비정형성정신병 환자에서 나타난 코로 증후군

박철수 최신의학사 1988 最新醫學 Vol.31 No.7

Rho-Associated Kinase 2 Polymorphism of Vasospastic Angina in Korean Population

박철수 대한심장학회 2012 Korean Circulation Journal Vol.42 No.6

관상동맥 질환에서 동맥 경화증의 새로운 지표인 혈청오스테오프로테게린 농도는 당뇨 및 연령과 연관이 있다

박철수,윤호중,최윤석,이동현,김지훈,오용석,백상홍,정욱성,김재형,최규보,홍순조 대한심장학회 2006 Korean Circulation Journal Vol.36 No.7

Background and Objectives:There have been reports of an association between osteoprotegerin (OPG) and cardiovasculardisease. Therefore, the aims of this study were to evaluate the association between the plasma OPG leveland the severity of atherosclerosis, as well as search for conventional cardiovascular risk factors associated with theplasma OPG level in patients with coronary artery disease (CAD). Subjects and Methods:Plasma OPG levels weremeasured in 583 consecutive patients (mean age: 62±10 yrs, M:F=398:185), using an ELISA method, withCAD confirmed from the coronary angiogram. The intima media thickness (IMT) of the common carotid arterywas also measured in 252 patients. Results:The plasma OPG level was correlated with the IMT (r=0.184, p=0.003), with the median level found to be elevated in accordance with the severity of CAD (2704 in 1VD vs. 2914in 2VD vs. 3046 pg/mL in 3VD, p=0.024). Median plasma OPG levels were significantly higher in female (3024vs. 2828 pg/mL, p=0.003) and DM patients (3098 vs. 2711 pg/mL, p<0.001), and positively correlated with age(r=0.340, p<0.001) and the HbA1C level (r=0.102, p=0.035), but showed an inverse correlation with BMI(r=-0.199, p<0.001). No correlation was found between high sensitive C reactive protein (hs-CRP) and the plasmaOPG level, and no relation was found between CRP and the severity of CAD or the IMT. From a multivariatelogistic regression analysis, increasing age (odds ratio, 1.053 [95% confidence interval, 1.034-1.073]), DM (oddsratio 1.664 [95% confidence interval, 1.149-2.410]) and a BMI less than 25 kg/mm2 (odds ratio, 1.625 [95% confidenceinterval, 1.142-2.314]) were associated with the supramedian OPG level (2831 pg/mL). Conclusion:Theplasma OPG level might be a biochemical marker of atherosclerosis, and is associated with cardiovascular risk factors,especially DM and age. (Korean Circulation J 2006;36:543-548) 배경 및 목적: 이전의 몇몇 연구에서 혈중 오스테오프로테게린(Osteoprotegerin, OPG) 농도는 심혈관 질환의 발생 및 관상동맥 질 환의 정도와 관계가 있다는 보고들이 있었다. 이에 본 연구 는 혈청 OPG농도와 관상동맥 질환 정도 및 동맥 경화증의 중 등도의 관계에 대해 살펴보고 혈청 OPG 농도와 연관 있는 고식적인 심혈관 질환의 위험인자를 도출해 보고자 하였다. 방 법: 관상 동맥 조영술을 통해 50%이상의 관상 동맥 협착이 확 인된 583명의 환자에서 ELISA방법을 이용해 혈청 OPG농도 를 측정하였고 이 중 252명은 경동맥 내막 중막 두께(Intima media thickness, IMT)를 측정하였다. 결 과: 혈청 OPG농도는 경동맥 IMT와 통계적으로 유의한 양의 상 관 관계를 보였고(r=0.184, p=0.003) 관상동맥 질환의 중등 도에 따라 유의하게 증가하였다(2704 in 1VD vs 2914 in 2VD vs 3046 pg/mL in 3VD, p=0.024). 또한 혈청 OPG농도는 여성(3024 vs 2828 pg/mL, p= 0.003)과 당뇨 환자(3098 vs 2711 pg/mL, p<0.001)에서 유 의하게 증가되었으며 연령(r=0.340, p<0.001) 및 당화 혈색 소(r=0.102, p=0.035)와 유의한 양의 상관 관계를, 체 질량 지수(r=-0.199, p<0.001)와는 유의한 음의 상관 관계를 보 였다. 고 민감성 C 반응성 단백질(high sensitive C reactive protein, hs-CRP)는 혈청 OPG농도와 연관이 없었으며 관상동 맥의 중등도 및 경동맥 IMT와 통계적으로 유의한 관련이 없 었다. 다 변량 분석에 의하면 중간치 이상의 혈청 OPG 농도와 연 관이 있는 독립적인 심혈관 질환 위험인자는 연령(odds ratio, 1.053[95% confidence interval, 1.034~1.073]), 당뇨(odds ratio 1.664[95% confidence interval, 1.149~2.410]), 25 gm/m2이하의 체 질량 지수(odds ratio, 1.625[95% confidence interval, 1.142~2.314])였다. 결 론: 혈청 OPG 농도는 동맥 경화증의 정도를 반영하는 생화학 적 지표이며 관상 동맥 질환에서 혈청 OPG의 상승은 특히 당뇨 및 연령과 연관이 있다.

