경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

오차드그래스(Dactylis glomerata L.)의 품종에 따른 종자유래의 캘러스 형성률과, 캘러스 크기 및 식물체 재분화 효율의 비교

배은경,이인애,김기용,이병현,손대영,이효신,정민섭,조진기 Plant molecular biology and biotechnology research 2002 Plant molecular biology and biotechnology research Vol.2002 No.-

Comparison results of callus formation ratio from seed explants, callus sizes, regeneration ratios from callus and regeneration efficiency [calculated by following formular; callus formation ratio(%) × regeneration ratio(%)/100]for 27 ochardgrass (Dactylis glomerata L.)varieties imported and Hapsung 2 developed in Korea are as follows; 1. Among ochardgrass varieties showing more than 50% callus formation ratios, the descending order of callus formation ratio after bedding the seed explants for 4 weeks was 93>Sparta>Pizza>Condor>Lidaglo>Glorus>Hapsung2>Frode. 2. The callus sizes after bedding for 4 weeks were in the range of φ 0.43cm~4.2cm in which there was 10 times size difference between the largest one and the smallest one but most of them were between φ2.5cm~4cm. 3. The regeneration ratio from callus among varieties were in the range of 0~36% and descending order of the upper 6 varieties was Plano>Akimidori>Justus>Lidacta>Currie>Hall mark. 4. The regeneration efficiency which is calculated by the ratios of regeneration from seed explant numbers was between 0 to 17.4% among which Justus showed the highest value in the 4-week treatment. 5. The correlation between callus formation ratios and the callus sizes, callus formation ratios and regeneration efficiency, and callus sizes and regeneration efficiency were r=0.5765, r=0.6365 and r=0.6246, respectively in 4-week callus and all the correlations were significant on the 1% level. 6. In 6-week callus, the descending order callus formation ratios from seed sxplants for the best 6 varieties was Condor>Sparta>93M>Justus>Potomac>Lidaglo>Frode. 7. The callus sizes formed were between φ1.5~5.7cm in which Sparta, the largest one of φ5.7cm was five times larger than the smallest one. The callus size of the control variety. Hapsung 2 was φ3.8cm, which belonged to larger size. 8. Regeneration ratio showed a great deviation among varieties from 6-week old calli by showing from 0% to 100% in which all the calli were regenerated in Plano while no callus was regenerated in Juno, 9. The range of regeneration effciency was between 0~28% among varieties in which the values from 6-week callus treatment were larger than those from 4-week callus treatment. Especially, the value of Potomac in 6-week was 3 times larger than that in 4-week. 10. The correlation between callus formation ratios and the callus sizes, callus formation ratios and regeneration efficiency, and callus sizes and regeneration effciency were r=0.8369, r=0.6683 and r=0.5937, respectively in 6-week callus, and all the correlations were significant on the 1% level.

뇌동맥류를 진단하는데 침습적 뇌혈관 조영술이 자기공명 혈관 조영술보다 언제나 더 유리한가?

사은희,김대성,정대수,박규현,배지호,김학진 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

치수유래 구심성 신경섬유의 삼차신경 감각핵군에서의 연접특성

배용철,이은희,최민기,홍수형,김현정,남순현,김영진 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.2

일차연접부위에서 악안면 영역에서 유래하는 유해자극의 전달 및 처리기전을 이해하고자 horseradish pe개xidase를 치수지배 구심성 신경섬유를 표식한 후 연수후각에서 미세구조 및 연절 양상을 분석하여 다음과 같은 결과를 얻었다. 표식종말은 소수의 큰 치밀소포가 관찰되는 종말 (S형) 및 다수의 치밀소포를 함유하는 종말 (LDCV형)등 2종류로 분류할 수 있었다. S형 및 LDCV형 표식종말의 연접양식은 유사하였으며, 다수의 표식종말이 1개 혹은 2개의 neurofile과 연접을 이루어 대단히 단순한 연접양상을 보였다. 표식종말은 가지돌기체 보다는 다수의 가지돌기가시와 연접을 이루는 빈도가 높았다. 표식종말이 세포체 및 이에 인접한 근심부 가지돌기와 연접하는 경우는 드물었으며, 소수의 표식종말에서 p-ending과 연접하는 경우를 보였다. 표식종말의 체적, 표면적, 사립체의 체적, neurofile과 접하는 면적, 활성부위의 면적, 단위표식종말당 연접소포의 수 및 연접소포의 밀도등은 넓은 범위의 계측치를 나타내었으며, 이는 5명 및 LDCV형 표식종말 사이에 유의한 차이가 없었다. 이상의 결과로 미루어보아 연수후각에서 치수유래 구심성 신경섬유 종말의 연접양식은 고유의 특징을 보이며 이는 신경회로의 기능과 밀접한 상관관계를 가지는 것으로 판단되었다. Little is known about processing mechanism of pain sensation of the oral cavity at the 1st synapse of trigeminal sensory nuclei. Serial ultrathin sections of tooth pulp afferent terminals, identified by the transganglionic transport of 1% wheatgerm agglutinin conjugated horseradish peroxidase, were investigated wih electron microscope. Quantitative ultrastructural analysis was performed on digitizing tablet connected to Macintoshi personal computer (software: NIH Image 1.60, NIH, Bethesda, MD). Labeled boutons could be classified into two types by the shapes of containing vesicles : S bouton which contained mainly spherical vesicles (Dia. 45-55 nm) and few large dense cored vesicles (Dia. 80-120nm), and LDCV bouton, which contained spherical vesicles as well as large number of large dense coredd vesicles. Most of the parameters on the ultrastruotural characteristic and synaptic organization of labeled boutons were similar between S and LDCV boutons, except shapes of containing vesicles. Majority of the labeled boutons showed simple synaptic arrangement. The labeled bouton were frequency presynaptic to dendritic spine, and to a lesser extent, dendritic shaft. They rarely synapsed with soma and adjacent proximal dendrite. A small proportion of labeled boutons made synaptic contacts with presynaptic pleomorphic vesicless containing endings and synaptic triad. Morphometric parameters of labeled boutons including volume and surface area, total apposed area, mitochondrial volume, active zone area, vesicle number and density showed wide variation and theme were not significantly different between S and LDCV boutons. The present study revealed characteristic features on ultrastructure and synaptic connection of pulpal afferents which may involved in transmission of oral pain sensation.

