당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

한국 초파리집단의 선택불리에 관한 지구 자기장의 5배인 자기장의 영향

박은규,정승문,김중현,최오목 圓光大學校 1995 論文集 Vol.29 No.2

본 연구에서는 한국 선유도의 자연집단 야생형 초파리와 가시돌연변이형 황색체-소시 초파리를 Helmholtz coils 장치를 이용해서 유도한 지구 자기장의 5배인 자기장내의 집단과 비교 집단인 지구 자기장내의 집단에서 발생율 변동과 성적 선택빈도를 조사하여, 선택불리에 관한 유전적 행동을 관찰해서 다음과 같은 결과를 얻었다. 1.야생형 유전자(+)를 운반하는 염색체의 선택빈도는 15세대까지 평균 빈도가 지구 자기장의 5배인 자기장내의 초파리 집단, 지구 자기장내의 초파리 집단이 각각 0.6489, 0.6553으로 관찰되었다. 이 결과는 지구 자기장의 5배인 초파리 집단에서 더 강한 선택불리 행동을 보여 주었다. 2.초파리 집단의 발생율 변동은 지구 자기장의 5배인 자기장내의 초파리 집단 3세대(13.60%), 지구 자기장내의 초파리 집단 6세대(22.35%), 8세대(22.30%)에서 아주 낮은 발생율의 변동을 보여주었으며, 2개의 상이한 자기장내 초파리 집단의 전체 평균 발생율은 지구 자기장의 5배인 자기장내의 초파리 집단, 지구 자기장내의 초파리 집단에서 각각 58.07%, 41.93%로 관찰되었으며, 후자보다 전자에서 발생율이 증가함을 보여 주었다. 3.돌연변이형 황색체-소시 유전자(ym)를 운반한 염색체의 선택빈도는 각각의 자기장내의 초파리 집단에서 0.0542, 0.0646으로 관찰되었다. 이 결과는 지구 자기장의 5배인 자기장내의 초파리 집단에서 0.0542로 상대적으로 강하게 선택불리 행동을 보여 주었다. 4.돌연변이형 황색체 유전자(y)를 운반한 염색체의 선택빈도는 각각의 초파리 집단에서 0.0185, 0.0144로 관찰되었다. 이 결과는 비교 집단인 지구 자기장내의 초파리 집단에서 0.0144로 더 강한 선택불리 행동을 보여 주었다. 5.돌연변이형 소시 유전자(m)을 운반한 염색체의 선택빈도는 각각의 조절된 자기장내의 초파리 집단에서 0.0328, 0.0190으로 관찰되었다. 이 결과도 지구 자기장내의 초파리 집단에서 0.0190으로 상대적인 강한 선택불리 행동을 보여 주었다. 6.수컷이 가지고 있는 Y-염색체의 선택빈도는 각각의 초파리 집단에서 0.2457, 0.2467로 관찰되었다. 이 결과는 지구 자기장의 5배인 초파리 집단에서 0.2457로 더 높은 선택불리 행동을 보여 주었다. 7.Duncan's multiple range test의 LSD값으로 유의 차이 유무 검정을 하였던 바 야생형 유전자의 A 그룹과 돌연변이형 유전자들의 B 그룹사이에서 고도의 유의 차이가 있음이 밝혀졌다. To elucidate the genetic behavior of selective disadvantage among visible mutants of Drosophila melanogaster bred and kept by the genetic study laboratory room. Wonkwang University and the wild type collected at Sunyoudo island in Korea, and reared under the influence of two different strength of magnetic fields, i.e. the quintuple and the ambient magnetic field, this study was carried out at the above indicated laboratory room. 1.The mean selective frequencies of wild gene(+)-carry chromosome up to 15th generation, affected by two different magnetic fields, showed 0.6489 and 0.6553 with the magnetic field strength as mentioned order before. The data explains that the population of Drosophila melanogaster reared in the quintuple magnetic field showed higher selective disadvantage. 2.The variations of emergence rates of the populations of Drosophila melanogaster altering by generation showed the drastic lowest values at the specified generation, for example, 13.60% under the quintuple magnetic field at the third generation and 22.35% and 22.30% under the ambient magnetic field at the 6th and 8th generation. The over-all mean emergence rates of the populations of Drosophila melanogaster reared in controlled magnetic fields, i.e. the quintuple and the ambient magnetic fields using Helmholtz coils, showed 58.07% and 41.93% respectively. Referring to these data, the population of flies raised in the quintuple magnetic field showed a relatively higher emergence rate than the ambient magnetic field. 3.The mean selective frequencies of the individual of ym gene-bearing chromosomes showed 0.0542 and 0.0646 by the same order of magnetic field strength indicated above. It was shown that the population of flies reared in the quintuple strength generated by Helmholtz coils cleared the relatively strong selective disadvantage being 0.0542. 4.The mean selective frequencies of the mutant that carries y gene-bearing chromosome showed 0.0185 and 0.0144 from the two different magnetic fields in the same magnetic order. The results indicated that the population of flies from the ambient magnetic field showed higher selective disadvantage frequency, 0.0144. 5.The mean selective frequencies for the mutant carrying m gene-bearing chromosome were calculated as to be 0.0328 and 0.0190 for the same order of magnetic field strength. The found from this results is that the selective disadvantage behavior for the mutant rearing m gene chromosome in the ambient magnetic field was stronger than the one, being 0.0190. 6.The mean selective frequencies of the male flies which carries Y-chromosome showed 0.2457 and 0.2467 respectively. The results indicated that the male flies from the quintuple magnetic field showed higher selective disadvantage being 0.2457. 7.Through Duncan's multiple range test and LSD value, the highly significant differences between A group of the wild type and B group of the other three mutants were calculated.

