Mild Cognitive Impairment 노인군의 점화효과 특성

박재우,김도관,고선규,고효정,김성환,김재경,서민영,이인수,김지혜 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.3

연구목적 : 이 연구에서는 K-MMSE에서 25점 이하를 받은 50대 이상 노인들을 MCI(Mild Cognitive Impairment) 군으로 보고 이들의 인지 기능 특성을 점화 효과를 중심으로 살펴보고자 하였다. 먼저, 점화 효과가 MCI 노인군에서 있어서도 유지되고 있는지를 알아보고, 인지 기능의 손상 정도에 따라 점화 효과가 유의미하게 변화하는 지를 살펴보고자 하였다. 방 법 : 본 연구에서는 K-NAME 점수 25점 이하의 노인 96명으 대상으로 ADAS-Cog와 일종의 간접 기억 검사 도구인 지각적 파악 과제를 제작하여 점화 효과를 측정하여 인지 기능의 퇴행이 시작된 고연령군이 나타내는 암묵 기억 능력 특성을 알아보았다. 점화효과는 컴퓨터 상에 사전 노출된 자극과 그렇지 않은 자극을 순간 노출시켜 미리 노출된 자극에 대해 반응 시간이 줄어들고 정확 반응이 증가하는 정도로써 측정하였다. 이 때 지능이나 연령, 학력 수준과 같은 변인이 미치는 영향을 통제하기 위해 한국판 웩슬러 지능 검사의 <어휘>, <토막> 소검사를 실시하였고, 인구통계학적 변인에 관한 면접을 실시하였다. 통계적 분석 과정에서는 먼저, 연구에서 측정된 점화효과의 특성을 알아보기 점화 효과 측정치의 기술 통계치를 구하였으며 다른 측정 변인들과의 상관 분석을 실시하였다. 마지막으로 측정된 점화효과가 인지 기능의 퇴행 수준에 비례하는 지의 여부를 파악하기 위해 ADAS-Cog 및 나이, 교육 연한 및 지능 수준을 독립변인으로 회귀분석을 실시하였다. 결 과 : 먼저 기술 통계 분석 결과에 의하면 본 연구에 참여한 피보험자들의 경우 점화효과에 의해 미리 노출된 자극을 평균 3.6개 더 정확히 파악하였으며 평균 59ms 더 빠르게 반응한 것으로 나타나 이들 집단에서도 점화효과가 유지되고 있음을 알 수 있었다. 다음으로 변인들 간의 상관 분석 결과에 따르면, 정확 파악 반응 점수에 따른 점화효과는 전반적인 인지 기능을 평가하는 K-MMSE 및 ADAS-Cog와 정적인 상관이 있는 것으로 나타났으며 반응 속도로 측정한 점화효과의 경우에는 나이와는 정적인 상관이, KWIS의 <어휘> 소검사 점수와는 부적인 상관이 있는 것으로 나타났다. 또한, 본 연구에서 사용된 점화 효과 측정치를 종속 변인으로 ADAS-Cog와 KWIS의 어휘 및 코막 소검사로 측정한 지능 수준, 나이와 교육 연한과 같은 인구 통계학적 변인을 독립 변인으로 회귀 분석을 실시한 결과에 따르면 정화간응 점수로 측정한 점화 효과의 경우 상관 분석 결과에서와 같이 ADAS-Cog 변인만이 유의미한 효과를 갖는 것으로 나타났으며 반응 속도로 측정한 점화 효과의 경우 나이의 효과만 유의미한 것으로 나타났다. 결 론 : 이러한 결과는 경미한 인지 기능의 손상이 진행되고 있는 고연령군의 경우에는 외현 기억 능력은 손상이 시작되지만 점화효과로 측정된 암묵 기억이 전반적으로는 유지되다가 인지 기능의 퇴행이 진행됨에 따라 노출된 자극을 더 정확히 파악하는 능력이 저하되고 점화 효과에 의해 인출 속도가 빨라지는 현상이 연령이 증가함에 따라 함께 증가하는 것으로 나타남을 말해 준다. Objectives : In this study, the cognitive characteristics, especially priming effect, of above 50 years old age group who had less than 25 points in K-MMSE were investigated. Methods : In this study, an implicit memory test measuring priming effect was made and administered ti old age people who had less than 25 points in k-MMSe in screening session. To control the effect of age, educational level and intelligence, demograohic variables were measured, and the subjects of KWIS, vocabulary and block design were administered. Descriptive statistical analysis of the two priming measures and correlational analysis between variables were done. To test the effect of cognitive functioning on priming effect multiple regression analysis was done. Results : Correlational analysis revealed priming score obtained from correct identification response was positively correlated with K-MMSE and ADAS-Cog. And priming score obtained from mean reaction time was positively correlated with age and negatively correlated with vocabulary substest of KWIS. The regression analysis results indicated from correct identification response, whereas age has significant effect on priming score obtained from mean reaction time. Conclusions : The results revealed that as cognitive deterioration progresses priming effect which identify primed stimulus correctly diminish, and as one grow older within age 50 to 70, priming effect which identifies primed stimulus quickly increase.

