당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

維新벼에 나타난 生育後期의 萎週

朴鍾聲,金文圭,禹基大,劉勝憲 충남대학교 농업과학연구소 1977 農業技術硏究報告 Vol.4 No.1

1. Chemical properties of soils and inorganic compositions of rice plants were analysed to explain the acute wilting occurred in the late stage of rice variety, Yusin. The results obtained were summarized as follows. 1) The amount of K and S_iO_2 of soils where severe rice wilting occurred was lower than that of soils where rice wilting didn't occurred. 2) The amount of N and FeO of wilted rice plants was higher than that of normal rice plants while the amount of K_2O and SiO_2 and the ratio of K_2O/N of former were lower than that of letter. 2. Severe wilting was occurred only in the rice variety, Yusin, when three varieties… Yusin, Milyang #15, Milyang #23……were interplanted. The amount of organic and inorganic compositions of three varieties and chemical properties of rhizosphere soils were analysed. 1) The rice variety, Yusin, was the lowest and that of the rice variety, Milyang #15, was the highest in the level of total carbohydrate and hemicellulose. 2) Comparatively higher levels of K were observed in rhizosphere soil where Yusin was planted, while the level of the K in the plant of Yusin was the lowest.

한국 초파리집단의 선택불리에 관한 지구 자기장의 5배인 자기장의 영향

박은규,정승문,김중현,최오목 圓光大學校 1995 論文集 Vol.29 No.2

본 연구에서는 한국 선유도의 자연집단 야생형 초파리와 가시돌연변이형 황색체-소시 초파리를 Helmholtz coils 장치를 이용해서 유도한 지구 자기장의 5배인 자기장내의 집단과 비교 집단인 지구 자기장내의 집단에서 발생율 변동과 성적 선택빈도를 조사하여, 선택불리에 관한 유전적 행동을 관찰해서 다음과 같은 결과를 얻었다. 1.야생형 유전자(+)를 운반하는 염색체의 선택빈도는 15세대까지 평균 빈도가 지구 자기장의 5배인 자기장내의 초파리 집단, 지구 자기장내의 초파리 집단이 각각 0.6489, 0.6553으로 관찰되었다. 이 결과는 지구 자기장의 5배인 초파리 집단에서 더 강한 선택불리 행동을 보여 주었다. 2.초파리 집단의 발생율 변동은 지구 자기장의 5배인 자기장내의 초파리 집단 3세대(13.60%), 지구 자기장내의 초파리 집단 6세대(22.35%), 8세대(22.30%)에서 아주 낮은 발생율의 변동을 보여주었으며, 2개의 상이한 자기장내 초파리 집단의 전체 평균 발생율은 지구 자기장의 5배인 자기장내의 초파리 집단, 지구 자기장내의 초파리 집단에서 각각 58.07%, 41.93%로 관찰되었으며, 후자보다 전자에서 발생율이 증가함을 보여 주었다. 3.돌연변이형 황색체-소시 유전자(ym)를 운반한 염색체의 선택빈도는 각각의 자기장내의 초파리 집단에서 0.0542, 0.0646으로 관찰되었다. 이 결과는 지구 자기장의 5배인 자기장내의 초파리 집단에서 0.0542로 상대적으로 강하게 선택불리 행동을 보여 주었다. 4.돌연변이형 황색체 유전자(y)를 운반한 염색체의 선택빈도는 각각의 초파리 집단에서 0.0185, 0.0144로 관찰되었다. 이 결과는 비교 집단인 지구 자기장내의 초파리 집단에서 0.0144로 더 강한 선택불리 행동을 보여 주었다. 5.돌연변이형 소시 유전자(m)을 운반한 염색체의 선택빈도는 각각의 조절된 자기장내의 초파리 집단에서 0.0328, 0.0190으로 관찰되었다. 이 결과도 지구 자기장내의 초파리 집단에서 0.0190으로 상대적인 강한 선택불리 행동을 보여 주었다. 6.수컷이 가지고 있는 Y-염색체의 선택빈도는 각각의 초파리 집단에서 0.2457, 0.2467로 관찰되었다. 