정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

가시발새우 껍질에서 제조한 키틴 키토산의 물리화학적 특성

정계환,김봉섭,허종화,노홍균 대구효성가톨릭대학교 식품과학연구소 1996 식품과학지 Vol.8 No.-

가시발새우 껍질을 부가가치가 높은 자원으로 활용하기 위하여, 이들로부터 키틴과 키토산을 제조하여 물리화학적 특성을 살펴 보았다. 가시발새우 껍질에서 추출한 키틴의 일반성분은 질소 6.84%, 지방 0.57%, 회분 0.32%였으며, 수율은 15.7%였다. 키토산은 질소함량이 7.52%였으며 지방과 회분함량은 각각 0.13%와 0.33%였다. 그리고 탈아세틸화도는 67.5%, 분자량은 9.1×10 exp (5)이었으며 수율은 75%를 나타내었다. 키틴 및 키토산의 잔류 아미노산은 각각 2.64㎎/g과 1.39㎎/g 검출되었고, 그 중 lysine이 가장 높게 나타났다. 한편 키틴과 키토산의 IR 스펙트럼과 고체상태 ^(13)C-NMR 스펙트럼 data는 분자구조를 확인하는데 도움이 되었다. The physicochemical properties of chitin and chitosan produced from lobster shrimp (Metanephrups thomosonii) shell were investigated. Lobster shrimp chitin contained 6.84% nitrogen, 0.57% fat and 0.32% ash, while chitosan contained 7.52% nitrogen, 0.13% fat and 0.33% ash. Degree of deacetylation and molecular weight of chitosan were 67.5% and 9.1×105, respectively. Yields of chitin from the shell portion and chitosan from the chitin were 15.7% and 75%, respectively. Chitin and chitosan contained 2.64 and 1.39㎎/g of residual amino acids, respectively, with both the most predominant being lysine. Chemical structures of the lobster shrimp chitin and chitosan have been investigated by the IR and solid state ^(13)C-NMR spectra.

자동차용 브레이크 마찰재에서의 환원분철의 마찰특성에 관한 연구

정진오,이경환,김옥삼,김봉수 순천대학교 2000 순천대학교 자연과학논문집 Vol.19 No.1

In most automotive brakes, the friction material is used to convert the kinetic energy into heat. The friction material is a complex composite consisting of a resin, reinforcing fibers, lubricants and filler materials. In an attempt to enhance the friction performance of the friction material, a trial was done to examine the substitution of filler material by the reduction iron powder. In this study, two types of reduction powder M1 and M3 was prepared by the reduction process developed by Hanta M&B Inc. M1 and M3 which has reduction ratio of 1.5 and 92% respectively was used in place of BaSO_4, which was conventionally used as a filler material. The amount of M1 and M3 was varied as 10, 20, 30%, while the other component remains the same except the replaced BaSO_4. For those specimens with different amount of reduction iron powder, friction performance tests such as friction coefficient, rotor compatibility were conducted by using brake dynamometer. The bonding strength and hardness tend to decrease with use of M1 and M3, but specific weight decreased with increase of M1 and M3. The friction coefficient increased with use of M1 up to 10%, but decreased for use of M1 more than 20%. However the use of M3 resulted in a decrease of friction coefficient all the way. The surface roughness decreased with the use of M1 and M3, except for a case of excessive use of M1 of 30%. The rotor surface roughness did not show any correspondence with hardness of friction material in this study.

알코올 중독증 환자 부인의 행동경향과 인성적 특성에 관한 연구

손봉기,정소영,한창환 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.5

This study was conducted with some questionnaires and psychological tests to investigate the behavioral trends and personality of the alcoholic's wives. The subjects were wives of 43 alcoholics who visited our department from March 1990 to July 1991, and wives of 43 patients with chronic medical illness. The results are as follows: 1) The level of education of the experimental group is lower than that of the control group, though statistically not significant. Alcoholics as a group earned much less money compared to the control group. 2) The differences between the present jobs and those at the time of marriage of the husbands in each group are not significant, and the differences of jobs between two groups in each time are not significant too. 3) Wives of alcoholics seem to have been more passie than the control group in determination to marry. 4) Alcoholics' wives usually treat their husbands either with decisively ordering manner of with indiffeence. 5) The preferred coping measures of the experimental group are shared concern, compliance and self-pity. 6) On MMPI, Hy scale is significantly higher in the experimental group than in the control group. 7) With digital coding of MMPI profile, the cumulation of the scales ofeach codes shows the higher frequency of occurrence of Pd scale and the lesser frequency of Ma scale in the experimental group. The differences are statistically significant. 8) It is suggested that the neurotic trends and the copings of wives of alcoholics are the results of the chronic cumulated alcohol-related stresses, the personality of wives have not effected the alcoholic marriage.

