정상 한국인에서 연령증가에 따른 혈장 Dehydroepiandrosteronesulfate ( DHEA-S ) 농도 및 DHEA - S / cortisol 비의 변화

박성우,유형준,임성희,최문기,유재명,박민숙,이권엽,박철수,김철홍,김현규,김두만,박규용 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.2

Backgroud: DHEA-S is the most abundant steroid hormone in circulation, and primarily secreted from the adrenal cortex, but its physiological role is little known. One of the characteristic features of DHEA-S is progressive decrement of plasma DHEA-S level with advancing age, in contrast, plasma levels of other adrenal hormones are not chaging or littie decreasing. To grasp the trends of plasma DHEA-S level and DHEA-S/cortisol ratio by age in healthy Korean, we measured the plasma DHEA-S levels and DHEA-S/cortisol ratios in healthy Korean. Methods: Healthy Korean(men: 99, women: 102, age range: 15-97 year old)were studied. Subjects were not taking drugs(such as glucocorticoid or androgenic medication) or cigarettes known to modify the plasma level of DHEA-S and cortisol, and had no evidence of hepatic, renal disease or hyperlipidemia as determined by serum lipid, bilirubin, SGOT, SGPT, BUN, creatinine. Data were analyzed by 10-year age group for men and women: i.e, 10-19, 20-29, 30-39, 40- 49, 50-59, 60-69, 70-79, 80-89 and 90 year or more. Plasma DHEA-S levels were measured by using a commercially available RIA kit with 125I labeled-DHEA-SO4(Coat-A Count DHEA-SO4), and for the measurement of plasma cortisol levels, commercial Gamma Coat TM[125I] Cortisol Radioimmunassay Kit was used. Results:. 1) In both men and women, plasma DHEA-S level showed high interindividual variation within the same age group. 2) There were individual sex differences in plasma levels of DHEA-S, in all age groups, plasma DHEA-S levels were significantly higher values for men than for women. 3) Maximum plasma DHEA-S levels(men; 237+-3.35 ug/dL, women; 108+-17.5 ug/dL) were at third decade in both men and women. 4) Both men and women showed the continuous decline in plasma DHEA-S level with age. These age-related decline was more prominent in men than in women(men; y= -3.152 * +292.6, r2= 0.8459, P$lt;0.05, women; y= -1.417 * +143.3, r2 = 0.7278, P$lt; 0.05). 5) As an index of aging, there was no stastical difference between DHEA-S and DHEA- S/cortisol ratio. Conclusion: In healthy Korean, there were high interindividual variation of plasrna DHEA-S levels. In both men and women plasma DHEA-S level was peak at third decade, and from when it declined progressively with age. These results suggest that although the reliability of single plasma DHEA-S measurement are limited, the decline of DHEA-S with advancing age might be a specific marker of endocrinologic hormonal milieu(aging index). Also, concerning to individual adrenal secreting capacity, we measured DHEA-S/cortisol ratio. But we did not found that plasma DHEA-S/cortisol ratio is superior to the plasma DHEA-S level as an aging index. (J Kor Soc Endocrinol 12:245-254, 1997)

Molecular subtypes of triple-negative breast cancer: understanding of subtype categories and clinical implication

Yong‑Moon Lee,Man Hwan Oh,Jai‑Hyang Go,Kyudong Han,Song‑Yi Choi 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Triple-negative breast cancer (TNBC) is a heterogeneous entity that encompasses several subtypes with distinct molecular characteristics. The patients with TNBCs show unpredictable response to the chemotherapy, and further there is the lack of effective agents. Thus, many studies have been underway to discover targeted therapy suitable for patients with specific genetic alterations in each molecular subtypes. TNBCs are classified as four major molecular subtypes according to the gene expression patterns. These are luminal androgen receptor (LAR), mesenchymal-like, immunomodulatory (IM), and basal-like types. Conclusion: Here, we discuss the unique molecular features of each subtype as well as promising targets for anti-cancer therapy.