알코올의 섭취가 흰쥐의 혈액과 간의 지질대사에 미치는 영향

이명숙,김영연,김효숙,김매하,전진순,서진숙,송선미,양영재,윤원손,이미라,이효영,정승현 誠信女子大學校 生活文化硏究所 2004 生活文化硏究 Vol.18 No.-

To investigate the effects of ethanol on the lipid metabolism in blood and liver, twenty one male Sprague Dawley rats had orally taken the 25% alcohol and 50% alcohol by 5g per Kg of weight during 3 weeks after the adjusting period. For the energy balance, 85% sucrose and 45% sucrose was added in control group and 25% alcohol group each. The weight was reduced by alcohol treatment according to the levels, otherwise the weight of liver and heart was little increased in alcohol groups rather than in control without significance. Moreover, RBC, WBC, hemoglobin and hematocrit were increased by alcohol treatment according to the levels without significance. Otherwise, adjusted bilirubin levels by 100g of weight was significantly increased by alcohol treatment dose dependently. Alcohol induced RBC degradation and increased circulated bilirubin because of liver damage. For blood lipid profiles, blood cholesterol was increased in 50% of alcohol group compared to that of 25% and control groups, otherwise, blood triglycerides (TG) was increased by 30% in 25% alcohol groups rather than in control but not significantly different. The hepatic lipid composition, cholesterol levels in alcohol treatment groups was lower than those in control. The hepatic TG was not influenced by alcohol treatment. The two reasons of decreasing hepatic lipids were suggested by 85% sucrose of control for energy balance more synthesized cholesterol and TG than those in 25 or 50% alcohol groups, and by cholesterol and TG could not be synthesized because of liver damage from alcohol.

그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

곡선형 강박스거더 도로교의 단면최적화에 관한 연구

김상효,조성범,정재익 연세대학교 산업기술연구소 1996 논문집 Vol.28 No.1

The steel-box girder decks are widely adopted for middle and long-span bridges due to many advantages, when comparing with other open-section girder types, such as higher torsional rigidity, better resistance against corrosion, etc. In current design practice, the design variables of steel-box girder are selected mainly on the basis of engineer's experience and direct observation. Then the assumed sections are checked for design limit states. Therefore, the resulted design sections are doubtful in the optimum viewpoint. To achieve more rational design, systematic design procedure is required, by which the design constraints on steel-box girders are satisfied and the design variables of minimum cost are obtained. Generally both bending moments by transverse loads and torsional moments by eccentric loadings are the most important load effects in curved steel-box girder bridges. Therefore, an optimization program is developed to consider the torsional moment in addition to other load effects. The efficiency of the developed program has been verified by redesigning some sections selected from existing bridge designs. The resulting optimum sections with discrete variables are found to be cost-saving and comparable with original sections. Based on the parametric studies performed for mainly radius of curvature on curved bridge and bridge width, some essential guidelines for rational design of curved steel-box girder bridges are suggested.