교사들의 인구통계학적 특성에 따른 생활양식과 생활만족의 관계

문태영,박승환 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

The purpose of this study was to determine the relationship among demographic characteristics, life style and life satisfaction in teacher community. Teachers should work out on a regular basis to improve their health and quality of life. Regular exercise is expected to allow them to lead a better life and be in good shape. And looking into the relationship among their demographic variables, life style and life satisfaction seemed to be a sure way to promote their emotional health. The subjects in this study were 230 teachers selected from Gangweon province. After a survey was conducted with self-administrated questionnaires, frequency analysis and t-test were implemented. The findings of this study were as follows: 1. Demographic Characteristics and Life Style The marital status, religion and monthly mean income of the teachers investigated made no difference to their ability to cope with the given situations. But that significantly varied with gender(t=2.08, p<.05) and age(t=4.61, p<.05). Their stress management was not affected by gender, marital status, age and monthly mean income, but that significantly differed with religion(t=3.01, p<.05). Their tolerance made no significant difference. 2. Demographic Characteristics and Emotional Health The teachers got a mean of 3.37 on emotional health. The marital status, age and monthly mean income gave no impact, but that was significantly different according to gender(t=2.12, p<.05) and religion (t=3.76, p<.05). 3. Demographic Characteristics and Life Satisfaction Their demographic characteristics made no significant difference on their life satisfaction. 4. Life Style and Life Satisfaction Their life pattern exercised no significant influence on their stress management, part of life satisfaction, but had a significant impact on ability of coping with the given situations(β = .179) and tolerance(β=.147).

관동맥 재개통 후 QTc간격분산의 감소 : 정량적으로 측정한 심근 허혈의 호전 정도와의 연관성 Relationships with the Quantitative Degree of Improvement in Myocardial Ischemia

박상선,최기준,남기병,이철환,홍멸기,박성욱,박승정,신중우,문대혁,김유호 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

하지의 동맥부전증 환자에서 동반된 복부 대동맥류

문인성,박장상,고용복,김용귀,홍성곤,김승남 대한혈관외과학회 1999 Vascular Specialist International Vol.15 No.1

The early diagnosis of abdominal aortic aneurysms are difficult, especially when they are not clinically evident. Because of the generalized nature of atherosclerosis, there is reason to believe that there is a high incidence of aneurysms of the abdominal aorta in patients with peripheral vascular disease. But the screening test for hidden abdominal aortic aneurysms in patients with peripheral arterial disease has not been used for routine manner. So we retrospectively reviewed the 9 patients who had asymptomatic abdominal aortic aneurysms with symptomatic peripheral arterial disease during the last four and half-year period: among them three aneurysms were screened preoperatively by physical examination with their diameter more than 5 cm and 6 aneurysms were found intraoperatively with their mean diameter of 3.8cm. The ages ranged from 66 through 84 years with the mean age 73 years. There were 7 men and 2 women. The sites of the peripheral occlusive disease is as follows: femoral artery only in 1, iliac artery only in 2, both iliac and femoral arteries in 5, and from iliac artery through tibial artery with thrombus formation in 1. We suggest that ultrasonographic screening for the presence of hidden abdominal aortic aneurysm preoperatively in patients with lower extremity occlusive arterial disease is needed, especially when the ages of patients is older than 65 years and the site of arterial disease include iliac segment.

