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김두만,고건일 圓光大學校 藥品硏究所 1992 藥品硏究所報 Vol.7 No.1
Streptozotocin(STZ; 40㎎/㎏ body wt.) was intraperitoneally administered to get hyperglycemic mice(blood glucose level, 290∼450㎎/dl) on 5 consecutive days. At day 7 after completion of low-dose streptozotocin treatment, the water extracts of crude drugs (Atractylodes Rhizoma, Aconiti Tuber, Anemarrhinae Rhizoma, Mori Radicis Cortex) were administered to the STZ-induced hyperglycemic mice for investigating the histopathologic changes of pancreatic islet. At this stage, blood glucose level decreased significantly when crude drugs were administered to streptozotocin-induced hyperglycemic mice. The single administration of crude drug to hyperglycemic induced by with low-dose streptozotocin inhibited significantly a decreasing tendency of plasma contrast and pancreatic β-cell granules, disruption of plasma membrane, lymphocyte infiltration of islet β-cells, swelling and disruption of mitochondria compared with streptozotocin-induced hyperglycemic mice by electron microscopy. Whin the water extract of Atractylodes Thizoma was administered with insulin, it did not show actions besides insulin-secreting action. Intracellular Ca^2- concentration was significantly increased when the water extract of crude drug stimulated pancreatic β-cell isolated in normal rat with 10% glucose. In this study, it was suggested that the water extracts of crude drugs showed hypoglycemic action because they promoted insulin- secreting action of pancreatic β-cell of STZ-induced hyperglycemic mice or rats by their β-cell stimulation.
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김두만,김상욱 대한기계학회 1986 대한기계학회논문집 Vol.10 No.5
본 연구에서는 타이어의 동적설계의 기초자료를 제시하는데 그 목적이 있다. 해석적 방법으로는 복합막트로이드 유한요소를 이용하여 타이어의 고유진동수 및 진동 모우드를 구하였으며, 그 정확성을 입증하기 위하여 멀디찬널 F.F.T.분소기를 이용한 실험적 결과 및 G.R. Potts의 해석결과와 비교하였다. The dynamic characteristics of a passenger radial tire were studied by the analytical method and the experiments. The purpose of this study is to obtain the natural frequencies and the mode shapes of a 2 ply steel belt radial tire fixed on the wheel in order to give datum of the dynamic design of tire. The governing equations are derived with the energy method. The composite toroidal finite elements with three degrees of freedom at each node are defined by specifying geometry, internal displacement functions, strain displacement and stress displacement relationships. In order to verify the capability of the present analysis, the natural frequencies and mode shapes of the passenger radial tire are obtained experimentally by using the multi-channel F.F.T. analyser and compared the numerically obtained values. The results show that the analytically obtained values are in good agreement with the experiment and in addition they are in line with the Pott's experimental results.
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김두만 대한의사협회 2008 대한의사협회지 Vol.51 No.9
The incidence of type 2 diabetes mellitus is increasing rapidly worldwide, primarily because of increases in obesity and decreases in physical activity. Type 2 diabetes is one of the leading problems for the health-care system. In South Korea type 2 diabetes affects approximately 7~8% of adults. Some risk factors of type 2 diabetes mellitus such as overweight, nutritional imbalance, and a sedentary lifestyle are reversible. To prevent type 2 diabetes two approaches are usually adopted. One is population strategy that is aimed at preventing obesity, and the other is high-risk strategy to prevent and delay the development of type 2 diabetes in high risk groups. Prevention of type 2 diabetes is backed by many research evidences like Finnish Diabetes Prevention Study (Finnish DPS) and Diabetes Prevention Program (DPP) of USA. In this article I discuss the results of Finnish DPS and DPP, and to propose the prevention strategy in South Korea.
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