한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

Original Article : Geographic difference of epidemiological features of HCV infection in Korea

( Kyung Ah Kim ),( Sook Hyang Jeong ),( Eun Sun Jang ),( Young Seok Kim3 ),( Youn Jae Lee ),( Eun Uk Jung ),( In Hee Kim ),( Sung Bum Cho ),( Mee Kyung Kee ),( Chun Kang ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4

Background/Aims: The prevalence of hepatitis C virus (HCV) infection in Korea exhibits significant geographic variation, with it being higher in Busan and Jeonam than in other areas. The reason for this intranational geographic difference was investigated in this study by conducting a comparative analysis of the risk factors related to HCV infection among three geographic areas: the capital (Seoul), Busan, and the province of Jeolla. Methods: In total, 990 patients with chronic HCV infection were prospectively enrolled at 5 university hospitals located in Seoul (n=374), Busan (n=264), and Jeolla (n=352). A standardized questionnaire survey on the risk factors for HCV infection was administered to these three groups of patients, and a comparative analysis of the findings was performed. Results: The analysis revealed significant regional differences in exposure to the risk factors of HCV infection. By comparison with patients in Seoul as a control group in the multivariate analysis, patients in Busan had significantly more experience of invasive medical procedures, acupuncture, cosmetic procedures, and multiple sex partners. In contrast, patients in Jeolla were significantly older, and they had a higher prevalence of hepatocellular carcinoma, a lower prevalence of multiple sex partners, and had experienced fewer invasive procedures. Conclusions: There was a significant geographic difference in the exposure to potential risk factors of HCV infection between patients from the three studied regions. This may explain the regional variation of the prevalence of HCV infection in Korea, and should be taken into account when planning strategies for the prevention and management of HCV infection. (Clin Mol Hepatol 2014;20:361-367)

침 시술로 발생한 Non-O1, Non-O139 Vibrio cholerae에 의한 패혈증

임태섭,지아영,이중희,장수연,김인수,김영주,김범경,김승업,박준용,안상훈,한광협,김도영 Ewha Womans University School of Medicine 2013 EMJ (Ewha medical journal) Vol.36 No.S

Vibrio cholerae is mainly known to cause gastrointestinal infection after seawater exposure or raw seafood intake. It is rarely reported to cause cellulitis or sepsis, but threre has been no known case after acupuncture. Herein, We report a 56-year-old cirrhotic patient of non-O1, non-O139 Vibrio cholerae septicemia caused by cellulitis of both lower extremities after acupuncture.

학술 커뮤니케이션의 변화와 PMC(PubMed Central)

김상준,김정아,이미나 충남대학교 사회과학대학 문헌정보학과 2002 文獻情報學論集 Vol.8 No.-

특정 세균으로 유도된 백서의 치수염에서 T 세포 아군집의 분포와 interleukin-2, interferon-γ, interleukin-4의 수준에 관한 연구

김선아,임성삼 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.1

Immune response associated with bacterial infection involve inflammatory cells. Clinical symptoms and pathologic features are particularly influenced by the predominant cells. Among inflammatory cells. T cells have the heterogenity. T cells may develop into the mature cell expressing the cell surface markers with different functions and T helper cells are categorized into Th1 and Th2 cells based on their different patterns of cytokine production. The objective of this study was to investigate the change of expression of surface markers on T cells and the Th1/Th2 immune response in pulpal inflammation associated with specific bacteria. We experimentally induced pulpal inflammation in rat incisors by drilling without coolant and innoculated with Streptococcus mutans (S.M. group), Porphyromonas endodontalis (P.E.group), or only sterile cotton (control group). After 1, 2, and 5 days, mandibular incisors were extracted and the pulptissues were extirpated. The expressions of IL-2 recepters (CD25) and ICAM-1 (CD-54) on CD4+ and CD8+ cells in the pulps were determined using a flow cytometer, and the concentration of IL-2, IFN-γ, and IL-4 was measured by enzyme-linked immunosorbent assay. The results were as follows; 1. In the S.M.group. CD4+ cells were more increased at 2nd day than 1st day and in the P.E.group, CD8+ cells were more increased at 2nd day than 1st day. 2. The percentages of CD4+, CD4+25+ and CD4_54+ cells were decreased in the pulp tissues at 5th day after irritation in all groups. 3. The ratios of CD4+/CD8+, CD4+/CD4+25+ and CD4+/CD4+54+ in the pulps at 2nd day after irritation by P.endodontalis were significantly lower than the other groups. 4. The higher concentrations of IFN-γ than IL-4 in the pulps at 2nd day after irritation by P.endodontalis showed that T helper 1 reaction were predominant in the early stage of the pulpal in flammation induced by P.endodontalis. 5. The higher concentrations of IL-4 than IFN-γ in the pulps at 1st day and 5th day after irritation by S.mutans were measured but the differences were not significant.