艾葉粉末의 添加給與가 肉鷄에 미치는 影響

文勝式,朴玉潤,宋瑛敏 진주산업대학교 1985 論文集 Vol.23 No.-

本 試驗은 1985년 9월 20일 孵化된 肉鷄用(Hubbard) 병아리 120首를 各區當 30首씩 4개區로 나누어 晋州農林 專門大學 養鷄場에서 3주간(1985.10.19~11.8)에 걸쳐 艾葉을 C(0%), T_1(1%), T_2(2%), T_3(3%)水準으로 飼料에 添加하여 給與試驗을 하였던 바 다음과 같은 성적을 얻었기에 報告하는 바이다. 1. 增體量은 T_1區(1296.32g), C區(1274.70g), T_3區(1264.32g) 및 T_2區(1259.64g)의 순으로 나타났다(p>0.05). 2. 飼料攝取量은 C區(2715. 13g), T_1區(2738.60g), T_2區(2754.16g) 및 T_3區(2811.46g)의 순으로 나타났고 飼料要求率은 T_1區(2.113), C區(2.130), T_2區(2.178) 및 T_3區(2.232)의 순으로 나타났다(p>0.05). 3. 産肉指數는 T_1區(306.48), C區(303.01), T_2區(293.38) 및 T_3區(284.86)의 순으로 나타났다. 4. 屠體率은 ♀는 T_1區(69.45), T_2區(69.30), T_3區(67.58) 및 C區(66.45)의 순이였고 ♂은 T_3(70.03), T_2區(69.13), T_1區(67.85) 및 C區(66.58)의 순이였다. 5. 臟器重量은 대조구와 처리구간에 차이를 볼 수 없었다. 6. 經濟性을 분석한 結果 各 區別 수당수익은 T_1區(613원), C區(590원), T_2區(583원) 및 T_3區(572원)의 순으로 나타났다. This experiment was all located to 4 plots by 30 chickens per each plot with 120 chickens of broiler-Hubbard hatched at the 20th of September, 1985 and the formula feed added in the levels of 0(C plot), 1(T_1 plot), 2(T_2 plot) and 3%(T_3 plot) of Artemisia was supplied for these of each plot during 3 weeks from October, 19 to November, 8, 1985 at the poultry house, Chinju Agricultral & Forestry Technical College. The results found out the effect of Artemisia meal addition on the growth of broiler-Hubbard were as follows: 1. The weight gain(g) was heavy in the order of T_1(1296.32), C(1274.70), T_2(1264.32) and T_3(1259.64) and non significant (p>0.05) between plots. 2. Feed consumption(g) was heavy in the order of C(2715. 13), T_1(2738.6), T_2(2754.16) and T_3(2811.46) and feed conversion, T_1(2.113), C(2.130), T_2(2.178) and T_3(2.232) (p>0.05). 3. Point spread was high in the order of T_1(306.48), C(303.01), T_2(292.38) and T_3(284.86). 4. Dressing percent of female ws high in the order of T_1(69.45), T_2(69.30), T_3(67.58) and C(66.45), and of male, T_3(70.03), T_2(69.13), T_1(67.85) and C(66.58). It was generally higher in the Artemisia meal addition plot than in the control. 5. Internal organies weight was non significant differences(p>0.05) between treatment plots and control. 6. In economical analysis, net income(won) per bird of each plot was 613(T_1), 590(C), 583(T_2) and 572(T_3).

