방사선 조사를 받은 두경부 병소의 재건을 위한 유리피판술

채수욱,고경석,김주봉,박상훈,한상훈,이택종,남순열,김상윤 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Radiation therapy is an effective cancer treatment modality as a primary treatment in early cancer and as an adjuvant treatment in advanced cancer, especially in head and neck lesions, but it also causes irreversible chronic damages to overlying normal tissues that may lead to wound complications. As well, at the microscopic level, radiation injury causes both stasis and occlusion of small vessels. Therefore, surgical reconstruction of previously-irradiated lesions in the head and neck poses a great problem. Fifth-six patients with head and neck lesions underwent 57 microsurgical reconstructions between 1990-1998. Thirteen patients were irradiated before surgery. The previous radiation dose was 30∼75.6 Gy. The free tissue transfer was successful in 52 of the 57 microsurgical reconstructions(91.2%). The success rate was 92.3%(12/13) in previously-irradiated patients and 90.9%(40/44) in nonirradiated patients. Postoperative complications, such as flap loss, fistula, and infection, developed in 4 irradiated patients and 8 nonirradiated patients. Overall complication rate was 30.8%(4/13) in previously-irradiated patients and 18.2%(8/44) in nonirradiated patients. Although the failure rate of previously-irradiated patients was higher than that of nonirradiated patients, there was no statistically significant difference between them. Thus, free tissue transfers in patients with previously-irradiated head and neck lesions are suitable for one-stage reconstruction.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

관동맥 질환 환자에서 전산화단층촬영상의 복부지방 분포 및 형광안저 촬영

한혜자,홍종면,차상훈,김동운,남기병,최미영,강세웅,박남규,이석재 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.2

배경 및 목적 : 죽상경화증의 원인 인자중 하나인 복부지방의 축적도를 복부 전산화 단층 촬영술로 정량화 하여 관동맥 질환과의 상관 관계를 살펴보고자 하려고, 또한 형광 안저 촬영 검사상의 죽상 경화증 정도와 관동맥 질환과의 상관 관계를 알아보고자 하였다 대상 및 방법 : 관동맥 조영술을 시행한 환자중 관동맥조영술 소견상 50% 이상의 협착이 있는 경우를 관동맥 질환군(n=15)으로 정의하였고, 관동맥 조영술 소견상 관동맥 질환이 없고 허혈성 뇌혈관질환, 당뇨병 및 고혈압이 없는 환자들을 대조군(n=11)으로 하였다. 배꼽 위치에서 복부 전산화 단층 촬영을 시행하여 총 복부 지방면적(total abdomen fat area, TAFA). 복강내 지방면적(abdomen visceral fat area, AVFA) 및 복부 피하지방면적(abdomen subcutaneous fat area, ASFA)을 측정하였고, 그 비를 구하여 비교 분석하였다 또한 형광 안저 촬영 검사를 시행하여 동-정맥비와 동-정맥교차수 및 팔망막 순환기 시간을 측정하여 비교 분석하였다. 결과 : 1) 복부 전산화 단층 촬영 : 대조군과 관동맥 질환군은 복강내 지방면적/(AVFA/TAFA)은 각각 53.9±8.3, 56.1±8.5으로 통계적으로 유의한 차이가 없었고, 또 복강내 지방면적/복부 피하지방면적(AVFA/ASFA)도 각각 0.90±0.30, 0.82±0.26으로 통계적으로 유의한 차이가 없었다 (p>0.05). 2) 형광안저 촬영 검사 ; 대조군과 관동맥 질환군에서 동-전맥비(%)는 각각 72.1±4.9, 62.5±6.1, 동-정맥 교차수는 0.3±0.5, 1.1±1.1, 팔망막 순환기 시간(msec)은 15.3±1.8, 17.8±4.0으로 세 지표 모두에서 통계적으로 유의한 차이가 있었다 (p<0.05). 결론 : 관동맥 질환 환자에서 전산화 단층촬영을 이용하여 구한 복부지방의 분포양상(복강내 지방의 구성 비율 등)은 정상 대조군과 차이가 없었다. 관동맥 질환 환자와 정상 대조군에서 형광 안저 촬영 검사로 측정한 동정맥 직경비, 동정맥교차현상수 및 팔망막순환시간은 각각 통계적으로 의미 있는 차이가 있었다 Background : We quantitatively evaluated the abdominal fat distribution by computed tomography(CT) in coronary artery disease patients and the findings of fluorescence angiography in coronary artery disease patients. Methods: Among the patients who were done coronary angiography(CAG), the control group(n=11) has no angiographically significant stenosis(<50%) and the coronary artery disease(CAD) group(n=15) has more than one significant stenosis(>52%). We examined abdominal CT at umbilicus level and fluorescence angiography in all patients. In abdominal CT, we calculated total abdominal fat area(TAFA), abdominal visceral fat asea(AVFA) and abdominal subcutaneous fat area(ASFA) and their ratios. In fluorescence angiography, we calculated that artery-vein ratio(AV ratio), artery-vein cross number(AV cross No) and antecubital-retinal circulation time. Results: 1) Abdominal CT A. AVFA/TAFA(㎡) ; Control group : CAD group = 53.9±8.3 : 56.1±8.5 (p〉0.05) B. AVFA/ASFA(㎡) ; Control group : CAD group = 0.90±0.30 : 0.82±0.26 (p〉0.05) 2) Fluorescence angiography A. AV ratio(%) ; Control group : CAD group = 72.1±4.9 : 62.5±6.1 (p〈0.05) B. AV cross No ; Control group : CAD group = 0.3±0.5 : 1.1±1.1 (p〈0.05) C. Antecubital - retinal circulation time(ms) Control group : CAD group = 15.3±1.8 : 17.8±4.0 (p<0.05) Conclusion : There was significant association between the FAG findings and CAG findings but there was no significant association between the abdominal fat distribution by abdominal CT and CAG findings.

