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      • KCI등재후보

        신경인지재활치료가 편마비 환자의 손 기능에 미치는 영향 이지현, 강보라

        이지현,강보라 한국인지운동치료협회 2019 한국신경인지재활치료학회지 Vol.11 No.2

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        목적: 본 연구는 손 기능이 손상된 급성기 편마비환자에게신경인지재활치료를 적용하여 손 기능과 과제를 수행하는능력에 미치는 영향을 알아보고자 한다. 방법: 대상자는 고양시 Y재활병원에 입원하여 치료받고있는 환자로 뇌졸중 진단을 받았으며, 실험의 내용을 이해하고 참여 의사를 밝힌 자로 선정하였다. 대상자는 49세 여성으로 2019년 2월 24일 발병되어 우측 뇌기저핵 부위의 뇌내출혈로 인한 좌측 편마비를 진단받았다. 연구 기간은 2019년3월 18일부터 5월 10일까지 진행되었으며, 8주 동안 주 5회30분씩 총 40회기의 신경인지재활치료를 실시하였다. 결과: 연구 결과 뇌졸중 상지 기능 검사에서 치료 전 오른쪽32점, 왼쪽 23점, 치료 후 오른쪽 32점, 왼쪽 29점으로 왼쪽상지의 기능변화가 나타났다. 그루브드 막대 검사 결과 치료전 오른손 57초(수행 개수 25개, 떨어진 개수 0개)에서 치료후 62초(수행 개수 25개, 떨어진 개수 0개)였으며, 왼손은323초(수행 개수 25개, 떨어진 개수 2개)에서 126초(수행 개수 25개, 떨어진 개수 0개)로 왼손의 시간 단축과 수행도의증가가 나타났다. 상자와 나무토막 검사에서는 오른손 80개에서 81개, 왼손 25개에서 48개로 오른손 1개, 왼손 23개로향상되었다. 결론: 신경인지재활치료가 급성기 뇌졸중 환자의 손 기능및 과제수행의 질에 효과가 있는 것으로 나타났다. The purpose of this study is to reveal the effect of neurocognitive rehabilitation therapy on hand function for hemiplegic patients. The subject of the study was a female patient aged 49 with left hemiplegia caused by intracranial hemorrhage, and the cognitive-therapeutic exercise was applied to her for 30minutes once a day from March 18, 2018 to May 10, 2019. In this study, after neurocognitive treatment, the results of the MFT found no change found in the right hand. The left hand improved from 23 to 29 scores. The results of the grooved pegboard test, which evaluated the hand function, were as follows. The right hand performed from 57 seconds (25 performed, 0 dropped) to 62 seconds (25 performed, 0 dropped) after treatment, and the left hand improved from 323 seconds (25 performed, dropped 2) to 126 seconds (25 performed, dropped 0) after the treatment. The results BBT, the right hand performed from 81 to 80, The left hand improved from 25 to 48. Neurocognitive rehabilitation therapy was found to be effective on hand function and task performance in acute stroke patients.

      • KCI등재

        1910년대 부산 극장가 문화 연구

        이지현(李智賢) 동북아시아문화학회 2018 동북아 문화연구 Vol.1 No.56

        The purpose of this study is to consider how the colonial modernity was substantialized, particularly based on the Busan theater district in the 1910s which is one of the modern urban culture treasures. In the circumstances where the American film industry was expanded in the 1910s, Hollywood silent movies entered into Joseon and the fever of action movie series was spreading in the entire area of Joseon including Kyungsung. The Busan theater district strongly showed cultural hybridism due to its geographical characteristic as a border area. This cultural hybridism continued even after action movie series were brought in. Entering into Joseon in 1916, “The Broken Coin”, a Hollywood movie, was released and very successful in the movie theater named Haeng Gwan. For the silent movie “The Broken Coin”, the role of narrator was magnified. In Kyungsung, there were two narrators for the audience: a Korean and a Japanese. In Busan, however, there is no sign of Korean narrator working and the then Korean audience is presumed to have enjoyed movies based on the performance by a Japanese narrator. In general, narrators played a role to induce the audience's emotions by expressing the original text in their own fashion. It is presumed that the narration or description of a Japanese narrator was significantly different from that of a Korean narrator, in terms of cultural translation. Moreover, the then Korean audience in Busan was not able to enjoy such theater culture as that of Kyungsung where Koreans gathered and enjoyed movies in a kindred language space. This can be deemed the coloniality of the Busan theater district behind the fever of action movie series in the 1910s.

