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Cocaine 및 Ether 痲醉와 Chlorpromazine 注射가 鼻中隔粘膜에서의 Reilly氏 現象에 미치는 影響에 관한 病理組織學的 硏究
崔炳益,申洪秀 고려대학교 의과대학 1974 고려대 의대 잡지 Vol.11 No.2
The significant role of sensory nervous system as well as autonomic nervous system, relating has been observed by Reilly's phenomenon which effects the distant organs by local stimulation, many researchers. Author studied histopathological changes of the lung, kidney, adrenal gland, liver and testicle after pilocarpine injection into the nasal septa1 mucosa under pretreated conditions with cocaine local anesthesia, ether general anesthesia, and chlorpromazine intramuscular injection. The experimental rabbits were divided as follows: 1. Control group: a. Normal saline injection group: 0.5cc of 0.85% saline solution was injected into the submucosa of the nasal septum. b. Pilocarpine injection group: 0.5cc of 1% pilocarpine solution was given into the same site as above. 2. Cocaine local anesthesia group: a. Cocaine local anesthesia group (control group): Local anesthesia to the left mucosa of nasal septum was performed with cotton ball soaked with 5% cocaine hydrochloride solution for 15 minutes. b. Pilocarpine injection group after cocaine local anesthesia: 0.5cc of 1% pilocarpine solution was injected into the left submucosa of nasal septum after cocaine local anesthesia as the same method. 3. Ether general anesthesia group: a. Ether general anesthesia group (control group) : general anesthesia was performed with ether open dropping for about 20 minutes. b. Pilocarpine injection group after ether general anesthesia: pilocarpine solution was injected as the same method after ether general anesthesia. 4. Chlorpromazine intramuscular injection group: a. Chlorpromazine inttamuscular injection group (control group) : 5mg. chlorpromazine was injected intramuscularly to the left buttock of rabbit and sacrificed 30 minutes later. b. Pilocarpine injection group after chlorpromazine intramuscular injection: Pilocarpine solution was injected as the same method after 30 minutes of chlorpromazine injection. The experimental animals were sacrificed immediately, then specimens were obtained from certain portions of lung, kidney, adrenal gland, liver and testicle and stained with H-E solution. The results obtained were: 1. Significant histopathological changes were observed in the lung, kidney, adrenal gland and liver of pilocarpine injection group(control group). 2. Pilocarpine injection group after cocaine local anesthesia showed less significant changes than that of the control group. 3. Pilocarpine injection group after ether general anesthesia showed less significant changes than that of the control group. 4. Pilocarpine injection group after chlorpromazine intramuscular injection also showed relatively slight changes than the control group. Under cocaine and ether anesthesia, and chlorpromazine injection, the nasal septa1 irritation with pilocarpine injection seems to be effective to disturb the occurence of Reilly's phenomenon.
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구형석출물을 갖는 무한 고체에 전수압이 가해지는 경우에 대한 탄소성해
최병익,엄윤용 대한기계학회 1981 대한기계학회논문집 Vol.5 No.2
Equation of equilibrium is derived and solved for an infinite isotropic solid under applied hydrostatic stress which is uniform at large distance, and disturbed by a spherical precipitate which has isotropoc elastic constants dirrerent form those of the matrix. A linear strain hardening behavior of the matrix is assumed, and an elasto-plastic sloution is obtained. The difference of the total strain energy stored inthe infinite solid with and without a precipitate is computed, and compared with that for purely elastic case. Finally the effect of the ratio of the bulk modulus of the precipitate to that of the matrix and the effct of linear strain hardening rate on the plastic zone size and the energy difference are discussed.
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