통상정보학의 실용성 제고를 위한 연구방향

박승락,박문서 한국통상정보학회 1999 통상정보연구 Vol.1 No.2

연구방법론의 관점에서 통상정보학은 매우 다양한 방법으로 접근이 가능하며, 특히 정보통신기술을 적극적으로 활용할 수 있기 때문에 항상 새로운 접근 방법이 출현할 수 있다. 또한, 정보기술의 급격한 발전으로 국제전자상거래가 급격히 확산되고 있는 현 시점에서 수출기업의 단순한 무역자동화 수준을 벗어난 국제간 B to B 전자상거래의 전략적 활용방안에 대한 연구가 필요한 때이다. 이에 본 연구에서는 통상정보학의 실용성 제고를 위한 구체적인 연구방향으로써 전략 정보시스템과 조직이론을 가미한 조직간 정보시스템 이론을 제시함으로써, 조직간의 전략적 연계를 통한 전략적 통합정보시스템 구축전략을 제시하고자 하였다. 이를 통하여 정보화의 이점을 통상학 분야에 도입하고, 전략적으로 활용 가치가 있는 정보를 생산, 저장, 유통 및 활용함으로써 학술적 비용발생을 최소화하며, 기업의 이윤발생을 촉진함으로써 국가경쟁력의 확보에 기여할 수 있도록 하는 것이 통상정보학의 궁극적인 지향 목표이다.

W-3계 고도 불포화지방산의 혼합비율이 다른 유지가 지질대사에 미치는 영향

박필숙,김성희,정승용,김경숙,문순열 慶尙大學校 1988 論文集 Vol.27 No.1

혈청 콜레스테롤 및 중성지방의 농도와 밀접항 관계가 있으며 혈청 lipprotein의 대사에 영향을 미치는 w-3계의 지방산의 적정한 섭취 비율을 구명하기 위한 일환으로써 들깨기름과 라아드의 혼합비율을 달리하여 흰쥐에게 급이한 결과 다음과 같은 결과를 얻었다. 1. 혈청 총-콜레스테롤 농도는 들깨기름 7.5%+라아드2.5%를 급이한 2군에서 유의성있게 낮은 반면 10%라아드 급이군은 현저히 높았다. 2. 혈청 HDL-콜레스테롤은 3군과 4둔이 1군, 2군에 비해 낮았으며, 혈청 총-콜레스테롤에 대한 HDL-콜레스테롤 비율은 2,3,4군이 5군에 비해 높았다. 3. 혈청 중 인지질과 중성지방 농도는 5군에 비해 2,3군에서 현저하게 낮았다. 4. 간장 중 총-콜래스테롤 농도는 4군이 1,2,3군에 비해 비교적 낮았다. 5. 간장 중 인지질 농도는 각 군간에 유의적인 차이는 없었으나 중성지방의 농도는 5군보다 1,2군에서 유의성 있게 낮았다. 6. 시험유지의 지방산조성은 1군에서 lionenic acid가 dir 58%이었으며, 5군에서는 w-3계 PUFA가 0.1%, oleic acid가 47.5%이었다. 7. 혈청 lipoprotein pattern은 2군에서 HDL함량이 가장 많은 반면 LDL함량은 가장 적은 경향이었다. In order to investigate the suitable composition of the w-3 series polyunsaturated fatty acid on lipoprotein metabolism related with cholesterol and triglyceride concentrations in serum, it was examined the effects of w-3 PUFA contents of mixed fat on oil lipid metabolism in serum and liver of rats. The results were summerized as follow ; 1. The concentration of T-cholesterol in serum of rats was lowest in the group 2 (7.5% perilla oil + 2.5% lard). whereas it was highest in group 5 (10% lard). 2. The concentration of HDL-cholesterol in serum was lower in group 3, 4 than in group 1, 2 and the ratio of HDL-cholesterol to T-cholesterol were higher in group 2, 3, 4 than in group 5. 3. The concentrations of phospholipid and trigyceride in serum were significantly lower in group 2, 3 than in group 5. 4. The concentration of T-cholesterol in the liver was relatively lower in group 4 than in group 1, 2, 3. 5. Phospholipid values in the liver were not significantly different between groups, but the concentrations of triglyceride were remarkably lower in group 1, 2 than those of the group 5. 6. Linolenic acid in group 1 (10% perilla oil), in the fatty acid composition of test lipids used in the experiment. was as much as about 58%, but w-3 PUFA in group 5 was only 0.1% and oleic acid was as much as about 58%, but w-3 PUFA in group 5 was only 0.1% and oleic acid was as much as 47.5%. 7. HDL contents, in lipoprotein composition of serum were the most in group 2 (7.5% perilla oil+2.5% lard), while LDL contents were the least.