초소형 구조물의 부착 방지를 위한 새로운 자기 집합 물질에 대한 연구

김봉환,오창훈,전국진,정택동,변장웅,이윤식 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

In order to achieve stiction-free polysilicon surfaces, we have suggested a new chemical grafting precursor and confirmed their excellent characteristics. When dichlorodimethylsilane(DDS, C_(2)H_(6)SiCl_(2)), a dialkyldichlorosilane widely used in silicon machining, have been used as a precursor, experimental results were clearly comparable to those of monoalkyltrichlorosilanes octadecyltrichlorosilane (OTS, C_(18)H_(37)SiCl_(3)) or 1H,1H,2H,2H-perfluorodecyltrichloro-silane (FDTS, C_(10)H_(4)F_(17)SiCl_(3)) in terms of stiction reduction. The polysilicon cantilevers were fabricated in the carefully controlled conditions and laser interferometer indicated that their residual stress gradient was 2 MPa/μm upward from the substrate. The SEM images of polysilicon cantilever beams with DDS coating are upward and no stiction is observed up to 2 mm in length.

농촌지역 오수처리시설의 성능평가 및 개선방안

박충환,박희동,이창균,임봉수 大田大學校 環境問題硏究所 2002 환경문제연구소 논문집 Vol.6 No.-

This study was carried out to evaluate performance of sewage treatment facility in rural area. Average effluent concentration was 7.6㎎/1 BOD. 10.3㎎/1 COD, 4.7㎎/1 SS, 19.140㎎/1 TN, and 1,631㎎/1 TP, within discharge quality standard. The removal efficiency rate of BOD, COD and SS was good as 89.8%. 78.5% and 90.1%, respectively. But that of TN, TP was very low as 25.0% and 31.4% respectvely. Average sewage flow rate was investigated by about 1.1㎥/d per household, 398ℓ pcd. In rainfall period, the removal efficiency rate of BOD. TN and TP was very low as 15%, 22% and 28%, respectively because of inflow and infiltration into sewer. In flowing concentration of sewage was diluted as rain is inserted into sewer and submerged facility was not operated at normal condition. Therefore it is required that the sewer will have to repair and hydraulic design for facility will have to be check. So it is necessary to support systematical, administrative measures for responsible management.

비침습적 검사를 이용한 수술후 하지 심부 정맥 혈전증의 감시

김영욱,정한준,윤봉호,김신윤,이상국,변경환,김태헌 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

Deep vein thrombosis is recognized as a common complication in surgical patients in western countries especially in patients with high risk factors. The purposes of this study were to detect leg DVTs in early postoperative period by non-invasive surveillance and to analyze the risk factors of DVT. One hundred seventy one patients who underwent major operations(67 curative resection of colorectal cancer, 64 total hip replacement, 38 femur operation for fracture, and 2 colon resections for benign colon disease) were included for the prospective surveillance of leg DVT within 2 weeks after the operations. For the surveillance of leg DVT, strain gauge plethysmography(SPG) and Duplex scanning of both legs were completed for all patients except 10 patients. These 10 patients were examined in only one leg. The patients with past history of leg DVT or under prophylactic anticoagulant therapy were excluded from this study. To determine the risk factors related with leg DVT formation, age and sex of the patients, indication of surgery or surgical procedures, duration of operation, position during the operation, duration of postoperative immobilization, and preoperative serum level of antithrombin III (AT- III) were analyzed using Chi-square test. After performing SPG of 342 legs, 38 legs, showed abnormal on venous outflow/venous capacitance discriminant line chart, and 13 legs of 12 patients showed the finding(s) suggesting DVT on duplex scanning. Among the patients with abnormal duplex findings, 7 limbs(53.8%) were symptomatic, but the remaining 6 legs were silent. In 6 (15.8%) patients of 36 femur operations, 3(4.7%) of 64 total hip replacements and 3(4.5%) of 67 curative resections of colorectal cancer developed DVT by duplex scanning in the iliac(5), femoral-popliteal(6), and isolated calf(2) veins. After analyzing the risk factors, we could not find any statistically significant(p<0.05) factor related with leg DVT.

忠南黑石溪谷 住民의 肺, 肝디스토마 感染率 및 그 中間宿主 調査

金鍾煥,鄭奉晳,金玉千 醫藥係社 1955 綜合 醫學 Vol.12 No.12

직렬 리액터를 이용한 계통연계형 태양광 발전 시스템

金大均,鄭春炳,全基英,李丞煥,吳鳳煥,李勳九,金容珠,韓慶熙 명지대학교 산업기술연구소 2005 産業技術硏究所論文集 Vol.24 No.-

Since the residential load is an AC load and the output of solar cell is a DC power, the photovoltaic system needs the DC/AC converter to utilize solar cell. In case of driving to interact with utility line, in order to operate at unity power factor, converter must provide the sinusoidal wave current and voltage with same phase of utility line. Since output of solar cell is greatly fluctuated by insolation, it is necessary that the operation of solar cell output in the range of the vicinity of maximum power point. In this paper, DC/AC converter is three phase PWM converter with smoothing reactor. And then, feedforward control used to obtain a superior characteristic for current control and digital PLL circuit used to detect the phase of utility line.

오탄당과 육탄당의 혼합용액에서 Pichia stipitis에 의한 에탄올 발효

정봉환(Bong-Hwan Chung),유연우(Yeon-Woo Ryu),서진호(Jin-Ho Seo) 한국생물공학회 1994 KSBB Journal Vol.9 No.4