서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

음경의 Mondor씨 병 1례

김욱현,문기혁,송윤섭,박영호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Superficial venous thrombosis of the chest wall was first described by Mondor in 1939. Braun-Falco reported in 1955 superficial penile vein involvement in diffuse thrombophlebitis of the abdominal wall and in 1958 Helm and Hodge first described isolated superficial dorsal penile vein thrombosis. Since then, fewer than 50 cases have been reported. The clinical presentation is usually redness and swelling of the dorsum of the penis, accompanied by a palpable, tender thrombotic vein. This acute and painful disease frightens the patients, who is concerned about his fertility and sexual function. The main cause of this disease is frequent sexual intercourse. Diagnosis is based upon anamnesis, physical examination and penile sonography with color Doppler imaging. It is usually a benign disease which resolves quickly under appropriate medical therapy. We present a man who was visited for this condition and was conservatively treated.

메치실린 내성 포도상구균에 대한 SK-302의 시험관내 및 생체내 효과

박윤선,김수기,신운섭,최선주,정종순,이종수 關東大學校醫科大學醫科學硏究所 1998 關東醫大學術誌 Vol.2 No.1

SK-302 is the active compound purified from culture filtrate of a streptomyces species (streptomyces sp. 302). The in vitro and in vivo antibacterial activities of SK-302 were evaluated against 6 clinically isolated MRSA strains and compared with the activities of vancomycin. SK-302 had node in virto antistaphylocoal activity stronger than that of vancomycin exhibiting MIC's, while vancomycin showed very weak 4 to 8fold lower than that of vancomycin. In SK-302 showed killing activity at the MIC, so SK-302 was superior to vancomycin. Furthermore, in acute systemic infections in mice, the ED_50s of SK-302 against infections by high-resistance MRSA were 30 to 40-feold less than that of vancomycin, therefore SK-302 showed potent in vive therapeutic efficacy against MRSA infection, These results suggest that SK-302 has excellent in virto in and in vivo activities against high-resistance MRSA.

사람의 비후성 반흔에서 면역조직화학기법에 의한 형질전환인자 알파와 표피성장인자 발현의 차이에 관한 면역조직화학적 연구

박영란,김현곤,김종중,문정석,송준섭,설경수,정윤영 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background and Objectives: Transforming growth factor-α (TGF-α) and epidermal growth factor (EGF) are polypeptides which interact with the epidermal growth factor receptor (EGFR) to produce their biological effects. The aim of the present investigation was to elucidate the immunolocalization of TGF-α and EGF in normal human skin, hypertrophic scar with skin graft on soft tissue defect, and postburn hypertrophic scar without graft. Methods: The data presented in this paper focused attention on differences of expression between two kinds of hypertrophic scars in relation to skin graft using immunohistochemistry. Formalin-fixed and paraffin-embedded tissues from 3 normal skin tissues, 3 hypertrophic scars after skin graft and 8 postburn hypertrophic scars without graft were immunolabelled with antibodies directed against TGF-α and EGF. Results: In normal epidermis of skin, strong TGF-α immunoreactivity (IR) was observed in all epidermal layers except the stratum (S.) basale, whereas EGF was immunopositive in a few cells over all epidermal layers. The staining for TGF-α was found in cell membrane, and EGF was seen either diffuse cytoplasmic or peripheral part of cells in normal epidermis. In hypertrophic scar after six months postoperation, TGF-α IR was observed in the upper part of S. spinosum and S. corneum, whereas EGF was diffusely expressed in the S. spinosum, also its intensity was slightly increased compared to normal skin. In hypertrophic scar without skin graft, very strong expression of EGF was detected in the S. spinosum and S. corneum, and intensity of EGF was increased when compared to normal skin and postoperative hypertrophic scar. EGF and TGF-α coexisted in the cells of S. spinosum in normal skin as well as hypertrophic scars. Double-labeled cells were increased in postburn hypertrophic scar compared to normal skin and postoperative hypertrophic scar. In addition, intensity of EGF and TGF-α double IR was the strongest in postburn hypertrophic scar. Conclusion: These results indicate that EGF may have a more complex regulatory role not only in the early stages of wound healing but also in hypertrophic scar.

