Folliculin 유전자 변이로 진단된 Birt-Hogg-Dubé 증후군 1예

윤승배,박찬권,강민규,이석종,한대희,기창석,김영균 대한내과학회 2011 대한내과학회지 Vol.81 No.1

Birt-Hogg-Dubé (BHD) syndrome is a rare, autosomal-dominant disorder that is caused by germ-line mutations in the folliculin gene. Clinically, BHD syndrome is characterized by cutaneous follicle tumors, pulmonary cysts, spontaneous pneumothorax, and an increased risk of renal cancer. A 65-year-old woman was admitted to Seoul St. Mary's Hospital to treat pneumonia, and we found that she had experienced recurrent spontaneous pneumothorax and had bilateral multiple pulmonary cysts with no history of smoking. Mutation analysis of the folliculin gene identified a novel mutation in exon 9 (c.997_998delTC; p.Ser333ArgfsX56). Except for the lung manifestation, no other features of BHD syndrome were detected in this case. Here, we report a case of BHD syndrome that manifested only as lung disease with a novel mutation. (Korean J Med 2011;81:102-106) 저자 등은 폐렴으로 치료받은 65세 여자 환자에서 흡연력이 전혀 없음에도 자발성 기흉 기왕력과 양측성 다발성 폐낭종 소견이 관찰되어 BHD 증후군을 의심하였고 folliculin 유전자 변이 검사를 통하여 이를 확인하였다. 특징적인 피부 병변 없이도 BHD 증후군의 발생 가능성이 있으므로 폐질환이 임상적으로 이 질환에 합당한 경우에는 folliculin 유전자 변이 검사를 고려해 보아야 할 것으로 생각한다.

사회적 기업가정신과 사회적기업의 직무 열의의 관계에서 임파워먼트의 매개 효과

윤승배,김상현,노광현 한국디지털정책학회 2018 디지털융복합연구 Vol.16 No.12

Social enterprises are companies that provide jobs to the vulnerable and provide social services. However, sustainable management of social enterprises is very difficult in a rapidly changing market environment. Therefore, for the sustainable management of social enterprise, it is assumed that the duty efficiency of the members of the social enterprise is most important in the limited resource environment, and that the social entrepreneur can increase the efficiency of the work by giving delegation to the members. Therefore, this study investigates how social entrepreneurs influence on the job efficiency of members when giving psychological empowerment to members of social enterprise based on social entrepreneurship. When giving empowerment leadership to members, And it has a significant effect on job efficiency. 사회적기업은 취약계층에게 일자리를 제공하고, 사회서비스를 제공하는 기업이다. 그러나 급변하는 시장 환경 속에서 사회적 기업의 지속가능 경영은 매우 어려운 실정이다. 따라서 사회적기업의 지속가능 경영을 위하여서는 제한된 자원 환경 속에서는 사회적기업의 구성원들의 직무열의가 무엇보다도 중요한바, 사회적 기업가는 구성원들에게 권한위임을 부여함으로서 직무열의를 높일 수 있다고 가정 하였다. 따라서 본 연구는 사회적 기업가가 사회적 기업가정신에 입각하여 사회적기업의 구성원들에게 심리적 임파워먼트를 부여 할 때 구성원들의 직무열의에 어떠한 영향을 미치는가에 대하여 연구하였고, 구성원들에게 임파워먼트 리더십을 부여 할 때 구성원들의 직무 열의에 유의미한 영향을 주고 있었다.

췌장암에서 간 문맥 순환 종양 세포의 임상적인 유용성

윤승배,고성우 대한소화기암연구학회 2023 Journal of Digestive Cancer Research Vol.11 No.1

Despite recent advancements in the diagnosis and treatment of pancreatic cancer, clinical results remain dismal. Furthermore, there are no reliable biomarkers or alternatives beyond carbohydrate antigen 19-9. Circulating tumor cells (CTCs) may be a potential biomarker, but their therapeutic application is constrained by their rarity in peripheral venous blood. Theoretically, the portal vein can be a more appropriate location for the detection of CTCs, because the first venous drainage of pancreatic cancer is portal circulation. According to several studies, the number and detection rate of CTCs may be higher in the portal blood than in the peripheral blood. CTC counts in the portal blood are strongly correlated with several prognostic parameters such as hepatic metastasis, recurrence after surgery, and survival. The phenotypic and genotypic properties analyzed in the captured portal CTCs can assist us to comprehend tumor heterogeneity and predicting the prognosis of pancreatic cancer. The investigations to date are limited by small sample sizes and varied CTC detection techniques. Therefore, a large number of prospective studies are required to confirm portal CTCs as a valid biomarker in pancreatic cancer.

췌장암에서 간 문맥 순환 종양 세포의 임상적인 유용성

윤승배,고성우,Seung Bae Yoon,Sung Woo Ko 대한소화기암연구학회 2023 Journal of digestive cancer reports Vol.11 No.1

Despite recent advancements in the diagnosis and treatment of pancreatic cancer, clinical results remain dismal. Furthermore, there are no reliable biomarkers or alternatives beyond carbohydrate antigen 19-9. Circulating tumor cells (CTCs) may be a potential biomarker, but their therapeutic application is constrained by their rarity in peripheral venous blood. Theoretically, the portal vein can be a more appropriate location for the detection of CTCs, because the first venous drainage of pancreatic cancer is portal circulation. According to several studies, the number and detection rate of CTCs may be higher in the portal blood than in the peripheral blood. CTC counts in the portal blood are strongly correlated with several prognostic parameters such as hepatic metastasis, recurrence after surgery, and survival. The phenotypic and genotypic properties analyzed in the captured portal CTCs can assist us to comprehend tumor heterogeneity and predicting the prognosis of pancreatic cancer. The investigations to date are limited by small sample sizes and varied CTC detection techniques. Therefore, a large number of prospective studies are required to confirm portal CTCs as a valid biomarker in pancreatic cancer.