      • KCI등재후보

        Genetic Variations of ABCC2 Gene Associated with Adverse Drug Reactions to Valproic Acid in Korean Epileptic Patients

        이지현,조양제,김원주,이민구,이지현 한국유전체학회 2013 Genomics & informatics Vol.11 No.4

        The multidrug resistance protein 2 (MRP2, ABCC2) gene may determine individual susceptibility to adverse drug reactions(ADRs) in the central nervous system (CNS) by limiting brain access of antiepileptic drugs, especially valproic acid (VPA). Ourobjective was to investigate the effect of ABCC2 polymorphisms on ADRs caused by VPA in Korean epileptic patients. Weexamined the association of ABCC2 single-nucleotide polymorphisms and haplotype frequencies with VPA related to adversereactions. In addition, the association of the polymorphisms with the risk of VPA related to adverse reactions was estimatedby logistic regression analysis. A total of 41 (24.4%) patients had shown VPA-related adverse reactions in CNS, and the mostfrequent symptom was tremor (78.0%). The patients with CNS ADRs were more likely to have the G allele (79.3% vs. 62.7%,p = 0.0057) and the GG genotype (61.0% vs. 39.7%, p = 0.019) at the g.‒1774delG locus. The frequency of the haplotypecontaining g.‒1774Gdel was significantly lower in the patients with CNS ADRs than without CNS ADRs (15.8% vs. 32.3%, p= 0.0039). Lastly, in the multivariate logistic regression analysis, the presence of the GG genotype at the g.‒1774delG locuswas identified as a stronger risk factor for VPA related to ADRs (odds ratio, 8.53; 95% confidence interval, 1.04 to 70.17). Wedemonstrated that ABCC2 polymorphisms may influence VPA-related ADRs. The results above suggest the possible usefulnessof ABCC2 gene polymorphisms as a marker for predicting response to VPA-related ADRs.

      • KCI등재

        At therapeutic concentration bupivacaine causes neuromuscular blockade and enhances rocuronium-induced blockade

        이지현,이수일,이승철,최소론,이원지 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.62 No.5

        Background: Partially paralyzed patients may be placed in the risk of pharyngeal dysfunction. Bupivacaine acts as acetylcholine receptor ion channel blocker and may synergistically interact with rocuronium to augment NM blockade. Thus, this study aims to elucidate whether or not, at a therapeutic concentration, bupivacaine by itself may cause NM blockade and reduce an effective concentration of rocuronium. Methods: Twenty-two left phrenic nerve-hemidiaphragms (Male SD rats, 150-250 g) were hung in Krebs solution. Three consecutive ST, 0.1 Hz and one TT, 50 Hz for 1.9 s were obtained before drug application and at each new drug concentration. A concentration of bupivacaine in Krebs solution (n = 5) was cumulatively increased by way of 0.01, 0.1, 1, (1, 2, 3, 4, 5, 6, 7) × 10 μM. In a Krebs solution, pre-treated with bupivacaine 0 (n = 5), 0.1 (n = 5), 1.0 (n = 5), 10 (n = 2) μM, and then concentrations of rocuronium were cumulatively increased by way of 1, 3, 5, 7, 9, 12, 14, 16, 18, 20 μM. EC for each experiment were determined by a probit. The EC50's of rocuronium were compared using a Student's t-test with Bonferroni's correction. Differences were considered significant when P < 0.05. Results: The potency of bupivacaine for normalized TF was 11.4 (± 1.1) μM. Below 30 μM of bupivacaine, the single twitch potentiation sustained despite the development of tetanic fade and partial inhibition of PTT. Bupivacaine significantly facilitated the NM blockade induced by rocuronium. Conclusions: Clinicians should be aware that bupivacaine by itself at its therapeutic concentration inhibit NM conduction and enhances rocuronium-induced muscle relaxation. Background: Partially paralyzed patients may be placed in the risk of pharyngeal dysfunction. Bupivacaine acts as acetylcholine receptor ion channel blocker and may synergistically interact with rocuronium to augment NM blockade. Thus, this study aims to elucidate whether or not, at a therapeutic concentration, bupivacaine by itself may cause NM blockade and reduce an effective concentration of rocuronium. Methods: Twenty-two left phrenic nerve-hemidiaphragms (Male SD rats, 150-250 g) were hung in Krebs solution. Three consecutive ST, 0.1 Hz and one TT, 50 Hz for 1.9 s were obtained before drug application and at each new drug concentration. A concentration of bupivacaine in Krebs solution (n = 5) was cumulatively increased by way of 0.01, 0.1, 1, (1, 2, 3, 4, 5, 6, 7) × 10 μM. In a Krebs solution, pre-treated with bupivacaine 0 (n = 5), 0.1 (n = 5), 1.0 (n = 5), 10 (n = 2) μM, and then concentrations of rocuronium were cumulatively increased by way of 1, 3, 5, 7, 9, 12, 14, 16, 18, 20 μM. EC for each experiment were determined by a probit. The EC50's of rocuronium were compared using a Student's t-test with Bonferroni's correction. Differences were considered significant when P < 0.05. Results: The potency of bupivacaine for normalized TF was 11.4 (± 1.1) μM. Below 30 μM of bupivacaine, the single twitch potentiation sustained despite the development of tetanic fade and partial inhibition of PTT. Bupivacaine significantly facilitated the NM blockade induced by rocuronium. Conclusions: Clinicians should be aware that bupivacaine by itself at its therapeutic concentration inhibit NM conduction and enhances rocuronium-induced muscle relaxation.

