두개인두종에 대한 수술경험

권택현,정용구,조태형,정흥섭,이기찬,이훈갑 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.5

뇌 전이를 동반한 크루켄베르크 종양 - 증 례 보 고 -

권택현,조태형,임동준,박정율,박윤관,정용구,정흥섭,서중근,Kwon, Taek-Hyun,Cho, Tai-Hyoung,Lim, Dong-Jun,Park, Jung-Yul,Park, Youn-Kwan,Chung, Yong-Gu,Chung, Hung-Seob,Suh, Jung-Keun 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.9

Krukenberg tumor has been traditionally defined as gastrointestinal malignancy metastatic to the ovary, and is known to account for 1 to 3% of ovarian neoplasms. The nature and behavior of this particularly virulent tumor still remains unclear. We have experienced a case of Krukenberg tumor with brain metastasis. A clinical description of our case is presented with a review of the literature.

청상보하탕(淸上補下湯) 전탕액(煎湯液)이 가토(家兎) 혈장(血漿) Cortisol 농도(濃度) 및 동맥혈(動脈血) $PO_2,\;PCO_2$에 미치는 영향(影響)

권택현,한상환,Kwon, Taek-Hyeun,Han, Sang-Whan 대한한방내과학회 1990 大韓韓方內科學會誌 Vol.11 No.2

The following results were obtained from the observation on the change of plasma cortisol concentration and arterial blood $PO_2,\;PCO_2$ in the experiment of intravenous and oral administration of Chung Sang Bo Ha Tang Water Extract in the rabbit. 1. In intravenous administration, the plasma cortisol conce-ntration increased significantly about 2 hours after with a dose of $0.2m{\ell}/kg$, while the case of $0.4m{\ell}/kg$ reveals this significant increase of concentration about 3 hours after. 2. In oral administration, a significant increase of the plasma cortisol concentration was shown about 2 and 4 hours after with a dose of $1.2m{\ell}/kg$, on the other hand, an increase of concentration was shown at each hour in the case of $0.2m{\ell}/kg$, but it was not significant. 3. In oral administration, $PO_2$ in arterial blood increased significantly in the case of $0.2m{\ell}/kg$, and both the case of $0.1m{\ell}/kg$ and that of $0.2m{\ell}/kg$ gave a significant decrease of $PCO_2$ in arterial blood. With these results, it is verified that Chung Sang Bo Ha Tang has therapeutic effects on JISU(止嗽), JEONG CHEON(定喘), GEO DAM(祛痰) because intravenous and oral administration of it increases the plasma cortisol concentration, However, in the examination of $PO_2$ and $PCO_2$ in arterial blood, any remarkable result was not obtained.

이방성을 고려한 자동속도분석

권택현,변중무,설순지 한국자원공학회 2013 한국자원공학회지 Vol.50 No.1

최근에는 탄성파 반사법 탐사기술의 발달로 먼 거리 벌림(offset)을 이용한 자료취득이 많이 이루어지고 있다. 이때 횡적 등방성(VTI) 매질에서 획득한 자료에 일반적인 NMO 속도분석을 적용하여 NMO 보정을 수행 할 경우 먼 거리 벌림에서 탄성파 이벤트들이 위로 말려 올라가는 현상이 나타나며 이는 정확한 속도분석이 이루어지지 않았음을 나타낸다. 이 연구에서는 이방성을 고려한 NMO 속도분석을 수행함과 동시에 이방성을 나타내는 이방성 변수 를 추출하는 모듈을 개발하였다. 또한 자동으로 닮음(semblance) 상에서 최대 에너지 지점을 선발하여 속도분석을 수행할 수 있도록 하여 3차원 탐사 자료와 같이 방대한 양의 자료의 경우에도 효율적이고 빠르게 자료처리를 할 수 있도록 하였다. 이러한 자동선발을 이용한 속도분석에 있어서 닮음의 해상도는 매우 중요한 요소이므로 보다 높은 해상도의 닮음을 제공하는 BDS(Bootstrapped Differential Semblance)를 이용하였다. 그리고 이 연구에서 개발한 모듈을 검증하기 위해 합성탄성파 탐사자료 및 축소모형 실험 자료에 적용하였고 그 결과 NMO 속도분석의 가정에 부합하는 경사가 크지 않은 지층의 경우 실제 모델과 거의 유사한 속도와 이방성 변수 값들을 추출하였고 중합결과 또한 향상됨을 확인하였다. Data acquisition including long spread offsets is recently implemented due to the development of exploration techniques. If NMO correction was carried out through the conventional NMO velocity analysis to data acquired at Vertical Transversely Isotropic (VTI) media, the shape of the moveout called “hockey-stick” could frequently appear in the part of long spread offset. This indicates that the conventional NMO velocity analysis dose not provide correct results. Thus, in this study, an NMO velocity analysis module was developed not only considering anisotropy but also extracting an anisotropic parameter η. In addition, the developed module can process huge amount of data like 3D data efficiently and rapidly because it picks the maximum energy points on the semblances automatically. It is important to obtain high-resolution semblances in order to pick the maximum points accurately. Therefore, the developed module uses a bootstrapped differential semblance (BDS) instead of a conventional semblance to provide better resolution. To validate our developed module, it was applied to the numerical and the physical modeling data sets. The extracted velocities and anisotropic parameters were reasonable except in the case of deeply tilted layers, and stacked results were also improved.

