남성화된 암컷 생쥐에서 Testosterone이 통각예민도에 미치는 영향

전명호,김명정,박제민,양구범,이국희,장세헌,강철중,Chon, Myong-Ho,Kim, Myung-Jung,Park, Je-Min,Yang, Gu-Beum,Lee, Kook-Hee,Jang, Sae-Heon,Kang, Cheol-Joong 한국정신신체의학회 2000 정신신체의학 Vol.8 No.1

연구목적 : 본 연구는 암컷 생쥐에서 출생직후 testosteorne에 노출시키면 testosterone과 연관된 통각억제계의 발달이 영향을 받으며 성인기의 testosterone 투여는 통각예민도를 감소시킨다는 가설을 검증하기 위하여 시행되었다. 방법 : 출생직후 testosterone에 노출시켜 남성화된 Institute for Cancer Research계 암컷생쥐 30마리와, 남성화 시키지 않은 정상 암컷생쥐 25 마리를 84일간 성장 시킨후 testosterone 1mg/kg를 1일 1회 3일간 투여하였다. testosterone 투여전후 통각 예민도를 tail flick latency로 실험 84일과 86일에 측정하였다. 1) 실험 84일째 기저통각 예민도는 남성화군이 $2.7{\pm}0.4$초로서 대조군의 $3.3{\pm}1.1$초에 비하여 유의하게 예민하였다. 2) 실험 84일째 testosterone 주사 후의 유해 감각 예민도는 남성화군이 $5.2{\pm}0.9$초로서 대조군의 $4.6{\pm}1.8$초에 비하여 유의하게 둔감하였고 두 군 모두에서 기저 통각 예민도에 비하여 유의하게 둔하여졌으나 남성화군에서 둔화의 정도가 유의하게 컸다. 3) 실험 86일째 testosterone 주사 전 통각 예민도는 남성화군이 $4.8{\pm}1.9$초로서 대조군의 $3.9{\pm}1.2$초에 비하여 유의하게 둔감하였다. 4) 실험 86일째 testosterone 주사 후 통각 예민도는 남성화군이 $5.9{\pm}0.9$초로서 대조군의 $4.9{\pm}1.5$초에 비하여 유의하게 둔감하였고 두군 모두에서 주사전에 비하여 유의하게 둔하여 졌으나 둔화의 정도에는 차이가 없었다. 5) 실험 84일과 비교하여 실험 86일째 주사전 통각 예민도의 변화는 남성화군이 $2.1{\pm}1.0$초로서 대조군의 $0.5{\pm}1.3$초에 비하여 유의하게 둔하여 졌으나 주사후 통각예민도의 변화는 유의하지 않았다. 결론 : 이상의 결과에서 저자는 testosterone 연관 통각억제계가 존재할 것이고 이 통각억제계의 발달은 신생아기에 testosterone 투여로 강화되며 성장후 이 통각억제계의 활성은 testosterone이 매개할 가능성을 제시한다. Objects : Aimed to test the hypothesis that neonatal testosterone exposure in female mice influences the development of testosterone-related pain inhibitory system and that testosterone administered in adulthood decreases the pain sensitivity. Methods : Thirty androgenized(testosterone propionate $100{\mu}g$ ip within 24 hrs after birth) adult female and twenty five control(normal saline $100{\mu}g$ ip within 24 hrs after birth) adult female mice were injected with testosterone propionate 1mg/kg/day for 3 consecutive days from 84th experimental days. Nociceptive sensitivity was measured before and after treatment of testosterone by tail flick latency on 84th and 86th experimental days. Results : 1) On the 84th experimental day, basal nociceptive sensitivity was significantly higher in the androgenized group($2.7{\pm}0.4$ sec) as compared to the control group($3.3{\pm}1.1$ sec). 2) Testosterone treatment on the 84th experimental day significantly lowered nociceptive sensitivity in both androgenized($5.2{\pm}0.9$ sec) and control groups($4.6{\pm}1.8$ sec). However the effect was significantly greater in the androgenized group. 3) Nociceptive sensitivity on 86th experimental day before administration of testosterone was significantly lower in the androgenized group($4.8{\pm}1.9$ sec) as compared to the control group($3.9{\pm}1.2$ sec). 4) Testosterone treatment on the 86th experimental day significantly lowered the nociceptive sensitivity in both groups, but the androgenized group($5.9{\pm}0.9$ sec) showed significantly lower post-treatment nociceptive sensitivity as compared to the control group($4.9{\pm}1.5$ sec). 5) Nociceptive sensitivity was decreased significantly after injection of testosterone once a day for two consecutive days in the androgenized group(${\Delta}2.1{\pm}1.0$ sec), but not in the control group(${\Delta}0.5{\pm}1.3$ sec). Conclusions : There may be a testosterone-related pain inhibitory system, the development of which is enhanced by exposure to testosterone in the neonatal period, and the activity of which is also mediated by testosterone in the later life.

