발열을 동반한 호중구감소증에서 Cefepime 단독투여와 Ceftazidime 및 Tobramycin 병합투여의 효능비교

정현욱,채제욱,강미라,양정채,문치숙,기현균,장현하,오원섭,김기현,백경란,이남용,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내에서 발열을 동반한 호중구감소증이 있는 악성 종양환자에게 경험적 항생제로 베타락탐계 항생제와 아미노배당체의 병합요법의 사용이 일반적이다. Cefepime은 광범위 항균 작용을 가지고 있어, 그람 음성균 뿐만 아니라 그람 양성균에 대해서도 우수한 효과를 나타낸다. 재료 및 방법: 발열을 동반한 호중구감소증이 있는 악성 종양환자를 대상으로 무작위, 공개, 비교 연구를 시행하였다. 대상 환자를 무작위로 cefepime 단독요법군과 ceftazidime 및 tobramycin 병합요법군으로 나누어 투여하고 각각의 임상적 효능과 안전성을 비교하였다. 구강및 인후 점막염이 있는 환자에서 분리된 녹색 연쇄알 구균에 대한 항생제 내성 정도를 조사하였다. 결과 : 대상환자 89명 중 CA 투여군이 48예(53.9%), CT 투여군이 41예(46.1%)이었다. 발열의 유형별로 MDI는 18예(20.2%), CDI는 9예(10.1%), UF는 62예(69.7%)로 두 군 간에 차이가 없었다. CA 투여군과 CT 투여군의 임상적 호전률은 시험약 투여 후 2-4일째 각각 91.7%, 85.4% (P=0.31), 치료 종료 시 각각 91.7%, 100% (P=0.15)로 두 군간에 유의한 차이가 없었다. 치료 종료 시 CA 투여군과 CT 투여군의 세균학적 소실률은 모두 100%로 두 군간의 유의한 차이가 없었다(P=0.78). 점막염이 있는 환자로부터 녹색 연쇄알 구균이 분리된 경우는 25예(28.1%)이었으며, 분리된 녹색 연쇄알 구균은 penicillin, ceftriaxone, cefepime, vancomycin에 모두 감수성을 보였다. 약제 관련 이상 반응의 발생 빈도도 두 군간에 유의한 차이가 없었다. 결론 : 발열을 동반한 호중구감소증이 있는 악성 종양환자의 경험적 항생제로서 cefepime 단독요법은 ceftazidime 및 아미노배당체의 병합요법만큼 효과적이고 안전하였다. Background : Broad-spectrum antibiotic therapy has been recommended as an empirical regimen in cancer patients with febrile neutropenia. Cefepime is a fourth generation cephalosporin with good activity against both gram-positive cocci and gram-negative bacilli. Materials and Methods : To compare the efficacy and safety of cefepime alone with ceftazidime plus tobramycin as empirical regimen for adult cancer patients with febrile neutropenia, a randomized, open label, comparative trial was performed. If the patient showed clinical improvent 72 hours, antibiotic could be changed to oral ciprofloxacin. Clinical and microbiological responses were determined at 72 hours and at the end of therapy. To investigate the antimicrobial resistance of viridans streptococci, swab cultures were obtained from throat in all enrolled patients and antimicrobial susceptibility tests were performed by using microdilution method according to the NCCLS. Results : A total of 89 patients were enrolled. Forty-eight patients received cefepime alone (CA), and 41 patients received ceftazidime plus tobramycin (CT). Demographic and baseline clinical characteristics were similar in both groups (P>0.05). The initial clinical success rate at day 2-4 in group CA (91.7%) was similar with that in CT group (85.4%) (P=0.31). At the end of therapy, the final clinical success rate in CA group (91.7%) was similar to that in CT group (100%) (P=0.15). In 18 patients, with microbiologically defined infections, the eradication rate was 100% in both groups. Adverse events including liver dysfunction (21.3%) and renal dysfunction (2.2%), were similar in both groups (P=0.87). Viridans streptococci were isolated from the throat cultures in 25 cases, and all of these strains were susceptible to penicillin (MIC_(90) 0.12 ㎍/mL), cefepime (1 ㎍/mL), and vancomycin (0.12 ㎍/mL). Conclusion : Efficacy and safety of cefepime monotherapy was comparable to the combination of ceftazidime and tobramycin. It could be used as an alternative empirical regimen for treating cancer patients with febrile neutropenia.

