태안해안국립공원 지역특화자원을 활용한 탐방프로그램 개발 연구

배준호(Joon-ho Bae),남승민(Seung-min Nam),허학영(Hak-young Heo),송창룡(Chang-ryong Song),박현숙(Hyun-suk Park) 국립공원연구원 2021 국립공원연구지 Vol.12 No.1

본 연구를 위해 먼저 국내·외 해상·해안국립공원의 운영프로그램 현황에 대한 조사를 시행하였으며, 조사된 일부 사례의 경우 기후 및 지형적 요인, 그에 따른 생태환경의 차이, 그리고 관련 법령 차이 등의 이유로 즉시 국립공원에 도입하기 보다는 중·장기적 운영계획과 인프라의 확충, 전문성 확보 등 체계적인 준비가 필요한 것으로 나타났다. 보다 적합한 탐방프로그램의 개발을 위해 사업대상지 현장방문을 실시하였으며, 기존 운영프로그램 현황, 각종 시설, 인력현황 파악, 주변 환경 분석, 담당자 인터뷰 등을 통해 맞춤형 탐방프로그램을 구성하였다. 태안해안국립공원의 경우, 연구원 협업 철새 가락지 부착체험, 태안 해변길 - 솔모랫길 탐방, 태안해변 드론 탐방, 마음의 의자, 연날리기, 새와 예술 그리고 … 등의 체험형 프로그램과 한서대학교와 함께하는 해양 안전 교육 프로그램, 유류 오염 교육 프로그램 등의 교육형 프로그램 등 모두 8가지 해양국립공원 운영프로그램이 도출되었다. 제안된 탐방프로그램을 운영하기 위해서는 별도의 장소 및 운영시설의 확충, 예산편성, 운영을 위한 타당성 검토 등이 우선되어야 할 것이다. 특히 탐방프로그램을 효율적으로 운영하기 위해서는 프로그램 지도자의 역량개발이 필요하며, 현재 운영되고 있는 프로그램을 보완하고 새로운 프로그램을 시행하기 위한 추가적 논의가 필요할 것으로 사료된다. For this study, we first examined the currently operating programs of domestic and overseas maritime and costal national parks. It was found that some of the programs require systematic preparations such as mid- and long-term operation plans, infrastructure expansion, and maintenance of professionalism rather than immediately introducing them into national parks due to the differences in climatic and geographic factors, ecological environment, and relevant regulations. To develop more suitable programs, on-site visits were made and the customized programs were suggested by closely examining the status quo and interviewing people in charge of running the currently offered programs. For Taean Coastal National Park, eight programs were recommended as feasible ones, including the experiential programs such as Bird Ringing, Taean Beach Trail - Sol Sand Trail Walking, Travel Taean Beach with Drone, Thinking Chair, Kite Flying, and Culture & Arts Program (Birds, Arts, and …), and the educational programs such as Marine Safety Training and Oil Pollution Awareness Program. For the suggested programs to be realized, the expansion of separate places and operating facilities for each program, budgeting, and feasibility study should be preceded. To operate the programs effectively and efficiently, in particular, it is necessary to develop the competency of program leaders, and additional discussion for supplement the currently operated programs and implement new programs.

당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

외부 프리스트레스 도입에 의한 노후된 콘크리트 거더교의 보강성능평가

박승범,홍석주,이봉춘,장석호,권혁준 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

One of the promising methods to enhance the flexural strength of a externally prestressed girder is to place the tendons with large eccentricities. The analysis and design of composite girders prestressed by external tendons involve difficulties related mainly to the position of anchorages and the construction sequences. This study was conducted on the concrete bridges reinforced by the continuous girders and the external prestressing. The test results in this study showed that the external prestressing of a composite girder increased the range of the elastic behavior, reduced deflections, increased ultimate strength, and added to the redundancy by providing the multiple stress paths.

