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이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
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정의권,성중기,정동화 중앙대학교 스포츠과학연구소 2002 體育硏究 Vol.- No.17
When we see the modem structure of industry, we’d like to analyse the future and the view of the Sports management with the science. The purpose of this study is that we propose materials in order to improve the quality of human’s life and the management of sports industry. 1. There are a lot of following problems in our future world; environmental pollution, the advancement of science, comparative social circumstances, the variety of value judgement. So it is necessary to study deeply about sports industry and sports management. 2. The scale of sports is so enormous that sports activity plays an important role in human’s leisure and influences on the sports industry. At the same time we have to study about sports management. 3. Sports at a lifetime that is, we must study sports which meet not only the child but also the old at the same time man or woman in the 21st century. 4. The popularization of science has raised economical level of sports in the society of sports industry. According to commercialization of sports, sports market is getting bigger.
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鄭基東 群山大學校 1983 論文集 Vol.5 No.-
Although our country had been at the point of being divided till 1945, it had never been divided fortunately. But in the middle of the twentieth century our country was divided into two parts at last. After liberation from Japan we have suffered from the division for about forty years. The first division of our country was plotted by Japan during the Hideyoshi Invasion in 1592. After the wicked Toyotomi Hideyoshi invaded Korea and gained a powerful cause, he proposed to Myeong that they should divided Korea. But the plot was not achieved because of Myeong's refusal. Just before the sino-Japanese War England offered the division of Korea to China and Japan. Though the crisis of division rose before and after the Russo-Japanese War, we passed through it with God's help. After the Second World War Korea was divided unfortunately. Some say that the division was decided at the Yalta Conference; some say at Potsdam and others say at Pentagon. But any case may not be an established opinion. All the three cases were related to the division, I think. The division of Korea originated at Yalta; it came near to the bud at Potsdam, and it was decided at Pentagon. Here it is clear that the United States and Soviet Union divided Korea into two parts, so they have responsibility to unite the two divided parts. But we also must make more efforts for the uniting the parts than the United States and Sovit Union. We must bear in mind that our neighboring countries(Soviet Union, Red China, Japan) don't want Korea to be strong and rich through unification. We never forget the today's Soviet Union, Red China, Japan are the descendants of the old Russia, Ching an Jap respectively which invaded and tormented our country through about a thousand year.
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鄭基東 群山大學校 1982 論文集 Vol.4 No.-
Any historian in future will refer to the ideological characteristic of the twentieth century as the age of liberalism versus communism, more or less. Through all human history we have not had so strong an ideology as the present communism, as the opposite thought against the existing order. At the gigantic, transitional period of the atomic age into which the steam engine age is transforming itself through the electric age, we can divide the world into the liberalistic bloc and the communist one, and we must solve the conflict of liberalism against communism, at any cost. Any doctrine has its philosophical foundation more or less and we all know that the communism is dependent upon materialsm as its philosophical ground. So we must know materialism and its history in order to know communism better. In this thesis I study the materialistic aspect of each age regardless of its historical background. In the olden western philosophy they regarded natural environment as the self-evident fact. Absolutely they didn't think of materialism as the philosophy for the oppressed, though the present Marxist maintains that materialism is the philosophy for the hav-nots. In olden eastern philosophy, they regarded matter as the ground of everything, but their method of thinking was within the limit of the mysterious realm. In the golden days of the mediaeval Christianity, materialism hadn't any chance of development, but some of the contemporaries criticized the extremism of scholastic philosophy. The materialism which extended from scholastic philosophy to Immanuel Kant tried to escape the bonds of Christianity and made preparation of materialsm of the nineteenth century. In the latter half of the twentieth century the ideological conflict is very serious. To say nothing of military, political and economic, social cultural and daily life is related to the serious conflicts. As the ideological one is the most serious among their conflicts, we make critical study of materialism to defeat communism.
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정인성,홍동표,박대원,유성기 全北大學校 1989 論文集 Vol.31 No.-
Generally machine tool has a lot of blocks and contact surfaces for the reason of easiness to manufacture, repair and transport. Even though B.B.S(Building Block System) has lower static stiffness than solid system, B.B.S has advantages of vibration reduction and dynamic stability. In this study, the column model was fixed to the bed by means of inserting thin metallic sheets or gilding on contact surface and obtained the interesting result-these bolted joints improve dynamic characteristics as well as static stiffness-. The result of the model test was applied at the actual lathe by inserting 0.3mm metallic sheets between headstock and bed among the cycle of workpiece-headstock-bed-tool. Similar conclusion was obtained in the actual lathe, that is, dynamic characteristics of spindle system and surface roughness of workpiece are improved according to the hardness of inserted materials.
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