정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

결합재 페이스트 충전에 따른 포러스콘크리트의 물성에 관한 기초적 연구

윤상혁,양동일,정근호,김성식,이영도,정상진 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

Although porous concrete is recently used as a pavement at a parking lot, a public squre and a bicycle road, we use without enough examining. Most the maintenance of quality for porous concrete is only dealt with strength and color tone. Also, there is not et enough fundamental data about dynamical properties for strength, rate of void and water permeability. Even when it is applied to at the scene, it is been a matter. Accordingly in this study analyzed influences through the dynamical properties, combination, and time to vibration. After the analyzation, they investigated peculiar dynamics which are strength of porous concrete, rate of void, and water permeability follow the rate of increase on an admixture making pozzolan reaction. This is purpose to improve capacity of the sidewalk permeable concrete and development of the economical technique for pavement.

성장과 운동수행능력 향상에 도움을 주는 식이조성물의 개발

윤승원,정은희,양동식,이홍석,윤유식 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.3

We developed a dietary supplement using natural herbs and nutrients for the growth and exercise performance improvement. It called JR-22 supplement containing distilled extracts of natural herbs to remove bitterness and the addition of Vitamin B1, B6, Ca and xylitol. We investigated on the effect of JR-22 supplementation on the maximal exercise performance, IGF-1 (insulin like growth factor-1) concentration and antioxidant activity in SD rat model. In result, JR-22 supplement group was better than control group about 10% in exercise performance test and increased about 63% of IGF-1 concentration in blood. In addition, the oxidative damage induced by exercise was reduced by JR- 22 supplementation. Therefore, we suggested that JR-22 supplementation enhanced effectively exercise performance and IGF-1 concentration and reduced to oxidative stress in muscles. Also, we analysed biochemical factors in blood for the safety of JR-22 supplement. We known that there is no change of blood lactic acid, ammonia, inorganic phosphorous ion and creatine kinase activity.

사례기반추론기법을 이용한 선체 횡부재 구조설계 지식 표현 방법론 연구

윤덕영,양동열,차명석 朝鮮大學校 機械技術硏究所 1998 機械技術硏究 Vol.1 No.1

This paper shows the knowledge representation method for the possibility of the automation of the design and modeling of ship web frame in the level of detailed design using parametric design and case-based reasoning technique. It turns out that Case-Based Reasoning(CBR) based on casual model is successfully applied for the design automation.

水銀耐性菌을 利用한 含水銀廢水處理에 關한 硏究 : Ⅰ. 土壤中의 水銀耐性菌의 分離 Ⅰ. Isolation of Mercury Resistant Bacteria from the Soils

梁成鎬,孫東和,尹水弘 대구산업정보대학 1988 논문집 Vol.2 No.-

This study was carry out to examine the treatment methods of waste water contaminated with mercury by mercury resistant bacteria Pseudomonas spp Isolated from the soils. The results obtained from this study were as follows 1. The mercury contents was respectivelly 2.4ppm, 0.8ppm and 0.3ppm at A, B, and C site from the soils polluted with mercury. 2. 12 strains of bacteria which showed a remarkable tolerance against Thimerosal was isolated from soils contaminted with Mercury. 3. Isolated bacteria from 40ppm of Thimerosal concentration was identified as Pseudomonas spp. by morphological and biochemical test.

自勵型 Brushless 單相同期發電機의 解析

尹良雄,金永炯,朴椿培 圓光大學校 1982 論文集 Vol.16 No.2

The theoretical analysis of the cylindrical magnetic fieldtyped self-excited brushless single-phase synchronous generator with inductive load was performed in this paper. The equations for the generator with inductive load was derived in considering of non-linearity character owing to the saturation of magnetic path, and the data for the design of generator was derived in this paper too. The following facts are concluded; 1) The generator characteristics with inductive load is depend upon saturation curve and the capacity of condenser. 2) The generator characteristics with inductive load has compound character as it has the shunt character by condenser currenet and the series character by load current.

본태성 고혈압이 동반된 당뇨병환자의 혈중 인슐린 농도

양동호,홍세용,성기범,안무영,윤신구,박형국,양광익,황주호,신현길 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Multiple lines of evidence link elevated blood pressure with diabetes mellitus. Specifically, it has been proposed that resistance to insulin-stimulated glucose uptake and hyperinsulinemia may play a central role in the cause and clinical course of hypertension. In diabetes mellitus, insulin resistance and/or hyperinsulinemia is an common finding and it is interesting whether the hyperinsulinemia may play a signigicant role in hypertension with DM in the same way as in essential hypertension without diabetes mellitus. The object of this study was to compare insulin and c-peptide levels between age, sex, and obesity matched two groups(DM with DM without hypertension). Method The study group consisted of 55 male diabetes mellitus patients, aged between 45-55 (years). Patients with obesity (body mass index · 30 ㎏/m2), renal disease (proteinuria · 300 ㎎/24hr urine), and secondary hypertension were excluded. Insulin and c-peptide were measured in overnight fasting state and after oral administration of glucose(75 gm). In the fasting, venous plasma glucose levels were similar in the hypertensive and control group(132 ±7 ㎎/dl vs 135 ±8 ㎎/dl). In the fasting, venous plasma insulin levels were higher in the hypertensive than in the control group (10.9 ±5.3 μIU/ml vs 5.5 ±3.9 μIU/ml, p = 0.0001). After loading with 75 gm glucose, venous plasma insulin level seems to be higher in the hypertensive patients than in the control patients, but the difference was not signigicant statistically (27.2 ±17.5 μIU/ml vs 19.9 ±18.9 μIU/ml, p = 0.1297). The mean insulin concentration of the essential hypertensive patients with diabetes mellitus was twice that of the normotensive patients with diabetes mellitus. In control group, there was a direct relations between insulin level and c-peptide, in both fasting state (R = 0.617, p = 0.0001) and glucose-loaded state (R = 0.531, p = 0.001). But in hypertensive group, there was no relations between insulin level and c-peptide, in both fasting state (R = 0.257, p = 0.2738) and glucose-loaded state (R = 0.307, p = 0.1885).