ATIS 최적 프로브차량대수 모형개발

박성식,고승영,서준석 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

To collect real-time link traffic information(Link Travel Time) for based on beacon and GPS technologies prove cars always have to be operate on the entire network. In this study, in case of taxi probe cars based with Beacon and GPS, method on determining required number of probe cars is studied to get traffic information of reality. Using taxis for probe cars, the the factors that influence the number of probe cars are operation time and distribution of prove cars over the network, operate distance and travel speed, the portion of revenue operation distance of taxis. The result of this study was ; As the collecting period for one traffic information prove cars travel more link, thus the number of prove cars decreases. The number of prove cars decreases when the allowable numer of links that no link travel times are collected increases.

ADP에 의해서 활성화된 혈관평활근 세포의 증식에 관여하는 Integrin의 종류와 신호 전달 경로

박찬복,이지현,류종철,차태준,주승재,이재우 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Background: Adenosine diphosphate(ADP), which is usually secreted from activated platelets activates integrin αvβ3. αvβ5, and α5β1 on human vascular smooth muscle cells. Integrins have an important role in the proliferation of vascular smooth muscle cells. ADP may stimulate the proliferation of vascular smooth muscle dells by the activation of integrins. Integrins mediating ADP-stimulate the proliferation of vascular smooth muscle cells and signal transduction pathway of ADP stimulation were investigated in this study. Methods: MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay was used to evaluate ADP or ATP-stimulated proliferation of human aortic smooth muscle cells (HASMC). In some experiments, HASMC were incubated with U73122, an inhibitor of phospholipase C, or monoclonal antibodies (mAb) to integrins after ADP of ATP stimulation. Results: ADP and ATP increased the proliferation of HASMC in a dose-dependent manner. U73122 inhibited ADP or ATP stimulated proliferation of HASMC ADP-stimulated proliferation of HASMC was inhibited either by c7E3, a blocking mAb to integrin β3 or by LM609, a blocking mAb to integrin αvβ3(37% and 26% inhibition, respectively: p<0.05), but neither by P1F5, a blocking mAb to integrin αvβ5 nor by JBSS, a blocking mAb to integrin α5β1. Conclusion: These results indicate that ADP increases the proliferation of human vascular smooth muscle cells through phospholipase C pathway, and only integrin αvβ3 mediates ADP-stimulated proliferation of human vascular smooth muscle cells.

유통경로에 있어서 공정성과 상호관계의 질에 관한 고찰

박준승 경복대학 2000 京福論叢 Vol.4 No.-

본 연구에서는 유통경로에 있어서 상호관계의 질이 장기적인 협력관계를 증진시키는 데 중요한 역할을 한다는 관점에 기초하여, 이전의 연구들의 한계점을 극복할 수 있는 이론적 토대를 제시하기 위해, 상호관계의 질과 공정성 사이의 포괄적인 관계뿐만 아니라, 상호관계의 하위구성개념들(예, 신뢰-신용성과 우호성, 결속-단기와 장기, 만족, 갈등)과 공정성의 하위구성개념들(예, 절차 및 분배 공정성) 사이의 개별적 관계에 초점을 맞추어 그 영향의 방향과 정도에 대한 이론적 토대를 제시하였다. On the basis of the concept that the relationship quality in marketing channel plays an important role in improving long-term cooperative relationship, this study have tried to provided theoretical basis to overcome the limitation of the previous research. That is, this study focused on the comprehensive relationship between relationship quality and fairness as well as the individual relationship between subconstructs of relationship quality(e.g., trust<credibility and benevolence>, commitment<short-term and long-term>, satisfaction, and conflict) and subconstructs of fairness (e.g., distributive fairness and procedural fairness). As well as this study provided theoretical basis of the direction and degree.