이 결과는 지구 자기장의 5배인 초파리 집단에서 0.2457로 더 높은 선택불리 행동을 보여 주었다. 7.Duncan's multiple range test의 LSD값으로 유의 차이 유무 검정을 하였던 바 야생형 유전자의 A 그룹과 돌연변이형 유전자들의 B 그룹사이에서 고도의 유의 차이가 있음이 밝혀졌다. To elucidate the genetic behavior of selective disadvantage among visible mutants of Drosophila melanogaster bred and kept by the genetic study laboratory room. Wonkwang University and the wild type collected at Sunyoudo island in Korea, and reared under the influence of two different strength of magnetic fields, i.e. the quintuple and the ambient magnetic field, this study was carried out at the above indicated laboratory room. 1.The mean selective frequencies of wild gene(+)-carry chromosome up to 15th generation, affected by two different magnetic fields, showed 0.6489 and 0.6553 with the magnetic field strength as mentioned order before. The data explains that the population of Drosophila melanogaster reared in the quintuple magnetic field showed higher selective disadvantage. 2.The variations of emergence rates of the populations of Drosophila melanogaster altering by generation showed the drastic lowest values at the specified generation, for example, 13.60% under the quintuple magnetic field at the third generation and 22.35% and 22.30% under the ambient magnetic field at the 6th and 8th generation. The over-all mean emergence rates of the populations of Drosophila melanogaster reared in controlled magnetic fields, i.e. the quintuple and the ambient magnetic fields using Helmholtz coils, showed 58.07% and 41.93% respectively. Referring to these data, the population of flies raised in the quintuple magnetic field showed a relatively higher emergence rate than the ambient magnetic field. 3.The mean selective frequencies of the individual of ym gene-bearing chromosomes showed 0.0542 and 0.0646 by the same order of magnetic field strength indicated above. It was shown that the population of flies reared in the quintuple strength generated by Helmholtz coils cleared the relatively strong selective disadvantage being 0.0542. 4.The mean selective frequencies of the mutant that carries y gene-bearing chromosome showed 0.0185 and 0.0144 from the two different magnetic fields in the same magnetic order. The results indicated that the population of flies from the ambient magnetic field showed higher selective disadvantage frequency, 0.0144. 5.The mean selective frequencies for the mutant carrying m gene-bearing chromosome were calculated as to be 0.0328 and 0.0190 for the same order of magnetic field strength. The found from this results is that the selective disadvantage behavior for the mutant rearing m gene chromosome in the ambient magnetic field was stronger than the one, being 0.0190. 6.The mean selective frequencies of the male flies which carries Y-chromosome showed 0.2457 and 0.2467 respectively. The results indicated that the male flies from the quintuple magnetic field showed higher selective disadvantage being 0.2457. 7.Through Duncan's multiple range test and LSD value, the highly significant differences between A group of the wild type and B group of the other three mutants were calculated.

