정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

구속된 비행 청소년들의 특성 및 석방 후 6개월간 재범여부와 관련된 변인

정선주,김원식,고승희,구영진,김홍창,서동혁 대한소아ㆍ청소년정신의학회 1999 소아청소년정신의학 Vol.10 No.2

야생 노랑제비꽃(Viola orientalis W.Becker)의 형태적 특성 및 Callus유도에 관하여

정용모,서정해,조만현,권오창 東亞大學校生命資源科學大學附設 農業資原硏究所 1996 農業生命資援硏究 Vol.5 No.1

부산근교의 고산 지대에 자생하는 야생 노랑제비꽃(Viola orientalis W. Becker)의 외부 형태적 특성과 줄기 조직으로부터 callus형성에 미치는 식물 생장조절제의 영양에 관한 실험을 실시하였던 바 그 결과를 요약하면 다음과 같다. 잎은 근생엽과 줄기상의 잎으로 구별할 수 있었으며, 엽장, 엽폭, 그리고 엽면적 각각 3.9㎝, 4.7㎝ and 15㎠로 모두 근생엽이 skjawl 줄기상의 잎보다 컸다. 그러나 엽형지수에 있어서는 근생엽이 0.83으로 가장 작았고 줄기상의 가장 작은 잎이 1.30으로 제일 크게 나타났다. 식물 생장조절물질의 단용에서 callus 유도는 Auxin의 NAA5×10??, 5×10??, 5×10??M에서 양호하였다. Auxin과 Cytokinin의 혼용에서 callus유도는 NAA 5×10??M 및 5×10??M에 BA 5×10??, 5×10??, 5×10??M의 전구에서 양호하였다. Callus 성장이 가장 양호한 조합은 NAA 5×10??M + BA 5×10??M 및 NAA 5×10??M + BA 5×10??M이었다. This experiment was conducted to study morphological feature and effect of plant growth regulators on callus induction of wild viola(Viola orientalis W. Becker). The results obtained were summarized as follows: In morphological feature, there was two distinctive leaf-forming types : one was rosette type derived from subterranean stem and the other was leaves formed on stem. Generally rosette type leaves were larger than others and the leaf length, leaf width, and leaf area were 3.9㎝, 4.7㎝ and 15㎠ on average, respectively. In the leaf shape index(the ratio of leaf length/width), the smallest value(0.83) was shown on rosette leaf while the greatest value(1.30) was determined from leaves on stems. Callus induction from the stem segments of wild viola was relatively higher at NAA concentrations of 5x10??M, 5x10??M or 5x10??M than at the same ones of other regulators used. The most effective combined concentrations of Auxin and Cytokinin for the callus formation were 5×10??M of NAA plus 5×10??M of BA or 5×10??M of NAA plus 5×10??M of BA.

녹농균의 혈청형에 관한 연구

서인수,조양자,정용훈,이열 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.2

The rabbit anti-group sera against thirteen representative standard strains of Pseudomonas aeruginosa, A to M groups were prepared for preparation of serological diagnostic factor. Using the grouping sera for both slide and tube methods, the agglutination reaction has been carried out for each of the thirteen groups of viable and various killed cells of Pseudomonas aeruginosa, A to M groups as agglutinogens to obtain the following results: 1. Of the thirteen anti-group sera eleven showed highly specific antisera for serological typing on the slide agglutination regardless of ind of agglutinogens i.e., viable, thermostable, thermolabile or formalized cells. 2. When serologicalcross reaction of the standard group strains with each of the anti-sera was estimated by using agglutination reaction, the anti-G group serum showed ?? To ?? Intensity of cross reaction with the viable cells of A, F and J grouping. 3. The viable cells of F group were reacted with all anti-group sera except one. 4. The thermostable agglutinogen (120℃, 2hr) of group F strain gave no cross reaction with any of the thirteen anti-group serum. By contrast group M showed the cross reactivity with almost all of the anti-sera. 5. In the course of the immunization, of the thirteen groups, the agglutinin titers of each of anti-group sera, except for the thermolabile antigen were highest in two weeks after immunization by tube method. 6. Of the standard groups strains the group E was highly immunogenic. The anti-E serum showed agglutinin titer 2,560 times more than other groups for various agglutinogens as mentioned previously. The agglutinin titers of anti-C, -D, -D and -K group sera were shown even at 1,280 to 2,560 times dilution when thermostable antigens were used. In case of thermolabile antigens, however, the above titers were not appreciable at 20 times dilution. 7. In the titration of the agglutinins of 0 antigen of Pseudomonas aeruginosa, A to M groups, the thermostable antigens were most sensitive agglutinogen, while the thermolabile antigens were lowest in sensitivity.

