정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Cadmium과 Di-(2-ethylhexyl) Phthalate에 의한 고환 독성 : 아연과 Apoptosis의 역할 The Role of Zinc and Apoptosis

권민,최병선,박언섭,홍연표,박정덕 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1

Cadmium (Cd) and di-(2-ethylhexyl) phthalate are used widely and distributed ubiquitously in the environment, which are well-known reproductive toxicants. DEHP and/or Cd causes the apoptosis, degeneration of spermatogenic cells, and massive necrosis, resulting in testicular atrophy. Zinc is an essential metal in spermatogenesis, the zinc concentration in testis is changed in DEHP- or Cd-treated animals. However, the role of zinc or apoptosis in testicular toxicity by DEHP or Cd has not been understood well. In this study, Sprague-Dawley male rats were given DEHP (2 g/kg, 5 ml corn-oil, PO) or Cd (CdCl₂2 mg/kg, 4 ml saline, sc) for 1, 2, 7 and 14 days. Control rats were given vehicle corresponding to each group. At day 1, 2, 7, and 14 after administration of DEHP or Cd, the morphological findings including apoptosis in testes were observed under the light microscope, and the zinc concentrations in testes were determined by atomic absorption spectrometry with flame method. Fas and FasL mRNA in testes were analyzed by RT-PCR method at 12 hours, 1, 7, 14 days after adminstration of DEHP or Cd. Absolute and relative testicular weight were lower in DEHP- or Cd-treated rats than control. DEHP or Cd produced morphological changes in testes, including apoptosis, degeneration, necrosis and massive loss of spermatogenic cells, resulting in testicular atrophy. The zinc concentration in testes was not different at day 1 after administration of DEHP, but was decreased at later times. Testicular zinc was lower at day 1, 2 in Cd-treated rats than control, but was higher at 7, 14 days after Cd administration. The levels of Fas and FasL mRNA were highly expressed in testes after administration of DEHP or Cd. These results suggest that the change of zinc level in testes might be a secondary effect of DEHP- or Cd-induced testicular toxicity, and Fas signal system might be play an important role in pocessing of apoptosis in testes by DEHP or Cd.

An Open Gradient Magnetic Separator Assembled Using NdFeB Magnets for a Use of Fine Particles Remover

Eon Byung Park,Seung Duck Choi,Choong Jin Yang,Won Sub Lee 한국자기학회 1998 Journal of Magnetics Vol.3 No.3

A drum type magnetic separator was designed and optimized by computer simulation. The separator consisted of rotating outer shell of drum, magnetic flux generator drum which was assembled with numbers of disk type magnet holders, and drum axis around which the magnet holders were fixed. NdFeB magnet blocks were inserted into the disks, and the disks were assembled layer by layer along the drum axis. Magnetic circuits of the separator were simulated on the basis of highest magnetic strength, least cost, and high yield of separation by using a Vector Field S/W employing the Opera-2D program. The separator proved a separation yield of 95% in removing fine iron-base particles, and installed at Hot Rolling Mill of Pohang Iron & Steel Co. in Korea.

Dual control of the vestibulosympathetic reflex following hypotension in rats

Park, Sang Eon,Jin, Yuan-Zhe,Park, Byung Rim The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.6

