당뇨병성(糖尿病性)족부병변(足部病變)의 임상적관찰

이홍규,민헌기,이문규,정민화,원암우,김성연 대한당뇨병학회 1984 Diabetes and Metabolism Journal Vol.8 No.1

혼성 Cresol 과 POCl3 의 반응에 의한 tri - Cresyl Phosphate 의 분리공정 연구

이상석,김장규,원성호,양승남,김남기 한국산업안전학회 1998 한국안전학회지 Vol.13 No.2

Tri-cresyl phosphate(TCP) was synthesized by reaction of phosphorus chloride with mixed cresol(mixture of m-cresol, p-cresol,and others) in the presence of AlCl₃. Some of unwanted products and unreactants colored TCP. In order to separate TCP from these, vaccume distillation was carried twice, but colorless TCP could not be producted. Separation of unwanted materials by 2% NaOH solution was introduced before first and second distillation and optimal separation conditions such as NaOH concentration, mixing volume ratio, mixing time, and rpm were investigated for new batch separation and production of colorless TCP. Optimal conditions were 2% NaOH solution, 36% mixing volume ratio of 2% NaOH solution, 1.5 hours of mixing time, and 20 rpm.

변형된 트랜스듀서 및 FM을 이용한 이식형 인공중이 시스템의 전력효율 개선

윤영호,원철호,송병섭,정영숙,김명남,박세광,이상흔,조진호 경북대학교 전자기술연구소 1997 電子技術硏究誌 Vol.18 No.2

In design of implantable middle ear system, it is necessary that the system has a high power-transfer efficiency because die internal circuit of the system has no power source. The FM transmission method transfers the signal power more efficiently than AM method because AM signal has large carrier component which act as the loss. Therefore, an implantable middle ear system using FM transmission and receiving method is proposed. And the new shape of vibrating transducer which vibrate more efficiently than the conventional type was designed. This tranducer is consisted of coil and small T-type cylindrical permanent magnet. The differences between conventional methods and proposed methods are investigated and compared through quantitive analysis. The advantages of proposed methods are proved by experiments.

EEA - VLDPE compound 의 Mg(OH)2 혼합에 의한 난연성

김경태,이상석,김장규,원성호,김남기 한국산업안전학회 1998 한국안전학회지 Vol.13 No.3

In order to study the change in mechanical properties and anti-flammablilty of ethylene-ethylacrylate copolymer(EEA) very low density polyethylene(VLDPE) compound that could be used as communication cable sheath using Mg(OH)₂ as a non-toxic flame retardant, 100, 125, and 150phr Mg(OH)₂ were added to 100 parts of EEA-VLDPE compound, 100 EEA : 0 VLDPE, 50 EEA : 50 VLDPE, and 0 EEA : 100 VLDPE, respectively. Mg(OH)₂ was a good non-toxic flame retardant for communication cable sheath and anti-flammability increased with the amount of Mg(OH)₂ in compound. The mechanical properties-MI, Ts, and Eb-decreased with increasing in the mixing ratio of EEA but oxygen index(OI) increased with increasing in the amount of EEA. The best composition of Mg(OH)₂ in this study was 150phr to 50 EEA : 50 VLDPE compound for the anti-flammability.

기관지내 전이암

김현수,이상수,오미희,이재갑,원구태,홍희승,용석중,신계철 대한내과학회 1991 대한내과학회지 Vol.40 No.4

The lung is the most common site of metastasis of extrapulmonary malignant tumor. According to past reports, metastatic cancer of the lung has been found in about 2% of all patients at autopsy. But these days, a diagnosis of endobronchial metastatic cancer utilizing bronchoscopy only is not easy. Thus we need other means of gathering more informaction, such as past history, discovery of other metastatic sites, and pathologic findings with special staining and electronmicroscope, especially in cases of poorly differentiated adenocarcinoma and epidermoid cancer, which are common types of primary lung cancer. We present 5 cases of endobronchial metastatic cancer. We found endobronchial metastatic cancer 2 cases of cervix cancer (epidermoid, adenocarcinoma), 1 case of colon cancer (adenocarcinoma), hypernephroma (renal cell carcinoma), and bladder cancer (transitional cell carcinoma). Since it was impossiole to diagnose the metastatic adenocarcinoma from the cervix only with lightmicroscopic findings, we could use past history and unusual radiologic and bronchoscopic findings which was thought to be the specific endoscopic finding of metastic endobronchial cancer. The interval between the diagnosis of the primary cancer and endobronchial metastatic cancer was 25.7 months. In the future, development of immunohistochemistry, monoclonal antibody, and molecular biologic techniques will give us diagnostic clue for differential diagnosis of metastatic endobronchial cancer from primary bronchogenic lung cancer.

