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문재동 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2
Although the final cumulative exposure has been used as a exposure variable on the cohort study for the relation between exposure and disease, the bias from the use of fixed exposure can be developed because the exposure amount changes across the time. We developed the program to handle the Cox model with irregularly changing time-dependent exposure variable and covariates, and the validity about the application of time-dependent exposure variable and lagged interval was practically evaluated by analyzing the data collected for typical retrospective cohort study with that program. The results were as follows : The exposure-response relations between the deaths from lung cancer and exposures(fixed or time-dependent) were not clear when 0 year lagged interval was applied. When 15 years lagged interval was applied, the exposure-response relations between the deaths from lung cancer and the time-dependent exposures to crystalline silica were observed and relative risks increased like 1.00, 1.17, 1.30 and 2.45 across the exposure levels. The relative risk estimates for lung cancer with time-dependent exposure variable were higher than those with fixed exposure variable without regard to the application of lagged interval. The exposure-response relations between the deaths from non-malignant respiratory disease(NMRD) and exposures (fixed or time-dependent) were observed across exposure levels when 0 year lagged interval was applied. When 15 years lagged interval was applied, the exposure-response relations between the deaths from NMRD and the time-dependent exposures to crystalling silica were observed, but were not with fixed exposure variable. The relative risk estimates for NMRD mortality with time-dependent exposure variable were higher than those with fixed exposure variable, and the application of lagged interval on the evaluation of NMRD mortality was meaningless. The results suggest that the application of time-dependent exposure variable on the study of exposure-effect relation should be considered and the application of lagged interval should be decided according to the time needed from disease detection to death.
수중(水中) 수은(水銀) 및 鉛(연)의 농도(濃度)가 BOD값에 미치는 영향(影響)에 관(關)하여
문재동,Moon, Jai-Dong 대한예방의학회 1984 예방의학회지 Vol.17 No.1
In order to estimate interfering effects of mercury and lead on biochemical oxygen demand (BOD), BOD in 18 effluent samples were measured under three different concentrations of mercury and lead. The results obtained were as follows: 1. Biochemical oxygen demand(BOD) was decreased under the presence of mercury and lead, with parallel correlation of mercury concentration. 2. High correlations were noted between original BOD concentration and decreasing amount of BOD when concentrations of mercury or lead were increased. 3. When the lead concentration was high, the close correlation was observed between total organic carbon(TOC) and decreasing amount of BOD. 4. There was a negative correlation between TOC/BOD ratio and decreasing amount of BOD when the mercury concentrations were high.
해저작업장(海底作業場)의 감압병(減壓病) 발생(發生)에 대(對)한 역학적(疫學的) 고찰(考察)
문재동,진일섭,김양옥,Moon, Jai-Dong,Chin, Ill-Sup,Kim, Yang-Ok 대한예방의학회 1984 Journal of Preventive Medicine and Public Health Vol.17 No.1
Forty one male workers employed in an underwater construction field were surveyed in the viewpoints of epidemiological analysis of decompression sickness (caisson's disease). Nineteen out of the entire forty one workers have been, or had been suffering from decompression sickness (as 46.3% of incidence rate) after decompression. The results obtained were as follows: 1. There was a significant relation between duration of work and incidence of disease. 2. Type II (severe type) comprised majority of cases (16 cases, 84.2%) despite any significant correlations were not present between severity types and recompression times. 3. Most frequently cited symptoms were lower limb pain (89.5%), upper limb pain (79.0%), pruritus (68.4%) and so on, however, 10% of patients complained of neurological symptoms. 4. There were not any significant correlations between disease incidence and worker's age or relative body weight.
여천공단지역의 아이소시아네이트 노출작업자에서 기도과민성
문재동,이강진,이숭,장안수,서정평,최인선,양승원 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.3
Objective: To investigate the prevalence of airway hyperresponsiveness induced by isocyanate at one petrochemical industry complex in Yeochon, Korea. Methods: Questionnaires, allergic skin prick test, toluene diisocyanate (TDI)-specific IgE, and non-specific airway hyperresponsiveness (AHR) were studied in 73 exposed workers and 27 control subjects. Methacholine challenge tests were done and bronchial responsiveness (BR index) was defined as log (% fall of FEV1)/ log (last concentration of methacholine +10). Results: Twenty-three workers (31.5% ) had respiratory symptoms, 21 had nasal symptoms, and eight had skin symptoms. Exposed workers with respiratory symptoms (n=22) had significantly higher BR index than those without them (0.82+-0.06 vs 0.60+-0.02, p<0.05). Exposed workers tended to have higher BR index than controls (0.67+-0.03 vs 0.62+-0.02). Three exposed workers had PC20 methacholine <2.0 mg/ml. There were no significant differences in atopy score between exposed workers and controls (p)0.05). Specific IgE antibodies were found in 19.7% of exposed workers. FEV, showed a significant negative correlation with BR index (r =-0.25, p<0.05). Poor correlation was noted between BR index and atopy, smoking status, or exposure duration. Conclusion: These findings suggest that workers exposed to isocyanates are at higher risk of airway hyperresponsiveness.
문재동,Won-Ju Park,Seok-Ju Yoo,Suk-Ho Lee,정재우,Keun-Ho Jang 대한예방의학회 2015 Journal of Preventive Medicine and Public Health Vol.48 No.1
Objectives: An outbreak of acute febrile illness occurred in the Republic of Korea Air Force boot camp from May to July 2011. An epidemiologicalinvestigation of the causative agent, which was of a highly infective nature, was conducted. Methods: Throat swabs were carried out and a multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) assay was performedto identify possible causative factors. Results: The mean age of patients who had febrile illness during the study period was 20.24 years. The multiplex RT-PCR assay identifiedrespiratory syncytial virus (RSV) as the causative agent. The main symptoms were sore throat (76.0%), sputum (72.8%), cough (72.1%), tonsillar hypertrophy (67.9%), and rhinorrhea (55.9%). The mean temperature was 38.75°C and the attack rate among the recruitswas 15.7% (588 out of 3750 recruits), while the mean duration of fever was 2.3 days. The prognosis was generally favorable with supportive care but recurrent fever occurred in 10.1% of the patients within a month. Conclusions: This is the first epidemiological study of an RSV outbreak that developed in a healthy young adult group. In the event of an outbreak of an acute febrile illness of a highly infective nature in facilities used by a young adult group, RSV should be considered among the possible causative agents.