정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

正常및 異常分娩中 母體와 臍帶血漿의 β-endorphin 및 ACTH値의 變動에 關한 硏究

鄭求烈,李揆玩,李珉載,洪性鳳 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1

β-endorphin and adrenocorticotrophic hormone (ACTH) are derived from the same precursor protein and they have been implicated as the modulators of pain during the labor process. To investigate their possible role during labor this study was undertaken to determine the levels of β-endorphin and ACTH during labor and delivery in healthy term pregnant women and their neonates after delivery. β-endorphin and ACTH were measured by radioimmunoassay in 22 spontaneous labors, 14 elective cesarean sections and 7 emergency cesarean sections during early and late labor, and after delivery. The results obtained are as follows: 1. In cases of spontaneous vaginal delivery and emergency cesarean section, maternal plasma β-endorphin and ACTH levels were significantly increased during late labor and remained and continuously elevated during the first postpartum hour. 2. In cases of elective cesarean sections, maternal mean plasma levels of β-endorphin and ACTH were significantly lower than levels in spontaneous vaginal deliveries and emergency cesarean sections. 3. There was a significant correlation between meternal plasma β-endorphin and ACTH levels during labor. 4. Umbilical arterial β-endorphin levels in newborn infants after spontaneous vaginal delivery and emergency cesarean section were significantly higher than levels in infants born by elective cesarean section, but only spontaneous vaginal deliveries showed higher umbilical arterial ACTH levels in newborn infants than infants born by elective cesarean section. 5. There was no relationship between meternal and umbilical cord plasma β-endorphin and ACTH. There was not significant correlation between umblical cord plasma β-endorphin and ACTH levels, and fetal weight and placental weight. 6. There was no correlation betwen umbilical arterial pH and Apgar score by mode of delivery, but statistical significance was found to exist in the umbilical arterial pH of emergency cesarean sections and elective cesarean sections. Present studies suggest that β-endorphin and ACTH are significantly increased during late labor due to stress and pain, and hypoxia may be important physiologic stiumuli controlling the release of β-endorphin and ACTH in the human fetus.

젤여과법을 이용한 토끼 심근 미오신의 분리 및 부분정제

정성탁,김대중,김호덕,라봉진 중앙대학교 의과대학 의과학연구소 1992 中央醫大誌 Vol.17 No.2

Myosin, the major protein required for the production of force and shortening in muscle, is a hexamer consisting two heavy chains (molecular mass∼200kDa) and pairs of light chains (molecular mass∼16 and 20kDa). Myosin and other contractile apparates from the left ventricular myocardium of rabbit were extracted using pyrophospate buffer system and was purified by using the gel filtration. And partially purified each protein component was confirmed by the electrophoresis in non-dissociation and dissociating conditions respectively. On Disc-PAGE of the crude extract, 4 bands clearly appeared and 3 protein components were separated by chromatography in the 5 fractions. In dissociating electrophoresis, each bands were separated into subunit in the pyrophosphate buffer. The first fraction contained the heavy chain of myosin, tropomyosin and myosin light chain 1 and 2. The second and third fraction were composed of tropomyosin and actin and the proteins that had molecular mass smaller than 15kDa were in the fourth and fifith fractions.

흰쥐 편도체에서 칼슘결합단백인 calbindin-D28K함유 신경세포의 생후 발달에 관한 면역조직학적 연구

정윤영,김종중,문정석,박영란,정상봉,김현곤,박상수 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Background and Objectives : The calcium-binding protein, calbindin-D28K(CB) is widely distribution of CB in rat amygdala during postnatal maturation, in order to provide an insight into the developmental role it may play in the amygdaloid neurons. Materials and Methods : The present study is based on 28 postnatal cases ranging from the day of birth, postnatal day 0 (P0) to 30 days (P5, P10, P15, P20, P30), and these cases were compared with adult rat amygdala. Cryostat sections processed free-floating with monoclonal antibody by immunohistochemistry. Results : CB-immunoreactive neurons were already found at birth in all amygdaloid nuclei except the intercalated nucleus. The intensity and number of immunoreactivity of CB-containing neurons increased during the first 10 days of postnatal life but dramatically decreased at P15. Mature patterns of CB-immunoreactive neurons were achieved at P20. In the adult amygdala, CB-immunoreactive neurons were distributed in almost all amygdaloid nuclei except the intercalated nucleus. Conclusion : The present results show early appearance of CB immunoreactivity in the amygdala. It may be related to the early appearance of CB immunoreactivity in many other brain regions, and suggests that CB may play a functional role during the development of the nervous system including amygdala.