임신과 동반된 난소섬유난포막종 1례

류은석,김윤숙,전섭,김종수,최승도,선우재근,배동한,양승화 순천향의학연구소 2005 Journal of Soonchunhyang Medical Science Vol.11 No.1

Fibrothecoma are mesenchymal tumors deriving from the ovarian stroma and consisting of theca-like elements and fibrous tissues. The reported incidence is between 0.4 and 8.0% of all ovarian tumors and this side variability can be attributed to the difficulty in differentiation fibrothecoma from ovarian fibroma or hyperplastic stroma nodules. We experienced a rare case of ovarian fibrothecoma in woman at 38 weeks gestation with previous repeat cesarean section diagnosed after tertiary cesarean delivery and bilateral tubal ligation with a brief review of literature.

외상성 신동맥 색전증 1례

한병규,김욱현,문기혁,송윤섭,박영호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Renal artery thrombosis may result from external trauma of a blunt nature. Such injury is induced by rapid deceleration resulting in the stretching of the renal vasculature, disruption of the arterial intima-the least elastic layer of the arterial wall and eventual thrombosis. The treatment of renal artery thrombosis is controversial, with physician's options divided between prompt surgical exploration with vascular repair and clinical observation. We experienced 1 case of traumatic renal artery thrombosis and report that with a brief review of the literature.

캔디다균이 분비하는 단백질 분해효소의 순수 분리와 특성 및 교차 항원성

이경호,신운섭,박주영,김수기,박윤선,고춘명 연세대학교 원주의과대학 1995 원주의대논문집 Vol.8 No.1

가막만에 출현하는 동물플랑크톤의 종조성과 계절별 출현 양상

서호영,이인태,윤양호,최상덕,이삼노,한명일,김병섭,강윤호,이우범 한국환경생물학회 2002 환경생물 : 환경생물학회지 Vol.20 No.2

가막만에 출현하는 동물플랑크톤을 계절별(2001년 4월, 7월, 9월, 12월)로 Norpac네트를 이용하여 수직 채집하였다. 우점적으로 출현한 분류군은 4월과 12월에 요각류, 7월에 요각류와 지각류,9월에 야광충이었다. 출현 개체수는 22~17,197indiv. m^-3으로 시·공간적으로 변동폭이 매우 컸다. 요각류의 우점종은 4월에 Euryte-mora pacifica, Acartio omorii, Cenfropages abdominalis, Colanus sinicus, 7월에 Lobidocera rofunda와 A. erythraea, 9월에 A. eryfhraea와 Paracalanus parvus s. l., 12월에 A. omorii와 E. pacifca로 주로 내만종으로 변하였다. 그러나, 9월에 외양종인 Eucalanus sp.와 Neo-calnus sp. 또한 다수 출현하였다. 이와 같은 출현 경향은 가막만이 폐쇄성 내만임에도 불구하고 동물플랑크톤의 분포 특성은 내만수 이외에 계절적으로 외만수의 영향을 강하게 받고 있음을 암시하고 있다. Zooplankton was sampled vertically with a Norpac net from Gamag Bay in April, July, September and December, 2001. Copepods were predominant in April and December, and cladocerans in July and Noctiluca scintillans in September, respectively. There are high spatio-temporal fluctuations in the abundance of zooplankton with a range of 22∼17,197 indiv./㎥. In the copepod community, neritic species, Eurytemora pacifica, Acartia omorii, Centropages abdominalis and Calanus sinicus were predominant in April; Labidocera rotunda and A. erythraea in July; A. erythraea and Paracalanus parvus s. l. in September; A. omorii and E. pacifica in December. However, oceanic species Eucalanus sp. and Neocalanus sp. were abundant in September. It indicates that although Gamag Bay is semi-closed, the distribution pattern of zooplankton is seasonally strongly affected by oceanic waters in addition to neritic ones.