마약길항제의 방출 제어형 제제 (제2보) : 나록손 이식제제의 생체적합성 및 약물속도론적 평가 Biocompatibility and Pharmacokinetics of Naloxone Implant

문미란,박주애,이승진,김형국,김길수 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

For the effective administration of narcotic antagonist, the application of sustained release implantable systems with biodegradable polyphosphazene was examined. Using poly[(diethyl glutamate)-co-(ethyl glycinate) phosphazene]. the implantable devices containing naloxone hydrochloride were prepared and in vivo implantation studies were carried out subcutaneously in rat and rabbit with this preparation for the biocompatibility and pharmacokinetics. The histological finding in rats at initial time period was the inflammation that occurred focally around the implants, but they were showed subsequent mild and limited chronic inflammations and the irreversible changes such as necrosis and degeneration of the muscle or connective tissues were not observed. Therefore the placebo and naloxone implants are considered to be biocompatible formulations histologically. In pharmacokinetic studies, the release of naloxone from the naloxone implants into blood plasma was maintained in 192 hours, but the initial burst effect was observed. If this problem was solved, the application for the narcotic antagonist sustained release systems can be expected.

CFRP 적층복합판의 충격 손상 예측 : PartⅡ: 실험 PartⅡ: Experiment

박승범,김문생 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.52 No.-

본 논문에서는 충격하중에 의하여 적층복합재의 내부에 발생하는 충격 손상의 발생과 진전에 대하여 연구하였다. 이를 위하여 강구에 의하여 횡방향 충격을 받는 CFRP 복합재료에 대하여 충격실험을 행하여, 초음파 탐조영상장치로 충격손상을 관찰하였다. 개발한 충격손상 유한해석에 의하여 예측된 결과와 비교 검토하였다. 충격에 의하여 발생하는 손상중 가장 큰 손상의 형태는 층간분리 손상으로서 충격이 계속 진행됨에 따라 경계면을 따라 진전되며, 길이방향은 경계면에 인접한 아래 단층의 섬유방향을 향한다. 충격을 가하는 외부 물체의 충격속도가 증가함에 따라 층간분리의 길이와 폭은 거의 선형적으로 증가하였다. 그리고 횡방향의 폭의 증가율 보다 종��향의 길이의 증가율이 더 크게 나타났으며, 층간분리의 진전은 주로 종방향인 길이방향으로 진행되었다. An investigation was performed to study the initiation and propagation of impact damages in laminated composites subjected to transversely impact of steel ball. For this purpose, transversely impact experiments for CFRP laminated composite plates were conducted, and impact damages were observed using the ultrasonic image scan system. As a results, interface delamination was a major impact damage mode and the longitudinal direction of the dilamination paralled to the fiber direction of the bottom layer below the interface. A linear relationship holds between impact velocity and the longiudinal length and transverse width of delmaination, and the ratio of growth in the longitudinal direction is high than in the transverse direction.

농촌지역 국제결혼 이주 여성들의 사회생활 적응 교육을 위한 실태 분석

박행모,문승태 한국농업교육학회 2008 농업교육과 인적자원개발 Vol.40 No.2

본 연구의 목적은 한국 남성과 국제 결혼한 이주여성들의 사회생활 적응 수용 실태를 조사분석하여, 이들이 한국 사회에서 적응할 수 있는 다양한 교육프로그램을 개발하고자 하는데 있다. 전남지역에 거주하는 국제 결혼한 이주여성 155명을 연구대상으로 삼아, 이들의 사회문화 적응 실태를 설문지로 파악하였고, 통계적 분석은 빈도, 백분율, F 검증, 사후검증을 실시하였다. 이 연구로부터 나타난 결과를 제시하면 첫째, 이주 여성들이 사회생활에서 가장 중점을 둔 활동은 가사활동으로 그 중에서 장 담그기, 김치 담그기 등의 활동을 가장 어려워하는 것으로 나타났다. 둘째, 이주민의 학력에 따른 만족정도에서는 학력이 중졸 이하인 이주민이 '가족과 한국의 소비문화 만족 정도', '한의학(민간요법) 만족 정도'에서 고졸 및 대졸이상보다 만족 정도가 높게 나타났다. '영화 감상'에서는 고졸이 중졸 및 대졸보다 더 많이 감상하는 것으로 나타났다. '한국인의 헤어 스타일 만족 정도'는 고졸이 중졸 및 대졸보다 더 만족하는 것으로 나타났다. 그리고 한국의 '한국의 상차림 문화 만족 정도'에서는 종졸이하가 고졸, 대졸보다 더 만족하고 있는 것으로 나타났다. 셋째, 한국에서의 생활기간에 따른 이주민의 만족 정도에서는 거주기간이 1년 미만과 5년 이상인 경우에 한국 생활에 더 만족하는 것으로 나타났다. 그 중 음식문화에 대해서는 생활기간이 1~3년인 경우에 만족도가 높은 것으로 나타났다. 이러한 연구를 바탕으로, 한국 남성과 결혼한 이주 여성들이 사회생활에 적응하기 위해서는 이주민 국가의 고유한 사회문화를 한국사회 문화와 자유롭게 향유할 수 있는 환경을 조성하여야 하며, 그들이 한국사회에 적응할 수 있는 다양한 다문화 교육 프로그램 등의 개발이 요구된다. This study examines and analyzes for society adjustment Education of Rural Area Immigrants' woman who married Korean men and lived in Jeonnam and aims to seek the methods for them to adjustment themselves to Korean society. It selected 155 immigrant women who live in Jeonnam regions as the subjects of research and they were asked to complete questionnaire of their awareness of multiculture in Korean society and their adjustment to social life. For statistical analysis, frequency, percentage, F test were conducted. Results of this study are suggested as follows; First, activity that immigrant women gave priority in Korean life was housework, but they felt making soy bean sauce and Kimchi was very difficult. Second, as a result of analyzing the influence of immigrant women's education on their social adjustment, life and food culture in Korea, it was found that immigrant women having education below middle school had higher satisfaction with 'consumption culture of Korea' and 'herb medicine (folk remedies)' than those who have education of high school and university graduation. In addition, in the degrees of their satisfaction with 'Korean style of setting the table', those who have education below middle school showed higher satisfaction with it than those who have education of high school or university graduation. Third, concerning their period of life, social adjustment and satisfaction with Korean life, those who live in Korea for less than one year and over five years showed more satisfaction with Korean life and those who live in Korea for one to three years had higher satisfaction with Korean food culture. Therefore, such an environment that immigrant women who married to Korean can enjoy their own culture and Korean culture should be established for their easy adjustment to Korean society.