실과 교육과정 평가의 기본 모형과 평가 영역에 관한 연구

정성봉,김종우 韓國實科敎育硏究學會 1999 實科敎育硏究 Vol.5 No.2

The purpose of this study was to suggest evaluation basic model and evaluation area of the Practical Arts curriculum evaluation. The study was carried out through review of literature on curriculum, curriculum development and curriculum evaluation. The curriculum evaluation basic model for Practical Arts were established three demensions; aspects of curriculum, levels of curriculum and evaluation methods of the curriculum. The aspects of curriculum include three major areas of curriculum--development, implementation and outcomes. The levels of curriculum include three layers of curriculum in Korea--national, regional and school curriculum. The third dimension represents evaluation methods by which the values of the curriculum are determined. The two evaluation methods include quantitative approach. The curriculum evaluation areas for Practical Arts were established three categories; curriculum development, implementation and outcomes.

실과 수행 평가의 이론적 기초와 연구 동향

정성봉 韓國實科敎育硏究學會 1999 實科敎育硏究 Vol.5 No.3

The purpose of this study was to review the research trends of performance assessment of practical arts education. The study was carried out through review of literature on evaluation theory, performance assessment theory, and practical arts education. The findings of this study were as follows: 1. Through reviewing literatures, the performance assessment approach such as qualitative approach, alternative assessment, process-oriented assessment were discussed in recent years. 2. For performance assessments to be useful, the following issues need to be kept in forefront: time and space restrict, difficulty of large scale enforcement, evaluator's error possibility, internal consistency insufficient, perception shortage and cost-feasibility given current high monetary and human resource costs for development and use. Based on this conclusions, the further researches for applying of performance assessment in practical arts education should be continually.

탈회동결건조골에 혼합한 형질 변형 성장인자(TGF-β1)가 골조직 재생에 미치는 효과

정성민,이만섭,박준봉 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.1

The purpose of ss this study was to observe the effect of TGF-Rl on the regeneration of bone in guided bore regeneration. Four adult dogs aged 12 to 24 months were used in this study. Experimental bone defects were created surgically with surgical bur and chisel on the 3th. premolars. In experimental group; bone defect were grafted with DFDB and TGF-R1. In control groups, bone defects were grafted with only Dl-.DB. At 1, 2, 3 and 4 weeks, dogs were serially sacrificed and specimens were prepared with Hematoxylin-Eosin stain and Goldner`s stain for light microscopic evaluation. The results of this study were as follows 1. The infiltration of inflammatory cells was prominent in control groups at 1, 2 and 3 weeks. 2. The lining of osteoblast was observed at 2 weeks in control group, but at 1 week in experimental group. 3. In both groups, osteoid was formed at 2 weeks. In control groups, osteoid was fromed on only bone surface. but in experimental groups, osteoid were formed on both bone & DFDB surfaces. 4. In only experimental groups, The fusion of new bone & DFDB was only observed at 3 weeks. and the fusion of new bone & DFDG was more prominent at 4 weeks. But in control groups, No fusion of new bone & DFDB was oberved at 3 and 4weeks From the above result, the TGF-01 was effective in bone formation and increased inductive effect of DFDB guided bone regeneration technique. Inductive effect of DFDB was increased with TGF-131.