직장에 발생한 원발성 악성 흑색종 1예

전명호,이상훈,최호수,전광수 대한내과학회 1992 대한내과학회지 Vol.42 No.6

직장-항문의 원발성 악성 흑색종은 드물며, 직장 항문악성 종양의 1%를 차지하고 있으며, 한국에는 1예가 보고되어 있다. 저자들은 설사와 배변 장애를 주소로 내원한 여자 환자에서 대장 촬영, 북부 CT 촬영, 복부 초음파검사, 흉부 X-선 등으로 간, 비장, 폐, 난소, 임파선에 전이된, 직장암으로 진단하고 조직 검사상에 원발성 악성 흑색종으로 확인된 예를 경험하였기에 이를 보고하는 바이다. Primary malignant melanoma of anorectum is rare, comprising approximately 1% of anal canal tumors, and reported only one case in Korea. A case of primary malignant melanoma of rectum is reported. This 57-year-old female patient was admitted to the hospital because of diarrhea & defication difficulty. She was revealed rectal mass on barium enema & abdominal CT scan and demonstrated malignant melanoma in histopathologic examination of rectal biopsy. Loop sigmoid colostomy was performed and she died of respiratory failure, hapatic failure from lung & liver metastasis.

청소년활동의 활성화 방안

전명호 한국지역사회연구소 2009 지역사회 Vol.60 No.-

병렬형 벽체의 구조성능에 대한 슬래브 영향 평가

전명호(Jeon, Myung Ho),권종훈(Kwon, Jong Hoon),박홍근(Park, Hong Gun),김성현(Kim, Sung Hyun) 한국콘크리트학회 2021 한국콘크리트학회 학술대회 논문집 Vol.33 No.1

공혈형 내측 활막추벽 증후군 - 1례 보고 -

배대경,전명호,표나실,이정희,Bae, Dae Kyung,Jun, Myung Ho,Pyo, Na Sil,Lee, Jeong Heui 대한관절경학회 1999 대한관절경학회지 Vol.3 No.2

공혈형 내측 활막추벽은 내측 활막추벽의 한 형태로 흔하지 않은 것으로 알려져 있으며 그 크기는 다양하여 직경 5mm에서 3-4cm 되는 것도 있다고 보고된다. 그 증상은 비특이적이나 다양한 내측 슬관절 증상을 유발하여 다른 슬관절 내장증의 원인들과 감별 진단이 요구된다. CT scan, MR imaging 등이 진단에 도움이 되지만 결정적인 진단은 관절경술에 의해 이루어지며 보존적 치료를 시행하고 이에 반응하지 않는 경우에 관절경적 절제술을 이용하여 치료를 시행하면 지속적이고 만족스러운 임상 호전을 얻을 수 있다고 보고된다. 본 정형외과 교실에서는 그 빈도가 흔하지 않은 양측 슬관절 공혈형 내측 활막추벽 증후군이 관찰되어 관절경적 절제술을 시행하고 술후 및 외래 추시시 즉각적이며 극적인 임상 호전을 보인 1례가 있어 문헌 고찰과 함께 임상 경험을 보고하는 바이다. Fenestrated medial patellar plicae are unusual. These fenestrated medial plica may vary in size and shape from being small circular and 5mm in diameter to being large opening 3-4cm long. Arthroscopic resection of the painful medial plica can provide lasting and satisfactory relief of symptoms. There is high percentage of associated medial knee symptoms that are relieved by complete resection. We had performed arthroscopic excision of the symptomatic fenestrated medial plicae present in both knees. The symptoms were dramatically relieved after arthroscopic surgery.