수부 주상골 요부의 전위골절에 대한 수술적 치료

조용만,이영기,강흥식,리건영,이천동,오상수 대한골절학회 1997 대한골절학회지 Vol.10 No.1

The authors surveyed the clinical study of 17cases of scaphoid fractures from March 1989 to September 1994 with minimal I year follow up at Department of Orthopedic Surgery, Lee-Rha general Hospital. The following conclusions were obtained through clinical survey. l. Of all l 7 cases, they were l3 males and 4 females; Among the 13 males, 10 cases were aged between 20 and 39 years. forming 56.8% of all. 2. All 17 cases were treated by open reduction. Unions were obtained at average l l.5 weeks in 7 cases treated with Herbert screw fixation and l 2 weeks in l 0 cases treated with K-wire fixation. 3. Two of ten K-wire treated cases resulted in delayed union, one of seven Herbert screw treated cases resulted in delayed union. 4. Unions were obtained at average 20 weeks in 3 cases of delayed union. We concluded that open reduction and K-wire fixation were recomanded for the compatible treatment method of displaced waist fracture of scaphoid.

거골 경부 골절의 치료

조용만,이영기,리건영,이천동 대한골절학회 1996 대한골절학회지 Vol.9 No.4

The talus has some important anatomic features. Approximately 60% of its surface is cartilage and The talus often has problems with circulation. Talar neck fracture have a high association with ostonecosis and osteoarthritis. Authors have analysed l6 cases of the talar neck fractures treated at Lee-Rha General Hospital from January l990 to December l995 with minimal I year follow up. The results were as follows; 1. In thr l6 cases, there were l4 males and 2 females. the age between 20 and 40 years old was 10 cases(63%). 2. The most common cause of injury was traffic accident(63%), with sudden hyperextension as its mechanism. 3. associated injuries were 4 malleolar fracutres, 3 calcaneous fractures, 3 spine fractures, 3 tiviofibular fractures and 2 femur fractures. 4. According to the Hawkins classification: 3 cases in type I, 4 cases in type I, 5 cases in type l. 4 case in type N fractures were observed. 5. The method of treatment, all 3cases of Hawkins type I fractures were treated by closed reduction and cast immobilization, 3 cases of Hawkins type l and I case of Hawtins type III fracture were treated by closed reduction and internal fixation, other 9 cases were treated by open reduction and internal fixation. 6. Excellent results were observed in 8 cases good in 5 cases, fair in 2 cases . poor in l case with the Hawkins' therapeutic criteria. 7. Complications was observed 3 avascular necrosis, 2 post-traumatic arthritis, 2 ankle stiffness and l skin necrosis. From the above results, authors believe that early anatomical reduction k internal fixation is impotent to get a satisfactory result in de treatment of talar neck fracture.

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

녹차(Camellia sinensis)와 감초(Glycyrrhiza uralensis Fischer) 추출 혼합물이 김치 숙성에 미치는 영향

이신호,박경남,배만종,임용숙 경산대학교 생명자원개발연구소 1999 생명자원과 산업 Vol.3 No.-

천연 보존제를 사용하여 김치 숙성 지연효과를 검토하기 위해서 항균력이 있는 녹차와 감초 추출물을 이용하여 김치 유산균에 대한 성장 억제 실험을 한 결과 대조구에 비해 첨가구가 높게 나타났으며 특히, 녹차와 감초 추출물 혼합 첨가구가 녹차추출물 단독 첨가구에 비해 김치 유산균에 대한 성장 억제 기능이 높게 나타났다. 이를 기초로 김치 제조시 추출혼합물을 첨가한 결과 pH의 경우 숙성 10일째부터 첨가구가 대조구보다 높게 나타났으며, 적정산도, 미생물변화의 경우 숙성 10일째부터 첨가구가 대조구에 비해 낮게 나타났다. 관능적 품질 면에서는 flavor, 맛, 종합적 기호성에서 대조구와 차이를 나타내지 않았고, color, 조직감에서는 첨가구가 대조구 보다 다소 높게 나타났다. The mixed effects of Camillia sinensis and Glycyrrhiza uralensis Fischer(CG) on Kimchi feermentation were investigated by measuring microbiological, physicochemical and sensory qualities of Kimchi during fermentation. The pH of CG-added Kimchi was a little higher than that of control during the fermentation. Titrarable acidity, the viable cell of total bacteria and lactic acid bacteria in mixed extracts(CG) added Kimchi were changed a little lower than those in control. The sensory score of flavor and sourness were the same to control for fermentation. But, The sensory score of color, texture and overall acceptability were a little superior to control for fermentation.

사회체육의 역할과 발전방향

이용우,최병익,최동만 공주대학교산업개발연구소 2000 産業開發硏究 Vol.8 No.-

Over the past 30 years, a great number of scientists have pursued the systems on the role of sport in society. As many scholars point out, sport includes most of all human activities, accordingly it is related with industry, politics, economy, art, and so on. Hence, development of social sport could improve quality of life. Several alternatives would be suggested such as (1) fostering qualified leaders, (2) providing multi-purpose facilities for efficient use, (3) even distribution of facilities between regions, (4) development of varieties in programs, (5) finding and networking human resource for the development of sport.