요양급여 적정성 평가체계 혁신 중장기 계획

김상지,전숙경,이창원,정영애,안재영,안유미,권아영,임상희,최정남,윤미선,변의형,조미현 건강보험심사평가원 2021 HIRA RESEARCH Vol.1 No.2

地黃의 품질평가

김남재,정은아,김희정,심상범,김종우 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

The dried roots of Rehmannia glutinosa(RG) have been used in the traditional medicine for treatment of diabetes, fever and dysuria, etc. In order to investigate the quality evaluation of the dried roots of RG, we conducted the physico-chemical and biological evaluation method. The amount of catalpol from commercial samples is very diverse about 0.00~3.89% by using HPLC method, because it is easily decomposed by processing of RG. So, we should try to identify the correlation with the contents of catalpol and biological activities of RG. We chose 3 samples which were a wide difference of catalpol contents between each sample(Sample-I; 3.4%, Sample-II; 2.8%, Sample-III; 0.05%). Sample-I and Sample-II were found to be more effective than Sample-III on the DPPH free radical scavenging effect and inhibitory effect on H₂O₂-catalyzed lipid peroxidation in rat liver in vitro. And, Sample-I and Sample-II exhibited more significant effects than Sample-III on accelerating actions of the small and large intestinal transport, and diuretic action in mice. So, it is suggested that the quantitative determination of catalpol should be required for the standardization of the dried roots of RG.