포장술을 시행한 뇌동맥류의 치료 성적

권택현,정흥섭,박윤관,조태형,임동준,박정율,정용구,이훈갑,이기찬,서중근,Kwon, Taek Hyun,Chung, Hung Seob,Park, Youn Kwan,Cho, Tai Hyoung,Lim, Dong Jun,Park, Jung Yul,Chung, Yong Gu,Lee, Hoon Kap,Lee, Ki Chan,Suh, Jung Keun 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.7

Objective : Although surgical clipping of intracranial aneurysm is the definite method of treatment, there remains a small number of patients in whom surgical clipping is not technically possible. In such difficult cases, surgeon has to consider other therapeutic alternatives. In this report, we analyze our aneurysmal cases treated by wrapping and coating method and evaluate their surgical outcome and follow-up results. Method : Among the total of 877 patients operated from 1990 to 1999 for intracranial aneurysms at our hospital, 40 cases(4.6%) were treated by wrapping and coating method. They included 24 cases of single ruptured aneurysms and 16 with unruptured ones in multiple aneurysms. Wrapping with temporalis muscle and/or muslin gauze and coating with bioadhesive agent such as fibrin glue were performed. Result : Wrapping and coating method was performed mostly to the anterior communicating artery aneurysm (35%), and mostly because of the broad-based neck of an aneurysm(43%). At the time of discharge, 30 out of 40 patients(80%) showed favourable outcome and three cases died. The patients were monitored for average of 37 months(3-75 months). Among 24 cases with single ruptured aneurysm, 4 cases(17%) had early rebleeding within 6 months from the initial hemorrhage, and such rebleeding occurred within the first postoperative month in 3 cases. However, there was no rebleeding after the 6 months. Among 16 patients whose aneurysms were unruptured ones, none of them showed bleeding episode. Conclusion : It seems likely that the wrapping and coating method would be some help to prevent the rebleeding of an intracranial aneurysm. In order to obtain more accurate results regarding the efficacy of such method, it will be necessary to perform a multi-center study for longer follow-up periods and various wrapping and coating materials.

내경동맥 분지부 뇌동맥류 : 임상 특징 및 수술 성적

권택현,조태형,박윤관,정용구,정흥섭,이훈갑,서중근 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.11

평면파 변환을 이용한 3차원 탄성파자료의 효과적인 2차원 완전파형역산

권택현,설순지,변중무 한국자원공학회 2016 한국자원공학회지 Vol.53 No.2

완전파형역산은 정확한 파동방정식의 해에 의해 얻어진 예측자료와 관측자료와의 잔차를 줄여가며속도모델을 업데이트 시키는 자료처리 방법이다. 그러나 실제 현장자료는 3차원적 송신원에 의해 얻어지게 되어2차원 파동방정식을 이용한 2차원 역산을 수행하면 서로 다른 그린함수로 인해 역산 수행에 근본적인 문제가발생한다. 이 연구에서는 이러한 문제를 해결하기 위해 3차원 자료를 평면파자료로 변환하여 2차원 평면파 완전파형역산을 수행하는 방법을 제안하였다. 평면파자료는 1차원 그린함수를 따르는 해가 되므로 그린함수의 차이에 의한 문제가 발생되지 않고 이 방법을 적용 시 계산비용이 줄어드는 장점도 갖게 된다. 제안한 방법의 효용성을 확인하기 위해 3층 층서모델 및 3차원 SEG/EAGE 충상단층(overthrust) 모델에 적용하였고 수치 실험 결과평면파 완전파형역산이 성공적으로 수행됨을 확인하였다. Full waveform inversion (FWI) provides accurate velocity information of subsurface media. FWI can update velocity as reducing the residual between the observed and estimated data which can be obtained by solving wave equation. Therefore, when we carry out 2D FWI with 3D data acquired in a field, critical problems happen in FWI, because 2D and 3D wave equations have different green functions. To overcome the problem we suggest 2D plane-wave FWI method using plane-wave gathers, which are transformed from 3D data, as observed data. Since plane-wave data follow 1D green function, the differences of amplitude and phase do not occur, it means that we can implement FWI by using different dimension data. In addition, this method has advantage that computational cost is considerably reduced. To verifythe validity of this method, we applied it to 3 layer model and 3D SEG/EAGE overthrust model and obtained reasonable inversion results.