전립선암의 색/출력도플러 경직장초음파검사 : Gleason 점수와의 비교 Correlation with Gleason Score

김효철,김승협,문민환,박병관,김건하,최혁재,윤창진 대한초음파의학회 2002 ULTRASONOGRAPHY Vol.21 No.3

성공적인 지방자치의 발전과제와 역할분담에 관한 연구

김재휴 朝鮮大學校 社會科學硏究所 2001 社會科學硏究 Vol.22 No.1

痛證硏究를 위한 東·西醫學의 觀點

金載孝,孫仁喆,金庚稙 한국전통의학연구소 1997 한국전통의학지 Vol.7 No.2

東西洋을 막론하고 痛證에 대한 人類의 認識은 곧 疾病이라는 관점을 세워왔다. 이러한 관점은 東洋의 最古의 字典인《設文解字》에서 뒷받침하여 "痛,病也病也"라는 의미로 痛證의 뜻을 疾病과 같은 개념으로 언급 하였고, 西洋에서는 "신에 의하여 지배되는 피할수 없는 중노동"이나 "전쟁에서의 부상이나 출산시 등 신에 의하여 운명지워진 아픔 또는 징벌"이란 의미를 지니고 있었다. 醫學的 견지에서 痛證의 정의를 살펴보면, 韓醫學에서는 "不通則痛, 不痛則痛"이라는 관점으로 모든 痛證을 이해한 반면 서양에서는 "실질적 또는 잠재적 조직 소상에 따른 불쾌한 감각과 정서적인 경험이다."라고 정의를 내림으로써, 痛證이라는 현상을 단지 물리적인 현상으로만 이해하기보다는 심리적인 요인이 관여하고 있음을 인정하였다. 이러한 痛證의 연구방향에 있어서, 西洋에서는 痛證에 대하여 神經系와 內分泌係를 통해 硏究를 진행되어 왔지만, 이러한 硏究結果에 心理的 要因에 대한 이해는 반영되지 못하였다. 반면 韓醫學에서는 痛證을 氣血 의 非正常的인 運行의 結果라는 認識 속에서 外感,內傷,情志 等 다양한 原因을 내세워 臨床的으로 활용하고 있었으나, 氣血理論을 現代的인 觀點으로 導出시키는데 不足하였다. 治療方面 에 있어서도 西洋醫學은 關門調節機構, 內在鎭痛系 等을 통해 痛證治療에 응용하고 있으며, 그밖에 禁物과 手術療去을 통해 神經傳導의 遮斷을 통한 鎭痛을 추구 하였지만, 韓醫學에서는 粟物療法은 整體觀的 觀點에서 原因을 治療 하고자 하였으며, 鍼灸療法은 氣血疏通에 障碍를 받는 部位를 解消시키고자하는 方向에서 應用되고 있고, 이러한 鍼灸療法을 통한 通證치료 機轉理解 鍼灸療法의 對象이 되는 氣血·經絡·經穴에 대한 客觀化 作嶪이 神經生理 및 雹氣生理的인 方法이 爲主가 되어 進行되고 있으며, 現在까지의 結果 속에서 볼때 經絡·經穴은 整體觀的인 이해보다는 오히려 神經解剖나 神經生理的인 理解로써만 가능하였다. 본 연구는 痛證 이라는 개념을 체계적으로 인식하기 위하여 病因,病梭,分類,지금까지의 연구방법, 그리고 台療法에 대한 東西洋의 觀點을 전개하여, 痛證硏究를 위한 方向을 정리하고자 하였다. Although the pain is withdraw response and learning in the physiological condition, most of pains have been considered that was the etiology of disease, the processes and the result in worse of the disease' states. Since the ancients, man' conceptions of pain have continually changed and the conceptions have been very subjective. In 1986, Wall and his colleagues recognized that pains are the unpleased sensations and emotional experiences following tissure injuries. This recognition has made pain involed pschycophysical facor and it was similar oriental medicine' theory. Originally western' scientists have considered that the sensation was mediated by the nervous system and their problems were nervous systems' interference. Until now many scientists ard evaluating the effect of pain control about the nervous system and endocrine system. However, oriental medicine's main conceptions are "Qi-Xue"(氣血) theorys and the etiology of pain has been considered that "Qi" was to be obstructed in the 14 collateral vessel or 361 acu-points. We evaluated about pain' concepion in western medicine and oriental medicine. Espescially, in this examination, it was involed that the physiology of the nociceptive sensation, the etiology of pain, mechanism, c1assificaion, therapeutic methods and a view of acupuncture' effects and new methods about pain studies.