톨루엔 노출 근로자에서 요중마뇨산 배설농도로 평가한 호흡보호구 착용효과에 관한 연구

김범석,박정일,임현우,김형아,오상용 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : 보호구 착용 효과에 대한 실제적, 구체적자료를 제시함으로서 예방목적의 보호구 사용에 대한 근로자들의 인식을 제고시키기 위함이다. 방법 : 서울시내에 소재한 일부 그라비아 인쇄소에서 톨루엔이 함유된 잉크 및 희석제를 취급하는근로자 26명을 대상으로 본 연구를 수행하였다. 유기가스용 방독마스크 미착용 상태와 유기가스용 방독마스크 착용후 작업환경 중 톨루엔 개인노출농도와 요중 마뇨산 시간별 농도를 측정, 비교하였다. 결과 : 그라비아 인쇄소의 공기중 톨루엔 개인노출농도는 유기가스용 방독마스크 미착용일과 착용일에서 각각 147.52+57.34 ppm 및 134.55+52.44ppm으로 통계학적으로 유의한 차이는 없었다. 방독마스크 미착용일파 착몽일의 작업종료 후 요중 마뇨산 농도의 기하평균값은 각각 1.5) 10.33:1 g/L 및0.49(0.14) 하였으며 두 일간에 유의한 차이를 보였단. 방독마스크 미착용일에서 요중 마뇨산 농도는 근무시작 4시간 후(오후 작업시작전, 13:00)부터 유의하게 증가하기 시작하였으며, 착용일에서는 근무종료시까지 유의한 증가를 보이지 않았다. 유기가스용 방독마스크 착용 효과를 톨루엔 대사산물인 요중마뇨산 농도로 평가하면 착용시 농도가 미착용시에비하여 89.3% 감소하였다. 보호구 미착용일에 있어서 공기중 톨루엔 개인노출농도와 요중 마뇨산 농도는 유의한 상관성을 나타났으며 회귀방정식은 Y(요중 마뇨산, g/L) =0. OO7x (공기중 톨루엔, ppm)+0.665로 계산되었다. 결론 : Fit Test등 올바른 보호구 착용 교육을 통한 전 작업시간에 걸친 유기가스용 방독마스크 보호구 착용은 직업적인 톨루엔 노출의 호흡기 흡수를거의 대부분 차단하였다. Objectives : This study was carried out in order to raise workers' recognition of the effects of respirator use by providing concrete and practical data. Methods : Twenty-six workers who dealt with toluene based ink and diluents at a gravure printing office in Seoul were investigated. The toluene exposure level and urinary hippuric acid level were monitored under respirator non-wearing (RNW) and under respiratory wearing (RW) conditions. Results : The mean concentrations of toluene exposed to each worker through the air of gravure printing office were 147.52±57.34 and 134.55±52.44 ppm on respirator non-wearing day and respirator wearing day, respectively. There was no significant difference in toluene exposure concentration for the two days. The mean concentration of urinary hippuric acid in RNW and RW groups were 1.51 (0.53) g/L and 0.49 (0.14) g/L, respectively, as measured at the end of the workday. There was a significant difference seen in urinary hippuric acid concentration between the two days. The urinary hippuric acid concentration began to increase at 4 hours after the start of the workday (13:00) in RNW. However, there was no significant increase until the end of the workday in the case of RW. The urinary hippuric acid concentration in RW reduced 89.3% as compared with the concentration seen in RNW. There was a significant correlation between the toluene concentration and the urinary hippuric acid concentration in RNW. The regression equation was Y (urinary hippuric acid concentration, g/L) = 0.007 ×χ(toluene concentration in the air, ppm) + 0.665. Conclusions : Our results indicate that the respirator intercepted most toluene that may have been absorbed Into the respiratory organs, and suggested that properly wearing a respiratory such as wearing the respirator during the entire workday and performing a proper fit test played an important role in the protection from toluene exposure