뇌경색후 Lipid Peroxidation에 미치는 Allopurinol 및 Deferoxamine의 효과에 대한 실험적 연구

권택현,박윤관,정용구,정흥섭,서중근,이훈갑,주정화,이기찬 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.1

It has been hypothesized that ischemia, followed by reperfusion, facilitates peroxidative free radical chain process in brain. This study was undertaken to investigate the effect of allopurinol and deferoxamine on cerebral lipid peroxidation, estimated by a thiobarbituric acid test, following transient bilateral forebrain ischemia in the rat model of four vessel occlusion. Sprague-Dawley rats fed ad libitum were subjected to transient but severe forebrain ischemia by permanently occluding the vertebral arteries and 48 hours later temporarily occluding the common carotid arteries for 20minutes. Carotid artery blood flow was restored and rats were decapitated after 48 hours. We assessed the lipid peroxidation capacity of cerebral homogenates obtained from hippocampus, basal ganglia, cortex and thalamus. The homogenates were subjected to 30 minutes of aerobic incubation. The production of lipid peroxides were decreased in all sampled area in the treated groups compared with the control group. Allopurinol and deferoxamine-treated groups showed decreased lipid peroxide levels in all the sampled area, but especially more in the hippocampus, (p=0.02), (p<0.01) repecxtively. Combined group (allopurinol and deferoxamine) showed decreased lipid peroxide levels in all the sampled area, but was not statistcally significant(p>0.05). The results suggest that allopurinol and deferoxamine play a role in protecting ischemic cellular damages by scavenging free radicals and subsequently lipid peroxides formed by oxygen supply through blood reperfusion.

체강의 접근법으로 치험한 동맥류성 골낭 : 증례보고 Case Report

권택현,서중근,박정율,이훈갑 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.12

A neurysmal bone cyst is an uncommon spinal tumor of vascular origin and represents less than 1% of primary bone tumors. A case of 15-year-old girl who presented with low back pain and severe left leg pain. The lesion was expansile in nature involving anterior and posterior bony elements of the spine. It also showed expansion into the intraspinal canal and paraspinal soft tissue, Surgical treatment consisted of tumor excision and pedicte screw fixation via extracavitary approach. Postoperative course was uneventful and her symptoms and signs were improved Extracavitary approach as applied to our case seemed to be an ideal surgical method in such cases because of its nature and extent of involvement.

국소성 뇌경색에 미치는 고혈당의 영향에 대한 실험적 연구

권택현,박윤관,정용구,정흥섭,서중근,이훈갑,주정화,이기찬 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.1

The present study was undertaken to investigate the influence of hyperglycemia on focal cerebral ischemia in view of morphometric assay and neuropathological examination. Forty Sprague-Dawley rats were divided into two groups of 20 each Rat MCA occlusion model was used for induction of focal ischemia. Hyperglycemia(20 rats, mean±SEM plasma glucose concentration 378±97.6㎎/㎗) was established 30 minutes before MCA occlusion by intraperitoneal injection of 50% dextrose in water ; the control group(20 rats, mean±SEM plasma glucose concentration 121±24.9㎎/㎗) received normal saline only. Twenty-four hours after MCA occlusion neutral red staining and perfusion fixation was performed and ischemic area were measured using computerized image analysis on cortical surface and coronal cut surface. There was no signifcant difference on coronal cut surface, but on cortical surface showed increase of non-stained area(infarct core) and decrease of lightly stained area(transitional zone) in hyperglycemic rats(p<0.05) and the sum of two area was not different between two groups. Pathological findings were evaluated under light microscopy, in which the field scanning was carried out from the midline by 0.5㎜ interval at cortical and basal ganglia level. There showed no significant difference at basal ganglia level, but at cortical level ischemic transitional zone was decreased in hyperglycemic rats(p<0.05). We conclude that hyperglycemia may worsen the brain from severe, focal ischemic neuronal damage.