정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

중금속-단백질 결합을 모방한 모델화합물의 합성 및 확인

이하진,노동윤 서울여자대학교 자연과학연구소 2000 자연과학연구논문집 Vol.12 No.-

The chemistry of mercury has attracted considerable interest due to its unique coordination mode and high toxicity to living systems. Mercurials exhibit an high affinity for organic thiol-containing compounds. Therefore, an investigation on the coordination chemistry of mercury with donor ligands is important to reveal a biological function of mercury in a body and to study a detoxification of heavy metals such as zinc, cadmium and lead as more extensive work. Mononuclear mercury(II) -thiolate complexes with three monothiolate ligands were reported as a model complex of Hg(II) - MerR. In this paper, we report the synthesis of mercury(II) complexes with multisulfur ligand such as dphdt, phdt, dddt and i-mnt and investigate their structural properties through FT-IR spectroscopy as well as the solution chemistry by UV/vis, 1H-NMR spectroscopy. This can be expected to be a model compound for heavy metal receptor site in the Hg-MerR metalloregulatory protein.

발전기 고정자 권선용 마이카/에폭시 수지의 표면 및 구조분석

이상교,심재선,정의남,송우창,박하용,심상흥,임윤희,박종국,심낙순 三陟大學校 1998 論文集 Vol.31 No.1

The purpose of this study is to determine the ageing mechanism of Mica/Epoxy composite material for large generator stator windings in order to estimate remaining life of generator. X-ray analysis is performed to investigate the position and structure of mica crystal in insulation materials. The phase change of aged and sound specimen under each atmosphere isn't observed. Surface analysis of insulation materials by optical microscope also show that the sound and aged specimen, sliding phenomenon by shear and thermal stress is observed both interface between mica and epoxy.

T subset定量을 위한 抗牛赤血球 IgG抗體의 分離·精製

夏潤文,李振鏞,林壽德 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1981 東西醫學硏究所 論文集 Vol.1 No.1

사람에 있어서 免疫담당세포의 하나인 T 細胞는 몇몇 subpooulation으로 나누어지고 있으며, 그중 ?? 및 ??를 同定하는 수단으로 사용되는 牛赤血球抗體중에서 우선 純粹 IgG抗體를 分離, 精裂하였으며, 이 精裂된 IgG抗體는 標準製品과의 比較實驗에서 ?? 細胞의 一致되는 成積을 얻을 수 있었다. Antisera to ox red blood cell were prepared by intraperitioneal hypermultiple injections without adjuvant in outbred white rabits. Purified IgG fraction from these rabbits anti-ox red blood cell antiserum for T subset assay was obtained by precipitation with 50% saturated ammonium sulphate followed by DEAE-cellulose chromatography and Sephadex G-150 gel filtration. These purified IgG fraction was compared with Cappel company standard IgG fraction for ?? subpopulation assay. We used home-made IgG fraction and obtained favorable results in ?? subpopulation assay as Cappel company standard IgG fraction.

대학 강의실 환경개선 후 평가(POE) 연구 : 강의실 리모델링을 중심으로

하미경,제해성,이경희,소윤경 대한건축학회 2004 대한건축학회논문집 Vol.20 No.10

According to the results from the evaluation, that was enforced by the Academic Affairs of Y University in the year 2002, the satisfaction level of interiors of classrooms appeared to be very low Only 11.6% of the respondents said that they felt comfortable in classroom environment The other 54.8% said that they were unsatisfied with the physical quality of classrooms at school In addition, students demanded a change in such items as lighting, air circulation, room temperature, worn out chairs and desks, and the size of the classrooms It is surprising to see that classrooms that have been built during the evolution of technology have created such a discomfort to students Therefore, creating a comfortable environment for all classrooms throughout the campus by applying a systematic approach that would meet students' needs is the purpose of research The results show that the project of remodeling has improved the quality of classrooms and increased the level of satisfaction on the overall classroom environment

대학 체육교육과와 체육학과의 전공교육과정에 대한 비교연구 : 과목명칭과 학점 및 시간수를 중심으로

이광재,하명수,김윤래 江原大學校附設體育科學硏究所 1988 江原大學校附設體育科學硏究所論文集 Vol.- No.13

To identify the difference of Major Curriculum between Department of Physical Education in College of Education of both different department were compared as follows. Theoritical Subjects had more Score than Practical Skill, and elective Subjects had more score than required subject in a credit of Major subject. There was no differencies in the name of Subject. The numbers of credit according to theoritical area on major subject which consists more score than other major subjects were following orders; Teaching of P.E, Measurement and Evaluation of Physical Education, Health Education, and Sports Philosophy in P.E Dept. of Educational College. Sports Philosophy, Sports History, Measurement and Evaluation of P.E, and Administration of P.E in P.E Dept. of College of Sports Science. On the other hand practical skill of major subjects was following order. Ball Game, Gymnastics, Dance, and Tract and Field in both Department. But there is much more needs of course of study for handcapped.

