위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

기지국 최적화를 위한 전역 탐색 알고리즘의 성능 해석

오정근,박미선,이성신,이민혁,변건식 동아대학교 정보기술연구소 2002 情報技術硏究所論文誌 Vol.10 No.1

In the design of mobile wireless communication system, Base station location is one of the most important parameters. Designing base station location, the cost of equipment makes low by combining various, complex parameters. We can solve this problem by combining optimization algorithm, such as Simulated Annealing, Tabu Search, Genetic Algorithm, Random Walk Algorithm that have been used extensively for global optimization. This paper shows the 4 kinds of algorithm to be applied to the base station location optimization of mobile communication system and then compares, analyzes the results and shows optimization process of algorithm.

만화 과제를 이용한 정신분열병 환자의 사회인지 능력의 측정

오정은,나명현,하태현,신용욱,노규식,홍순범,이경진,신민섭,이영호,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : This study is to investigate the hypothesis that schizophrenic patients have difficulty in inferring mental state of others. Methods : Twenty schizophrenic patients and twenty normal subjects were administered to the Cartoon Task required inferring the character's intention in a given context. Results : The schizophrenic patients showed a statistically significant impairment in the Cartoon Task. Both groups chose the card depicting a frequent everyday action significantly more rather than the similar card to the last picture in each story for wrong answers. Conclusion : These preliminary results suggest that schizophrenia is associated with a specific deficit of the cognitive ability referred to as social cognition, and this deficit can be detected not only in the acute phase as found in previous research studies, but also in remission. Also when subjects fail to appreciate what is going on in the minds of other people, they seem to rely on a socially familiar experience.

상수처리 시스템에서의 막분리 공정의 개발

오중교,이태진,정두식,이용택 경희대학교 환경연구소 1995 環境硏究 論文集 Vol.6 No.-

Membrane filtration process seems to have many advantages such as improvement of drinking water quality, saving water purification chemicals and operation cost, easier operation and maintenance and saving time and cost for construction of a water purification plant. A study was conducted to optimize the use of a membrane process to produce potable water from Lake water in singal, Kyungkido, South Korea. We try to optimize the process by adjusting different pretreatment, various MWCO(Molecular Weig염(salt), alignate와 같은 천연고분자 또는 ht cut-off), hydrauric conditions.

Mg-Fe 산화물계 NTC 서미스터의 特性

오영우,김현식,허정섭,이승관 경남대학교 신소재연구소 1997 論文集 Vol.9 No.-

조정식 Mg₁-χFe₂+χO₄(이하 Mg계)에서 x를 0.0, 0.025, 0.1, 0.2로 변화시키고, 소결온도를 1100°C~1250°C로 50°C간격으로 변화시켰다. 그 결과, NTC 서미스터의 특성을 잘 나타내었고, 저항온도계수 α는 Mg계일 때 -1.6%/°C로 높은 값을 나타내었고, B정수는 1500 [K]에서 2920 [K]의 범위를 나타내었다. 본 조성의 실험결과로써 Mn-Ni-Co계 서미스터를 Mg-Fe 산화물계 NTC 서미스터로 대체가 가능함을 확인할 수 있었다. Mg_{1-x}Fe_{2+x}O₄was prepared by sintering at from 1100℃ to 1250℃ with 50 C intervals, while x was varied from 0.0 to 0.025. 0.1, and 0.2. The results showed the typical properties of NTC(Negative Temperature Coefficient) thermistor. The best temperature coefficient of resistance, α was -1.6%/℃ in the Mg-based sample at 25 C. Thermistor parameter, B was in the range of 1500 [K]∼2920 [K]. As a result, the possibility that Mn-Ni-Co based thermistor could be substituted by the composition used in this study was confirmed.

이동 통신 시스템 설계에서 전역 최적화 알고리즘의 성능해석

오정근,장은영,이성신,변건식 동아대학교 정보기술연구소 2003 情報技術硏究所論文誌 Vol.10 No.2

In the design of mobile wireless communication system, Base station location is one of the most important parameters. Designing base station location, the cost of equipment makes low by combining various, complex parameters. We can solve this problem by combining optimization algorithm, such as Simulated Annealing, Tabu Search, Genetic Algorithm, Random Walk Algorithm that have been used extensively for global optimization. This paper shows the 4 kinds of algorithm to be applied to the base station location optimization of mobile communication system and then compares, analyzes the results and shows optimization process of algorithm.