남자 알코올 의존 환자의 퇴원후 추적 치료에 관한 연구

김성곤,전명호,박제민,김명정 釜山大學校 醫科大學 精神科學敎室 1997 釜山精神醫學 Vol.6 No.-

For abstinence in alcoholics, the follow-up treatment following admission is one of the most important factors. We investigated how many patients had follow-up treatments among alcohol dependent patients who admitted to psychiatric ward at Pusan National University for the first time and which factors influenced on whether they had follow-up treatments. The results were that 12% of the patients had follow-up treatments for at least 2 months after discharge and the longer they had admitted, the older they were on admission, the longer they had follow-up treatments.

부산 경남지방에 발생한 쭈쭈가무시병 64예의 임상적 고찰

이상훈,전명호,신병철,박기찬,김영효,배성,전광수,김종성 동아대학교의과대학 1992 동아의대학술지 Vol.4 No.1

서울특별시립 청소년시설 이용자의 만족도 조사연구

오치선,최병익,김두현,박광민,전명호,김지환 明知大學校 學生生活硏究所 2004 學生指導 Vol.16 No.-

암 생쥐에서 Testosterone으로 인한 유해감각예민도 둔화와 이에 대한 Naloxone의 차단효과

양구범,박제민,김명정,전명호,이국희 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

In order to examine the effect of testosterone on antinociception and the role of opioid system as an underlying mechanism, thirty-seven adult female mice(Institute of Cancer Research) were randomized to Naloxone(n=18) and Control group(n=19). Testosterone propionate(1mg/kg, ip) with naloxone HCL(2mg/kg, ip) or with normal saline(5ml/kg, ip) was administered on the first and the third experimental days. Nociceptive sensitivity was measured by Tail flick test(TFL, sec) before and after injection on the first and the third experimental days. The same dose of testosterone was injected on the second experimental day. The results were as follows; 1.TFL of control group was significantly increased by testosterone. TFL of control group measured on the first experimental day before and after injection were 5.5±1.1 sec(mean±sd) and 6.3±1.2 sec, respectively, and the change was significant(t=4.06, p=0.001). That measured on the third experimental day before injection was 5.9±1.0, showing a significant increase compared to that of the first experimental day(t=2.37, p=0.029). 2.Testosterone-induced antinociception was blocked by naloxone. In naloxone group, change in TFLs measured before(5.6±0.8) and after(5.3±0.9) injection was not significant on the first experimental day. On the third day, TFL measured before injection(6.6±1.2) was increased significantly than that of the first experimental day(t=2.87, p=0.011), but it decreased to baseline level after injection of naloxone(5.3±1.3; t=4.73, p=0.000). From these results, it is suggested that testosterone has antinociceptive effect, which is mediated by endogenous opioid system.

희귀한 대장게실증 2례

신병철,김경일,최철호,이상훈,전명호,이상기,이찬세,최하진 인제대학교 1991 仁濟醫學 Vol.12 No.2

우리나라에 있어서 대장게실의 발생빈도는 서양에 비하면 아주 적고 특히 다발성 대장게실의 경우는 아주 희귀하므로 중례보고하는 바이다. It has been usually believed that diverticular disease of the colon were more frequent in western countries than in Asia and in Korea. It was formerly considered to be rare, but according to recent Korean literatures, the incidence of colon diverticulums found on the barium enema studies were salts to be not so rare and the rates ranged between 0.33% (our own experince out of 1800 exams) to 11.8%. However, the following cases we report here were thought to be very rare in any literatures as far as we have known. The first case we experinced was a 37 years old male patient with multiple cecal diverticulosis visible on the films and the next one was 41 years old male patient with numerous widely distributed down to sigmoid colon. They were diagnosed on routine exam for nonspecific gastrointestinal symptoms, that is irregular frequent abdominal pains and frequent diarrheas after some alcoholic drinks. Their daily diets were usual Korean food stuffs with large amount of vegetable fibers. As for the developmental mechanism of above two cases were thought to be due to congenital malformation rather than acquired relating to the diet or intestinal Internal pressures, because of their location and multiplicites.