버섯 피클(Pickle) 제조 및 저장 중의 품질변화

김상철,김소연,하효철,박경숙,이재성 동아시아식생활학회 2001 동아시아식생활학회지 Vol.11 No.5

The mushroom pickles were prepared as a processed mushroom product. The changes in pH, total acidity, brix, color and texture of the mushroom pickles (Lentinus edodes, Pleurotus ostreatus, Agaricus bisporus and Pleurotus eryngii) were measured during storage at 4℃. In addition, sensory evaluations on the mushroom pickles were performed. While the pH of Lentinus edodes and Pleurotus ostreatus pickles declined slowly, the pH of Agaricus bisporus and Pleurotus eryngii pickles declined rapidly during storage, The total acidity of Lentinus edodes pickles rose slowly, while the acidity of Pleurotus ostreatus, Agaricus bisporus and Pleurotus eryngii pickles rose rapidly, As for the color of mushroom pickles, "L", "a" and " b" values changed slightly. The changes in texture were determined by a rheometer, Hardness, cohesiveness, springiness, gumminess and brittleness of Lentinus edodes pickles were lower than those of the other mushroom pickles. In the sensory evaluation of mushroom pickles, Lentinus edodes showed higher acceptability ratings than the other mushrooms in taste, color, clearness, texture and overall acceptability. This study showed that among the mushrooms tested, Lentinus edodes was the most acceptable mushroom pickle for storage.

젊은 성인에서의 하악 매복 제 3 대구치의 맹출과 위치변화에 대한 방사선학적 평가

김효섭,이재훈 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4

The third molar appears to be the most frequently impacted tooth. In most studies, the frequency of mandibular third molar impaction has been found to be 20-30%, with females showing third molar impaction significantly more often than males. During development, the position of the mandibular third molar changes countinously before reuption or impaction. Unless this movement is disturbed, the mandibular third molar will erupt normally into the functional position. Panoramic tomographs are usually taken for clincal examinaion and treatment planning. To determine the timing of surgical intervention, it would be beneficial to dertermine certain predictive signs about the future eruption from the panormic radiograph while the tooth is still developing. To estmate whether mandibular third molar are likely to erupt after the age of 20 by determining radiographic feature, we took a study on 25 patients (Average age was 20.2±0.7)with 30 impacted mandibular third molars. Panoramic radiograph was taken at age 20 and 25. The results were as follows. 76.9% of the mandibular third molars with initially complete root development fully erupted by the age of 25 years. however, teeth with incomplete root development more often remained unerupted. The mandibular third molar which impacted in only soft tissue or by the occlusal level to the mandibular second molar erupted more often than other impactions. Initially vertical angulated teeth erupted more often than other angulations. There was a statistically significant difference of angulations change between age 20 and age 25(P<0.05). In the retromolar space/MD width of mandibular third molar ratio, there was a statistically significant difference between the erupted group and the impacted group(P<0.01). It was conclued that we could find the predictive radiographic features to estimate future eruption of mandibular third molars from a panoremic tomograph taken at age 20 years.

성인에 발생한 외상성 뇌경막하 수활액낭종

김기동,이종수,이현개,이승재,박효일 인제대학교 1983 仁濟醫學 Vol.4 No.3

저자 등은 성인에서 외상 후 발생한 뇌경막하수활액낭종 26예를 보고하고 이 질환의 임상 및 방사선학적 양상, 처치, 수술 결과, 그리고 발병 원인 등에 대하여 기술하였다. 이 질환은 손상의 정도 및 발병 유형이 다양하였고, 수술 전 요추천자시의 뇌척수액은 흔히 황백색을 보이면서 단백치의 증가를 보였다. 두개골절은 35%데서 발견되었으며 뇌경막하수활액낭종은 대뇌피질 위축, 뇌좌상, 뇌경막하혈종 및 뇌경막상혈종과 동반되어 발생하였다. 병변의 위치는 뇌혈관 조영술에 의해서도 확인할 수 있었으나 뇌경막하혈종과의 수술 전 감별은 Brain CAT Scan에 의해서만 가능하였다. 사망율은 15.4%이었으며 만족할만한 결과를 보인 것은 76.9% 이었다. 저자 등은 Simple burr hole(s) drainage를 선택적 치료 방법으로 택하였으며 때로 수활액낭종이 재발하여 재수술을 시행한 경우도 있었다(Fig.5). The authors reported a series of 26 cases of post-traumatic subdural hygroma in adults and discussed the clinical and radiological features, management, 'surgical results, and pathogenesis. There was marked diversity in the severity of injury and in chronictiy. The lumbar cerebrospinal fluid often showed xanthochromic nature and elevation of the protein content. Skull fracture were found in 35% of the cases, and subdural hygroma were associated with cerebral atrophy, cortical contusions, subdural hematomas, and overlying epidural hematomas. The sites of the lesion was delineated by angiography, but preoperative differentiation from subdural hematoma was possible only with computed tomography. The mortality rate was 15.4%. Satisfactory outcome occurred in 76.9%. The authors advocated simple burr hole drainage as the treatment of choice. Significant reaccumulation may occur occasionally.