AE 신호 분석에 의한 구성인선의 감지

오민석,원종식,정윤교 창원대학교 공작기계기술연구센터 1999 연구업적집 Vol.1 No.1

This paper investigates the feasibility of using acoustic emission signal analysis for the detection of built-up edge during machining. Experiments were conducted on a CNC-lathe using conventional carbide insert tools under various cutting conditions. The cutting forces were also measured for comparisons. Experimental evidence is presented which indicates that the presence of a built-up edge can significantly affect the generation of acoustic emission in metal cutting. It is shown that under conditions in which a built-up edge is generated, the variation of AErms signal with cutting speed can be quite different from the generally accepted linear, monotonic increase as previously reported. The feasibility of utilizing AErms in built-up edge sensing is suggested.

안모의 수직적 양태에 따른 골격 및 치조골의 위치 관계에 관한 연구

오중식,국윤아,김상철 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.3

교정 증례의 분석 예후 추정은 두개골의 수평 및 수직적인 관계가 동시에 고려되는 입체적 관점에서 평가되어야 한다. 따라서 본 연구에서는 성장이 완료된 성인 남녀 각 100명을 추출하여 두부 방사선 사진을 채득한 후 하안면 고경과 상안면 고경의 비율로 안모의 수직적 수직적 형태를 구분하여 군을 설정하였으며 이들 군간의 골격 및 치조골의 크기와 위치 관계를 비교하고 상호 관련성을 조사하여 다음과 같은 결과를 얻었다. 1. 치조고경, 안면 고경, lower gonial angle, 그리고 FMA 항목에서 하안면 고경이 큰 군의 것이 작은 군에 비하여 유의하게 크게 나타났다. 2. 치조고경, 안면고경, 하악지 고경, 그리고 Jarabak ratio 항목에서 남서이 여성에 비하여 유의하게 크게 나타났다. 3. 치성 및 골격성의 수직계측항목과 UAFH/LAFH의 상관관계 조사에서 치조고경,안면고경, lower gonial angle, FMA 그리고 Bjok's Sum 항목이 UAFH/LAFH와 유의한 상관관계를 보였다. The purpose of this study was to investigate the variations of the skeletal and dentoalveolar dimensions in relation to vertical facial patterns. Lateral cephalogram of 200 cases (100 cases of male and 100 cases of female, average age of which was 23.2 years) were traced and some measurements of skeletal and dentoalveolar dimensions were measured. The ratio of UAFH/LAFH was employed to classify the samples into groups of excess and short lower anterior facial height. And the comparison between two groups were taken statistacally. The following results were obtained. 1. The dentoalveolar height, lower anterior facial height, lower gonial angle, and FMA in the excess-lower-anterior-facial-height group were significantly larger than those in short-lower-anterior-facial-height group. 2. The dentoalveolar height, ramus height, and Jarabak ratio in the male subjects were significantly larger than those in the female subjects. 3. The UAFH/LAFH ratio showed a significant correlation to upper, lower facial height, AUDH, PUDH, ALDH, PLDH, Lower gonial angle, FMA, and Bjork's Sum.

수행에 대한 지식의 상대적 빈도가 편마비 환자의 균형 재훈련에 미치는 영향

오동식,최흥식,김택훈,노정석 한국전문물리치료학회 2001 한국전문물리치료학회지 Vol.8 No.1

During therapy sessions, feedback is often provided concurrently by the physical therapist as the patient attempts to perform a movement and after the movement attempt. This feedback is provided to enhance the patient's balance abilities. However, recent studies in nondisabled populations have suggested that frequent feedback may be detrimental to retention or learning of motor skills. This study compared the effects of 100% relative frequency of knowledge of performance (KP) with 66% relative frequency of KP for motor learning on balance retraining in patients with hemiplegia. Twenty patients with hemiplegic were randomly assigned to one of two experimental groups. The acquisition phase consisted of 16 blocks of 5 trials for 2 days (80 total practice trials). The retention chase consisted of 2 blocks of a short-term retention test, one day after the end of the acquisition phase and a long-term retention test, one week after the end of the short-term retention test. In the 100% feedback condition, participants received feedback after every practice trial. A faded KP schedule was used in the 66% condition. No significant differences were found between the two groups during all experimental phases (acquisition and retention phases), (p>.05). However, there were significant decreases in balance index for both groups of acquisition phase (p<.05). These results suggest that 66% relative frequency of KP is not more effective than 100% relative frequency of KP with respect to retention over time when hemiparetic patients attempt to learn balance.

당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.