배엽부전성 신경상피종 : 1예 보고

한기석,차상훈,박길선,신환식,김성진,김대영 충북대학교 의과대학 충북대학교 의학연구소 1998 忠北醫大學術誌 Vol.8 No.2

배엽부전성 신경상피종은 최근에 분류된 양성 뇌종양이며 임상적으로 간질발작를 주증상으로 하는 드문 뇌종양이다. 증례는 20세 여자환자로 복합부분발작을 주소로 내원하였다. 자기공명영상에서 전두엽의 피질에 T1 강조영상에서 저신호강도, T2 강조영상에서 고신호강도의 소엽상의 종괴가 있었으며, 주위에 종괴효과나 부종은 동반되지 않았으며, 조영제 투여시 조영 증강되지 않았다. 주인 뇌조직과 잘 구별되는 흰색의 부드러운 종괴를 흡입하여 제거하였으며, 병리학적으로 배엽부전성 신경상피종으로 확진되었다. 배엽부전성 신경상피종은 자기공명영상에서 교종과 유사하게 보일 수 있으나, 특징적 위치와, 조영 증강이나 종괴 효과가 없다는 점에서 자기공명영상으로 감별 진단되어질 수 있다 Dysembryoplastic neuroepithelial tumor is a newly categorized benign brain tumor manifesting as a intermittent convulsion. A 20 year old girl visited due to complex partial seizure. Well marginated lobulating contoured gyriform mass was detected on cortex of parietal lobe by MR Imaging. That mass was detected as low signal intensity on T1 weighted image and high signal intensity on T2 weighted image and there were no mass effect nor peritumoral edema nor enhancement. Dysembryoplastic neuroepithelial tumor is similar to gliomas but the characteristic location, no mass effect, nor enhancement are differentiating findings on MR imaging.