Orthostatic hypotension (OH) is associated with symptoms including headache, dizziness, and syncope. The incidence of OH increases with age. Attenuation of the vestibulosympathetic reflex (VSR) is also associated with an increased incidence of OH. In order to understand the pathophysiology of OH, we investigated the physiological characteristics of the VSR in the disorder. We applied sodium nitroprusside (SNP) to conscious rats with sinoaortic denervation in order to induce hypotension. Expression of pERK in the intermediolateral cell column (IMC) of the T4~7 thoracic spinal regions, blood epinephrine levels, and blood pressure were evaluated following the administration of glutamate and/or SNP. SNP-induced hypotension led to increased pERK expression in the medial vestibular nucleus (MVN), rostral ventrolateral medullary nucleus (RVLM) and the IMC, as well as increased blood epinephrine levels. We co-administered either a glutamate receptor agonist or a glutamate receptor antagonist to the MVN or the RVLM. The administration of the glutamate receptor agonists, AMPA or NMDA, to the MVN or RVLM led to elevated blood pressure, increased pERK expression in the IMC, and increased blood epinephrine levels. Administration of the glutamate receptor antagonists, CNQX or MK801, to the MVN or RVLM attenuated the increased pERK expression and blood epinephrine levels caused by SNP-induced hypotension. These results suggest that two components of the pathway which maintains blood pressure are involved in the VSR induced by SNP. These are the neurogenic control of blood pressure via the RVLM and the humoral control of blood pressure via epinephrine release from the adrenal medulla.

Complete mitochondrial genome of the endemic species Korean aucha perch <i>Coreoperca herzi</i> (Teleostei, Centrarchiformes, Sinipercidae)

Park, Chang Eon,Park, Gun-Seok,Kwak, Yunyoung,Hong, Sung-Jun,Khan, Abdur Rahim,Jung, Byung Kwon,Park, Yeong-Jun,Kim, Min-Chul,Kim, Kgu-Hwan,Park, Hee Cheon,Lee, In-Jung,Shin, Jae-Ho Informa UK (Informa Healthcare) 2016 Mitochondrial DNA. Part A Vol.27 No.5

Genomic and phenotypic analyses of <i>Serratia fonticola</i> strain GS2: a rhizobacterium isolated from sesame rhizosphere that promotes plant growth and produces <i>N</i>-acyl homoserine lactone

Jung, Byung Kwon,Khan, Abdur Rahim,Hong, Sung-Jun,Park, Gun-Seok,Park, Yeong-Jun,Park, Chang Eon,Jeon, Hwang-Ju,Lee, Sung-Eun,Shin, Jae-Ho Elsevier 2017 Journal of biotechnology Vol.241 No.-

<P>The genus Serratia incorporates many agriculturally important species. Serratia fonticola strain GS2, isolated from a sesame rhizosphere, can produce N-acyl homoserine lactone quorum sensing signal molecules and indole-3-acetic acid (IAA). Here we report the complete genome sequence and phenotypic characteristics based on genomic information of this bacterium. The complete genome sequence of S. fonticola strain GS2 consists of a chromosome of 6.1 Mbp and two plasmids of 132 kbp and 94 kbp. The genome clusters for IAA and N-acyl homoserine lactone biosynthesis were identified in the genome. Subsequently, the Salkowski test and gas chromatography-mass spectrometry (GC-MS) analysis also revealed that the strain GS2 produces indolic compounds (27.1 mu gmL(-1)) and IAA (6.7 mu gmL(-1)) in its culture broth. HPLC analysis confirmed that the strain GS2 produced the quorum sensing signal molecules N-hexanoyl-(L)-homoserine lactone and N-octanoyl-(L)-homoserine lactone. This new information on the genome sequence and phenotype features will inform future ecological studies related to plant-microbe interactions. (C) 2016 Elsevier B.V. All rights reserved.</P>

Phylogenetic Analysis of Caterpillar Fungi by Comparing ITS 1 - 5.8S - ITS 2 Ribosomal DNA Sequences

(Joung Eon Park),(Gi Young Kim),(Hyung sik Park),(Byung Hyouk Nam),(Won Gun An),(Jae Ho Cha),(Tae Ho Lee),(Jae Dong Lee) 한국균학회 2001 Mycobiology Vol.29 No.3

N/A N/A

Dual control of the vestibulosympathetic reflex following hypotension in rats

Sang Eon Park,Yuan-Zhe Jin,Byung Rim Park 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.13 No.3