단감나무의 品種別 生理 및 形態的인 特性에 관한 硏究(Ⅰ) : 잎의 生理 및 形態 Physiology and Morphology of Leaves

李容門,鄭景泰,李龍載,金萬洙 東亞大學校 大學院 1995 大學院論文集 Vol.20 No.-

Experiments on the 1eaf characteristics have been carried out in sweet persimmon cultivars. The results obtained are as followings : Mikado and Daean-Dangam were the largest for leaf length, leaf width, leaf area and leaf weight in all cultivars, while Suido was the smallest for leaf width, leaf area and leaf weight. Suruga was the thickest for the leaf thickness, but Johongsi was the thinnest. The largest leaf stalk diameter was observed in Mikado and Ichimogkei-Jiro, but the smallest was Hana-Gosho. For the leaf stalk length, Kyara was the longest and Zenjimaru the shortest. For the index of leaf shape, RO-19 showed the largest as 66.5% for the south-facing leaf and 68.3% for the north-facing leaf, but Kyara and Suido showed smallest. The south-facing leaf showed large values in lcaf shape index, leaf thickness, leaf stalk diameter and leaf stalk length, but the north-facing leaf was relatively large in leaf length, leaf width, leaf area and leaf weight. For the content of chlorophyll, Hana-Gosho and RO-19 cultivars contained higher, but Yido and Bang-Gosho contained lower. In average for all cultivars, the contents of N, Ca and B were low, that of P seemed in sufficient and those of K and Mg were difficient. However, the contents of Na, Cu, Zn, Fe and Mn were moderate. The content of Al in particular, were high(81-148ppm) for all cultivars.

野球選手 傷害에 關한 調査 硏究

李鎔滿,元忠熙 公州大學校 스포츠科學硏究所 1991 스포츠科學硏究所論文集 Vol.- No.4-5

Ⅰ. Purpose ; The major purpose of this paper is to provide data not only to improve performance of the player and to discover a modern, Scientific, and psychological training method suitable for the high-standards and delicacy modern sports, but also to find a better way of improving the physical status and the injury treatment of the middle-school players through a survey of their major causes and treatments of injuries in base-ball games. Ⅱ. Method For the studies and analysis of cause of injuries and its treatment in baseball. this report was completed through the survey of 486 players form 27 middle school teams. The survey was made form November 1988 to september 1990 and its results of analysis are as follows Ⅲ. Result 1) The frequency according to the time is the order of afternoon morning and nights respectively and according to events, it is in the order of practice official games and personal practice respectively 2) The events of injury occurs mostly in defense practices and last in personal practices. In the defense of official games, the major cause of injuries are by thrown of batted balls and injury caused by collision to fenses are the least Injuries in offense are caused majorly by pitched of thrown balls and the injuries caused by obstacles such as bats are considered the least causes. 3) The injured parts of the body are in the order of arms, waist, leg, foot and finally the neck. 4) the muscular injuries are the major & injuries followed by skin injuries and respectively. 5) In the case of first-aid, self-treatment was the leading treatment and given by doctors at the ball - park was the least common case And in the case of treatments after injuries hospital treatments was the most common case 6) In the case of medical treatments, hospital treatments and bone-setting clinic treatments were the most and the least common case of treatment respectively.

Captopril과 Nifedipine 병합요법의 강압효과에 관한 임상적 연구

이영수,문언수,김준호,공수정,정시진,주용진,정상만 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

Background: The hypotensive effect of captopril(angiotensin converting enzyme inhibitor) and nifedipine(calcium channel blocker) was studied. Method: Captopril(75mg) and nifedipine(30mg) were administered in 30 hypertensive adults during twelve weeks after a week observation for washout with stepwise increments of the dose according to the patient's blood pressure in every two weeks. Result: The supine blood pressure were decreased from 169.5±22.3/104.0±20.3 mmHg to 130.4±21.3/82.4±19.5mmHg at the end of twelve weeks during therapy.(p<0.05) The standing blood pressure were also decreased conferrably and to the some lower level. Hematologic examination and blood chemistry revealed no discernible abnormal findings before and after the treatment. During the period of the study a few probably drug-related symptom such as cough and headache, gastrointestinal disturbance developed but not troublesome enough to administering. Conclusion: Captopril and nifedipine regimen is well tolerated and effective in the treatment of hypertensive patients.