기업 구조조정에서 발생하는 환경문제에 대한 대응 : 미국의 폐기물 관리 제도를 중심으로 A Case of the U.S. Waste Management System

鄭瑞溶 한국환경법학회 2003 環境法 硏究 Vol.25 No.1

This paper centers on the US waste management system, focusing on the Comprehensive Environmental Response, Compensation and Liability Act (hereinafter CERCLA) and Resources Conservation and Recovery Act (hereinafter RCRA) to understand what kind of liability and regulatory systems have been developed to deal with various environmental issues that arise in the middle of corporate restructuring. Even if CERCLA and RCRA have developed comprehensive liability and regulatory systems, it is important to keep in mind that excessively strict liability and regulatory rules and regulations may act as an obstacle to the process of proper corporate restructuring, as also found in Brownfields problems in the US. This suggest that careful design is important in establishing such rules and regulations in Korea.

심장수술이 심전도에 미치는 영향 : Ⅰ. 개방성동맥관 수술 52례 Report of 52 Cases

이영균,정경원,유세영,손광현,김종환,서경필 최신의학사 1970 最新醫學 Vol.13 No.3

Fifty-two cases of patent ductus arteriosus were operated on, consisting of 32 females and 20 males. The youngest was 10 month old girl and the oldest 38 years old woman. Severe pulmonary hypertension of 110mmHg was found in two cases, both of which succumbed, one during surgery due to cardiac arrest and the other died one week after operation. In the later case severe tracho-bronchial tree obstruction was found by autopsy. One and a half years old girl expired 3 days after operation. By autopsy bronchopneumonia was found. A fourteen years old girl died of bacterial endocarditis one month after discharge from the hospital. Two cases associated with pulmonary hypertension and an adult were operated on under general hypothermia. All the survival cases showed satisfactory results.

無聲放電의 電氣的 考察

金容柱,金正洙,徐相壽 忠州大學校 1968 한국교통대학교 논문집 Vol.2 No.-

We have been studying on the discharged phenomena of compound dielectrics which is very important in electric machinery. In this paper we come to the conclusion that, as a result of studying on the electric design of one Ozonizer, the higher the frequency becomes, the more output we can get, and then the discharge power can be the greatest by moderating the distance of the discharge gap preperly, and the atmospheric pressnre under the sane applied voltage and power factor of Ozonizer reachod the maximum power at a particular frequency when the discharge power is maintained constsantly.

림프구성 뇌하수체염 - 증 례 보 고 -

임동준,정용구,이훈갑,이기찬,서중근 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.11

癩 接觸兒童의 末梢血液中 T-淋巴球와 Immunoglobulin의 動態에 관하여

金蘭姬,河龍馬,宋浚榮,徐舜鳳,鄭泰浩 大韓癩學會 1979 癩學 會誌 Vol.12 No.1

만정 뇌경막하혈종에서 술전 CT음영 및 천두폐쇄배액술후 배액량과 재발과의 상관관계에 대한 연구

임동준,박윤관,정용구,김봉룡,정흥섭,이기찬,이훈갑,서중근 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.10