급성 심근허혈에 의해 윤발된 승모판 폐쇄부전의 기전에 관한 실험적 연구

강덕현,송현,송재관,김현숙,이재환,임희영,이재원,박성욱,박승정,송명근 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.8

한국 어린이에서 하악 유절치와 그 계승 영구치의 선천적 결손 간의 관계

김현진,현홍근,김정욱,이상훈,김종철,한세현,장기택 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

많은 연구에서, 유치와 그 계승 영구치의 선천적 결손 간에는 상당한 연관관계가 있는 것을 보고하였다. 그러나 하악 전치부에서, 유치의 선천적 결손에도 불구하고, 그 계승 영구치는 정상적으로 존재하는 증례가 임상적으로 종종 관찰되기도 한다. 본 연구의 목적은 한국 어린이에서 하악 유절치와 그 계승 영구치의 선천적 결손 간의 상호 연관관계를 평가하는 데에 있다. 2005년 1월 1일부터 2008년 9월 5일까지 서울대학교치과병원에 내원하여 파노라마 방사선사진을 촬영한 6세 이하의 남녀 어린이 총 14,307명을 대상으로 하악 전치부의 치아양상을 관찰하여 유치와 영구치의 선천적 결손 관계를 평가하여 다음과 같은 결과를 얻었다. 1. 하악 유절치의 결손률은 0.24%였으며, 하악 유절치가 존재 시 후속 영구치가 존재할 승산(odds)은 7163.5였으며, 유절치의 결손 시 후속 영구절치가 존재할 승산(odds) 0.79였다. 2. 하악 유절치 결손의 증례 중 후속 영구치가 모두 존재하는 경우는 44.12%였다. 유절치의 양측 결손 시 후속 영구치가 하나라도 존재할 승산(odds)은 유절치 편측 결손 시에 비하여 1.57 배였다. 3. 유절치 결손이 있을 때 유절치의 편측 결손일 승산(odds)은 여자가 남자에 비해 2.2 배였다. 또한, 유절치 결손이 있을 때 후속 영구절치가 존재할 승산(odds)은 남자가 여자의 경우에 비하여 2.22 배였다. Many studies have shown that there is a strong relationship between the congenitally missing primary teeth and their succedaneous permanent teeth. However, especially in case of lower anterior region, we can observe the existence of permanent teeth even though their precedent primary teeth were missed at times. The purpose of this study was to reveal the relationship between the congenitally missing primary lower anterior teeth and their succedaneous permanent teeth in Korean children. Total of 14,307 children, under 6 years of age, who attended the department of pediatric dentistry, Seoul National University Dental Hospital, Seoul, Korea from January 1st 2005 to September 5th 2008 were radiologically examined using the panoramic x-ray in order to analyze the relationship between the congenitally missing primary lower anterior teeth and their succedaneous permanent teeth. The results were as follows : 1. The prevalence of congenitally missing lower anterior teeth in primary dentition was 0.24%. The odds ratio of both the primary and permanent anterior teeth being present was 7163.5 and only the permanent anterior teeth being present was 0.79. 2. The percentage of all succedaneous permanent teeth being present was 44.12% in cases of missing lower primary anteriors. The odds ratio of at least one succedaneous permanent teeth being present in cases of bilateral primary anterior teeth missing was 1.57 times more common than in cases of unilateral primary teeth missing. 3. The odds ratio of primary missing teeth being unilateral was 2.2 times higher in females. Moreover, the odds ratio of succedaneous permanent teeth being present in cases of primary teeth missing was 2.22 times higher in males.