Leukocytoclastic Vasculitis Associated with Ulcerative Colitis

( Yoon Seob Kim ),( Hyun Jeong Ju ),( Kyung Ho Lee ),( Chul Jong Park ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.9

Approximately 15% of patients with inflammatory bowel disease have cutaneous manifestations, and pyoderma gangrenosum and erythema nodosum are frequently observed1. To our knowledge, only eight cases of leukocytoclastic vasculitis (LCV) in patients with ulcerative colitis (UC) have been reported1-5. In most cases, the occurrence of LCV preceded intestinal symptoms1. Here, we report a case of LCV associated with UC in which both diseases were diagnosed simultaneously. A 20-year-old woman was referred from the department of gastroenterology for asymptomatic, erythematous patches for 2 months (Fig. 1A∼C). Physical examination revealed several erythematous patches on her right forearm, right lower leg, and buttock. She was admitted to our hospital for evaluation of recurrent intestinal symptoms such as abdominal pain, nausea, vomiting, and diarrhea for 10 months. Colonoscopy revealed edematous mucosal erythema and exudates on the entire colon and the terminal ileum (Fig. 1D). The patient had no fever or other systemic manifestations. Laboratory findings were within normal limits, except for elevated white blood cell (WBC) count (25,230/mL), erythrocyte sedimentation rate (ESR) (47 mm/h), and C-reactive protein (CRP) levels (38.14 mg/dL). Antinuclear and other autoantibodies including anti-neutrophil antibodies were absent. Histopathological findings from the right lower leg showed infiltration of moderate perivascular inflam-matory cells, which mainly consisted of neutrophils, with leukocytoclasia, red blood cell extravasation, and fibrinoid deposition on the vessel wall (Fig. 2). After systemic evaluation for differentiation from intestinal tuberculosis and Behcet`s disease, a diagnosis of UC was established. After 1-month treatment with prednisolone and mesalazine, the gastrointestinal symptoms and cutaneous lesions almost cleared, and the WBC count, ESR, and CRP levels were found to be within normal limits. Based on these clinical and histological findings, the patient was diagnosed with LCV associated with UC. Interestingly, LCV began to develop in association with the flare-up of UC in our case, and both conditions were diagnosed at the same time. We could not exclude the possibility that both conditions were coincidental. However, the skin manifestations were aggravated, and they improved along with the intestinal symptoms after treatment of UC. There is no specific medication history that could lead to the development of LCV. Considering the previously reported cases of LCV in patients with UC, it is likely that LCV occurred as an extraintestinal manifestation (EIM) of UC in our case. LCV is considered as an immune complex disorder associated with medication, infection, malignancies, and systemic and autoimmune disorders¹. UC is also char- acterized by the deposition of immune complex in the intestinal mucosa². One hypothesis to explain the association between the two entities is that immune complexes that are formed in the inflamed intestinal mucosa in response to fecal antigens are deposited in the cutaneous vessel wall4. In our case, the cutaneous lesions did not show palpable and grouped purpura confined to the lower extremities, which are the typical clinical findings of LCV; therefore, this condition could be underdiagnosed or missed as an EIM of UC. Dermatologists should be aware that LCV could present as an EIM of UC. Moreover, gastrointestinal evaluation should be considered in patients with LCV and intestinal symptoms.

Natural course and comorbidities of chronic spontaneous urticaria in Korea: a nationwide, population-based study

( Yoon Seob Kim ),( Kyung Do Han ),( Ji Hyun Lee ),( Nack In Kim ),( Joo Young Roh ),( Seong Jun Seo ),( Hae Jun Song ),( Min-geol Lee ),( Jee Ho Choi ),( Young Min Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: There have been no reports regarding the natural course of CSU using a population-based database. Objectives: The purpose of our study was to investigate natural course and comorbidities and of CSU using the Korean National Health Insurance Service National Sample Cohort 2002-2013. Methods: We enrolled patients into a CSU group (N=4,281) and an age- and sex-matched control group (N=21,405) between 2003 and 2007. Demographic data and comorbidities were compared between cases and controls. CSU remission rates were calculated in 1, 2, 3, 4, and 5 years after initial diagnosis. Demographic differences and profiles of comorbidities were analyzed between patients who underwent CSU remission within 1 year and patients who did not. Results: Proportions of metabolic, autoimmune, chronic infectious, allergic, and H. pylori-related diseases in the CSU group were significantly higher, compared to the control group. CSU remission rates 1, 2, 3, 4, and 5 years after initial diagnosis were 30.74%, 42.44%, 47.21%, 49.12%, and 50.29%, respectively. Age greater than 65 years, male sex, a history of type 2 diabetes mellitus, hypertension, and dyslipidemia were poor prognostic factors affecting the 1-year remission rate. In contrast, age younger than 19 years, Grave’s disease, and asthma were good prognostic factors. Conclusion: Results from this study will help to highlight both awareness of comorbidities and chronicity of CSU.