Association between the Serum Osteoprotegerin Level andTarget Lesion Calcium in Coronary Artery Disease

박철수,정욱성,윤호중,신용주,김지훈,오용석,승기배,김재형,최규보,홍순조 대한심장학회 2006 Korean Circulation Journal Vol.36 No.5

Background and Objectives:Osteoprotegerin (OPG) is a decoy receptor for receptor nuclear factor-kB ligand(RANKL). We sought to evaluate the association between the serum OPG level and the target lesion calcium(TLC) in those patients suffering with coronary artery disease (CAD). Subjects and Methods:We assayed theserum OPG levels in 65 CAD patients (mean age: 62±10 yrs, M:F=46:19) with using enzyme immunoassay,and these patient underwent intravascular ultrasound (IVUS) examinations of their target lesions. The degree ofTLC was estimated by the maximum arc of calcium and also the calcified plaque surface area that was calculatedfrom the serial cross-section IVUS images. Results:The median serum OPG levels were greater in the subjects withTLC than in the subjects without TLC (1.36 vs 0.95 ng/mL, respectively, p<0.05). Significant correlation was notedbetween the serum OPG levels and the maximum arc of calcium (r=0.274, p=0.027). The median serum OPGlevels were significantly increased more in the subjects who had a maximum arc of calcium ranging from 90 to 180degrees than in those subjects who had a maximum arc of calcium less than 90 degrees (1.63 vs 1.14 ng/mL, respectively,p<0.05) and the median serum OPG levels were also increased more in the subjects who fell within thesecond tertile of the calcified plaque surface area than that in those subjects who fell within the first and thirdtertile (0.96, 1.53, 1.40 ng/mL for the first, second, third tertile, respectively, p<0.05). On the stepwise multivariatelogistic regression analysis, the serum OPG level remained a risk factor for TLC after adjustment was made forthe other risk factors such as age, diabetes mellitus, HbA1C and a smoking history (p=0.019, odds ratio 5.208[95% confidence interval: 1.308-20.744]). Conclusion:In patients with CAD, an increased serum OPG levelis associated with target lesion calcification. (Korean Circulation J 2006;36:337-342)

뇌파 분석을 위한 Empirical Mode Decomposition Algorithm

박철수 대한전자공학회 2015 전자공학회지 Vol.42 No.2

[건축환경설비 커뮤니티 정보] 신간 소개

박철수 한국건축친환경설비학회 2008 건축환경설비 Vol.2 No.2

오적산(五積散)을 투여한 흰쥐의 간장, 신장, 골중 금속농도 비교에 관한 연구

박철수,이선동,박해모,박영철,Park Chul-Soo,Lee Sun-Dong,Park Hae-Mo,Park Yeong-Chul 대한예방한의학회 2002 대한예방한의학회지 Vol.6 No.2