공공사업의 사업성평가 방법론에 관한 연구 : 새만금사업의 사업성 평가에 있어서 비용·편익항목 선정의 문제점을 중심으로 A Case Study of the Saemankum Project focused on the Selection of Evaluation Variables

한상훈 경주대학교 건설환경연구소 2004 建設環境論叢 Vol.- No.6

This study aims to examine the usefulness and limits of cost-benefit analysis in the evaluation of the feasibility of a certain public project. To accomplish this research objective two different examinations were proceeded in this study. One of which is the literature review of the cost-benefit analysis in terms of the role and function of the analysis in the feasibility study of a certain public project. The other is a case study of the Saemankum Project. This case study examines the selected variables for the cost-benefit analysis in order for conducting the feasibility study of the project. The results of these examinations show that cost-benefit analysis is very useful mean to examine the feasibility of a certain public project and its usefulness could be improved if the following conditions were satisfactorily considered in the analysis: (1) selection of the cost- and benefit-variables for analysis is proceeded under the same condition and time span, (2) the analysis should include a certain mediation process in advance to determine the final selection of the cost- and benefit-variables to secure the reliability of the results of the analyses.

Chlamydia psittaci strain fransis의 plasmid pCpA1과 C. psittaci strain 6BC의 plasmid의 염기서열 상동성 분석

한상훈,정규회,G. V. Stokes,윤병수 경기대학교 1999 論文集 Vol.43 No.2

In Chlamydia, there is not efficient transformation vector system. This defect makes hard to study of Chlamydia. As a first process for E. coli-to-chlamydia shuttle vector construction, we executed DNA sequencing analysis of Chlamydia psittaci 6BC plasmid whole origine and parts of ORFs. We compared them with already known Chlamydia psittaci francis pCpA1 whole origine and parts of ORFs sequences using Computer DNA sequence analysis program PCGENE and demonstrated that partially analyzed origins and ORFs on two plasmids matched perfectly each other.

방사선으로 照射된 Polyethylene의 光電氣傳導

韓相勳,金永銓,조성석 충남대학교 자연과학연구소 1984 忠南科學硏究誌 Vol.11 No.1

Electronic conduction in various polymeric insulating material was investigated. Specially photo-current was observed in low density and 30 μ thick polyethylene when the sample was exposed by low-intensity white light from a tungsten lamp. A large photo-current was observed for the pre-irradiated sample by high dosage γ-ray. Photo-current was measured for many factors, wave length, voltage, temperature. Photo-current is fairly sensitive to photons with a certin range of energy (about 0.83eV), which might support that charge carriers are optically released from trap centers, it has approximately the same activation energy as the dark current. A tentative energy diagram for irradiated polyethylene is proposed on the assumption of band model. It includes two kinds of shallow trap and deep trap which are considered to play an important role in electrical conduction of polymeric insulator.

Si 기판 위에 CeO_2 유전체 박막 성장

한재원,김상훈,한영기,최무용 성균관대학교 기초과학연구소 1994 論文集 Vol.45 No.1

CeO_2 single target을 사용하여 on-axis rf magnetron 스퍼터링 방법으로 Si(100) 단결정기판 위에 CeO_2 유전체 박막을 성장시킬 때 기판온도, 산소 부분압력, rf input power, 두께 등의 성장변수들이 박막 성장에 미치는 영향을 조사하여 (ℓ00) 방향 in-situ 성장의 적정조건을 찾는 연구를 하였다. 각기 다른 조건에서 제조된 박막의 X-ray 회절 방법에 의한 구조 분석과 SEM(Scanning Electron Microscopy)에 의한 표면의 미세 구조 분석을 통하여 그 특성을 조사한 결과 기판 온도, 산소 부분압력, rf input power 세기, 박막의 두께가 박막 성장에 결정적인 영향을 미치는 중요 성장 변수임을 확인하였다. CeO_2 박막은 target과 기판사이 거리 50㎜, 총압력 30mTorr일 때 기판 온도 800℃, 산소 부분압력 3 mTon, power 90 W(이때 성장속도 0.83Å/s), 성장시간 2시간(이때 두께 500Å)일 때(ℓ00) 방향으로 잘 성장되는 것을 발견하였다. We have studied systematically the optimum condition for in-situ perparation of CeO_2 thin film on Si(100 substrate by single-target rf-magnetron sputtering method. We examined effects of the substrate temperature, oxygen partial pressure, rf input power, and thickness by studying X-ray diffraction patterns and photographs of scanning electron microscopy of the grown films. We found that all of these parameters influence decisively on the struture of the grown films. We also found that the CeO_2 thin film grows well at∼800℃ of the substrate temperature, 3 mTorr of the oxygen partial pressure, 90 W of the rf input power(corresponding to 0.83Å/s of the deposition rate), and 5000 Å of the thickness for the total sputtering gas of 30 mTorr and the sputtering target of 2 inch diameter used.