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

폐암과 동반되어 나타난 기관기관지병증 골연골형성증 1예

이영진,전현수,박시형,김모세,김현주,이승헌,이영민,이현욱,이현경 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

Tracheobronchopathia osteochondroplastica (TPO) is a rare benign disease of unknown etiology characterized by multiple cartilaginous or bony submucosal nodules, which project into the tracheobronchial lumen. Although some disorders were reported combined with TPO, these seemed to be considered casual. We report a case of TPO that combined with adenocarcinoma of lung. She was 50-year-old non smoking woman presented with chronic cough with right chest pain. Lung mass on right lower lobe was found on chest x-ray, so lung cancer was suspected. Multiple scattered whitish small elevations from trachea to bronchial trees were found on bronchoscopic exam. We mistook these lesions for metastases from lung cancer and biopsies of these lesions were done. Transbronchial biopsy for right lower lobe mass lesion was also done. But biopsies from trachea and bronchus revealed TPO rather than lung cancer. Transbronchial lung biopsy of right lower lobe mass was diagnosed adenocarcinoma of lung. So TPO combined with adenocarcinoma of lung was diagnosed.

고능력 젖소 축군의 집단번식관리프로그램 적용에 의한 번식효율의 개선

노경수,김의형,남현욱,서국현,강현구,김일화 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

We investigated the effect of reproductive herd health program (RHHP) on the reproductive performance in high yielding dairy herds. Data collected from 205 lactations at Boeun County, Chungbuk from April 2001 to Dec. 2003 included postpartum reproductive and metabolic diseases, body condition score (BCS), reproductive performance and milking records. First we compared the reproductive performance of cows without RHHP (pre-RHHP group) and cows with RHHP (RHHP group). Intervals from calving to first service (99.6 vs. 81.8 days) and to conception (160.3 vs. 131.8 days) were shorter in the RHHP group than in the pre-RHHP group. Secondly, we determined the effect of milk yield (305 days) on the occurrence of postpartum diseases, BCS changes, and reproductive performance in cows under RHHP, The occurrence of metritis and metabolic diseases were greater in the over-10,000 kg group than in the under-l0,000 kg group. The over-10,000 kg group lost more body condition than the under-10,000 kg group from calving to month 3 postpartum. Nevertheless, reproductive performance did not differ between the two groups. These results indicate that reproductive performance can be improved by the application of RHHP in high yielding dairy herds and that reproductive performance in the cows under RHHP are not affected by high milk yielding.

골반통증을 동반한 폐쇄신경 기원의 퇴행성 신경초종

이상욱,김두상,조현득,이창호,전윤수,이남규 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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英語敎師 現職敎育에 關한 硏究

崔錄郁 釜山大學校 師範大學 1977 교사교육연구 Vol.4 No.1

The purpose of this study is to do two things: first, to elucidate the significance of in-service training for teachers of English; second, to find an answer to the programme of in-service training that senior teachers of English propose to meet their needs in their profession. The former was done through the study of the literature dealing with in-service education, particulary for teachers of English, and the latter through a questionnaire to be answered by the teachers of English in mid-career. At the present time, it is to some extent true that in Korea the main stage of English teaching is the secondary sohool, whose teachers of English must be the basis for English education. In addition, educational social change has brought a new attitude to teaching and learning of English, and technological change electro-mechanical equipment and its associated techniques into the classroom. To be brief, teachers of English must remain abreast with recent developments in English education. As for the specific programme for the in-service training, its contents above all things must be connected with the new mechanical aids and the things that teachers of English need in their profession and in which they are unlikely to have had any training during their initial training. In order to do this, it is a sine qua non that we should make use of the opinions and ideas about the in-service training that its participants suggest. The reason is that most of them have not only a lot of teaching experience but also sound knowledge of fundamental academic disciplines of linguistics, psychology, English teaching, and so on; moreover, they can usually judge what is and what is not relevant to them in their profession. Summing up, the materials gained from them have come to the following result. The courses they took in the past in-service training were under a bias toward theoretical speculative ones. Therefore, the courses they want to take are practical, descriptive, and theoretical ones in that order. From what has been mentioned above, the courses of in-service training for teachers of English can be seen to have three interrelated aspects: the practical aspect, the descriptive aspect, and the theoretical aspect. What I wish to suggest finally here is that any in-service training cannot be effective without the participants' strong willingness to learn, a desire to promote their professional growth.

