스프렌딜 지속정(펠로디핀 5㎎)에 대한 스타핀 지속정의 생물학적동등성

조혜영,강현아,이석,백승희,박은자,최후균,문재동,이용복 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4

Felodipine is a calcium antagonist that lowers blood pressure by reducing peripheral resistance by means of a direct, selective action on smooth muscle in arterial resistance vessels. Furthermore, it have been approved for the effective in angina pectoris and cardiac failure. The purpose of the present study was to evaluate the bioequivalence of two felodipine extended release (ER) tablets, Splendil (YuHan Corporation) and Stapin (Hana Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). THe felodipine release from the two felodipine formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method at pH 6.5 buffer solution. Twenty six healthy male subjects, 22.73±1.78 years in age and 66.66±7.28 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 5 ㎎ as felodipine were orally administered, blood sample was taken at predetermined time intervals and the concentrations of felodipine in serum were determined using column-switching HPLC method with UV detector. The dissolution profiles of two formulations were similar at pH 6.5 buffer solution. Besides, the pharmacokinetic parameters such as AUG_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t) and C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Splendil were 2.53%, 1.32% and 18.32% for AUC_(t), C_(max) and T_(mzx), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.86)∼log(1.20) and long(0.89)∼long(1.23) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Stapin ER tablet and Splendil ER tablet are bioequivalent.

중소기업 전자상거래의 활성화전략에 관한 연구

조세형,김승철,정용균 한국중소기업학회 2004 中小企業硏究 Vol.26 No.2

전자상거래에 관한 대부분의 선행연구들은 기업의 전자상거래 채택 및 확산 요인에 초점을 두었으며, 대기업 중심의 자료를 바탕으로 연구가 수행되었다. 그러나, 기업에서의 전자 상거래 활용은 선택이 아닌 기정 사실화되었고 이제는 어떻게 활용하는가에 초점을 두어야할 때이다. 한편, 대기업을 대상으로 한 연구결과가 중소기업에 지침으로 제공되고 있으나, 중소기업이 단순히 대기업의 축소판이 아니며 많은 점에서 고유의 특성을 지니고 있기 때문에 중소기업 자체의 연구가 필요하다. 본 연구는 세 가지 측면에서 전자상거래에 환한 선행연구를 확장한다. 첫째는 많은 선행연구들이 주로 정보기술의 채택 및 확산이란 차원에서 전자상거래를 다루어 온 것에 비하여 본 연구에서는 전자상거래의 실행을 성과와 연관시켜 다룬다. 둘째는 국가경제에 커다란 비중을 차지하고 영향을 미치는 중소기업에 초점을 둔다. 끝으로, 중소기업에 적합한 전자상거래 활성화 전략을 제안하고자 한다. 연구결과 중소기업에 적합한 특유의 전자상거래 활용형태는 없으며, 기업상황에 적합한 활용형태를 찾는 것이 필요할 것으로 보인다. 한편, 정보시스템 성숙도 수준에 따라 IC실행형태가 성과에 미치는 영향에 차이가 있음을 발견하였다. 예를 들어, 비용우위 전략은 성숙도가 낮을수록 가치시스템형 IC는 성숙도가 높을수록 높은 성과를 나타냈다. Business firms are increasingly taking part in online business activities through internet as the size of the e-commerce market is rapidly growing in the recent years. Electronic commerce (EC) activities now become an essential part of the business strategy for survival as well as growth for both large enterprises and small- to medium-sized enterprises (SMEs). Previous studies on e-commerce mostly focused on the factors leading to adoption and diffusion of EC by business firms, and also have been carried out with the data from big enterprises. More often than not, the results obtained from the large business firms are used to provide the guidelines for SMEs. SMEs are, however, different from large business firms in many aspects, and need to be studied on their own. This paper extends the previous researches on EC in three aspects. Firstly, we study the e-commerce issues in the area of implementation in relation to EC performance, beyond the adoption and diffusion of IT technology which has been the research issues in many previous researches. Secondly, we focus on small and medium enterprises which comprise a large portion of national economy with significant influence. Finally, we propose desirable EC strategies for SMEs upon consideration of SMEs' characteristics.

기초화장용 제품 중 크림과 로션제의 안정성 평가방법

조혜영,이석,백승희,최후균,이용복 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4

This study was attempted to develop the physicochemical and morphological stability test methods for the cream and lotion formulations among the cosmetic foundations and to provide the guidance for the stability methods with respect to basic emulsions and creams. With these developed stability test methods, we can evaluate the expired date or life time of the available basic cosmetics, especially basic lotions and creams. Also, the stability test methods established in this study can be used as a guideline to test physical and morphological stability of cosmetics in the future. Thus, we selected two types of basic cosmetics such as lotions and creams made by four different cosmetic companies and applied them to stability test methods depending on the temperature changes such as temperature cycling and freezing-thawing cycling test. After the temperature changes, the conductivity, turbidity, particle size, creaming ratio and pH changes of the creams and lotions were evaluated and morphological changes such as crystal formation, oder, color and feeling of the creams and lotions were also tested. As the results of the stability tests, all the tested creams and lotions except for one lotion were stable. Therefore, it may be concluded that these short-term accelerated stability tests as physical stability test depending on the temperature change study were suitable for the stability testing methods for the basic cosmetics and may be useful for the establishment of the guideline for the stability test of cosmetics.

