2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

교정용 고무탄성재료의 생역학적 성질에 관한 연구

송현섭,김상철 대한치과교정학회 1991 대한치과교정학회지 Vol.21 No.3

The purpose of this study was to investigate and compare the biomechanical properties of orthodontic rubber elastic materials. Latex bands, nylon-covered elastic threads and polyurethane-based elastic modules, delivering 205 ±10 grams force at 30mm stretching state were selected and stored separately in 3 environments-air(22±3℃), distilled water(37±1℃), or natural saliva(37±1℃). And, the amount of remaining force and permanent elongation of each sample were measured on Instron at interval of 1 hour, 6 hours, 12 hours, 24 hours, 1 week, and 2 weeks. So the data derived were analyzed statistically. The results were as follows; 1.Force decay and permanent elongation of all materials increased with time lapsed; elastic module, latex band and nylon-covered elastic thread in that order of the amount of force decay; elastic module, elastic thread, latex band in that order of the amount of permanent elongation. 2.Among environmental conditions,force decay and permanent elongation in natural saliva, most increased, and those in air, least in increased. 3.There was a negative correlation between force decay and permanent elongation. 4.Force decay and permanent elongation were most affected by the material itself, time and environments in That order. 5.After 24 hours in saliva, the percentage of remaining force in elastic module was 51,9%(107.37grams); in latex band, 83.2%(172.62grams); in elastic thread, 85.0%(179.25grams). After 2 weeks in saliva, the percentage of remaining force in elastic module was 42.9%(88.75grams);in latex band, 74.5%(154.50grams); in elastic thread, 77.6%(163.75grams).

다핵균 및 단핵균으로부터 고protease 생산균주의 Screening

송상호,임현수,최명락,유은정,김성영 여수대학교 1998 論文集 Vol.13 No.2

4 multinucleate and 7 mononuclear fungi were investigated for screening of high protease productive strains. The protease activity of mononuclear strains was generally greater than that of multinucleate strains. For acid proteinase, Aspergillus awamori AOK 1007 and Asp. oryzae shoyu 2 as mononuclear strains were selected in glucose-polypeptnoe medium. For acid carboxypeptidase, two mononuclear strains were screened as Asp. awamori AOK 1007 and Asp. usamii mut. shirousami AOK 1011 in glusose-sodium glutanate medium. In this result, mononuclear fungi appeared higher protease production than that of multinuclear fungi. So, mononuclear fungi may gave many merits to improve protease activity by using of mutation or cell fusion technology.

두부 외상 환자의 고혈당과 예후와의 상관관계

현석천,이종안,박준석,박상문,김갑득,장인성,김승열,송화식 대한응급의학회 1996 대한응급의학회지 Vol.7 No.2

Severe head injury is associated with a stress response that includes hyperglycemia, which has been shown to worse outcome during cerebral ischemia. To better define the relationship between head injury and hyperglycemia, admission glucose level were analyzed in 150 head injured patients from January 1995 to December 1995. Our retrospective study demonstrated a higher glucose level in patients with low Glasgow Coma Scale(GCS) score, especially at 3-5 GCS score, compared to those with high GCS scores. Also a higher glucose level was noted in patients with vegetative state and dead than in those with good recovery and moderate disability. Hyperglycemia(serum glucose level≥200mg%) was associated with decreased level of consciousness and a poor outcome. We conclude that admission hyperglycemia is a significant indicator of severity of injury(p<0.001), but not significant predictor outcome from head injury. After controlling for the influence of the GCS score, glucose levels do not have an independent effect on outcome.

트라이애슬러의 비타민Q 섭취가 호흡순환기능 및 항산화 효소활성에 미치는 영향

현송자,김귀백,박상일,석혜경 東亞大學校附設스포츠科學硏究所 2002 스포츠科學硏究論文集 Vol.20 No.-

The purpose of this present study was to investigate the effect of VitaminQ supplementation on antioxidant enzyme activities and cardiorespiratory function following prolonged exercise in trained triathlers. Male 14 healthy college students of trained triathlers participated in exercise sessions. The subjects were divided into 2 groups, as Non-supplement(NS) or VitaminQ supplement(VQ) groups. VitaminQ subjects were participated in two exercise sessions: an initial prolonged exercise(swim 750m, running 10㎞) and 70%V O2max treadmill running exercise. The Non-supplement group fed normal diet. VitaminQ group adminstated 90㎎/day for 4weeks. Venous blood samples were drown from the forearm antecubital vein pre-supplement, pre-exercise and immediately post-exercise. The results of this study can be summarized as follow: First, the SOD activity of RBC was not changed, while the GPx, GR or GR/GPx activies of Hb were significantly increased following prolonged exercise with CoQ10 supplementation. Second, 70%VO2max treadmill running exercise increased significantly the V O2max and VE, but the heart rate significantly decreased. In conclusion, the present results clearly show that the VitaminQ supplementation gave rise to increase the GPx or GR activies and to improve the cardiorespiratory function.