원인에 있어서 자유로운 행위의 연혁과 최근독일의 논의상황

韓尙勳 國民大學校 法學硏究所 2003 법학논총 Vol.15 No.-

Die Geschichte der actio libera in causa(alic) stammt aus Aristoteles. Er befurwortete Doppelvorwurf fu¨r eine Straftat im Vollrauschtat. Im Kircherecht des Mittelalters war das Thema in bezug auf die Handlung des Loths in Bibel sehr umstritten. Thomas von Aquin and Pufendorf entwickelten eigene Lehren. Erstmal in Deutchland war eine Regelung u¨ber alic im Codex juris Baarici criminlis von 1751 enthalten. 1794 hatte das Allgemeine Landrecht fu¨r die PreuBischen Staaten auch eine Vorschrift zu alic. Diese Regelung bestand im wesentlichen bis Mitte 19. Jahrhundert. Das geltende deutsche Strafgesetzbuch hat keine Vorschrift zu alic mehr. Deswegen werden verschiedene Ansichten nun in Deutschland vertreten: von Straflosigkeitslehre bis Tatbestandsmodell, Ausnahmemodell, Unrechtsmodell, Ausdehnungsmodell, usw. In Korea kann man keine bedeutsame Regelung oder Lehre fiber alic bis 20. Jahrhundert finden. Nur Jong Yak-yong schrieb 1819 in seinem Buch, dass eine Milderung der Straftat wegen Vollrausches nicht akzeptabel war and er kritisierte eine Entscheidung des Ko¨niges. Als das geltende Koreanische StGB 1953 entworfen and vero¨ffentlicht wurde, war §10 Ⅲ u¨ber alic neu eingefu¨hrt. Aber man kann nichts u¨ber Begrundung im Material finden. Aus diesem Grunde besteht es viele Unklarheiten u¨ber Auslegung des §10 Ⅲ. Trotzdem kann man vermuten, dass der Gesetzgeber einige auslandische Regelungen in Riicksicht nahm: z.B. Schweiz, Italien, Spanien. Aber man muss nicht iibersehen, class der Wortlaut des §10 Ⅲ nicht gleich mit den ausla¨ndischen ist. Das bedeutet, die Auslegung des §10 Ⅲ and alic stellt eine theoretische Aufgabe fu¨r die Koreanischen Strafrechtler and Rechtsprechung dar.

양궁선수의 자신감과 각성조절에 관한 연구

한태준,오상훈 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

This study is to provide basic data of event of archery in the matter of dealing mental training program according to a characteristic of players, the difference of self-confidence and awakening control among several physical factors which influence on performed assignments in events, are compared and analyzed. The total subjects are 178 archery players (92 man and 86 women) in high school, university, and pro-team, we came to conclusion as the result of comparative analysis on self-confidence and awakening control of archery player. 1)Self-confidence and awakening control of archery player in man and woman according to the level of event. Regarding self-confidence according to sex, woman is higher than woman, it did not show significant difference. Regarding the level of events, it showed superior player group is higher in man and non-superior player group is higher in women, there is a significant difference. Regarding awakening control, man is higher than women, regarding the level of performance is higher in the group of non-superior player, but there is not a significant difference. 2)Self-confidence and awakening control of man's archery player according to his place. The result of self-confidence according to his place of man's archery, the pro-team is the highest, university team is the lowest, no significant difference. Regarding the difference of the level of events, superior players are higher than non-superior players group with significant difference. No significant difference is in the awakening control according to the level of events in man. (3)Self-confidence and awakening control of woman's archery player according to her place. The result of self-confidence of woman's archery according to her place, it is the highest in high school and the lowest in university. Regarding the level of events, non-superior high school group is the highest and superior high school group is the lowest but no significant difference is in both place and the level of events. Regarding the control of awakening, the university is the highest and the player in high school is the lowest, in the matter of the level of events, there is not much significant difference between superior player group and non-superior player group.