수중환경 변수의 변화에 따른 능동소나 표적검출 성능분석에 관한 연구

윤대희,이충용,성하종,박성범,정형성 연세대학교 산업기술연구소 1997 논문집 Vol.29 No.2

In this paper, the performance of active sonar system is analyzed under various underwater acoustic environments using the multipath eigenray model in shallow water. In addition, an approximated shallow-water propagation model is proposed for the active sonar based on MacPherson and Daintith's model and corresponding equations comprising active sonar parameters are derived. To analyze the sonar performance according to the changes of various sonar parameters, a large number of measurements and results in ocean acoustics and digital signal processing are combined. The proposed model is compared with the multi-path eigenray model in terms of the echo level passed through the beamformer, the input SNR of the detector and the detection probability.

한국 자생 구절초 종류의 정유성분 비교분석 및 항생제 내성 Salmonella 속 균주에 대한 억제효과

변연희,정은영,정하숙,이연희,신승원 德成女子大學校 藥學硏究所 2008 藥學論文誌 Vol.19 No.-

The essential oils from the aerial parts of three varieties of Chrysanthemum zawadskii cultivated in the herbal garden of Duksung Women' s University were extracted by steam distillation method and their compositions were compared by GC-MS analysis. The composition of essential oil fractions from the three varieties of C. zawadskii significant differences in their compostion. While the predominant components of C. zawadskii were camphor and borneol, C. zawadskii var. tenuisectum contained myrtenol and germacrene D as representing compound of its essential oil. C. zawadskii var. nakdongense oil showed higher contents of germacrene D than other two varieties of C. zawadskii. As the results of the determination of the effects of this oil and its main components on antibiotic-susceptible and -resistant strains of Salmonella enteritidis and S. typhimurium, the main components of C. zawadskii oil fraction, borneol and camphor, significantly inhibited all strains of the two Salmonella species examined, while its oil fraction showed relatively weak activity. In evaluation tests of the combination effects of the oils with kanamycin or streptomycin using a checkerboard microtiter assay, C. zawadskii oil fraction combined with streptomycin resulted the most significant synergism in this study with the fractional inhibiting concentration index (FICI) of 0.19.

竹茹와 蘿蔔子가 實驗的 糖尿에 미치는 영향

明聖河,李學仁,金蓮燮 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

This experiment was performed into investigate the effect of Bambusae Caulis and Raphani Semen on the diabetic rats induced by streptozotocin. Experimenal diabetes was induced by 55㎎/㎏ of streptozotocin injection and administered Bambusae Caulis and Raphani Semen extract during 3 days after streptozotocin injection. Glucagon and insulin granules in Langerhans islets were stained by use of immunohistochemical method and observed the relative amount of the each granules in Langerhans islet by light microscope and image analysis system. The results obtained are as follows: 1. Area % of insulin granules in Langerhans islets of Bamhusae Caulis extract adminstration group increased and showed the statistically significant difference with the control group at 7th day and 14th day. 2. Area % of insulin granules in Langerhans islets of Raphani Semen extract adminstration group increased and showed the statistically significant difference with the control group at 14th day. 3. Area % of glucagon granules in Langerhans islets of Raphani Semen extract adminstration group decreased and showed the statistically significant difference with the control group at 14th day. With the above result, we know that Bambusae Caulis and Raphani Semen has a control effect on glucagon and insulin granules in Langerhans islets of diabetic rats induced by streptozotocin.

소아천식의 급성기 치료에 있어서 Jet-Nebulized Isoproterenol의 효과 -제1보-

안연모,이하백 한양대학교 의과대학 1989 한양의대 학술지 Vol.9 No.2

Inhalation therapy has dramatically improved the lifestlye of the younger children with asthma, reflecting both the availability of more effective and safer drugs and alternative methods for their delivery appropriate for the child's age. Requiring further studies, isoproterenol inhalation by the new jet-nebulizer seems to be useful for the management of acute childhood asthma.