LMS 기반 에듀테크 교수학습 플랫폼 모형 설계 연구

윤승배,양승혁,박현순,Yoon, Seung­-Bae,Yang, Seung Hyuk,Park, Hyunsoon 한국디지털정책학회 2021 디지털융복합연구 Vol.19 No.10

목적: 이러닝 활성화를 위해 여러 방식의 LMS와 접목하여 연동 가능한 최적의 에듀테크 교수학습 플랫폼 모형을 설계한 연구이다. 방법: 이를 위해 사이버대학교와 일반대학교의 4차 산업기술에서 활용 가능한 이러닝 시스템을 횡단적으로 내용분석 하였다. 결과: 사이버대학교에서는 전적으로 LMS에 의존하였고, 일반대학교에서는 LMS 이외에도 구글 클래스룸, 줌 비디오 커뮤니케이션, 유튜브 등 교수별 각기 다른 에듀테크 방법을 보완 활용하고 있어, LMS에 구글 및 유튜브 등 메타데이터를 공유할 수 있도록 최소한의 알고리즘 매핑을 제공하는 것이 에듀테크 교수학습 플랫폼 모형에 유의미할 것으로 보았다. 이에 본 연구는 LMS 기반 에듀테크 교수학습 플랫폼 모형을 통해 교수법 향상과 학업성취도 향상에 기여할 것으로 사료된다. Purpose: This is a study to design an optimal Edutech teaching-learning platform model that can be linked with various types of LMS to activate e-learning. Methods: For this purpose, the contents of e-learning systems that can be used in the 4th industrial technology of cyber universities and general universities were cross-sectionally analyzed. Results: Cyber universities relied entirely on LMS, and general universities supplemented and utilized different Edutech methods for each professor such as Google Classroom, Zoom video communication, and YouTube in addition to LMS. It was considered that it would be meaningful to provide a minimal algorithm mapping to LMS to share metadata such as Google and YouTube for the Edutech teaching and learning platform model. Conclusion: Therefore, this study is expected to contribute to the improvement of teaching methods and academic achievement through the LMS-based Edutech teaching and learning platform model.

광대역대 활성광촉매를 활용한 융.복합 구조 공기살균정화장치 개발

윤승배,황윤정,김승천 한국융합학회 2019 한국융합학회논문지 Vol.10 No.4

현대인들은 가정, 학교 혹은 직장, 병원, 쇼핑몰, 지하철역과 객실, 주차장 등 일상생활의 대부분을 실내에서 보내게 된다. 이렇듯 실내에 갇힌 현대인들은 갇힌 공기 속에서 살아갈 수밖에 없다. 이에 실내 공기질 향상을 위한 공기정화장치는 많이 개발되었으나 대다수의 공기정화장치는 필터에 의한 필터링과 유해세균 살균방식에 있어 자외선이라는 제한된 영역에서의 살균방식에 국한 할 수밖에 없었다. 여기서는 실내 공기질 향상은 물론 원천적으로 실내공기중의 부유 세균을 제거하고, 자외선뿐만 아니라 가시광선에서도 활동하는 광촉매를 적용한 미디어광촉매필터를 활용한 광대역대 활성광촉매를 활용한 융.복합 구조 공기살균정화장치 개발하고자 한다. Modern people spend most of their daily lives in their homes, schools, or workplaces, hospitals, shopping malls, subway stations, rooms, and parking lots. According to the survey, air quality management at the multi-use facility is less than 50% satisfied. In this study, a photocatalytic filtration system is developed by utilizing a broadband-to-active photocatalyst that utilizes a media photocatalyst filter that removes airborne germs from indoor air as well as indoor air quality and operates on visible light as well as ultraviolet light.

Sedation for Gastrointestinal Endoscopy: Practical Issues in Patient Safety and Quality Management

윤승배,조영석 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.1

COMMENTARY

[이달의 그림] 남산공원

윤승배 샘터사 2000 월간 샘터 Vol.31 No.5

임상화보 : 혈관 내 초음파를 이용한 경피적 동맥관열림증 폐쇄

윤승배 ( Seung Bae Yoon ),유기동 ( Ki Dong Yoo ),김지훈 ( Ji Hoon Kim ),임은주 ( Eun Joo Im ),이정우 ( Jeong Woo Lee ),문건웅 ( Keon Woong Moon ),김철민 ( Chul Min Kim ) 대한내과학회 2009 대한내과학회지 Vol.77 No.2

췌장액체고임의 치료

윤승배 ( Seung Bae Yoon ),장재혁 ( Jae Hyuck Chang ),이인석 ( In Seok Lee ) 대한소화기학회 2018 대한소화기학회지 Vol.72 No.3

Pancreatic Fluid Collection (PFC) develops as a result of acute pancreatitis, chronic pancreatitis, trauma, and postoperation. Although percutaneous drainage, surgery and Endoscopic Retrograde Panceatogram are used as conventional treatments in complicated PFC, the clinical course of PFC is unsatisfactory due to its clinical success rate and the risk of procedure-related complications. Endoscopic ultrasonography-guided transmural drainage of PFC is a safe and effective modality for the management of PFC, particularly in patients with pancreas necrosis. A range of techniques and stents have been introduced and a newly designed metal stent is now available. (Korean J Gastroenterol 2018;72:97-103)