Mo 함유 Zr 합금의 인장 및 크리프 특성

이원식,권숙인,황선근,이창규,김명호,변재원 대한금속재료학회(대한금속학회) 2000 대한금속·재료학회지 Vol.38 No.5

One of the major reasons for utilizing Zr-base alloys in nuclear reactors is its good resistance to creep. Tension and creep deformation behaviors of Zr-1Nb-1Sn-0.1Fe alloy (0%Mo alloy) and Zr-1Nb-1Sn-0.1Fe-0.5Mo (0.5%Mo alloy) were evaluated to investigate the effect of Mo addition on mechanical properties and anisotropy. The addition of Mo increased the tensile strength through solid solution hardening. Room and high temperature tensile strength of TD(transverse direction) specimens were higher than those of RD(rolling direction) specimens. The TD specimen of 0.5Mo alloy showed higher elongation at room temperature than the RD specimen due to lattice rotation resulted from twin deformation. The stress exponent, n, obtained in creep test lied between 2.3 and 4.5 in both RD and TD specimens and the viscous glide was the predominant mechanism in creep deformation. The 0.5%Mo alloy showed higher creep resistance than the one without Mo.

하기도 감염증 환자의 치료에 있어서 Ceftibuten과 Cefaclor의 유효성 및 안전성 비교평가를 위한 임상시험

이홍렬,김세규,장준,김성규,이원영 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2

Ceftibuten은 β-acyl side chain에 carboxye-thylidine moiety를 가진 aminothiazolyl cephalosporin으로, 전형적인 plasmid β-lactamase 및 새로운 TEM 효소에 대하여 구조적이 안정성과 경구 복용시의 흡수 정도가 향상되었다. 다른 3 세대 경구용 cephalosporin과 마찬가지로 항균력이 비경구용 cephalosporin와 비슷하고 약력학적으로는 더 우수하기 때문에 외래 환자들의 하부 호흡기계 감염에 비경구용 약제의 차선책으로 사용이 가능하다. 본 연구에서 병원외에서 발생한 하부 호흡기계 감염을 대상으로 ecftibuten과 cefaclor를 투여한 결과 임상 양상은 모두 치료후에 호전되었다. 임상적으로 유효한 cure와 improvement의 예는 ceftibuten군에서 89.7%, cefaclor군은 87.5%씩 이었고 양군간에 유의한 차이는 없었다. 세균학적으로 ceftibuten 군에서 elimination이 더 많았으나 역시 양군간에 유의한 차이는 없었다. Ceftibuten군중 3.0%, cefaclor군은 7.4%에서 부작용이 관찰되었다. 이상의 결과로써 ceftibuten은 병원외에서 발생한 하부 호흡기계 감염에 대하여 외래에서 효과적으로 사용할 수 있는 항생제라고 생각된다. Ceftibuten is the aminothiazolyl cephalosporin, which contains a carboxyethylidine moiety at position 7 of the β-acyl side chain. The provides β-lactamase stability against both the classic plasmid β-lactamases, and also the new TEM enzymes, and excellent absorption by the oral route. Because, similarly to other oral third-generation cephalosporins, ceftibuten has the expanded antimicrobial spectrum like parenteral third-generation cephalosporins and better pharmacokinetic properties, it may be a good alternative against lower respiratory tract infection, mainly in the outpatient setting. In this study, we examined the efficacy and safety of ceftibuten in the patients with the community-acquired lower respiratory tract infection. We administrated ceftibuten or cefaclor in randomized comparative manner. Clinical manifestations were improved in both groups and overall effective rates were 89.7% in ceftibuten group and 87.5% in ceftclor group with no significant difference. Most isolated pathogens were eliminated by ceftibution such as Haemophilus influenzae, Streptococcus pneumoniae and so on, even though cases were not sufficient. There was no serious adverse effect by ceftibuten. Conclusively, ceftibuten was thought to be an effective oral antobiotic against community-acquired lower respiratory tract infection in the outpatient setting.