완전뇌허혈후 재관류시에 국소뇌혈류, 체성감각유발전위 및 신경학적 회복에 대한 Mannitol과 Thiopental의 효과

박춘근,이상원,박영섭,최승진,허필우,정동섭,강준기,최창락 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2

The cardiopulmonary bypass or cerebral circulation arrest is often used in the treatment of complex aneurysm or of arteriovenous malformation to decrease the risk of intraoperative aneurysm rupture. Although experimental studies have suggested that some drugs may protect the brain from ischemic injury, there are limitations in maintaining cerebral perfusion arrest without incurring neurologic deficits due to the initiation of detrimental processes including excitotoxic neuronal injury, activation of phospholipases, influx of calcium, and generation of damaging free radicals. The purpose of this study is to determine wheter mannitol or thiopental has any favorable effects on the recovery of neurologic deficits and on the regional cerebral blood flow(rCBF), somatosensory evoked potential(SEP) and electroencephalogram(EEG) in cats which underwent 15 minutes-complete global ishcemia-reperfusion. The complete global ischemia was produced in 38 cats by temporary intrathoracic occlusion of the innominate artery and the subclavian artery following ligation of bilateral mammary arteries and simultaneous induction of hypotension. The cats were allocated randomly to one of 4 treatment groups : (1) control group, 8 cats received equal volume of saline solution : (2) thiopental group, 10 cats received 45㎎/㎏ thiopental intravenously, (3) mannitol group, 10 cats received 2g/㎏ mannitol intravenously, (4) combined mannitol and thiopental group, 10 cats received equal dose of mannitol and thiopental intravenously. The drugs were administrated in a equally divided dosage before and after the ischemic episode. The results were as follos : 1) Eight animals which received saline showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours after the ischemia. 2) Ten thiopental-treated animals also showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours the ischemia. 3) Both mannitol-and combined treated groups showed early recovery of EEG, good recovery of SEP and EEG without the severe postischemic hypoperfusion, and 7 of 10 mannitol-treated animals and 8 of 10 combined treated animals were significantly recovered in all parameters. There were not significant differences in all parameters between the mannitol-and combined treated groups. 4) Thirty-four of 38 animals involved in this 15 minutes-ischemia resulted in the severe neurologic deficits inspite of treatment with mannitol, thiopental or both of them. These results suggest that, in cats, mannitol treatment is effective but not thiopental in preventing severe neurologic injury following complete global ischemia and the duration of complete ischemia should be far less than 15 minutes.