      • KCI등재

        Radiologic Findings of the Pancreatic Lymphoepithelioma-Like Carcinoma: A Case Report

        이지현,김재운,이은주,최준혁 대한영상의학회 2014 대한영상의학회지 Vol.70 No.6

        A 76-year-old man with fatigue was admitted to our hospital. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a well-circumscribed mass with delayed heterogeneous enhancement between the pancreas head and the second portion of the duodenum. A surgical resection was performed and a lymphoepithelioma-like carcinoma (LEC) was pathologically confirmed, originating from the head of the pancreas. After the surgery, the patient did not have additional treatment and his LEC did not recur for four years and 10 months. We report MRI and CT findings with histopathologic findings of an extremely rare case of LEC arising from the pancreatic head.

      • KCI등재

        대화전략 지도의 가능성에 대한 연구: 언어발달을 중심으로

        이지현 영상영어교육학회 2015 영상영어교육 (STEM journal) Vol.16 No.3

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Teaching communication strategies (CS) to make communication effective is of crucial importance for language learning and should contribute to language development. This study examines the possibility of teaching CS for successful communication and the feasibility of incorporating them into language development. An experiment was conducted using the movie Love Actually and the sitcom Friends. The aim of the experimental group (n=100) was to become aware of the CS used to make communication effective, which results in noticing the language used in the CS. The group watched the scenes and found effective strategies, which they discussed. They also discussed the language which revealed the strategies were effective. The teacher guided them to focus on the CS. The control group (n=100) focused on expressions of high frequency. The experimental group showed an improvement in the test of CS and significantly outperformed the control group in the test for long-term memory retention in the language of a touching scene. Results suggest that CS are a teachable domain and especially the language of CS that moves the learners' hearts can lead to long-term memory retention, which has an effect on language development.

      • 2P-35 : Thiophene- and fluorinated quinoxaline- based d-a alternating conjugated polymers in photovoltaic solar cells

        이지현,진영읍 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1

        Novel conjugated copolymers (DTDFQx, DTFQx), which were synthesized through palladium catalyzed the stille coupling reaction were composed of di- or mono- fluorinated quinoxaline (Qx) as electron-deficient acceptor. Thiophene was used as a more electron-rich donor. Quinoxaline- based copolymers with two different side chains had variable results from the solubility, thermal properties, absorption spectra, energy levels, and photovoltaic propertises. Among them, the polymers containing Hexyl alkyl side chain were insoluble in common types of organic solvents. The polymer solar cell device introducing dodecyl alkyl side chain into polymer showed a high open circuit voltage (V<sub>OC</sub>) of 0.87eV and efficiency value over 2.0% was obtained for the resulting copolymers.

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