텔레비전 브라운관 생산업체 남자 근거리 검사작업자에서 시력, 눈물분비기능의 변화

김성아,천병렬,김상우,정상재,이광자 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : 장기간의 근거리검사작업이 굴절력 및 눈물분비량의 감소를 초래하는지를 관찰하고자 3년간추적 연구를 시행하였다. 방법 : 구미소재 일개 TV브라운관 제조공작의 미세한 이상여부를 확인하는 검사작업에 종사하는 남자 근로자 396명 중 정시안, 눈물분비기능이 정상, 40세 미만이며 3년간 추적가능했던 65명을 대상으로 하였다. 시력, 색신 검사 외에 자동굴절력검사, 누액분비검사, 안증상, 근무기간, 실제 검사작업을 수행하는 시간, 일상생활중 TV시청 및 VDT사용시간,작업환경에 대한 불편감, 안경착용여부 등에 대한 설문조사를 시행하였다. 이중 누액분비검사는 쉬르머 I검사로써 1996년과 1998년에만 실시되었으며, 시력및 누액분비기능의 변화가 안증상과 관련이 있는지를 보기 위한 설문조사는 1999년에 시행되었다. 결과 : 32개월간의 구면굴절력의 변화량은 좌우안모두 0.18D(diopter)였으며, 년간 변화량은 0.068D/yr로서 근시화되는 방향으로 진행하였다 20개월간의 눈물의 변화량은 좌안이 6.57 mm/s min, 우안이 6.40 mm/5 min만큼 감소하였다. 30세 이하 연령군과 2년 미만 근무군에서 0.5 D 이상 감소한 빈도가 높았으나 유의한 차이는 없었으며, 조명, 소음,공기에 대한 주관적인 상태와 작업시간외 영상화면사용시간에 따른 차이도 없었다 안불편감의 호소율은 52.3 %이었고 굴절력의 변화, 나안시력의 변화, 눈물분비변화량에 따른 차이는 없었다. 연령, 근무기간과도 관계가 없었고, 조명, 공기, 소음에 대한주관적인 상태에 따른 차이도 없었으나 작업시간외영상화면사용시간이 4시간 이상에서 4시간 미만에 비해 유의하게 높았다. 구면굴절력, 나안시력 및 눈물분비 변화량, 20개월 후의 눈물분비상태, 나이,근무기간, 불량한 조명, 일상생활중 VDT 혹은 TV시청을 독립변수로 하고 안불편감여부를 종속변수로하여 로지스틱 회귀분석을 실시하였다. 유의한 변수는 작업시간외 영상화면의 사용시간으로 4시간 이상인 군이 4시간 미만인 군이 비해 비차비가 10.5(95% 신뢰구간 1. S~73.9)이었다. 결론 : 근거리 검사작업자에서 굴절력 및 눈물분비의 저하가 관찰되었으며, 그 방향은 근시화 및 건성안의 진행방향이었으나, 눈물분비의 저하는 유의한 정도는 아니었고, 근거리검사작업으로 인한 부가적인 근시화의 영향은 관찰되지 않았다. 근거리작업자의 안건강관리측면에서 시력뿐만 아니라, 눈물분비기능, 눈물층의 상태 등을 포함한 안건강프로그램이 필요하다. Objectives : The aim of this field-based longitudinal study was to investigate the effects of near-work on lacrimation and visual function, particularly refractive power. Methods : Our study tracked sixty five male workers for about three years by means of ophthalmologic examinations and questionnaires, to collect data including eye symptoms and subjective work environmental factors. Ophthalmic examinations included visual acuity, Shirmer I test, and autorefractometry. In the first year, the inclusion criteria were ages less than 40 years, no history of ophthalmic diseases, emmetropia (-1.0 ≤spherical refractive power〈 1.0) and normal lacrimation. Results : Over a period of 32 months, spherical equivalents were decreased as much as 0.18D (diopter) for LE(left eye) and 0.18D for RE (right eye). Lacrimation by Shirmer's I test during 20 months were decreased as much as 6.57 mm/5min for LE, and 6.40 mm/5min for RE. Although more myopic-changed workers demonstrated young age (〈30 years) and short work duration (〈2 years), there was no significance to this correlation. Additionally, subjective work environmental factors such as poor illumination, noise, uncomfortable air and daily use of VDT and/or TV were shown to have no significant effect. However, as for eye discomfort, which was reconstructed from several dry eye symptoms, the daily use of VBT and/or TV was a significant variable. According to a logistic regression analysis concerning the effects of refractive power, lacrimation, work duration, poor illumination, and daily use of VDT and/or TV on eye discomfort, only daily use of VDT and/or TV greater than 4 hours displayed OR of 10.5. Conclusions : Myopic changes due to near work were not observed, however lacrimal function was changed in workers. These results suggest that we should consider various factors such as lacrimation, tear film and refraction as well as visual acuity in order to establish an eye care program among near-work performing employees.

KOSDIC 포맷의 응용수준별 활용모델 개발 : KOSDIC-XML의 개발 제안을 중심으로 Proposing the Development of KOSDIC-XML

김성아,윤기병,이명식,김성식 대한건축학회 2004 대한건축학회논문집 Vol.20 No.4

This study proposes a methodological framework for extending the KOSDIC format, which has been developed as a standard for construction drawing file exchange. The Ministry of Construction and Transportation, in cooperation with the KICT(Korea Institute of Construction Technology), has recently finished the development of the KOSDIC 1.0, and is now seeking for strategic application scenarios in order to disseminate the KOSDIC format throughout the field works as well as the government institutes. The basic idea is that the KOSDIC format may not be well accepted in favor of legacy CAD systems unless otherwise clear benefits are experienced. Thus, we need first to define the next levels of KOSDIC development based on technical requirement and advances, second, to provide a progressive operation framework which extends the KOSDIC functionalities. Through the investigation of similar research efforts and by applying recent advances in Information Technology area, the authors have formulated futuristic application scenarios of KOSDIC format. Among the suggested methods, this paper presents the proposal of KOSDIC-XML. The KOSDIC-XML is an XML based application framework which extends the KOSDIC format by integrating various web technologies. They include channel based XML technology, Webservice framework, and distributed computing. The result of the research will be used for a theoretical framework KOSDIC-XML schema and its prorotype applications at the next phase of this research.