Penstemon penlandii 의 발아촉진방법

이석영,최원열,백형진,윤문섭,줄리라프만 한국국제농업개발학회 1999 韓國國際農業開發學會誌 Vol.11 No.2

Penstemon penlandii는 미국의 록키산맥에서 소집단으로 발견되나 자연상태에서는 발아가 불량하여 멸종위기에 처해있어 이 식물의 보존을 위한 발아방법을 구명하기 위하여 본 시험을 수행한 결과는 다음과 같다. 1. P. penlandii종자는 thermogradient에서 발아시킨 결과 10-30, 15-25, 20-30, 25, 25-30 그리고 15-30℃ 등의 변온조건에서 발아가 증진되었으며 높은 온도 조건에서는 미생물 오염에 의해 발아 및 유묘생장이 장해를 받았다. 2. 30psi에서 10-20초 동안 종피에 자극을 주었을 때 발아율 및 발아속도지수가 높았으나 일부 종자는 휴면타파가 이루어지지 않았다. 3. 종피에 물리적자극을 준 종자를 1mM의 GA3에 24시간 동안 침지하면서 15ccs-1속도로 aeration 시킨 후 blotter에 치상하였을 때 발아가 가장 촉진되었다. This study was undertaken to determine the germination requirements of Penstemon penlandii. The highest germination occurred using the scarified seeds (either hand or mechanical) on the thermogradient plate at 10-30, 15-25, 20-30, 25, 25-30 and 15-30℃. Individual germinators were used to verify thermogradient plate results, and speed of germination analysis suggested that 15-30℃ was the optimum temperature for rapid germination of P. penlandii after mechanical scarification. Laboratory germinations at 15-30℃ of mechanically scarified seeds (20-30 psi and 10-80 seconds) were correlated with seedling emergence in the greenhouse. Scarification rates of 30psi for 10-20 seconds produced highest rates of germination and emergence in laboratory and greenhouse tests. The germination procedure of submerging seeds in aerated 1mM GA3 for 24hours, placing seed on water moistened blotters at 15-25℃, and hand scarifying ungerminated seeds after 14days and allowing them to germinate for an additional week gave comparable germination percentage to hand scarification, mechanical scarification, and tetrazolium viability. Based on these data the recommended germination method for this species would be to submerge seeds in aerated (15ccs-1)1mM GA3 for 24h, place seeds on water moistened blotters, make the first counts at 14d and hand scarify the remaining dormant seed with final counts at 21d, or scarify seed by hand or with a mechanical scarifier before germination on blotters moistened with 1mM GA3, and counted after 7, 14, and 21 days.

Dieulafoy 양 병변에 의한 십이지장게실 출혈 1 예

김상현,김경환,이동현,송철수,정노원,박상제,김은규,하홍성,나일환,황윤이,성은영,최익수,신영기 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.1

Duodenal diverticula are first reported by Chomel in 1710. Duodenal diverticula are relatively common in adults with a prevalence of 23% in SRCP. The most duodenal diverticulum is asymptomatic. Complications such as obstruction, cholangitis, blliary stones, ulceration, perforation and hemorrhage can occur in approximately 10%. However, relatively few cases of bleeding from a duodenal diverticulum have been reported. The cause of bleeding from a duodenal diverticulum is uncertain and various suspected etiologies were suggested, such as ectopic gastric mucosa, stasis-induced ulceration, erosion into major vessels, aortoenteric fistuias, intradiverticujar polyp, aspirin-induced erosion. We report a case of a bleeding duodenal diverticulum by a Dieulafoy-like lesion and suggest this 1esion as one of posslble causes of blee4ng in duodenal diverticulum.

성인에서 반복적인 위장관출혈로 발현한 공장 거대 중복성 낭종

김영호,이경수,이상수,문원,강태욱,최규완,박동일,도재혁,백승운,이풍렬,이종철,김재준,류민규 대한내과학회 2001 대한내과학회지 Vol.61 No.3

Duplication of the alimentary tract is an unusual congenital anomaly which may occur at any level, from the oral cavity to the rectum. Jejunal duplication cyst is quite rare and most of them are presented in infancy with the symptoms of abdominal mass, obstruction, hemorrhage and perforation. But some cases has not been diagnosed till adult if duplication cyst was too small enough to cause symptoms. We report a case of a 28-year-old woman who presented with recurrent gastrointestinal hemorrhage as a result of an ulceration without ectopic mucosa in jejunal duplication cyst and was successfully treated with surgery.(Korean J Med 61:264-269, 2001)