糖蜜吸着 煉炭灰飼料의 添加가 肉鷄의 發育에 미치는 影響

朴成振,文勝式,宋瑛敏 진주산업대학교 1989 論文集 Vol.27 No.-

본 시험은 육용계(Arbor acres) 160수를 공시하여 당밀 흡착연탄재사료(Molasses-absorbed briquette ash feed : MBF)를 육계사료에 0, 2, 4 및 6% 수준으로 첨가하였을 때 사양성적, 도체율, 복강지방, 소화기관, 계분의 수분과 회분 및 경제성 등에 미치는 영향을 조사하기 위하여 실시하였다. 1. 종료시 체중과 증체량은 MBF첨가에 의해 개선되었고 그 경향은 2% 및 4% 구에서 크게 나타났다(P<0.05). 2. 사료효율은 2%구에서 가장 좋은 경향이었고 2%구와 6%구를 제외한 다른 구에서는 차이가 없었다(P>0.05) 3. 도체율과 복강지방은 각구에서 큰 차이가 없었다. 4. 소화기관의 중량 및 길이는 각구에서 큰 차이가 없었다. 5. 계분의 수분함량은 각구에서 비슷하였으나 회분함량은 첨가 수준이 높을수록 증가되었다. 6. 경제성 분석 결과는 2% 및 4%에서 양호한 편이었다. This experiment was performed to study the effects of addition levels 0, 2, 4 and 6% of molasses-absorbed briquette ash feed(MBF) on 180 broilers. On the growth, dressing percentage, abdominal fat, gastrointestinal tract, moisture and ash content in excreta and economics were investigated. The results are summarized as follows : 1. Final weight and weight gain were significantly higher in MBF added 2% and 4% group(P<0.05) 2. Feed efficiency was significantly(P<0.05) higher in 2% group and was not differences between other expect 2%, 6% group. 3. Dressing percentage and abdominal fat was not significantly each group. 4. Gastrointestinal tract weight and length was not significantly each group. 5. Moisture contents in excreta were didn't show significant differences between the each treatment group, but ash contents in excreta increases according to the increasing level of MBF. 6. Optimun level of maximum profit on economic analysis was found to be 2% and 4% group with broiler chicks.

産卵鷄에 대한 練炭灰添加給與 效果에 關한 硏究

朴成振,文勝式,鄭場龍 진주산업대학교 1982 論文集 Vol.20 No.-

This experiment was conducted to investigate the effect of Briquette ash treatment on egg production rate, egg weight, feed conversion and egg quality with date obtained from 100 pieces egg type fowls Babcock (B 380, 230days-age) fed and allotted 5 treatments at the rate of 0%(C), 0.5%(T_1) 1.0%(T_2), 1.5%(T_3)AND 2.0%(T_4) during the experiment period of 119 days from May 21, 1982 to September 20, the same year ar Department of Animal science, Jin Ju Agricultural and Forestry Junior Technical College. The results obtained are summarized as follows; 1. Average egg weight at each experiment plot was 62.21g(T_2) 61.62g(T_3), 60.88g(T_4), 60.42(T_1) and 60.04g(C), but the difference was not significant. Feed conversion at each experiment plot was 2.52(T_2) 2.60(T_3), 2.65(C) and 2.67(T_4). 2. Average egg production rate at each experiment plot was 82.02%(T_2) 81.85%(C) 81.43%(C), 79.41%(T_3) and 78.23(T_4), but the difference was not significant. 3. Weight of egg yolk and albumen were higher at fed with the treated Briquette ash plot than that without Briquette ash plot, and weight of egg shell and thickness were not significant.