엔진회전계의 전달함수 산정을 위한 개루우프(Open loop) 시험

鄭泰相,鄭鳳守,金明奎 진주산업대학교 농업기술연구소 1993 農業技術硏究所報 Vol.6 No.-

농용엔진이 부하변동에도 일정한 회전수를 유지할 수 있는 제어기법을 개발코자, 개루우프 시험에 의해 회전계의 동특성을 이용하여, 통계적으로 산출하여 엔진회전계 방정식을 정리하였으며, 그 결과는 아래와 같다. 1. 엔진회전계의 전달함수와 이산시계열 방정식을 이론과 실험결과를 이용하여 정립하였다. 2. 실제 엔진회전수와 전달함수를 이용한 추정회전수가 일치하였다. This research was carried out to find out a revolution equation of the engine system using regression analysis. The dynamic characteristics of revolution part of an engine were measured by open loop test. Thus, a transfer function and a discrete-time equation relating the engine speed as ouput of the control system to the torque equivalant to throttle opening angle as imput of the control system were derived from the results of the open loop test. 1. The transfer function and the discrete time equation of the revolution system of the engine were derived from the control theory and experimental results. The calculated and measured engine speed were in good agreement.

지리산 면양목장 조성에 관한 연구 : Ⅰ보. 면양목장 조성 및 면양사육 단지화 조성을 위한 기초조사 Ⅰ. Fundamental Survey of Resources for the Development of Sheep Range and Sheep Farm Grouping

정현승,강봉태 진주산업대학교 1970 論文集 Vol.4 No.-

This survey reports the availability of the various resources such as geography, meteology, traffic condition, soil property, labor resource, pasture distribution and water resource, for the development of sheep range and sheep-farm group, on the first step to the three-year plan in an area around the Forestry Experiment Station of Chinju Agricultural and Forestry Junior Teachnical College in Mt. Chiri. 1. The geographical conditions of the region found to be fit for the establishment of sheep range were as follows; longitude:127˚44'east,latitude:35˚22'north,elevation:600-900m above marine surface level, slope:5-25˚, total area: 280 ha, and administrative district: from high level flats to Yeo-gok and Dusuk village, Yupyung-ri, Samjang-myun, Sanchungkun, Kyung Sang Nam Do, Korea. Especially, eighty seven farm households and Karangip primary school distriduted around this region were found to be the reasonable resources for the development of sheep farm group in this region. 2. The soil of the area was composed of most of sand-loam with PH 5.3∼5.8, 2-5% of grit and 13.3% of humus (4.6-19.3%) among 30∼50㎝ depth of surface soil. These fertile soil properties were found to be fit for the development of pasture. 3. The meteological records of this region were found as follows: frosty period: from October 16 to April 22, yearly mean air temperature: 9.2℃ , ranging from 26.6℃ in August to (-)12 in January, annual rainfall: 2,346mm, yearly mean wind velocity: 6.2m/sec, direction of the wind: north-west in winter and south-east in summer. According to the above results from only one-year observation, the meteological conditions of this region were similar to those of Dae-Kwan Ryung area and were estimated to be favorable for sheep raising. 4. In this region 35 species of wild grasses were prosperous. The green yield of the grasses averaged 1,584㎏ per 10a and 0.87a was required for grazing a sheep. Therefore, it was estimated that about 3,000 heads of sheep would be well raised in this region. The fact that about 30 percent of Mt. Chiri area is available for sheep pasture suggested that 400,000㎏ of wool, or 250,000,000 won in price(equivalent to 1/10 of the total wool imported in 1967)could be gained from grazing about 100,000 heads of sheep in the whole area of Mt. Chiri, 54,000 ha. 5. Sufficient water resources, conclusive of mooring by the farmers around this region, irrigation water, underground water and especially the pond situated in high level flats were found to be available and the quality of water was satisfactory for watering sheep. 6. Concerning the traffic situation of this region, the construction of 1.5㎞ of road to Dusuk village (with 200m of bridge) and three 2㎞ range path from Dusuk village were required. However, such traffic problems are not serious because the sheep farming requires the road only for disposal of wool produced once a year. 7. From the managment survey for 87 farms around this area, it was found that each farm had 1,019.6 hours of unemployed labour per year, which was sufficient for raising 60 heads of sheep. So it could be estimated. that potential labour enough for raising 5,200 heads of sheep was reserved in this area. Moreover, the Karangip primary school boys are available as a good resource of labour for sheep grazing. The great deal of by-products of sericulture and potato-farming, which were the major industries in this region, was available for sheep raising.

벨마비 환자의 예후와 신경생리 검사소견의 관련성

백봉수,박성파,서정규 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5