Pb-62% Sn 공정합금의 초소성에 관한 연구

배은현,고광진,장현구 成均館大學校 科學技術硏究所 1989 論文集 Vol.40 No.2

The effects of reduction ratio and purity on the superplasticity of Pb-62%Sn eutectic alloys were studied. The alloys of two values of reduction ratio(r=10 : 1, 25 : 1) and impurity content(alloy A : 0.075%, alloy B : 0.216%) were prepared to compare the flow stress and elongation at constant strain rate. Also, the effect of temperature on the tensile behavior and the structural changes of the surfaces were investigated. Larger elongations were achieved for more worked(r=25 : 1) alloys because of their finer equiaxed grains, and for more purified alloy A in which less impurities inhibit the grain boundary sliding. Maximum elongation of 2300% was obtained for alloy A at room temperature, r = 25 : 1 and strain rate, ε˙= 1.4 x 10 exp(-4)/s. Increase in temperature, caused increase in strain rate sensitivity and decrease in flow stress, which explains that atomic accommodation process and grain boundary migration arc more enhanced at elevated temperature.

약물전달체로서의 고분자 미셀의 특징 및 고분자 미셀을 이용한 제품

김준배, 손진영, 이은주, 조정원 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

The amphiphilic block copolymers forms the self -assembled micelles in aqueous solution. that is called as polymeric micelle. Polymeric micelles as drug delivery carriers can protect the drug against bio-logical environments (eg. low pH. enzymes). allow drug ellcapsulation in the hydrophobic inner center. in-crease the solubility of hydrophobic drugs). facilitate drug targeting. and reduce the side effects of chemotherapy. Another advantage is that polymeric micelles can prolong the circulation time of the drug us-ing the ligand for the specific target because the surface properties of the drug delivery system affect the circulation time in the blood and are related to the life span of the drug delivery system. Recent advances in the properties and application of polymeric micelles as drug delivery carriers for poorly soluble drug have been discussed in this review.

여성빈곤의 실태와 극복방안 : 도시 저소득층 여성을 중심으로 With Special Reference to Underprivileged Women in Urban Areas

