로 쏠리는 경향이 나타났다. 부산에서 새로 생기면 좋은 것에 대한 설문에서는 놀이공원이 13.3%, 워터파크10.8%, 공원 8.7%, 체육관 8.2%, 수목원과 박물관이 각각 5.8%로 나타나 학생들은 놀이시설을 가장 원하고 있었으며 그 다음으로 공원과 체육관을 선호하였다. 부산사람들의 성격에서 좋은 점이 무엇인가에 대해서는 ‘의리있다’가 17.8%로 가장 많았고, 나쁜 성격은 32.5%의 압도적인 비율이 성격이 ‘급하다’로 나타났다. 즐겨마시는 음료에는 커피가 33.3%로 가장 높았고, 그 다음은 26.9%의 콜라였다. 주중 술 마시는 횟수에 대한 설문에는 ‘전혀 마시지 않는다’는 학생이 38.5%로 약 40%에 해당하는 학생이 전혀 술을 마시지 않는 것으로 나타났다. 부산국제영화제에 참여한 횟수, 부산에서 열린 프로야구 경기에 참여한 경험, 해외 여행 횟수에 대한 설문에 대해서는 각각 전체의 64.1%, 35.9%, 33.3%의 학생들이 한번도 없는 것으로 나타났다. 하루 휴대전화 사용시간의 평균은 271분, 친한 친구수의 평균은 13명, 수면시간은 평균은 6.8시간, 한달 용돈은 평균 35만원이었다. 부산의 인구가 얼마나 되겠는가 하는 설문에 대한 응답은 매우 다양하였는데, 2만명에서부터 3,800만명까지 넓은 범위에 걸쳐 분포하였다. 그런데 부산의 실제인구 345만명 선보다 적다고 응답한 학생의 비율이 약 절반이었고 나머지 절반은 그보다 많다고 응답하였다.
소규모사업장 용접근로자들의 소음·용접흄·망간 노출에 관한 연구
김동구,문덕환,이채관,박명희,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5
Objective : This study was conducted for the purpose of investigating the level exposure of welders to noise, welding fume and Manganese(Mn) related to this process. Methods and Material : All subjects in this study were welders engaged in CO2 arc and coated arc welding process especially in small-scale enterprises classified by type of manufacture of ship building, repairing and of other fabricated metal products, which is located in Gimhae and Milyang of Kyeongsang province in south Korea. Air sampling of welding fume was measured, shipped and analyzed on the basis of national institute for occupational safety and health(NIOSH) method in U.S. and work environment measurement method established in south Korea. To measure Noise in the work environment, Noise dosimeter was used on the basis of work environment measurement method established in south Korea. Result : This study was performed during a period from January, 2000 to December, 2001 and Results were as follows: 1. Noise level measured in this work environment was higher than national criteria for permissible exposure limit on health examinations related to hearing loss. 2. The concentration of welding fume and Mn in manufacture of ship building and repairing was higher than those in manufacture of other fabricated metal products. 3. In conditions of existing in ventilation system installed and operated, the concentration of welding fume and Mn was slightly lower than those of not existing. 4. In conditions of existing in sufficient air supply from out door into the work place relied on natural exhaust system, the concentration of welding fume and Mn was slightly lower than those of in not sufficient. 5. In all subjects, a rate of wearing ear plug and respiratory mask for dust and fume was lower than that of not wearing. Conclusion : According to above results, this study suggests that more positive work environment managements such as the use of portable local ventilation system, the supply of highly qualified personal protective equipment, and consecutive education and training related to health protection should be need to acquire suitable health protection program for welders engaged in small-scale enterprises in Korea.