악안면 계측을 위한 3차원 컴퓨터 단층촬영시의 정확성과 신뢰도 평가

송재철,장현중,이상한 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.5

The purpose of this study was to evaluate the reliability and accuracy of measurements obtained from 3- dimensional reconstructions of computerized tomography(CT) scans. The CT scans of six human dry skulls were 3-dimensional image reconstructed, and the cephalometric landmarks were recorded as X, Y, Z coordinates by two observers. Computerized cephalometrics were performed on the frontal and lateral cephalograms. Intraobserver and interobserver variations were calculated for each method and tested for statistical significance. And measurements taken from 3-dimensional CT were compared with corresponding manual measurements taken from the dry skulls. The results were as follow: 1.Intra-observer standard deviation of landmarks of the 3-dimensional CT by two observers were 0.49mm and 0.37mm in X axis, 0.26mm and 0.20mm in Y axis, and 0.29mm and 0.32mm in Z axis. There were highly significant, and large correlation between two observers(p<0.01). 2.Intra-observer standard deviation of landmarks of the frontal and lateral cephalogram by two observers were less than 1mm in all landmarks, but in the frontal cephalogram, standard deviation and range of right and left orbitale was larger than 3-dimensional CT about two times. There were highly significant, and large correlation between two observers(p<0.01) except for ROr in X axis of frontal cephalogram and Po of lateral cephalogram. 3.In comparison with manual measurements, 3-dimensional CT measurements increased 0.37mm and decreased 0.46mm in maximum and the mean difference between two methods was 0.29mm. There were highly significant, and large correlation between two methods(p<0.01). This study showed that landmarks recorded from 3-D CT reproduced very accuratly and there were little differences between 3-D CT and manual measurement. Therefore 3-D CT is very accurate and reliable method for measurement of maxillofacial region.

有限要素法을 이용한 過壓密粘土의 壓密沈下豫測

현상락,류제천,김송만,박춘수 충남대학교 산업기술연구소 2002 산업기술연구논문집 Vol.17 No.1

Consolidation is the time-dependent settlement of soils resulting from the expulsion of water from the soil pores. When a saturated compressible clay layer is subjected to a stress increase, consolidation settlement occurs greatly. Because the hydraulic conductivity of clay is significantly small, the excess pore water pressure generated by loading gradually dissipates over a long period. The settlement caused by consolidation in clay may be several times greater than the immediate settlement. A number of researches are carried out to predict the consolidation behavior in field, however, most of researches show the discrepancies between the prediction and the field settlement data. Therefore, the estimation of consolidation rate is one of the important factors in the construcion on soft clayey deposits. In this paper, laboratory tests have analyzed to apply accurately the soil parameters that executed the plan of stage construction. This study analyzes consolidation behavior of overconsolidated clay with two-dimensional consolidation analysis program by use of the numerical method. By using this program, the time dependent consolidation behavior of soft deposits can be analyzed appropriately. Elastic and elastic-plastic finite element analysis are compared with Terzaghi's theory of one-dimensional consolidation.

Methylene blue와 Sodium Bis(2-ethl hexyl) sulfosuccinate 사이의 용매효과

송기동,김성현 조선대학교 기초과학연구소 1992 自然科學硏究 Vol.15 No.1

The metachromatic behavior of methylene blue(MB) with sodium bis (2-ethyl hexyl) sulfosuccinate(AOT or Aeorsol, OT), reversed micelle has been studied by absorption spectra viscosity, and refractive index. The effect of organic solvents(methanol, ethanol, isopropyl alcohol, and ethylene glycol) on the spectra has also been investigated. The critical micelle concentration (CMC) values of MB-AOT system are found to be 2.0mM and 2.1m M by means of the method of measurement of spectrophotometer and viscosity, respectively.

극미세 입자 Aluminosilicate 계 졸의 합성 및 응용 : (Ⅰ) SiO₂및 γ-AIOOH졸의 제조 및 케릭터라이제이션

현상훈,송재권,강범석 연세대학교 산업기술연구소 1993 논문집 Vol.25 No.1

Nanoparticulate silica sols could be synthesized by an interfacial hydrolysis reaction between TEOS and high alkaline water. The silica sols were extremely stable at pH of 8 and their average particle sizes were less than 3 nm, while very unstable between 4 and 5 of pH. The sol particles grew up to about 10 nm within 1 day in the region of pH less than 7. It was found that the silica sol with pH less than 2 was stabilized without further growing after 1 day-aging. The particle size of γ-AlOOH sols synthesized via the modified Yoldas-method could be controlled according to the mole ratio of nitric acid/aluminium tri-sec-butoxide(0.07∼1.0). The stable γ-AlOOH sol with the average particle size of 45 nm, which was prepared using the mole ratio of 0.07, was estimated to be suitable for coating reproducible γ-AlOOH membrane layers with the high specific surface area.

공간구조 분석에 있어서 GIS기술을 이용한 건축물 [근접성]의 정량화 방법에 관한 연구

송병호,정명진,배상현 조선대학교 기초과학연구소 2003 自然科學硏究 Vol.26 No.-

In this paper quantitative method about buildings and land use pattern is discussed by distance among near buildings(DNB). We considered the worth of DNB as urban planning method following two points : 1) DNB average and Building area ratio were pretty independent each other. That is to say DNB did not show density but arrangement. 2)DNB would express not just near buildings pattern and small vacant apace but also lot-street patterns. We analyzed following three steps. Firstly, we figured a calculating algorithm, secondly we analyzed characteristics of 4 index about DNB and statistical relations of DNB to building area ratio by each lot unit, thirdly we discussed combination patterns of DNB average and urban space pattern. The aim of this study is to theoretically develop a simple yet efficient system of data generation for urban planning and spatial structure analysis based on the application of GIS technique.