이배용,박진숙,황은자,정현숙,이제진 이화여자대학교 한국여성연구원 1996 여성학논집 Vol.13 No.-

Since the 1960's, the rapid industrialization of Korea has been propelled full-scale by a handful of big business groups and effort- oriented trade, which has resulted in external and quantitative economic growth, but has also produced problems of poverty arising out of the unequal distribution of wealth. Industrialization led to impoverishment in rural areas and stimulated migration by the rural population to urban areas, who were marginalized, excluded from public sectors of labor market and led lives of poverty. In this context, a number of young Korean women were employed in the industrial sector as low waged and unskilled laborers to support their families. Women workers from poor families had to participate in economic activities from their youth in order to avoid "absolute poverty" and they grew up with economic, cultural, and educational limitations. After marriage, they still played crucial roles to maintain their poor families by taking charge of whole family subsistence, and/or trying to generate family income through part- time jobs. However, up to the present, academic concerns as well as governmental support for the underprivileged women have been limited. This study was started with this critical factor of women's rote in urban poor families in mind. It examines the women's conditions and how they can actively overcome their poverty, so as to lead qualitatively better lives, particularly through organizational activities. This paper, in the first place, surveys theories and research results on issues of poverty and various anti- poverty measures adopted by foreign countries such as U.K., USA, Germany, Japan, Taiwan and Singapore. Issues such as "feminization of poverty" and the "culture of poverty" are also discussed. Furthermore, existing research on poverty, including women's poverty in Korea, were examined to identify problems which have not been conceptualized so far. Genera1 living conditions of the poor were surveyed with emphasis on their unstable living conditions. Socio- economic and sexual discrimination were discussed in connection with the lives of underprivilged women. Alternatives were sought to solve the poverty problem. Women's organizations that have spontaneously formed in underprivileged areas and their communal economic activities were examined. The latter especially have turned out to be rewarding for those women who have only limited economic opportunities. It was not only helpful to them to generate income for their families, but also to realize the value of their labor, while having the pleasant experience of working together. Futhermore, through organizational activities, their communal consciousness and self-consciousness as women was promoted and their familial relationships were also altered for the better. Women could thus acquire self-confidence and become psychologically self-reliant members of their organization. These results show us tha4 women's organizations, especially those established in poor areas, are significant for the members, because they work as self-help groups preventing them from falling into pauperism in a situation where a relevant social welfare system is absent. Lastly, vocational traiillng programs and the rehabilitation funding system were examined and alternatives for re-vitalizing communal activities for women's organizations in poor communities were suggested as follows : Firstly, various communal economic activities, based on diverse aspects of women's lives, are needed. In doing so, Government should endeavor to construct a network between underprivileged women's organizations including their communal economic activity groups and "small and poor enterprises" which may employ them as well as provide workplaces for their communal activities. Also financial support by the Government, such as a rehabilitation fund which will be crucial for successfully implementing their small scale communal economic activities and/or loans in the long-term. Secondly, established vocational training programs should be reinforced. In order that vocational training programs may be functioned as an effective system of supporting the self-help groups of underprivileged women, more training programs should be developed and provided, based on an understanding of their lives and desires. In addition, for stimulating their positive/active participation in these programs, the following factors should be taken into account, i.e., educational/training programs should be held at welfare centers or women's centers located near their homes; development of programs for practical training and follow-up is needed; extension of child-care facilities for trainees; and group training programs for community women's organizations are also required. Thirdly, women living in underprivileged communities have psychological problems such as self-centeredness, heteronomy, and lack of communal consciousness, owing to their experionces in a distorted life, which sometimes hamper their communal economic activities. Accordingly, educational support to promote and encourage their communal consciousness and collective autonomy, as well as physical support, is essential. However, these inputs should be based on a deep understanding of the lives of underprivileged women, so that the policies are fruitful and rewarding. Therefore long-term plans, with the establishment of supportive agencies, involving community activists who share their lives with poor women over a long time, are required for solving these problems and eliminating women's poverty.

알코올 용매로부터 알콕사이드졸겔법에 의한 알루미나 미분말의 제조

김창은,이해욱,안용진,김배연 연세대학교 산업기술연구소 1989 논문집 Vol.21 No.1

Al(??)₃를 알코올 용매하에 아세틸아세톤과 반응시킨 후 부분가수분해 하여 alumina precusor sol을 얻었다. 생성된 졸의 특성을 알아보기 위하여 산의 농도에 따른 졸의 상태를 조사하였다. 또한 이 졸로부터 얻어진 분말은 각 온도별로 열처리하여 결정의 전이과정 및 각 온도에서의 결정상태 등을 조사하였다. 건조분말은 90℃에서 비정질로서 polymenc sol의 특성을 나타내었으며 900℃에서는 ? -Al₂O₃, 1050 ℃에서는 α- Al₂O₃의 단일상이 각각 관찰되었다. 또, 비정질분말과 α- Al₂O₃에서는 6배위한 Al을, 그리고 ??-Al₂O₃에서는 4배위한 Al을 각각 확인할 수 있었다. Alumina precusor sol was obtained by the reaction of Al(??)₃ and acetylacetone in the alcohol solvent followed by the partial hydrolysis. In order to investigate the characteristics of the obtained sol, the state of the sol with the concentration of the acid was investigated. The powders obtained from this sol were calcined at the various temperatures. The transition of crystals and crystal state were investigated at the various temperatures. The powders dried at 90 ℃ showed the characteristies of polymeric sol and at 900℃ showed ??-Al₂O₃, at 1050℃ showed the single phase of α-Al₂O₃.

(±)-Camphor가 ICR 마우스 수컷의 간 cytochrome P450 효소 활성에 미치는 영향

오은경,박형건,배기현,최옥진,최은경,최창근,한진희,정태천 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

Effects of (±)-camphor on liver cytochrome P450 enzymes were investigated in male ICR mice. Mice were treated intraperitoneally with 0, 200, 400 and 800 mg/kg of (±) -camphor in corn oil for 3 consecutive days. Twenty four hr after the final treatment, the animals were subjected to necropsy. The activities of serum aspartate aminotransferase and serum alanine aminotransferase were slightly changed by the treatment with (±)-camphor at the doses used. Administration o(±)-camphor to mice significantly induced the hepatic activities of pentoxyresorufin O-depentylase and benzyloxyresorufin O-debenzylase and weakly induced ethoxyresorufin O-deethylase in dose-dependent manners. The present results suggested that (±)-camphor might act as a relatively specific inducer of hepatic cytochrome P450 213 in male ICR mice.