UASB 반응기에서 제지폐수 처리를 위한 생물학적 속도론 모델에 관한 연구

박승조,이성식,전성균,김 광,신미옥,김미양,이영상 東亞大學校 大學院 1993 大學院論文集 Vol.18 No.-

The granulation of sludge in the UASB reactor is beneficial to stable operation of the reactor at a high volumetric COD loading rate and high hydraulic loading rate, because it improves the setting ability of sludge and the granular sludge acquired has high methanogenic activity. The design of integral biogas?/liquid/solids seperators varies among suppliers of UASB technology. Comples, soluble organic compounds are the first to be hydrolyzed (Stage 1) to simple organics. These simple organics are converted by acid-forming bacteria to C₄H?COOH, C₃H?COOH, CH₃COOH, H₂ and CO₂ in a acidogenic phase(STAGE 2). The higher organic acids are subsequently converted to CH₃COOH and H₂(Stag 3) by acetogenic bacteria. The final step(Stage 4) to produce CH₃ is carried out by me-thano-bacterium. The kinetics of anaerobic digestion of paper wastewaters largely depends on the environmental conditions. The purpose of this study was to elucidate the kinetics of methane production from paper was tewaters in the UASB. A four-step reaction mechanism was proposed for modeling methanogenesis of anaerobic treatment of paper waterwaters.

3DFT-CISS를 이용한 감각신경성 난청 환자의 MBI

김성원,여상원,김상후,김종수,조재흥,이동희,이승균 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

흡연력을 고려한 궤양성 대장염 발생과 충수 절제술 사이의 상관 관계

남승우,양석균,정훈용,심기남,조병동,김승용,박의련,홍원선,민영일 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.1

상태관측기에 의한 영구자석동기전동기의 슬라이딩모드제어에 관한 연구

조광승,박성원,노태균,우정인 동아대학교 정보기술연구소 2001 情報通信硏究所論文誌 Vol.8 No.2

According to the rapid growth of high speed and precise industry, the application of synchronous motor has been increased. In the application fields, the fast dynamic response is of prime importance. In particular, since the PMSM has characteristics of high speed, high thrust, it has used in high-performance servo drive. From these reasons, it is recently used for high precise position control, and machine tool. In this paper, using the state observer, robust vector position control method for the purpose of improving the system performance deterioration caused by parameter variations is proposed.

In vitro and in vivo mechanical stability of orthodontic mini-implants.

Cho, Il-Sik,Kim, Sung-Kyun,Chang, Young-Il,Baek, Seung-Hak Angle Orthodontists Research and Education Foundat 2012 The Angle orthodontist Vol.82 No.4

<P>To compare in vivo and in vitro mechanical stability of orthodontic mini-implants (OMIs) treated with a sandblasted, large-grit, and anodic-oxidation (SLAO) method vs those treated with a sandblasted, large-grit, and acid-etching (SLA) method.</P>

국내 2세 이하 영아에서 모체로부터 전달된 A형 간염 항체의 변화

조형준,이미희,김종현,허재균,이정현,김진택,정승연,강진한 대한감염학회 2001 감염 Vol.33 No.5

Background : Although the incidence of hepatitis A infection has dramatically declined in developed countries, it is still endemic in many of developing countries, and sporadic outbreak has developed in many middle classed endemic area. Many reports indicate that hepatitis A vaccine would have to be used for widespread immunization of infants, who live in endemic or non-endemic region, for eliminating this infection from circulation. Therefor, the optimal immunization schedule and dose of vaccine should be determined. Recent several studies suggested that high dose hepatitis A vaccination at the time of disappearance of maternal antibody promise protectable immunogenicity in infants. The purpose of our study to find out the prevalence and persistence of material HAV antibodies in Korean infants (below 2 years old age). Methods : 60 mother without past-history of hepatitis A, and 300 heathy infants without history of hepatitis A vaccination and intra-familial contact history of hepatitis A were enrolled in this study. The infants below 2 years old age were classified into 5 groups as following; 0∼3 months, 4∼6 months, 7∼9 months, 10∼ 12 months, 13∼24 months, and the number of each group were 60 and sex distribution of each group was equal. Positive rates of Anti-HAV were determined by ELISA. And comparisons of seroprevalence of anti-HAV between groups were analyzed by ANOVA repeated t-test. Results : The seropositive rate of maternal group was 81.7%, and the seropositive rate of 0∼3 months of age group was 43.3%. The seroprevalence of anti-HAV significantly declined after 4∼6 months of age, and reached below 10% at the age of 7∼9 months of age and the low rate of anti-HAV maintained until 2 years old age. And positive rates of anti-HAV showed no significant differences between males and females. Conclusion : The results of our study showed that the seroprevalence of anti-HAV significantly declined after 4∼6 months of age and the anti-HAV almostly disappeared at 7 ∼9 months of age. So, low seropositive rate of anti-HAV at 7 months of age may justify trials on infant vaccination in ]Korea. (Korean J Infect Dis 33:331∼337, 2001)