서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

하악골에 발생한 골막 골육종

김태우,김승범,권혁찬,문선재,윤정훈,김형준,차인호,육종인,김진 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Periosteal osteosarcoma is a distinct entity of malignant bone tumor with characteristic clinical, morphological, and histological features within the group of juxtacortical osteosarcoma. Periosteal osteosarcoma is predominantly located in the tubular long bones, and extremely rarely involving the jaws. A case of periosteal osteosarcoma of the right mandible is presented. A 27-year-old woman complained of the gingival swelling and bleeding tendency of the right posterior mandible. Clinical examination revealed a reddish brown strawberry-like swelling on the affected mucosa, which measured 1.5㎝×1.5㎝. The tumor was located on the lingual cortex of the mandible and extended into the surrounding soft tissues. Microscopically, the tumor consisted exclusively of atypical chondroblastic cells with a small osteoblastic area. A minimal bone marrow involvement was noted and the adjacent cortex was free of tumor. These findings suggested that the tumor originated from the periosteal cambium layer, which lies between the periosteal fibrous layer and the cortex of mandible.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

TNF-α로 유도된 혈관내피세포의 혈관염증에 미치는 오적산(五積散)의 억제 효과

한병혁 ( Byung Hyuk Han ),윤정주 ( Jung Joo Yoon ),김혜윰 ( Hye Yoom Kim ),안유미 ( You Mee Ahn ),홍미현 ( Mi Hyeon Hong ),손찬옥 ( Chan Ok Son ),나세원 ( Se Won Na ),이윤정 ( Yun Jung Lee ),강대길 ( Ho Sub Lee ),이호섭 대한본초학회 2018 大韓本草學會誌 Vol.33 No.4

Objectives : Ojeoksan, originally recorded in an ancient Korean medicinal book named “Donguibogam” and has been used for the treatment of circulation disorder of blood which was called blood accumulation (血積) in Korean medicine. Therefore, this study was carried out to investigate the beneficial effect of OJS on vascular inflammation in HUVECs. Methods : We evaluated the effect of OJS on the expression of cell adhesion molecules and protective role in HUVEC stimulated by TNF-α by using Western blot. Results : Pretreatment with OJS decreased the adhesion of HL-60 cells to TNF-α-induced HUVEC. OJS suppressed TNF-α-induced expression level of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and endothelial cell selectin (E-selectin). Moreover, OJS significantly decreased TNF-α-induced production of intracellular reactive oxygen species (ROS); and inhibited the phosphorylation of IκB-α in the cytoplasm compared to the experimental group. Pretreatment with OJS inhibited the trans-location of NF-κB p65 to the nucleus. OJS also inhibited phosphorylation of MAPKs compared to the experimental group. OJS significantly increased the protein expression of Nrf2 and HO-1. Conclusions : Ojeoksan has a protective effect on vascular inflammation, and might be a potential therapeutic agent for early atherosclerosis.

근관감염세균의 분포에 관한 연구

김승윤,최호영,박상혁,최기운 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.4

It has been documented that periodontopathic bacteria are also implicated in endodontic infections. 16S rDNA gene-directed PCR was to examine the prevalence of periodontopathic bacteria including Actinobacillus actinomycetemcomitans (Aa), Prevotella intermedia (Pi), Prevotella nigrescens (Pn), Porphyromonas gingivalis (Pg), Porphyromanas endodontalis (Pe), and Treponema denticola (Td) in the root canals of 36 endodontically infected teeth having apical lesions with or without clinical symptoms like pain, swelling, and fistula. 1. In 36 infected root canals, most frequently detected bacterial species was Pg (61.1%), followed by Td (52.8%) and Pe (38.9%). 2. Of 36 infected root canals, Aa was detected in 6 canals (16.7%) of the teeth, all of which showed clinical symptoms. 3. Of 36 infected root canals, Pi and Pn Were found in 4 (13.9%) and 5 (33.3%), respectively. Notably, prevalence of Pn in the symptomatic teeth was 50.0%. 4. One of black-pigmented anaerobic bacteria (BPB) including Pi, Pn, Pe, and Pg was detected in all of the teeth that showed pain or especially swelling but not fistula. It was, however, found that prevalence of BPB in the asymptomatic teeth or the teeth with fistula was only 40%. 5. Pe and Pg were detected in the teeth regradless of the presence or absence of symptoms. High prevalence of BPB in the symptomatic teeth but low in the asymptomatic teeth suggested that BPB may play an important role in the pathogenesis of periapical lesions.