외상성 뇌손상 환자의 삶의 질 수준에 대한 연구

박준순,노승호 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.4

이 연구는 TBI 환자의 삶의 질이 실제로 정상인에 비하여 어느 정도인지 전반적인 면에서 그리고 정신사회적인 면과 신경행동 증상적인 면으로 나누어 알아보고자 하였다. TBI 환자 31명과 정상대조군 31명을 대상으로 하였고 삶의 질에 대한 평가는 QL-Index, SIP, HISCL, NRS을 사용하였다. 그 결과는 다음과 같다. 1) TBI군과 대조군 사이의 삶의 질 수준을 비교한 결과 QL-Index, SIP, HISCL, NRS 척도 모두에서 두 군간의 유의한 차이가 있었다. (p〈0.01). 2) QL-Index에서 보고한 TBI군의 삶의 질 저하의 정도는 67.4±19.2였고 대조군은 8.1±6.4였다. TBI군은 사회적 활동에서 손상이 가장 심했고 삶에 대한 전망, 건강상태, 일상적 활동, 그리고 지지적 유대관계 순이었다. 3) SIP에서 보고한 정신사회적 장해 정도는 TBI군이 67.2±20.1이었고 대조군은 8.5±6.9였다. TBI군은 업무수행에서 손상이 가장 심했고 집안관리, 사회적 상호관계 순이었으며 신체관리 및 운동성과 섭식에서 가장 낮았다. 4) HISCL에서 보고한 TBI군의 주관적인 증상은 기억력 감퇴가 가장 심했고 집중력, 소음 과민성 순이었으며 광과민성과 불면이 가장 적었다. 5) NRS로 평가한 TBI군의 객관적인 증상은 신체적 염려를 가장 높게 평가하였고 우울감, 불안 순이었으며 환각적 행동, 이해력 결손을 가장 낮게 평가하였다. NRS 4가지 요인들로 나누어 손상의 정도를 평가한 결과 요인 Ⅲ(신체/불안)이 가장 높았으며 요인 Ⅰ(인지/에너지), 요인 Ⅱ(이인지기능), 그리고 요인 Ⅳ(언어)의 순이었다. 6) TBI군의 QL-Index, SIP, HISCL 그리고 NRS 점수들의 상관을 구해 본 결과 각 척도 점수들 사이 모두에서 유의한 상관을 보였다(p〈0.01), 그리고 상관의 정도는 객관적인 삶의 질 척도에 비해 주관적인 삶의 질 척도에서 더 높았다. 이상을 요약하면 삶의 질의 전 영역에서 TBI군의 저하가 큰 것으로 평가되었다. TBI 환자는 업무수행력과 사회적 어려움을 놓게 평가한 반면 의사들은 신체 증상과 우울 증상 등의 정서적 어려움을 높게 평가하였다. This study was designed to investigate the quality of life(QOL) in the patient with traumatic brain injury(TBI), in view of the global, psychosocial and neurobehavioral aspects of QOL. Thirty-one patients with TBI and corresponding matched controls were rated with a global measure(Quality of Life-Index ; QL-Index), a psychosocial measure(Sickness Impact Profile : SIP), and a self-rating(Head Injury Symptom Checklist : HISCL) and an objective symptom scales(Neurobehavioral Rating Scale : NRS). The results were as follows : 1) There were significant difference between the TBI and the control groups in the level of QOL measured by all scales(p〈0.01). 2) On QL-Index, the decrement of QOL was 67.4±19.2 in TBI group, and 8.1±6.4 in control group. In TBI group, the severity of impairment was highest in Activity(involvement in own occupation), and the following items were 'Outlook in Life', 'Perception of own Health', 'Activities of Daily Living', Support of Family and Friends' in decreasing order of severity. 3) On SIP, the degree of psychosocial dysfunction was 67.2±20.1 in TBI group, and 8.5±6.9 in control group, the impairment was highest in 'Work' and the following items were ‘Home Management’ and ‘Social Interaction’, with ‘Body Care and Movement’ and ‘Eating’ the lowest. 4) On HISCL the severity of subjective symptoms of TBi patients was highest in ‘Memory’, and the next were ‘Concentration’ and ‘Noise sensitivity’ and the lowest ‘Light sensitivity’ and ‘Insomnia’. 5) On NRS, the severity of objective symptoms of TBI patients was highest in ‘Somatic concern’, ‘Depressive mood’, and ‘Anxiety’ in decreasing order. Among the four factors of NRS, the severity of impairment was highest in Factor Ⅲ(Somatic/Anxiety), and the next were Factor Ⅰ(Cognition/Energy), Factor Ⅱ (Metacognition), and Factor Ⅳ(Language). 6) There was significant correlation among the total scores of all the above scales in the patients with TBI(p〈0.01).

박목월 시에 나타난 기독교적 시의식

박승준 배화여자대학 1999 培花論叢 Vol.18 No.-

This study aims at examining the major aspects of christianity in Park Mokwol's Poetry including the characteristics. Mokwol's poetic element of, Christianity first appears in his work orchid and others. Deeply rooted in the diverse aspccts of Christianity in this work is his simple religious wish to lead a natural life of selflessness. It was also one of his living strategics to effectively cope with the heartless world of reality and the worldly greed to accumulate riches. In his work Clearness and Cloud we also find some important aspects of Christianity, particularly when we notice that he matures into a Christian gladly accepting the pains of life in this world patiently as well as with an attitude of willing obedience to the law of nature. In his work Kyungsangdo Fallen Leaves, which was written in his sixties, we notice that his life is colored with a sense of futility and loneliness. He then pursues a life of eternity through God and His help,and in due course his religio us sentiments turn to a transcendental will. A totality of Mokwol's devout religiosity is most clearly revealed in his work A Big and Soft Hand. Mokwol is surely a creative poet of a new mental world. In this work, howe ver, he realizes the futility of the poet's attempt to interpret and praise the world with the limits of human perspectives. He then gets to overcome the worldly self who could never be free from the fundamental limitations of mortality (such as death, old age, etc.), and he is born again as a man of faith who has the ability to see through man and the world, and eventually he finds a way of his own salvation.