Orthostatic hypotension (OH) is associated with symptoms including headache, dizziness, and syncope. The incidence of OH increases with age. Attenuation of the vestibulosympathetic reflex (VSR) is also associated with an increased incidence of OH. In order to understand the pathophysiology of OH, we investigated the physiological characteristics of the VSR in the disorder. We applied sodium nitroprusside (SNP) to conscious rats with sinoaortic denervation in order to induce hypotension. Expression of pERK in the intermediolateral cell column (IMC) of the T4~7 thoracic spinal regions, blood epinephrine levels, and blood pressure were evaluated following the administration of glutamate and/or SNP. SNP-induced hypotension led to increased pERK expression in the medial vestibular nucleus (MVN), rostral ventrolateral medullary nucleus (RVLM) and the IMC, as well as increased blood epinephrine levels. We co-administered either a glutamate receptor agonist or a glutamate receptor antagonist to the MVN or the RVLM. The administration of the glutamate receptor agonists, AMPA or NMDA, to the MVN or RVLM led to elevated blood pressure, increased pERK expression in the IMC, and increased blood epinephrine levels. Administration of the glutamate receptor antagonists, CNQX or MK801, to the MVN or RVLM attenuated the increased pERK expression and blood epinephrine levels caused by SNP-induced hypotension. These results suggest that two components of the pathway which maintains blood pressure are involved in the VSR induced by SNP. These are the neurogenic control of blood pressure via the RVLM and the humoral control of blood pressure via epinephrine release from the adrenal medulla.

하이브리드 웹 기반의 스마트 발권 시스템

박병언(Byung-Eon Park),박진섭(Jin-Sub Park),정일홍(Il-Hong Jung) 한국디지털콘텐츠학회 2011 한국디지털콘텐츠학회논문지 Vol.12 No.4

In this paper, we have designed and implemented a commercial web system for the future which resolves the necessary security and compatibility to the existing issues in various fields such as theater or the ball park that tickets are issued. The system presents the OTP (One Time Password) system using the mobile in order for defense in the bypass hacking technique such as screen hacking and for greater security. Also, we presents a smart ticketing system that improve the existing responsive hybrid web. It uses Non-ActiveX System which solve compatible problems with present systems that dont use ActiveX. Also, it is available in a variety of environments and equipment. In addition, the system provides an intelligent screen switching systems using the characteristics of mobile devices, an automatic discount system, and a venue information system which shows the shortest distance to the venue considering the commercial portion.

행정업무 능률향상을 위한 통합 계정 및 접근 관리 방안

박병언(Byung-eon Park),양재수(Jaesoo Yang),조성제(Seong-Je Cho) 한국정보보호학회 2015 정보보호학회논문지 Vol.25 No.1

최근 공공기관 및 대형 포털 사이트에 이르기까지 개인정보관리의 효율적인 관리의 부재로 대량의 고객 정보와 정보유출 관련 사고들이 연이어 발생하고 있다. 이에 내부 자료의 외부유출을 근원적으로 차단할 수 있는 보안 인프라 구축이 그 어느 때 보다도 중요한 이슈로 등장하고 있다. 이에 사용자의 접근과 권한 관리, 인증, 감사 등을 수행하는 계정 및 권한관리시스템이, 업무의 효율성 향상은 물론, 시스템에 대한 접근과 계정 관리를 위한 안전하고 효과적인 방안으로 대두되고 있다. 본 논문에서는 지방자치 행정업무에서 전산 업무능률 향상과 보안성강화를 위해 어떻게 계정 및 권한관리시스템을 구축해야 하는지 분석하고, 그 방안을 제시하였다. Recently large amounts of customer information has leaked ranging from public institutions to the large-scale of portals, and similar information leakage incidents owing to the absence of personal information management have subsequently occurred. Therefore, the security infrastructure in which leakage of internal data can be blocked fundamentally is emerging as a key issue. An integrated identity and access management architecture which performs user access and its rights management, authentication and audit of the business systems is more important to improve the efficiency of business. In addition, this approach is emerging as a safe and effective ways for identity and access rights management. In this paper, we analyze how an integrated approach for identity and access management to improve the efficiency of the computational work and to strengthen the security in local government administration should be constructed, and proposed the preferred solution.