대사산물이 Dictyostelium discoideum의 성장과 분화에 미치는 영향 김

김상혁,최호형 공주대학교 사범대학 과학교육연구소 1992 과학교육연구 Vol.23 No.1

세포 분화및 성장에 영항을 주는 대사성 물질들이 D. discoideum의 성장과 분화에 미치는 영향을 조사하였다. D. discoideum의 생활환 중에서 단백질 함량은 Aggregation 시기에 가장 높았고, 포자시기에 가장 낮았다. 외래성 cAMP의 효과는 뚜렷하지 않았으나, Aggregation 시기에 다소 촉진 현상을 보였다. GA의 경우는 분화 전반에 걸쳐 얼마간의 촉진을 보였다. Nicotinic acid와 Caffeic acid는 성장과 분화 모두에 있어서 뚜렷한 억제작용을 나타내었다. The present experiment was investigated chemical effects of natural products on the cyto-differentiation during the life∼cycle in the cellular slime mold Dictyostelium discoideum. Some protion of the cells were taken out at each stages during the synchronous culture, and protein amount measured, and chemical effects of cAMP, GA₃, Caffeic-acid, and Nicotinic-acid were investigated. The changes in the content of protein was increased maximum level in aggregation stage and decreased markedly at the spore stage. The addition of GA₃was increased 12% growth and differentiation compared with those of basic medium, and cAMP too, increased 26%. However, Caffeic-acid and Nicotinic-acid were decreased 26%.

응급의학과로 내원한 환자중 내원시 예상치 못했던 사망에 대한 고찰

김승렬,김상은,양혁준,정호성,박철완,이 근 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Patients die in the emergency department frequently ; however, there has been little about the incidence and cause of Emergency Department death in the emergency medicine literature. This study was conducted retrospectively to gain insight into the patients who die suddenly and unexpectedly in the Emergency Department(ED). A total of 360 patients were pronounced dead in the ED from 1991 through 1994 in Chung Ang Gil Hospital. Of the 360 patients, 309 (86%) were brought to the ED with cardiopulmonary resuscitation in progress or as do not resuscitation(DNR) patients, leaving 51(14%) patients who met the unexpected death criteria. Of the unexpected deaths, 32(62.7%) patients presented to the ED with either abnormal vital sign (24 of 32) or some alteration in consciousness (18 of 32), or both of them (10 of 56). Medical and surgical causes of death represented 47.1% (24 patients) and 15.6% (8 patients) of the unexpected deaths respectively. Trauma represented 19 (37.3%) of the unexpected deaths, with 14 of these being the result of motor vehicle collision. The yearly incidence of unexpected ED death is presented in numbers of deaths per 10,000 ED visits. In 1991, the incidence was 3.4, and in 1992, 1993 and 1994 those were 2.7, 2.2 and 2.1 respectively.

豫備考査의 入試反映에 對한 調査硏究

朴載昊,張赫杓,金鶴守 釜山大學校 師範大學 1976 교사교육연구 Vol.3 No.1

This study attempts to seek a way of adequate application of the national preliminary examination to the entrane examination of university. Data of examinations during four years(1973-1976)was collected and corelation between two was analysed. The results of this analysis are as follows; a)the corelation between two examinations is very high. and, thus, the following is strongly recommendable; 1.7 multiples of capacity of student entollments may be primarily selected by means of preliminary examinations and the necesary or instrumental subject for the higher education may be imposed on these chosen applicants. b)dropping precedure in each curriculum is desireble because without this applicants are liable to devote themselves only to their interesting curricula disregarding others not well achieved.

SPSA에 근거한 Tylor 모델 근사화와 전력계통 안정화 시스템에 적용

김정혁,김호찬 제주대학교 공과대학 첨단기술연구소 2004 尖端技術硏究所論文集 Vol.15 No.2

This paper presents a Taylor model approach for a closed-loop system identification using input and output data and its application to design a power system stabilizer (PSS). The Taylor model concept is introduced as an alternative intelligent system technique to design a controller for an unknown system with input and output data only, and without the detailed knowledge of mathematical model for the system. In the Taylor model, the data used has incremental forms using backward difference operators. The parameters of the Taylor model can be obtained by the simultaneous perturbation stochastic approximation (SPSA) method. The feasibility of the proposed method is demonstrated in a one-machine infinite-bus power system. The linear quadratic regulator (LQR) method is applied to the Taylor model to design a PSS for the system, and compared with the conventional PSS in different loading conditions and system failures such as the outage of a major transmission line or a three phase to ground fault which causes the change of the system structure

우리 나라 해외여행객의 동기에 따른 시장세분화에 관한 실증적 연구

김성혁,고호석 동국대학교 관광산업연구소 1999 관광·호텔경영연구 Vol.1 No.1

This study is trying to be segmented the market through the analysis the motive on foreign tourists. Through the market segmentation, we can establish the marketing strategy according to the factor, and concentrate on the special market. But, there are some limitation of the segmentation. that are the tourists' psychological motive on the travel market and samples which are not enough for the analysis.