Traditional herbal medicine is used extensively among the Korean populations, and other Asian countries employ similar therapies as well In recent years, extensive focus was laid on adulteration of the herbal medicine with heavy metals. This may be mainly due to a soil contamination by an environmental pollution. The objective of this study is to identify the contents of various heavy metals in the blood from OhJeokSan-Decoction (OD) treated-rats. For this study, 13 kinds of metals including essential and heavy metals, i.e. Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se and Zn were analyzed by a slight modification of EPA methods and the following results are obtained. ; 1. There is no significant difference between the OD-treated groups and control group in liver, kidney, bone, brain, weight, food intake. 2. The amount of each metal analyzed in the liver are as follows; Al ; $0.235{\sim}4.215mg/kg$, As ; $0.103{\sim}0.461mg/kg$, Cd ; $0.005{\sim}0.010mg/kg$, Co ; $0.017{\sim}0.046mg/kg$, Cr ; $0.137{\sim}0.403mg/kg$, Cu ; $1.736{\sim}4.827mg/kg$, Fe ; $54.472{\sim}381.447mg/kg$, Hg ; not detected, Mn ; $1.159{\sim}2.803mg/kg$, Ni ; $0.007{\sim}0.095mg/kg$, Pb ; not detected, Se ; $0.682{\sim}1.887mg/kg$, Zn ; $10.213{\sim}26.119mg/kg$, by groups, respectively. In control and other experimental group, several metal (Co, Cu, Mn, Zn, As, Cr) has a significant difference, but in experimental I and other experimental II, III, IV, V groups, there are no significant difference. 3. The amount of each metal analyzed in the kidney are as follows; Al ; $1.712{\sim}31.230mg/kg$, As ; $0.062{\sim}0.439mg/kg$, Cd ; $0.010{\sim}0.062mg/kg$, Co ; $0.000{\sim}0.101mg/kg$, Cr ; $0.125{\sim}0.636mg/kg$, Cu ; $3.385{\sim}12.502mg/kg$, Fe ; $41.148{\sim}99.709mg/kg$, Hg ; $0.000{\sim}0.270mg/kg$, Mn ; $0.433{\sim}2.301mg/kg$, Ni ; $0.000{\sim}0.221mg/kg$, Pb ; $0.000{\sim}0.584mg/kg$, Se ; $0.540{\sim}1.600mg/kg$, Zn ; $8.775{\sim}17.060mg/kg$, by groups, respectively. The concentration of Cu, Se, Cr, and Hg are variated significantly in control and other experimental group, and Cu, Se, Cd, Cr are variated significantly in experimental I and other experimental II, III, IV, V groups. 4. The amount of each metal analyzed in the bone(tibia and fibula) are as follows; Al ; $9.557{\sim}119.464mg/kg$, As ; $0.139{\sim}12.250mg/kg$, Cd ; $0.000{\sim}0.295mg/kg$, Co ; $0.022{\sim}0.243mg/kg$, Cr ; $0.239{\sim}1.999mg/kg$, Cu ; $0.000{\sim}2.291mg/kg$, Fe ; $240.249{\sim}841.956mg/kg$, Hg ; $0.000{\sim}0.983mg/kg$, Mn ; $0.214{\sim}7.353mg/kg$, Ni ; $5.473{\sim}11.453mg/kg$, Pb ; $0.000{\sim}8.502mg/kg$, Se ; $0.000{\sim}3.005mg/kg$, Zn ; $61.158{\sim}195.038mg/kg$, by groups, respectively. The concentration of Se, Cd are variated significantly in control and other experimental groups, and Se is variated significantly in experimental I and other experimental II, III, IV, V groups. 5. Exceptionally several metal concentration is increased or decreased. but there is no significant harmful difference of metal concentration in the liver, kidney and bone, from the OD-treated-rats compared to those of the control group even if higher dosage($1{\sim}8$ times dosage of person) of OD was administered. Thus, it is expected that the herbal decoction in the traditional herbal medicine would not lay any burden on the body and the heavy metal toxins would not affect our physiological system. However, other kinds of herbal treatment, such as i.v. and i.p. should be considered in terms of

아파트 중심의 일상공간과 삶의 궤적

박철수,Park, Cheol-Su 한국주거학회 2009 住居 Vol.8 No.-

Environmental Impacts of Korean and CIMMYT Wheat Lines on Protein Characteristics and Bread Making Quality

박철수,Hong-Sik Kim,김대호,Jong-Nae Hyun,강천식 한국작물학회 2012 Korean journal of crop science Vol.57 No.1

This study was conducted to compare the protein characteristics, dough rheology and bread loaf volume of Korean wheat cultivars and CIMMYT lines produced in diverse environments and to determine the genetic and environmental effects on bread making quality. Protein characteristics, including protein content and SDS- sedimentation volume, mixing properties during dough development and bread loaf volume were primarily influenced by the environment. Wheat cultivated in Jinju exhibited higher SDS-sedimentation volume based on constant protein weight and bread loaf volume than those in Suwon and Iksan. SDS-sedimentation volume based on constant protein weight, mixing time of mixograph and mixing tolerance of mixograph were positively correlated with bread volume. Korean wheat cultivars showed different allelic variations of Glu-1 and Glu-3 compared to CIMMYT wheat lines. Alchanmil, Keumkangmil and Tapdongmil could be suitable for bread making because these cultivars exhibited a 10 point Glu-1 score. However, Korean wheat cultivars should be introduced specific alleles in Glu-3 loci, including Glu-A3b or d and Glu-B3b, d, f or g, to improve gluten strength related to increase bread loaf volume.

명색과 허울만 남은 북한 복지정책 대해부(下)

박철수 북한연구소 2013 北韓 Vol.- No.496