용액 증착법으로 증착된 CdS 박막 특성 : Characteristics of CdS thin film by chemical Bath Deposition

박용욱,신현용 남서울대학교 2008 남서울대학교 논문집 Vol.14 No.2

Cadmium sulfate thin films were deposited by the chemical bath deposition method using tartaric acid and triethanolamine as acomplexing agent. Deposition Parameters such as pH, temperature,deposition time and concentration of the reactant species were optimizedso as to obtain reflecting, good adherent uniform thin films on the glasssubstrate. Reaction mechanism of the thin film formation is also reported.The crystallographic structure and the crystallite size were studied by theX-ray diffraction pattern. The optical band-gap of deposited film isidentified by measuring the transmittance in the visible region. Key Word : Cadmium sulfate thin films, Chemical bath deposition,pH

1인승 운송체계로서의 스쿠터 디자인에 관한 연구

정주현,이욱영 홍익대학교 산업디자인 연구소 2004 미술디자인 논문집 Vol.- No.9

오늘날 지구촌을 도심어디로 가더라도 날로 증가하는 차량으로 인해 극심한 교통전쟁을 치르고, 베기가스에 의한 환경오염은 심각한 수위에 와있다. 도시 생화자들에게 차량이용의 주목적이 출퇴근용이라는 것을 감안한다면 나 홀로 차량이 시내 운행의 대부분을 차지한다고 해도 과언이 아닐것이다. 나라마다 나름의 해결책으로 차량의 시내 진입을 억제하기 위해 대중교통의 활성화 또는 시내 진입 시 활증료의 부과 등 정책적인 방법으로 도시 운전자들에게 가하는 압박은 수위를 높여가고 있다. 본 연구는 이와 같이 시내를 중행하는 대부분의 차량이 1명만 탑승한다는 점과 항상 주차가 고민이라는 점을 해결하기 위한 새로운 방향을 모색하였다. 이에 최근 다시금 주목 받고 있는 스쿠터의 효율성을 인식하고 향후 1인승 운송기기로서의 새로운 가능성을 토대로 본 연구를 지행하였다. 스쿠터는 많은 모터사이클과 달리 경제적인 가격대와 실용성(수납박스, 쉬운 조작성, 저연비) 등 다른 모터사이클에서 느낄 수 없는 장점이 있다. 최근 이러한 실용성을 극대화한 BMW C1과 같은 새로운 형태의 스쿠터들이 많이 연구되고 있다. 이와 같은 스쿠터들은 기존의 실용성뿐만 아니라 운전자의 안전성을 극대화해주며, 또한 자동차와 같은 운전환경을 제공하고 있다. 본 연구는 기존의 실용성뿐만 아니라 운전자의 안전과 새로운 라이프 스타일에 부합하며 새로운 교통문화를 창출할 수 있는 스쿠터 디자인을 사례를 통해 제안하였다. Today, our world suffers severe traffic war since car is increasing day by day in every corner of the world and environmental pollution due to waste gas threatens to be aggravated. In view of present situation that main reason for using vehicles for citizen is going for work, it is not too much to say that most of running vehicles in city area should be driver only vehicles. Therefore, each countries intensify their pressure on drivers in city through employment of policies such as recommendation to use public transportation and imposition of premium charge for entering city area to restraint vehicles' entering to city. In this study, we had searched new direction to solve the problems that lack of parking lots and most of vehicles driving in city are single occupant's vehicles. Moreover, we could recognized that the effectiveness of Scooter that noticed again recently and had been studying based on new possibility of Scooter as a future single riding transportation tool. Scooter has many merits like economical price and practicalities such as container box, convenient control and high efficiency of gasoline that couldn't be felt from other motorcycles. Recently, new types of Scooter such as "BMW C1" that maximized practicality has been studied. These kind of Scooters not only maximize existing practicality but also safety of drivers, moreover, can provide driving circumstances as vehicles. This study proposed new design of Scooter that not only corresponds practicality and safety as well as new life style but also can create new traffic culture.