초음파검사자 기량검증 체제를 위한 다자비교시험

윤병식,양승한,김영호,김용식,양동순 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.4

국내 원자력발전소의 Class1과 Class2 배관검사에 적용할 수 있는 초음파탐상 검사자, 장비 그리고 절차서에 대한 한국형 기량검증(KPD) 시스템을 구축하였다. PD 방법을 적용한 검사결과와 전통적인 dB-drop 방법을 이용한 검사결과를 상호 비교하기 위하여 Round Robin Test(RRT)를 수행하였다. RRT 결과는 PD 방법의 신뢰성이 dB Drop 방법보다 우수한 것으로 나타났다. 이러한 결과로부터 원자력발전소 가동중검사에 PD 방법을 적용함으로써 초음파탐상검사 결과의 신뢰성이 더욱 향상될 것으로 기대된다. The Korean Performance Demonstration(KPD) System for the ultrasonic testing personnel, equipments and procedures applicable to the Class 1 and 2 piping examination for nuclear power plant in Korean has been established. A round robin test was conducted in order to compare the examination results by the method of Performance Demonstration(PD) with the traditional dB-drop method. As a result, adoption of the PD method to the in-service inspection of the nuclear power plants will improve the reliability of the ultrasonic test results.

DW1029M, a novel botanical drug candidate, inhibits advanced glycation end-product formation, rat lens aldose reductase activity, and TGF-β₁ signaling

Yoon, Joobyoung,Lee, Hyunyong,Chang, Hwan Bong,Choi, Hyunsik,Kim, Yong Sung,Rho, Yang Kook,Seong, Seungkyoo,Choi, Dong Hwa,Park, Dongeun,Ku, Bonchul American Physiological Society 2014 American Journal of Physiology Vol.306 No.10

<P>DW1029M is a botanical extract consisting of Morus bark and Puerariae radix, produced by Dong-Wha Pharmaceutical, for nephroprotective drug development; it has been in phase II clinical trials in Korea. In our mechanistic investigations, we found that DW1029M inhibits advanced glycation end products (AGEs), rat lens aldose reductase (RLAR), and transforming growth factor (TGF)-beta(1) signaling, all of which are implicated in diabetic complications such as diabetic nephropathy and diabetic retinopathy. DW1029M inhibits AGE formation via Fe2+ chelation. The extract contains 13 active constituents that inhibit AGE formation, 8 active constituents that inhibit RLAR activity, and 1 inhibitor of TGF-beta(1) signaling. Our results suggest DW1029M protects against diabetic nephropathy via blockade of AGE formation, RLAR activity, and TGF-beta(1) signaling.</P>

항정신병약물로 야기되는 초과민성 정신병에 관한 연구

양동균,윤진상,이형영 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.2

Chronic antipsychotic treatment can induce tardive dyskinesia and supersensitivity psychosis, and these may be explained by supersensitivity phenomena of the dopamine receptor in the brain. This study was conducted to compare the clinical characteristics between tardive dyskinesia and supersensitivity psychosis in schizophrenia. The subjects of the study were composed of 8 schizophrenics with tardive dyskinesia(TD ), 10 schizophrenics with supersensitivity psychosis(SP), and 5 schizophrenics with both syndromes(TD with SP). They all had been treated with antipsychotics. We compared the difference in general and antipsychoti-related characteristics among the three groups. The results are as follows : 1) In the comparison of general characteristics ; There was a significant difference in the number of hospitalizations among the three groups. The number of hospitalizations was most frequent in SP group, and this was followed by TD with SP group(P<0.05). There was also a significant difference in the length of hospitalization : the longest in SP group and the shortest in TD group. Among the schizophrenic subtypes by Andreason-0lsen's criteria, the number of positive schizophrenics were significantly greater in SP and TD with SP group than in TD group(P<O.05) . 2) In the comparison of antipsychotic-related characteristics : There was a significant difference in the current antipsychotic dose among the three groups. The current antipsychotic dose was highest in SP group and this was followed by TD with SP group(P<0.05). The therapeutic response to antipsychotics was significantly better in SP group than in TD group, and the serum prolactin level was significantly higher in SP group than in TD group, and the serum prolactin level was significantly higher in SP group than in TD group(P<0.05; respectively) 3) Regardless TD, if SP was present, the serum prolactin level was significantly correlated to the current antipsychotic dose(P<0.05). 4) But, there was no significant difference in mean age, age of onset, duration, schizophrenic subtype by DSM-Ⅲ criteria, duration of antipsychotic treatment, prognosis, and antipsychotic potency among the three group.